{"id":"https://openalex.org/W2081908269","doi":"https://doi.org/10.1371/journal.pone.0033953","title":"Maxadilan Prevents Apoptosis in iPS Cells and Shows No Effects on the Pluripotent State or Karyotype","display_name":"Maxadilan Prevents Apoptosis in iPS Cells and Shows No Effects on the Pluripotent State or Karyotype","publication_year":2012,"publication_date":"2012-03-23","ids":{"openalex":"https://openalex.org/W2081908269","doi":"https://doi.org/10.1371/journal.pone.0033953","mag":"2081908269","pmid":"https://pubmed.ncbi.nlm.nih.gov/22457805","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3311553"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0033953","doi":"https://doi.org/10.1371/journal.pone.0033953","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0033953","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033953&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033953&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100531396","display_name":"Zhiyi Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyi Zhao","raw_affiliation_strings":["Ophthalmology Department, First Affiliated Hospital of Jinan University, Guangzhou, China","Institute of ophthalmology, Medical College, Jinan University, Guangzhou, China","Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]},{"raw_affiliation_string":"Institute of ophthalmology, Medical College, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002323402","display_name":"Rongjie Yu","orcid":"https://orcid.org/0000-0001-9285-5783","observed_orcids":["https://orcid.org/0000-0001-9285-5783"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongjie Yu","raw_affiliation_strings":["Bio-engineering Institute of Jinan University, Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-engineering Institute of Jinan University, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035118082","display_name":"Jiayin Yang","orcid":"https://orcid.org/0000-0001-9134-1959","observed_orcids":["https://orcid.org/0000-0001-9134-1959"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayin Yang","raw_affiliation_strings":["Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102018176","display_name":"Xiaofei Liu","orcid":"https://orcid.org/0000-0001-8786-8758","observed_orcids":["https://orcid.org/0000-0001-8786-8758"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofei Liu","raw_affiliation_strings":["Bio-engineering Institute of Jinan University, Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-engineering Institute of Jinan University, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Meihua Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meihua Tan","raw_affiliation_strings":["Institute of ophthalmology, Medical College, Jinan University, Guangzhou, China","Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China","Ophthalmology Department, First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of ophthalmology, Medical College, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Ophthalmology Department, First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037555270","display_name":"HongYang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HongYang Li","raw_affiliation_strings":["Institute of ophthalmology, Medical College, Jinan University, Guangzhou, China","Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China","Ophthalmology Department, First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of ophthalmology, Medical College, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Ophthalmology Department, First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039085310","display_name":"Jiansu Chen","orcid":"https://orcid.org/0000-0001-6703-9573","observed_orcids":["https://orcid.org/0000-0001-6703-9573"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiansu Chen","raw_affiliation_strings":["Institute of ophthalmology, Medical College, Jinan University, Guangzhou, China","Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China","Ophthalmology Department, First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of ophthalmology, Medical College, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Ophthalmology Department, First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5039085310"],"corresponding_institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.5246,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.57617056,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"3","first_page":"e33953","last_page":"e33953"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.06310000270605087,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maxadilan","display_name":"maxadilan","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pacap-type-i-receptor","display_name":"PACAP type I receptor","score":0.8690000176429749},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/ultraviolet-c-radiation","display_name":"ultraviolet C radiation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9750000238418579},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":1.0},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.9350000023841858},{"id":"https://openalex.org/keywords/karyotype","display_name":"karyotype","score":0.9819999933242798},{"id":"https://openalex.org/keywords/vasodilatory-peptides","display_name":"vasodilatory peptides","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.6572278141975403},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6538207530975342},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6349207162857056},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6247087717056274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5944059491157532},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.5779953002929688},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5006401538848877},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4282812774181366},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4271399974822998},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.4159356951713562},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.3679819703102112},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.3605644702911377},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35735857486724854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13988730311393738},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019476","descriptor_name":"Insect Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0033953","doi":"https://doi.org/10.1371/journal.pone.0033953","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0033953","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033953&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:22457805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22457805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3311553","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3311553/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.815.7647","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.815.7647","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/19/00/pone.0033953.PMC3311553.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:32f409b7eb0a40e1940ab07bca6e02fe","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/32f409b7eb0a40e1940ab07bca6e02fe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 3, p e33953 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0033953","doi":"https://doi.org/10.1371/journal.pone.0033953","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0033953","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033953&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322292","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62"},{"id":"https://openalex.org/F4320335785","display_name":"Project 211","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2081908269.pdf","grobid_xml":"https://content.openalex.org/works/W2081908269.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1499034239","https://openalex.org/W1967912613","https://openalex.org/W1978502066","https://openalex.org/W1987785848","https://openalex.org/W1993709600","https://openalex.org/W1996487331","https://openalex.org/W2002503549","https://openalex.org/W2011177881","https://openalex.org/W2017350087","https://openalex.org/W2018040575","https://openalex.org/W2019712205","https://openalex.org/W2028856874","https://openalex.org/W2040091260","https://openalex.org/W2050038444","https://openalex.org/W2072469132","https://openalex.org/W2079357667","https://openalex.org/W2087210107","https://openalex.org/W2089851292","https://openalex.org/W2095263129","https://openalex.org/W2106110407","https://openalex.org/W2107277218","https://openalex.org/W2111650534","https://openalex.org/W2119683782","https://openalex.org/W2120473562","https://openalex.org/W2125987139","https://openalex.org/W2126532344","https://openalex.org/W2151319808","https://openalex.org/W2151875422","https://openalex.org/W2162986335","https://openalex.org/W2164884735","https://openalex.org/W2170917361","https://openalex.org/W2322829102"],"related_works":["https://openalex.org/W7100120364","https://openalex.org/W2360732999","https://openalex.org/W2254512964","https://openalex.org/W2046081315","https://openalex.org/W2382823543","https://openalex.org/W4225129665","https://openalex.org/W2007204853","https://openalex.org/W7027994966","https://openalex.org/W2050713640","https://openalex.org/W2602551010"],"abstract_inverted_index":{"Pituitary":[0],"adenylate":[1],"cyclase-activating":[2],"polypeptide":[3],"(PACAP)":[4],"is":[5,38,225],"a":[6,15,109,116],"structurally":[7],"endogenous":[8],"peptide":[9],"with":[10],"many":[11],"biological":[12],"roles.":[13],"Maxadilan,":[14],"61-amino":[16],"acid":[17],"vasodilatory":[18],"peptide,":[19],"specifically":[20],"activates":[21],"the":[22,53,58,79,87,105,133,156,169,198,213,245],"PACAP":[23],"type":[24],"I":[25],"receptor":[26],"(PAC1).":[27],"Although":[28],"PAC1":[29,61,224],"has":[30],"been":[31],"identified":[32],"in":[33,45,62,91,112,188,227],"embryonic":[34],"stem":[35,49],"cells,":[36,121],"little":[37],"known":[39],"about":[40],"its":[41],"presence":[42],"or":[43,248],"effects":[44,81,163],"human":[46,63],"induced":[47,96],"pluripotent":[48,199,246],"(iPS)":[50],"cells.":[51,160,203,217],"In":[52,218],"present":[54,226],"study,":[55],"we":[56,85],"investigated":[57],"expression":[59],"of":[60,89,119,144,147,158,164,171,201,215],"iPS":[64,106,151,202,216,228,235],"cells":[65,107,229,236],"by":[66,83,97,124],"reverse":[67],"transcriptase":[68],"polymerase":[69,182],"chain":[70,183],"reaction":[71,184],"(RT-PCR)":[72],"and":[73,115,132,154,173,187,230],"western":[74,177],"blot":[75,178],"analysis.":[76],"To":[77],"study":[78],"physiological":[80],"mediated":[82],"PAC1,":[84],"evaluated":[86],"role":[88],"maxadilan":[90,148,165,194,209,232],"preventing":[92],"apoptotic":[93,120,159,239],"cell":[94,113,152,240],"death":[95,241],"ultraviolet":[98],"C":[99],"(UVC).":[100],"After":[101],"exposure":[102],"to":[103,168],"UVC,":[104],"showed":[108,192,207],"marked":[110],"reduction":[111],"viability":[114,153],"parallel":[117],"increase":[118],"as":[122],"demonstrated":[123],"WST-8":[125],"analysis,":[126,179],"annexin":[127],"V/propidium":[128],"iodide":[129],"(PI)":[130],"analysis":[131,186,206],"terminal":[134],"transferase":[135],"dUTP":[136],"nick":[137],"end":[138],"labeling":[139],"(TUNEL)":[140],"assay.":[141],"The":[142,161],"addition":[143],"30":[145],"nM":[146],"dramatically":[149],"increased":[150],"reduced":[155],"percentage":[157],"anti-apoptotic":[162],"were":[166],"correlated":[167],"downregulation":[170],"caspase-3":[172],"caspase-9.":[174],"Concomitantly,":[175],"immunofluorescence,":[176],"real-time":[180],"quantitative":[181],"(RT-qPCR)":[185],"vitro":[189],"differentiation":[190],"results":[191,221],"that":[193,208,223,231],"did":[195,210],"not":[196,211,243],"affect":[197,212],"state":[200,247],"Moreover,":[204],"karyotype":[205,214],"summary,":[219],"these":[220],"demonstrate":[222],"effectively":[233],"protects":[234],"against":[237],"UVC-induced":[238],"while":[242],"affecting":[244],"karyotype.":[249]},"counts_by_year":[{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
