{"id":"https://openalex.org/W2081992875","doi":"https://doi.org/10.1006/exer.1993.1008","title":"Differential Laminar Expression of Particulate and Soluble Guanylate Cyclase Genes in Rat Retina","display_name":"Differential Laminar Expression of Particulate and Soluble Guanylate Cyclase Genes in Rat Retina","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2081992875","doi":"https://doi.org/10.1006/exer.1993.1008","mag":"2081992875","pmid":"https://pubmed.ncbi.nlm.nih.gov/8094339"},"language":"en","primary_location":{"id":"doi:10.1006/exer.1993.1008","doi":"https://doi.org/10.1006/exer.1993.1008","is_oa":true,"landing_page_url":"https://doi.org/10.1006/exer.1993.1008","pdf_url":null,"source":{"id":"https://openalex.org/S129637156","display_name":"Experimental Eye Research","issn_l":"0014-4835","issn":["0014-4835","1096-0007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Eye Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1006/exer.1993.1008","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050216645","display_name":"Iqbal Ahmad","orcid":"https://orcid.org/0000-0003-1920-9835","observed_orcids":["https://orcid.org/0000-0003-1920-9835"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iqbal Ahmad","raw_affiliation_strings":["Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06510","Yale University  ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06510","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University  ;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001481519","display_name":"Colin James Barnstable","orcid":"https://orcid.org/0000-0002-7011-4068","observed_orcids":["https://orcid.org/0000-0002-7011-4068"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colin J. Barnstable","raw_affiliation_strings":["Department of Ophthalmology and Visual Science and Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, U.S.A","Yale University  ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Science and Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, U.S.A","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University  ;","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":4010,"currency":"USD","value_usd":4010},"apc_paid":{"value":4010,"currency":"USD","value_usd":4010},"fwci":4.1179,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.95305737,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"56","issue":"1","first_page":"51","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/particulate-guanylyl-cyclase","display_name":"particulate guanylate cyclase","score":0.9670000076293945},{"id":"https://openalex.org/keywords/soluble-guanylate-cyclase","display_name":"soluble guanylate cyclase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/retina","display_name":"retina","score":0.6899999976158142},{"id":"https://openalex.org/keywords/guanylyl-cyclase-a","display_name":"guanylyl cyclase-A","score":0.6539999842643738},{"id":"https://openalex.org/keywords/cgmp-signaling","display_name":"cGMP signaling","score":0.7210000157356262},{"id":"https://openalex.org/keywords/rod-photoreceptors","display_name":"rod photoreceptors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/inner-nuclear-layer","display_name":"inner nuclear layer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cdna-sequence","display_name":"cDNA sequence","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C27093228","wikidata":"https://www.wikidata.org/wiki/Q18026679","display_name":"GUCY1A3","level":5,"score":0.8593918681144714},{"id":"https://openalex.org/C117644","wikidata":"https://www.wikidata.org/wiki/Q18026682","display_name":"GUCY1B3","level":5,"score":0.8358206748962402},{"id":"https://openalex.org/C31519591","wikidata":"https://www.wikidata.org/wiki/Q18026719","display_name":"GUCY2D","level":5,"score":0.7312585711479187},{"id":"https://openalex.org/C13121076","wikidata":"https://www.wikidata.org/wiki/Q1552797","display_name":"Guanylate cyclase 2C","level":4,"score":0.6461835503578186},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.6347918510437012},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5700553059577942},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5666614770889282},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5477610230445862},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5361255407333374},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5330983996391296},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.48460516333580017},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.47359755635261536},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4476296007633209},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43230563402175903},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4107424318790436},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.2848813533782959},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/exer.1993.1008","doi":"https://doi.org/10.1006/exer.1993.1008","is_oa":true,"landing_page_url":"https://doi.org/10.1006/exer.1993.1008","pdf_url":null,"source":{"id":"https://openalex.org/S129637156","display_name":"Experimental Eye Research","issn_l":"0014-4835","issn":["0014-4835","1096-0007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Eye Research","raw_type":"journal-article"},{"id":"pmid:8094339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8094339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental eye research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1006/exer.1993.1008","doi":"https://doi.org/10.1006/exer.1993.1008","is_oa":true,"landing_page_url":"https://doi.org/10.1006/exer.1993.1008","pdf_url":null,"source":{"id":"https://openalex.org/S129637156","display_name":"Experimental Eye Research","issn_l":"0014-4835","issn":["0014-4835","1096-0007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Eye Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4091965640","display_name":null,"funder_award_id":"EY-05206","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5841967311","display_name":"IMMUNOLOGICAL ANALYSIS OF THE MAMMALIAN VISUAL SYSTEM","funder_award_id":"5r01ey005206-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6661595526","display_name":"Yale Core Grant For Vision Research","funder_award_id":"P30EY000785","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G746631196","display_name":null,"funder_award_id":"EY-00785","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087280841","https://openalex.org/W1987029335","https://openalex.org/W2031704852","https://openalex.org/W1989300603","https://openalex.org/W2037854344","https://openalex.org/W2069904409","https://openalex.org/W2057244767","https://openalex.org/W2028476583","https://openalex.org/W1559944678","https://openalex.org/W2436784601"],"abstract_inverted_index":{"Expression":[0],"of":[1,7,21,26,51,60,69,79,83,133,135,153,172,183,221],"both":[2,77],"particulate":[3,37,159],"and":[4,24,109,199,211],"soluble":[5,81,137,170],"forms":[6,68],"guanylate":[8,38,84,138,160],"cyclase":[9,39,85,139,161],"have":[10],"been":[11],"identified":[12],"in":[13,45,55,88,140,146,165,177,188,208,219],"adult":[14,154],"rat":[15,102],"retina":[16,141,155],"using":[17],"reverse":[18],"transcriptase-PCR":[19],"amplification":[20],"retinal":[22,36,179],"RNA":[23],"sequencing":[25],"the":[27,35,48,52,61,70,80,94,110,114,131,136,158,169,173,181,189,222],"cloned":[28],"cDNAs.":[29],"Over":[30],"a":[31,105,124],"267-amino":[32],"acid":[33,107,121,126],"region,":[34],"was":[40,72,97,142,162,175,185],"found":[41,54],"to":[42,47,76,93,99,113,151],"be":[43],"identical":[44,98],"sequence":[46,91,111],"GC-A":[49],"form":[50,82,171],"enzyme":[53,71,174],"many":[56],"tissues.":[57],"No":[58],"expression":[59,134,184],"closely":[62],"related":[63],"GC-B":[64],"or":[65],"GC":[66],"alpha":[67],"found.":[73],"mRNA":[74],"corresponding":[75,92,112],"subunits":[78],"were":[86],"detected":[87,176],"retinal.":[89],"The":[90,193],"70-kDa":[95],"subunit":[96,116],"that":[100,145,157,196,212],"from":[101],"lung":[103],"over":[104,123],"304-amino":[106],"region":[108],"82-kDa":[115],"showed":[117],"only":[118],"one":[119],"amino":[120],"difference":[122],"275-amino":[125],"region.":[127],"From":[128],"Northern":[129],"analyses":[130],"level":[132,182],"higher":[143,187],"than":[144],"lung.":[147],"In":[148],"situ":[149],"hybridization":[150],"sections":[152],"indicated":[156],"expressed":[163],"predominantly":[164],"rod":[166,209],"photoreceptors.":[167],"Although":[168],"all":[178],"layers,":[180],"much":[186],"inner":[190,223],"nuclear":[191],"layer.":[192],"results":[194],"suggest":[195],"multiple":[197,201],"enzymes":[198],"hence":[200],"regulatory":[202],"pathways":[203],"may":[204,214],"control":[205],"cGMP":[206,213],"levels":[207],"photoreceptors":[210],"play":[215],"an":[216],"important":[217],"role":[218],"neurons":[220],"retina.":[224]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}