{"id":"https://openalex.org/W2082013458","doi":"https://doi.org/10.1073/pnas.0408422102","title":"Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium","display_name":"Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium","publication_year":2005,"publication_date":"2005-01-11","ids":{"openalex":"https://openalex.org/W2082013458","doi":"https://doi.org/10.1073/pnas.0408422102","mag":"2082013458","pmid":"https://pubmed.ncbi.nlm.nih.gov/15644448","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/545558"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0408422102","doi":"https://doi.org/10.1073/pnas.0408422102","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0408422102","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC545558","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083743508","display_name":"Ming Dan Zhao","orcid":"https://orcid.org/0000-0002-1025-8895","observed_orcids":["https://orcid.org/0000-0002-1025-8895"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Zhao","raw_affiliation_strings":["AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210121314","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083408391","display_name":"Meng Yang","orcid":"https://orcid.org/0000-0001-5630-6357","observed_orcids":["https://orcid.org/0000-0001-5630-6357"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meng Yang","raw_affiliation_strings":["AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210121314","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452145","display_name":"Xiaoming Li","orcid":"https://orcid.org/0000-0003-1795-0371","observed_orcids":["https://orcid.org/0000-0003-1795-0371","https://orcid.org/0009-0005-9675-1144","https://orcid.org/0009-0008-6865-4867","https://orcid.org/0000-0002-0431-8564"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao-Ming Li","raw_affiliation_strings":["AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210121314","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068765890","display_name":"Ping Jiang","orcid":"https://orcid.org/0000-0001-5123-5705","observed_orcids":["https://orcid.org/0000-0001-5123-5705"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping Jiang","raw_affiliation_strings":["AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210121314","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061291030","display_name":"Eugene Baranov","orcid":"https://orcid.org/0000-0003-1793-6676","observed_orcids":["https://orcid.org/0000-0003-1793-6676"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene Baranov","raw_affiliation_strings":["AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210121314","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023556030","display_name":"Shukuan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shukuan Li","raw_affiliation_strings":["AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210121314","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004722743","display_name":"Mingxu Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingxu Xu","raw_affiliation_strings":["AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210121314","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110114490","display_name":"Sheldon Penman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheldon Penman","raw_affiliation_strings":["AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220","AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210121314","https://openalex.org/I63966007"]},{"raw_affiliation_string":"AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604;","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Hoffman","raw_affiliation_strings":["AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220","AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and Department of Surgery, University of California, 200 West Arbor Drive, San Diego, CA 92103-8220","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210121314","https://openalex.org/I63966007"]},{"raw_affiliation_string":"AntiCancer, 7917 Ostrow Street, San Diego, CA 92111-3604;","institution_ids":["https://openalex.org/I4210121314"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.9992,"has_fulltext":false,"cited_by_count":488,"citation_normalized_percentile":{"value":0.99672333,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"102","issue":"3","first_page":"755","last_page":"760"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salmonella-typhimurium","display_name":"Salmonella typhimurium","score":0.8859999775886536},{"id":"https://openalex.org/keywords/bacterial-cancer-therapy","display_name":"bacterial cancer therapy","score":0.7850000262260437},{"id":"https://openalex.org/keywords/tumor-targeting-bacteria","display_name":"tumor-targeting bacteria","score":0.7820000052452087},{"id":"https://openalex.org/keywords/amino-acid-auxotrophy","display_name":"amino acid auxotrophy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.8640000224113464},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.75},{"id":"https://openalex.org/keywords/intracellular-bacterial-replication","display_name":"intracellular bacterial replication","score":0.8320000171661377},{"id":"https://openalex.org/keywords/intratumoral-injection","display_name":"intratumoral injection","score":0.6470000147819519},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.6650000214576721},{"id":"https://openalex.org/keywords/whole-body-imaging","display_name":"whole-body imaging","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.7600709199905396},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.7162728309631348},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7025483846664429},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.6996345520019531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6210214495658875},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6165174245834351},{"id":"https://openalex.org/C20950039","wikidata":"https://www.wikidata.org/wiki/Q578111","display_name":"Auxotrophy","level":4,"score":0.6019555330276489},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5435367822647095},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4517393410205841},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.435147762298584},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3906472325325012},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.22377455234527588},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16555094718933105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15016603469848633},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10872349143028259},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D001691","descriptor_name":"Biological Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.0408422102","doi":"https://doi.org/10.1073/pnas.0408422102","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0408422102","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:171090","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC545558","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:545558","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/545558","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:15644448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15644448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:171090","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC545558","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W152438524","https://openalex.org/W1249821927","https://openalex.org/W1566193276","https://openalex.org/W1595241211","https://openalex.org/W1603275927","https://openalex.org/W1682474579","https://openalex.org/W1829739203","https://openalex.org/W1844565319","https://openalex.org/W1953452243","https://openalex.org/W1975520558","https://openalex.org/W1975899736","https://openalex.org/W1984593515","https://openalex.org/W1990161819","https://openalex.org/W1994711799","https://openalex.org/W2028567355","https://openalex.org/W2029150803","https://openalex.org/W2039383456","https://openalex.org/W2042048278","https://openalex.org/W2046894146","https://openalex.org/W2073447587","https://openalex.org/W2078576368","https://openalex.org/W2108447763","https://openalex.org/W2114406100","https://openalex.org/W2115205513","https://openalex.org/W2136246490","https://openalex.org/W2143036860","https://openalex.org/W2150565980","https://openalex.org/W2169032395","https://openalex.org/W2314390305","https://openalex.org/W6600805005","https://openalex.org/W6607099389","https://openalex.org/W6703258720"],"related_works":["https://openalex.org/W1996304408","https://openalex.org/W1964065596","https://openalex.org/W2901736909","https://openalex.org/W1974548520","https://openalex.org/W2161133478","https://openalex.org/W8964198","https://openalex.org/W1988990076","https://openalex.org/W2312499055","https://openalex.org/W2600156919","https://openalex.org/W2082923627"],"abstract_inverted_index":{"Here":[0],"we":[1],"report":[2],"a":[3],"genetically":[4],"modified":[5],"bacteria":[6,32,71,108,173,195,221],"strain,":[7],"Salmonella":[8],"typhimurium":[9,39,148,203],"A1,":[10],"selected":[11],"for":[12,224,241],"anticancer":[13],"activity":[14],"in":[15,20,34,66,73,90,95,102,130,152,164,217,239],"vivo.":[16],"The":[17,120,201],"strain":[18,205],"grows":[19],"tumor":[21,110,178],"xenografts.":[22],"In":[23,65,105],"sharp":[24],"contrast,":[25],"normal":[26],"tissue":[27,52],"is":[28,41,62,216],"cleared":[29],"of":[30,76,114,233],"these":[31],"even":[33],"immunodeficient":[35],"athymic":[36],"mice.":[37,143],"S.":[38,147,202],"A1":[40,149,204],"auxotrophic":[42],"(Leu/Arg-dependent)":[43],"but":[44,159],"apparently":[45],"receives":[46],"sufficient":[47],"support":[48],"from":[49],"the":[50,69,74,96,103,107,153,165,172,177,191,194,208,234,242],"neoplastic":[51],"to":[53,162,220,230],"grow":[54],"locally.":[55],"Whether":[56],"additional":[57],"genetic":[58],"lesions":[59],"are":[60],"present":[61],"not":[63],"known.":[64],"vitro":[67],"infection,":[68],"GFP-expressing":[70],"grew":[72,206],"cytoplasm":[75],"PC-3":[77,131,166],"human":[78],"prostate":[79,132],"cancer":[80,133,225],"cells":[81,91,134],"and":[82,98,112,127,157],"caused":[83,109],"nuclear":[84],"destruction.":[85],"These":[86],"effects":[87,189],"were":[88,174,185,196,228],"visualized":[89,116],"labeled":[92,135],"with":[93,136],"GFP":[94],"nucleus":[97],"red":[99,137],"fluorescent":[100,138],"protein":[101,139],"cytoplasm.":[104],"vivo,":[106],"inhibition":[111],"regression":[113],"xenografts":[115],"by":[117,181,198],"whole-body":[118],"imaging.":[119],"bacteria,":[121],"introduced":[122],"i.v.":[123],"or":[124],"intratumorally,":[125,176],"invaded":[126],"replicated":[128],"intracellularly":[129],"grafted":[140],"into":[141],"nude":[142],"By":[144],"day":[145,182],"15,":[146],"was":[150],"undetectable":[151],"liver,":[154],"lung,":[155],"spleen,":[156],"kidney,":[158],"it":[160],"continued":[161],"proliferate":[163],"tumor,":[167,209,235],"which":[168,236],"stopped":[169],"growing.":[170],"When":[171],"injected":[175,197],"completely":[179],"regressed":[180],"20.":[183],"There":[184],"no":[186],"obvious":[187],"adverse":[188],"on":[190],"host":[192],"when":[193],"either":[199],"route.":[200],"throughout":[207],"including":[210],"viable":[211],"malignant":[212],"tissue.":[213],"This":[214],"result":[215],"marked":[218],"contrast":[219],"previously":[222],"tried":[223],"therapy":[226],"that":[227],"confined":[229],"necrotic":[231],"areas":[232],"may":[237],"account,":[238],"part,":[240],"strain's":[243],"unique":[244],"antitumor":[245],"efficacy.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":36},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":35},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
