{"id":"https://openalex.org/W2082066720","doi":"https://doi.org/10.1002/j.1552-4604.1994.tb02033.x","title":"Digoxin Disposition in Elderly Humans with Hypochlorhydria","display_name":"Digoxin Disposition in Elderly Humans with Hypochlorhydria","publication_year":1994,"publication_date":"1994-07-01","ids":{"openalex":"https://openalex.org/W2082066720","doi":"https://doi.org/10.1002/j.1552-4604.1994.tb02033.x","mag":"2082066720","pmid":"https://pubmed.ncbi.nlm.nih.gov/7929867"},"language":"en","primary_location":{"id":"doi:10.1002/j.1552-4604.1994.tb02033.x","doi":"https://doi.org/10.1002/j.1552-4604.1994.tb02033.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1552-4604.1994.tb02033.x","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"James Hui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Hui","raw_affiliation_strings":["College of Pharmacy, Ohio State University, Columbus 43210","Colleges of Pharmacy, The Ohio State University, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Ohio State University, Columbus 43210","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Colleges of Pharmacy, The Ohio State University, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017825821","display_name":"Douglas R. Geraets","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas R. Geraets","raw_affiliation_strings":["Colleges of Pharmacy, The Ohio State University, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colleges of Pharmacy, The Ohio State University, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110533065","display_name":"Appavu Chandrasekaran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Appavu Chandrasekaran","raw_affiliation_strings":["Colleges of Pharmacy, The Ohio State University, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colleges of Pharmacy, The Ohio State University, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053619865","display_name":"Yow\u2010Ming C. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yow\u2010Ming C. Wang","raw_affiliation_strings":["Colleges of Pharmacy, The Ohio State University, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colleges of Pharmacy, The Ohio State University, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103372982","display_name":"James H. Caldwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James H. Caldwell","raw_affiliation_strings":["Medicine, The Ohio State University, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, The Ohio State University, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Larry W. Robertson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry W. Robertson","raw_affiliation_strings":["Colleges of Pharmacy, The Ohio State University, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colleges of Pharmacy, The Ohio State University, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016989127","display_name":"Roy L. Donnerberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy L. Donnerberg","raw_affiliation_strings":["Medicine, The Ohio State University, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, The Ohio State University, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032408554","display_name":"Richard H. Reuning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard H. Reuning","raw_affiliation_strings":["Colleges of Pharmacy, The Ohio State University, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colleges of Pharmacy, The Ohio State University, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032408554"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.7052,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.71066191,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"7","first_page":"734","last_page":"741"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.05909999832510948,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/digoxin","display_name":"digoxin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hypochlorhydria","display_name":"hypochlorhydria","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-disposition","display_name":"drug disposition","score":0.6330000162124634},{"id":"https://openalex.org/keywords/gastric-acid","display_name":"gastric acid","score":0.4779999852180481},{"id":"https://openalex.org/keywords/intestinal-metabolism","display_name":"intestinal metabolism","score":0.8029999732971191},{"id":"https://openalex.org/keywords/bacterial-reduction","display_name":"bacterial reduction","score":0.8029999732971191},{"id":"https://openalex.org/keywords/lactone-reduction","display_name":"lactone reduction","score":0.753000020980835},{"id":"https://openalex.org/keywords/fecal-excretion","display_name":"fecal excretion","score":0.859000027179718},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.878000020980835},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6570000052452087},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2777707475","wikidata":"https://www.wikidata.org/wiki/Q422222","display_name":"Digoxin","level":3,"score":0.7736344933509827},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.7012165784835815},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6947582960128784},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.6666112542152405},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.61005699634552},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5692246556282043},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4841897785663605},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46337762475013733},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.4271267056465149},{"id":"https://openalex.org/C5140985","wikidata":"https://www.wikidata.org/wiki/Q483866","display_name":"Anaerobic exercise","level":2,"score":0.4257052540779114},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.4204901456832886},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39044997096061707},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3634948432445526},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23108357191085815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21240156888961792},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.18599268794059753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18005982041358948},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.14455276727676392},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000126","descriptor_name":"Achlorhydria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004077","descriptor_name":"Digoxin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004077","descriptor_name":"Digoxin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004077","descriptor_name":"Digoxin","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005744","descriptor_name":"Gastric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/j.1552-4604.1994.tb02033.x","doi":"https://doi.org/10.1002/j.1552-4604.1994.tb02033.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1552-4604.1994.tb02033.x","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:7929867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7929867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2124107224","display_name":null,"funder_award_id":"RR 34","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4874806135","display_name":null,"funder_award_id":"NIA RO1-AG04119","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8787116854","display_name":"EFFECT OF AGING AND GI DISEASE ON DIGOXIN METABOLISM","funder_award_id":"R01AG004119","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W5002502","https://openalex.org/W1506883618","https://openalex.org/W1556847348","https://openalex.org/W1628114825","https://openalex.org/W1759446768","https://openalex.org/W1980795899","https://openalex.org/W1988776641","https://openalex.org/W1989918976","https://openalex.org/W2014089366","https://openalex.org/W2014640778","https://openalex.org/W2035055997","https://openalex.org/W2039610785","https://openalex.org/W2046079958","https://openalex.org/W2050815455","https://openalex.org/W2054810699","https://openalex.org/W2060193668","https://openalex.org/W2062258917","https://openalex.org/W2065057616","https://openalex.org/W2066873235","https://openalex.org/W2078005075","https://openalex.org/W2083212229","https://openalex.org/W2092657305","https://openalex.org/W2886334101"],"related_works":["https://openalex.org/W2418221204","https://openalex.org/W2054810699","https://openalex.org/W2092657305","https://openalex.org/W2062258917","https://openalex.org/W2237294996","https://openalex.org/W2336041220","https://openalex.org/W1991845555","https://openalex.org/W252342817","https://openalex.org/W1995462022","https://openalex.org/W1490429700"],"abstract_inverted_index":{"Digoxin":[0,145],"(D3)":[1],"metabolism":[2,127],"is":[3,203,208],"partially":[4],"mediated":[5],"by":[6,75,121,210],"the":[7,21,60,87,153,217],"gastrointestinal":[8],"tract":[9],"via":[10],"acid":[11,123],"hydrolysis":[12,118],"of":[13,20,79,86,97,119,139,152,178,181,186,190,216],"digitoxose":[14],"sugar":[15],"moieties":[16],"and":[17,36,51,54,71,114,124,142,156,212],"bacterial":[18,179],"reduction":[19,180],"lactone.":[22],"The":[23],"hypothesis":[24],"that":[25,205,213],"hypochlorhydria":[26],"influences":[27],"digoxin":[28],"disposition":[29,207],"was":[30,134,146,157,168],"tested":[31],"in":[32,81,89,93,99,128,148,160,170,175,187,199],"six":[33],"normochlorhydric":[34],"(NC)":[35],"four":[37],"hypochlorhydric":[38,173],"(HC)":[39],"subjects.":[40,201],"D3":[41,70,80,98,120,133,182,206],"tablets":[42],"were":[43,57,67,108,183,196],"administered":[44],"daily":[45],"for":[46,69],"19":[47],"to":[48,91,104,136],"28":[49],"days,":[50],"quantitative":[52],"urine":[53,82],"fecal":[55,154],"samples":[56],"collected":[58],"over":[59],"last":[61],"3":[62],"days":[63],"(steady":[64],"state).":[65],"Samples":[66],"analyzed":[68],"its":[72],"extractable":[73],"metabolites":[74,195],"fluorescence-derivatization":[76],"HPLC.":[77],"Excretion":[78],"increased":[83,125],"from":[84,102],"37%":[85],"dose":[88],"NC":[90],"46%":[92],"HC,":[94],"whereas":[95],"excretion":[96,189],"feces":[100,141],"decreased":[101,117],"29":[103],"14%.":[105],"These":[106],"changes":[107],"statistically":[109],"significant":[110],"(P":[111],"<":[112],".05)":[113],"consistent":[115],"with":[116],"stomach":[122],"intestinal":[126],"HC.":[129],"In":[130],"each":[131],"subject,":[132],"added":[135],"anaerobic":[137],"cultures":[138],"both":[140],"jejunal":[143,162],"fluid.":[144],"reduced":[147,159,191,194],"all":[149],"but":[150],"two":[151,172],"incubates,":[155],"not":[158,184,197],"any":[161,200],"fluid":[163],"incubates.":[164],"Because":[165],"dihydrodigoxin":[166],"(DHD3)":[167],"found":[169,198],"only":[171],"subjects,":[174],"vitro":[176],"measures":[177],"predictive":[185],"vivo":[188],"metabolites.":[192],"Sugar-hydrolyzed,":[193],"It":[202],"concluded":[204],"altered":[209],"hypochlorhydria,":[211],"an":[214],"understanding":[215],"metabolic":[218],"mechanisms":[219],"requires":[220],"further":[221],"study.":[222]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
