{"id":"https://openalex.org/W2081925297","doi":"https://doi.org/10.1002/jcb.21460","title":"Mechanisms that mediate stem cell self\u2010renewal and differentiation","display_name":"Mechanisms that mediate stem cell self\u2010renewal and differentiation","publication_year":2007,"publication_date":"2007-07-23","ids":{"openalex":"https://openalex.org/W2081925297","doi":"https://doi.org/10.1002/jcb.21460","mag":"2081925297","pmid":"https://pubmed.ncbi.nlm.nih.gov/17647265"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.21460","doi":"https://doi.org/10.1002/jcb.21460","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.21460","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102000141","display_name":"Haojian Zhang","orcid":"https://orcid.org/0000-0003-2371-843X","observed_orcids":["https://orcid.org/0000-0003-2371-843X"]},"institutions":[{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haojian Zhang","raw_affiliation_strings":["Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA","Center for Molecular Medicine; Maine Medical Center Research Institute; Scarborough Maine 04074"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA","institution_ids":["https://openalex.org/I4210146345"]},{"raw_affiliation_string":"Center for Molecular Medicine; Maine Medical Center Research Institute; Scarborough Maine 04074","institution_ids":["https://openalex.org/I4210146345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013154537","display_name":"Z Wang","orcid":"https://orcid.org/0000-0002-6702-2648","observed_orcids":["https://orcid.org/0000-0002-6702-2648"]},"institutions":[{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zack Z. Wang","raw_affiliation_strings":["Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074","institution_ids":["https://openalex.org/I4210146345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013154537"],"corresponding_institution_ids":["https://openalex.org/I4210146345"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":0.1795,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.11907954,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"103","issue":"3","first_page":"709","last_page":"718"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stem-cell-self-renewal","display_name":"stem cell self-renewal","score":0.9950000047683716},{"id":"https://openalex.org/keywords/stem-cell-differentiation","display_name":"stem cell differentiation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/adult-stem-cells","display_name":"adult stem cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/molecular-mechanisms","display_name":"molecular mechanisms","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.83992600440979},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7645124197006226},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6637815237045288},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6437175869941711},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5967943668365479},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.589413583278656},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.5446852445602417},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5311497449874878},{"id":"https://openalex.org/C27390768","wikidata":"https://www.wikidata.org/wiki/Q862600","display_name":"Cell potency","level":5,"score":0.44722405076026917},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4285547435283661},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2200152575969696},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1054585874080658},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07292905449867249}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcb.21460","doi":"https://doi.org/10.1002/jcb.21460","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.21460","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:17647265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17647265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5529095544","display_name":"COBRE in Stem Cell Biology and Regenerative Medicine","funder_award_id":"P20RR018789","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5957945507","display_name":"EphB4 modulates hemangioblast development","funder_award_id":"K01DK064696","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W134790102","https://openalex.org/W209719701","https://openalex.org/W1608762409","https://openalex.org/W1970200774","https://openalex.org/W1976878409","https://openalex.org/W1977836335","https://openalex.org/W1979544334","https://openalex.org/W1981088384","https://openalex.org/W1988719795","https://openalex.org/W1992525863","https://openalex.org/W1992949513","https://openalex.org/W1994758141","https://openalex.org/W1995140011","https://openalex.org/W1996449402","https://openalex.org/W1998706588","https://openalex.org/W2001627351","https://openalex.org/W2001675896","https://openalex.org/W2007921976","https://openalex.org/W2009383189","https://openalex.org/W2009886857","https://openalex.org/W2010031978","https://openalex.org/W2010493387","https://openalex.org/W2010608530","https://openalex.org/W2011842366","https://openalex.org/W2015036988","https://openalex.org/W2015396326","https://openalex.org/W2016696563","https://openalex.org/W2018855387","https://openalex.org/W2022399725","https://openalex.org/W2022489847","https://openalex.org/W2036324628","https://openalex.org/W2038723730","https://openalex.org/W2039551265","https://openalex.org/W2043178104","https://openalex.org/W2053911973","https://openalex.org/W2053997148","https://openalex.org/W2056089399","https://openalex.org/W2057069431","https://openalex.org/W2060926602","https://openalex.org/W2066307520","https://openalex.org/W2067801401","https://openalex.org/W2073157961","https://openalex.org/W2078556117","https://openalex.org/W2082019843","https://openalex.org/W2086943348","https://openalex.org/W2091605975","https://openalex.org/W2091835858","https://openalex.org/W2093958228","https://openalex.org/W2095690095","https://openalex.org/W2099724117","https://openalex.org/W2102085111","https://openalex.org/W2107575419","https://openalex.org/W2108451330","https://openalex.org/W2109538121","https://openalex.org/W2110301828","https://openalex.org/W2118453722","https://openalex.org/W2119739306","https://openalex.org/W2122229386","https://openalex.org/W2124843892","https://openalex.org/W2125164793","https://openalex.org/W2126851387","https://openalex.org/W2134128560","https://openalex.org/W2134309794","https://openalex.org/W2138442302","https://openalex.org/W2140559522","https://openalex.org/W2144152247","https://openalex.org/W2146707026","https://openalex.org/W2147044487","https://openalex.org/W2147640763","https://openalex.org/W2148099781","https://openalex.org/W2149790281","https://openalex.org/W2150163104","https://openalex.org/W2152237832","https://openalex.org/W2153424791","https://openalex.org/W2156555850","https://openalex.org/W2158610627","https://openalex.org/W2160266371","https://openalex.org/W2161949020","https://openalex.org/W2165061154","https://openalex.org/W2165781463","https://openalex.org/W2169529166","https://openalex.org/W2172326429","https://openalex.org/W2325068802","https://openalex.org/W2395959362","https://openalex.org/W2411812181","https://openalex.org/W2443595222","https://openalex.org/W7097749369"],"related_works":["https://openalex.org/W2141582526","https://openalex.org/W7100450688","https://openalex.org/W3009968739","https://openalex.org/W7096916555","https://openalex.org/W7101213522","https://openalex.org/W2017359436","https://openalex.org/W1532171596","https://openalex.org/W2060738125","https://openalex.org/W4386773646","https://openalex.org/W438924001"],"abstract_inverted_index":{"Stem":[0],"cells":[1,25,36],"have":[2],"two":[3,30],"common":[4],"properties:":[5],"the":[6,11,63],"capacity":[7],"for":[8,54],"self-renewal":[9,70],"and":[10,37,71,73],"potential":[12,53],"to":[13],"differentiate":[14],"into":[15,29],"one":[16],"or":[17],"more":[18],"specialized":[19],"cell":[20,69],"types.":[21],"In":[22,56],"general,":[23],"stem":[24,35,39,49,68],"can":[26],"be":[27,79],"divided":[28],"broad":[31],"categories:":[32],"adult":[33],"(somatic)":[34],"embryonic":[38,67],"cells.":[40,83],"Recent":[41],"evidence":[42],"suggested":[43],"that":[44],"tumors":[45],"may":[46,78],"contain":[47],"\"cancer":[48],"cells\"":[50],"with":[51],"indefinite":[52],"self-renewal.":[55],"this":[57],"review,":[58],"we":[59],"will":[60],"focus":[61],"on":[62],"molecular":[64],"mechanisms":[65,77],"regulating":[66],"differentiation,":[72],"discuss":[74],"how":[75],"these":[76],"relevant":[80],"in":[81],"cancer":[82]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}