{"id":"https://openalex.org/W2081925270","doi":"https://doi.org/10.1507/endocrj1954.36.687","title":"Effects of Beta-Adrenergic Blockers with Different Ancillary Properties on Lipid Peroxidation in Hyperthyroid Rat Cardiac Muscle.","display_name":"Effects of Beta-Adrenergic Blockers with Different Ancillary Properties on Lipid Peroxidation in Hyperthyroid Rat Cardiac Muscle.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2081925270","doi":"https://doi.org/10.1507/endocrj1954.36.687","mag":"2081925270","pmid":"https://pubmed.ncbi.nlm.nih.gov/2575990"},"language":"en","primary_location":{"id":"doi:10.1507/endocrj1954.36.687","doi":"https://doi.org/10.1507/endocrj1954.36.687","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj1954.36.687","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1954/36/5/36_5_687/_pdf","source":{"id":"https://openalex.org/S2755219162","display_name":"Endocrinologia Japonica","issn_l":"0013-7219","issn":["0013-7219","2185-6370"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologia Japonica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/endocrj1954/36/5/36_5_687/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086215826","display_name":"Kei Asayama","orcid":"https://orcid.org/0000-0003-3365-0547","observed_orcids":["https://orcid.org/0000-0003-3365-0547"]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KOHTARO ASAYAMA","raw_affiliation_strings":["Department of Pediatrics, Yamanashi Medical College","Department of Pediatrics, Yamanashi Medical College, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Yamanashi Medical College","institution_ids":["https://openalex.org/I66906201"]},{"raw_affiliation_string":"Department of Pediatrics, Yamanashi Medical College, Japan","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058548805","display_name":"Kazushige Dobashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KAZUSHIGE DOBASHI","raw_affiliation_strings":["Department of Pediatrics, Yamanashi Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Yamanashi Medical College","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111599906","display_name":"Hidemasa Hayashibe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIDEMASA HAYASHIBE","raw_affiliation_strings":["Department of Pediatrics, Yamanashi Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Yamanashi Medical College","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113941488","display_name":"Kiyohiko Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KIYOHIKO KATO","raw_affiliation_strings":["Department of Pediatrics, Yamanashi Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Yamanashi Medical College","institution_ids":["https://openalex.org/I66906201"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I66906201"],"apc_list":null,"apc_paid":null,"fwci":0.5676,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.67738861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"36","issue":"5","first_page":"687","last_page":"694"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.9190000295639038},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.7940000295639038},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6909999847412109},{"id":"https://openalex.org/keywords/myocardium","display_name":"myocardium","score":0.7170000076293945},{"id":"https://openalex.org/keywords/carteolol","display_name":"carteolol","score":0.9049999713897705},{"id":"https://openalex.org/keywords/atenolol","display_name":"atenolol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/arotinolol","display_name":"arotinolol","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"cytochrome c oxidase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8920000195503235},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alpha-adrenergic-blockade","display_name":"alpha-adrenergic blockade","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2776525901","wikidata":"https://www.wikidata.org/wiki/Q411325","display_name":"Atenolol","level":3,"score":0.837912380695343},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.7405081987380981},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6132766008377075},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5909403562545776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5231971740722656},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5000307559967041},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46172064542770386},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4528357684612274},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.42003610730171204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23306003212928772},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013858","descriptor_name":"Thiobarbiturates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1507/endocrj1954.36.687","doi":"https://doi.org/10.1507/endocrj1954.36.687","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj1954.36.687","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1954/36/5/36_5_687/_pdf","source":{"id":"https://openalex.org/S2755219162","display_name":"Endocrinologia Japonica","issn_l":"0013-7219","issn":["0013-7219","2185-6370"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologia Japonica","raw_type":"journal-article"},{"id":"pmid:2575990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2575990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologia japonica","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1507/endocrj1954.36.687","doi":"https://doi.org/10.1507/endocrj1954.36.687","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj1954.36.687","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1954/36/5/36_5_687/_pdf","source":{"id":"https://openalex.org/S2755219162","display_name":"Endocrinologia Japonica","issn_l":"0013-7219","issn":["0013-7219","2185-6370"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologia Japonica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2081925270.pdf","grobid_xml":"https://content.openalex.org/works/W2081925270.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1492322138","https://openalex.org/W1550989404","https://openalex.org/W1570052704","https://openalex.org/W1576158258","https://openalex.org/W1687199552","https://openalex.org/W1775749144","https://openalex.org/W1974801737","https://openalex.org/W1995486522","https://openalex.org/W1997869774","https://openalex.org/W2000145730","https://openalex.org/W2003004584","https://openalex.org/W2018208831","https://openalex.org/W2051886699","https://openalex.org/W2078913854","https://openalex.org/W2080996575","https://openalex.org/W2081564450","https://openalex.org/W2109426112","https://openalex.org/W2131852577","https://openalex.org/W2133767522","https://openalex.org/W2146073594","https://openalex.org/W2309241413","https://openalex.org/W2411709335","https://openalex.org/W2417264245","https://openalex.org/W2971308852"],"related_works":["https://openalex.org/W2010637471","https://openalex.org/W2410323843","https://openalex.org/W2052169491","https://openalex.org/W2020125297","https://openalex.org/W2012626781","https://openalex.org/W2075262051","https://openalex.org/W2121641608","https://openalex.org/W2080996575","https://openalex.org/W2972482869","https://openalex.org/W2420280470"],"abstract_inverted_index":{"To":[0],"determine":[1],"whether":[2],"beta-blockade":[3,179],"protects":[4,184],"rat":[5],"heart":[6,101,185],"against":[7,187],"thyroxine":[8],"(T4)-induced":[9],"accelelation":[10],"of":[11,17,129,163,197],"lipid":[12,32,130],"peroxidation,":[13],"in":[14,99,111,190],"vivo":[15],"effects":[16],"3":[18,49,165],"beta-blockers":[19,198],"with":[20,55,60,73,107],"different":[21],"ancillary":[22,195],"properties":[23,196],"on":[24],"the":[25,100,126,172,194,208],"mitochondrial":[26,181],"oxidative":[27,188],"enzyme,":[28],"antioxidant":[29],"enzymes":[30,166],"and":[31,51,142,149,183,192,204],"peroxide":[33],"were":[34,38,52,151,167],"investigated.":[35],"The":[36,79,161],"rats":[37],"rendered":[39],"hyperthyroid":[40],"by":[41,85,93,105,134,159,171],"adding":[42],"T4":[43,106],"to":[44,156],"their":[45],"drinking":[46],"water":[47],"for":[48],"weeks":[50],"treated":[53],"simultaneously":[54],"either":[56,86],"carteolol":[57,119],"(a":[58,71],"blocker":[59,72],"partial":[61,201],"agonist":[62,202],"activity;":[63],"30":[64],"mg/kg/day),":[65],"atenolol":[66,87,135],"(50":[67],"mg/kg/day)":[68],"or":[69,88,154],"arotinolol":[70],"weak":[74],"alpha-blocking":[75,205],"action;":[76],"50":[77],"mg/kg/day).":[78],"T4-induced":[80,127],"tachycardia":[81],"was":[82,103,132,139],"alleviated":[83],"completely":[84],"arotinolol,":[89,121],"but":[90,117],"only":[91,168],"partially":[92],"carteolol.":[94],"Cytochrome":[95],"c":[96],"oxidase":[97],"activity":[98,203],"muscle":[102,186],"increased":[104],"a":[108],"parallel":[109],"increase":[110],"manganese":[112],"(mitochondrial)":[113],"superoxide":[114,147],"dismutase.":[115],"Atenolol,":[116],"neither":[118],"nor":[120],"suppressed":[122,133],"this":[123],"increase.":[124],"Similarly,":[125],"acceleration":[128],"peroxidation":[131],"alone.":[136],"Glutathione":[137],"peroxidase":[138],"markedly":[140],"decreased,":[141],"both":[143],"copper":[144],"zinc":[145],"(cytosolic)":[146],"dismutase":[148],"catalase":[150],"also":[152],"decreased":[153,158],"tended":[155],"be":[157],"T4.":[160],"levels":[162],"these":[164],"minimally":[169],"affected":[170],"beta-blocker":[173],"treatments.":[174],"These":[175],"results":[176],"suggest":[177],"that":[178,193],"suppresses":[180],"hypermetabolism":[182],"stress":[189],"hyperthyroidism,":[191],"such":[199],"as":[200],"action":[206],"negate":[207],"protection.":[209]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}