{"id":"https://openalex.org/W2082046153","doi":"https://doi.org/10.1080/15287398809531118","title":"Calcium transport, thiol status, and hepatotoxicity followingN\u2010nitrosodimethylamine exposure in mice","display_name":"Calcium transport, thiol status, and hepatotoxicity followingN\u2010nitrosodimethylamine exposure in mice","publication_year":1988,"publication_date":"1988-03-01","ids":{"openalex":"https://openalex.org/W2082046153","doi":"https://doi.org/10.1080/15287398809531118","mag":"2082046153","pmid":"https://pubmed.ncbi.nlm.nih.gov/3351980"},"language":"en","primary_location":{"id":"doi:10.1080/15287398809531118","doi":"https://doi.org/10.1080/15287398809531118","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287398809531118","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004030822","display_name":"Fred A. Reitman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. A. Reitman","raw_affiliation_strings":["Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267-0056"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267-0056","institution_ids":["https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072813910","display_name":"Marc L. Berger","orcid":"https://orcid.org/0000-0003-4322-3637","observed_orcids":["https://orcid.org/0000-0003-4322-3637"]},"institutions":[{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. L. Berger","raw_affiliation_strings":["Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038728826","display_name":"Daniel J. Minnema","orcid":"https://orcid.org/0000-0002-0101-8646","observed_orcids":["https://orcid.org/0000-0002-0101-8646"]},"institutions":[{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. J. Minnema","raw_affiliation_strings":["Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I92156820"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025906356","display_name":"Howard G. Shertzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. G. Shertzer","raw_affiliation_strings":["Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio, 45267\u20130056"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio, 45267\u20130056","institution_ids":["https://openalex.org/I92156820"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I92156820"],"apc_list":null,"apc_paid":null,"fwci":1.1779,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.76530023,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"23","issue":"3","first_page":"321","last_page":"331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-nitrosodimethylamine","display_name":"N-nitrosodimethylamine","score":1.0},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9629999995231628},{"id":"https://openalex.org/keywords/thiol-depletion","display_name":"thiol depletion","score":0.8289999961853027},{"id":"https://openalex.org/keywords/protein-sulfhydryls","display_name":"protein sulfhydryls","score":0.8949999809265137},{"id":"https://openalex.org/keywords/calcium-transport","display_name":"calcium transport","score":0.8999999761581421},{"id":"https://openalex.org/keywords/calcium-uptake-inhibition","display_name":"calcium uptake inhibition","score":0.7680000066757202},{"id":"https://openalex.org/keywords/reactive-metabolites","display_name":"reactive metabolites","score":0.8059999942779541},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.9229999780654907},{"id":"https://openalex.org/keywords/liver-subcellular-fractions","display_name":"liver subcellular fractions","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8270263671875},{"id":"https://openalex.org/C2777359374","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"Carbon tetrachloride","level":2,"score":0.7652598023414612},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.7269593477249146},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7241677045822144},{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.6878628730773926},{"id":"https://openalex.org/C2776946247","wikidata":"https://www.wikidata.org/wiki/Q410597","display_name":"Bromobenzene","level":3,"score":0.6778679490089417},{"id":"https://openalex.org/C2780750100","wikidata":"https://www.wikidata.org/wiki/Q409367","display_name":"N-Nitrosodimethylamine","level":3,"score":0.6478351950645447},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6388977766036987},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.47170329093933105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4624585807323456},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.44883817434310913},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40052610635757446},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.26312869787216187},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1791917383670807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.108266681432724},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004128","descriptor_name":"Dimethylnitrosamine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/15287398809531118","doi":"https://doi.org/10.1080/15287398809531118","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287398809531118","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health","raw_type":"journal-article"},{"id":"pmid:3351980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3351980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of toxicology and environmental health","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2790776122","display_name":"CHEMOPROTECTION FROM N-NITROSAMINES BY DIETARY INDOLE","funder_award_id":"R01CA038277","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G524041225","display_name":null,"funder_award_id":"ES07073","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6221672225","display_name":"PROTECTION FROM ENVIRONMENTAL TOXINS/MUTAGENS BY INDOLES","funder_award_id":"R01ES003373","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W125994795","https://openalex.org/W1427746131","https://openalex.org/W1539133138","https://openalex.org/W1616183675","https://openalex.org/W1627867690","https://openalex.org/W1947419963","https://openalex.org/W1963672399","https://openalex.org/W1971081936","https://openalex.org/W1999051928","https://openalex.org/W1999349095","https://openalex.org/W2009931729","https://openalex.org/W2011713385","https://openalex.org/W2013863845","https://openalex.org/W2019436085","https://openalex.org/W2051670539","https://openalex.org/W2061052410","https://openalex.org/W2063576996","https://openalex.org/W2065997722","https://openalex.org/W2069391035","https://openalex.org/W2071899992","https://openalex.org/W2105262783","https://openalex.org/W2233447257","https://openalex.org/W2236512810","https://openalex.org/W2260383328","https://openalex.org/W2263549022","https://openalex.org/W2337492705","https://openalex.org/W2413751853","https://openalex.org/W2432055397"],"related_works":["https://openalex.org/W1990840416","https://openalex.org/W1968803660","https://openalex.org/W1983616439","https://openalex.org/W2479111616","https://openalex.org/W2098968367","https://openalex.org/W2463685192","https://openalex.org/W2064864656","https://openalex.org/W2258346247","https://openalex.org/W2003636267","https://openalex.org/W2060798973"],"abstract_inverted_index":{"The":[0],"hepatotoxicant":[1],"N-nitrosodimethylamine":[2],"(NDMA)":[3],"is":[4,13,25,52,185],"presumed":[5],"to":[6,18,82],"exert":[7],"toxicity":[8,114,184],"through":[9,188],"reactive":[10,189],"metabolites.":[11,190],"NDMA":[12,51,165],"similar":[14],"in":[15,62,70,104,141],"this":[16],"respect":[17],"numerous":[19],"other":[20,175],"hepatotoxicants,":[21],"for":[22,50,182],"which":[23,183],"hepatotoxicity":[24,49,166],"also":[26,116,186],"associated":[27],"with":[28],"a":[29,148,172],"rapid":[30,139],"depletion":[31,56,94,103],"of":[32,40,59,85,95,121,164,171,174],"soluble":[33],"and/or":[34,57],"protein":[35,101],"thiols,":[36],"and":[37],"an":[38],"inhibition":[39,58,120],"calcium":[41,60,122,143],"transport":[42,61],"systems.":[43],"We":[44],"examined":[45],"the":[46,137,162],"hypothesis":[47],"that":[48,151,161,170],"preceded":[53,92,118],"by":[54,93,100,119,125,147],"thiol":[55],"isolated":[63],"liver":[64,68,96,105],"subcellular":[65],"fractions.":[66,112,131],"Centrizonal":[67],"necrosis":[69,150],"mice":[71],"was":[72,90,115,152],"evident":[73],"at":[74,78,154],"24":[75,156],"but":[76],"not":[77,91,117],"12":[79],"h":[80],"subsequent":[81],"intraperitoneal":[83],"administration":[84],"40":[86],"mg":[87],"NDMA/kg.":[88],"Hepatotoxicity":[89],"protein-free":[97],"sulfhydryls,":[98],"nor":[99],"sulfhydryl":[102],"whole":[106],"homogenate,":[107],"microsomal,":[108,126],"or":[109,128],"plasma":[110,129],"membrane":[111,130],"NDMA-mediated":[113],"uptake":[123,144],"capability":[124],"mitochondrial,":[127],"In":[132],"contrast,":[133],"carbon":[134,178],"tetrachloride":[135],"produced":[136],"expected":[138],"decrease":[140],"microsomal":[142],"capability,":[145],"followed":[146],"centrizonal":[149],"maximal":[153],"about":[155],"h.":[157],"These":[158],"studies":[159],"suggest":[160],"mechanism":[163],"may":[167],"differ":[168],"from":[169],"number":[173],"hepatotoxicants":[176],"(e.g.,":[177],"tetrachloride,":[179],"acetaminophen,":[180],"bromobenzene)":[181],"mediated":[187]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}