{"id":"https://openalex.org/W2081898623","doi":"https://doi.org/10.1093/nar/20.5.1075","title":"Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases","display_name":"Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2081898623","doi":"https://doi.org/10.1093/nar/20.5.1075","mag":"2081898623","pmid":"https://pubmed.ncbi.nlm.nih.gov/1549469","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/312093"},"language":"en","primary_location":{"id":"doi:10.1093/nar/20.5.1075","doi":"https://doi.org/10.1093/nar/20.5.1075","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/20.5.1075","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC312093","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061131591","display_name":"Nina Raben","orcid":"https://orcid.org/0000-0001-9519-3535","observed_orcids":["https://orcid.org/0000-0001-9519-3535"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nina Raben","raw_affiliation_strings":["Connective Tissue Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connective Tissue Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053500125","display_name":"Frank Borriello","orcid":"https://orcid.org/0000-0003-3957-3685","observed_orcids":["https://orcid.org/0000-0003-3957-3685"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Borriello","raw_affiliation_strings":["Connective Tissue Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connective Tissue Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jay Amin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay Amin","raw_affiliation_strings":["Connective Tissue Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connective Tissue Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007947694","display_name":"Randy Horwitz","orcid":"https://orcid.org/0000-0001-9527-8926","observed_orcids":["https://orcid.org/0000-0001-9527-8926"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randy Horwitz","raw_affiliation_strings":["Connective Tissue Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connective Tissue Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044796646","display_name":"DAVID D. FRASER","orcid":"https://orcid.org/0000-0003-3995-2503","observed_orcids":["https://orcid.org/0000-0003-3995-2503"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Fraser","raw_affiliation_strings":["Connective Tissue Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connective Tissue Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056507445","display_name":"Paul H. Pl\u00f6tz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Plotz","raw_affiliation_strings":["Connective Tissue Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connective Tissue Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":3.0424,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.92553674,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"20","issue":"5","first_page":"1075","last_page":"1081"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histidyl-trna-synthetase","display_name":"histidyl-tRNA synthetase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/aminoacyl-trna-synthetase","display_name":"aminoacyl-tRNA synthetase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cdna-sequence","display_name":"cDNA sequence","score":0.7049999833106995},{"id":"https://openalex.org/keywords/sequence-divergence","display_name":"sequence divergence","score":0.421999990940094},{"id":"https://openalex.org/keywords/acceptor-stem","display_name":"acceptor stem","score":0.6549999713897705},{"id":"https://openalex.org/keywords/helical-motifs","display_name":"helical motifs","score":0.8180000185966492},{"id":"https://openalex.org/keywords/rna-binding-motif","display_name":"RNA-binding motif","score":0.949999988079071},{"id":"https://openalex.org/keywords/rna-polymerase","display_name":"RNA polymerase","score":0.4350000023841858},{"id":"https://openalex.org/keywords/termination-factors","display_name":"termination factors","score":0.7599999904632568},{"id":"https://openalex.org/keywords/hepatoma-cells","display_name":"hepatoma cells","score":0.49799999594688416},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9155112504959106},{"id":"https://openalex.org/C2779315393","wikidata":"https://www.wikidata.org/wiki/Q415968","display_name":"Aminoacyl tRNA synthetase","level":5,"score":0.8397002220153809},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.7343751788139343},{"id":"https://openalex.org/C2910418148","wikidata":"https://www.wikidata.org/wiki/Q415968","display_name":"Amino Acyl-tRNA Synthetases","level":5,"score":0.6815771460533142},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5134811997413635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47194451093673706},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.45476606488227844},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2379574179649353},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.23023319244384766}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000604","descriptor_name":"Amino Acyl-tRNA Synthetases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000604","descriptor_name":"Amino Acyl-tRNA Synthetases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006643","descriptor_name":"Histidine-tRNA Ligase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006643","descriptor_name":"Histidine-tRNA Ligase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/20.5.1075","doi":"https://doi.org/10.1093/nar/20.5.1075","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/20.5.1075","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:280854","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC312093","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:312093","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/312093","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:1549469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1549469","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:280854","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC312093","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1487554032","https://openalex.org/W1516271347","https://openalex.org/W1528870087","https://openalex.org/W1540435940","https://openalex.org/W1560844399","https://openalex.org/W1568949798","https://openalex.org/W1630596600","https://openalex.org/W1972326289","https://openalex.org/W1980510932","https://openalex.org/W1981529363","https://openalex.org/W1984915289","https://openalex.org/W1994671725","https://openalex.org/W1997748787","https://openalex.org/W2009396375","https://openalex.org/W2027354239","https://openalex.org/W2041418072","https://openalex.org/W2047865546","https://openalex.org/W2051380480","https://openalex.org/W2057481603","https://openalex.org/W2062815348","https://openalex.org/W2063038072","https://openalex.org/W2065375777","https://openalex.org/W2071674430","https://openalex.org/W2081690388","https://openalex.org/W2085816567","https://openalex.org/W2097671812","https://openalex.org/W2098758937","https://openalex.org/W2132395219","https://openalex.org/W2134812217","https://openalex.org/W2139305314","https://openalex.org/W2139568685","https://openalex.org/W2164043257","https://openalex.org/W2397250649","https://openalex.org/W2419305533","https://openalex.org/W2422932519"],"related_works":["https://openalex.org/W1981529363","https://openalex.org/W2041418072","https://openalex.org/W2032553250","https://openalex.org/W752015704","https://openalex.org/W2030328702","https://openalex.org/W2154457088","https://openalex.org/W929289056","https://openalex.org/W2529910509","https://openalex.org/W1990257248","https://openalex.org/W2060658020"],"abstract_inverted_index":{"We":[0],"have":[1,54,69],"determined":[2,30,60],"the":[3,8,58,76,113,117,147,153,159],"sequence":[4,31,46,61,84],"of":[5,75,98,112,116,129,166],"cDNA":[6],"for":[7,110,152,158],"human":[9,167,179,202],"histidyl-tRNA":[10],"synthetase":[11],"(HRS)":[12],"in":[13,21,33,64,92,178,189],"a":[14,41,170,181,190,194],"hepatoma":[15],"cell":[16,26],"line":[17],"and":[18,24,38,49,67,102,124,139,157,198,201],"confirmed":[19],"it":[20,206],"fetal":[22],"myoblast":[23],"fibroblast":[25],"lines.":[27],"The":[28,80,162],"newly":[29,59],"differs":[32],"48":[34],"places,":[35],"including":[36],"insertions":[37],"deletions,":[39],"from":[40],"previously":[42],"published":[43],"sequence.":[44],"By":[45],"specific":[47,132],"probing":[48],"by":[50],"direct":[51],"sequencing,":[52],"we":[53,68],"established":[55],"that":[56,205],"only":[57],"is":[62,186],"present":[63],"genomic":[65],"DNA":[66],"sequenced":[70],"500":[71],"hundred":[72],"bases":[73],"upstream":[74],"translation":[77],"start":[78],"site.":[79],"predicted":[81,106],"amino":[82,107,130,160,172],"acid":[83,108,131,173],"now":[85],"clearly":[86],"demonstrates":[87],"all":[88],"three":[89,111],"motifs":[90],"recognized":[91],"class":[93,118,182],"2":[94,138],"aminoacyl-tRNA":[95],"synthetases.":[96],"Alignment":[97],"E.":[99],"coli,":[100],"yeast,":[101],"when":[103],"available,":[104],"mammalian":[105],"sequences":[109],"four":[114],"members":[115],"2a":[119],"subgroup":[120],"(his,":[121],"pro,":[122],"ser,":[123],"thr)":[125],"shows":[126],"strong":[127],"preservation":[128],"signature":[133],"regions":[134,151],"proximal":[135,140,154],"to":[136,141],"motif":[137,142],"3.":[143],"These":[144],"probably":[145],"represent":[146],"active":[148],"site":[149],"binding":[150,211],"acceptor":[155],"stem":[156],"acid.":[161],"first":[163,176],"two":[164],"exons":[165],"HRS":[168],"contain":[169],"32":[171],"helical":[174],"motif,":[175],"described":[177],"QRS,":[180],"1":[183],"synthetase,":[184],"which":[185],"found":[187],"also":[188],"yeast":[191],"RNA":[192,210],"polymerase,":[193],"rabbit":[195],"termination":[196],"factor,":[197],"both":[199],"bovine":[200],"WRS,":[203],"suggesting":[204],"may":[207],"be":[208],"an":[209],"motif.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}