{"id":"https://openalex.org/W2081832007","doi":"https://doi.org/10.1021/ar9002015","title":"Electrochemistry in Diabetes Management","display_name":"Electrochemistry in Diabetes Management","publication_year":2010,"publication_date":"2010-04-12","ids":{"openalex":"https://openalex.org/W2081832007","doi":"https://doi.org/10.1021/ar9002015","mag":"2081832007","pmid":"https://pubmed.ncbi.nlm.nih.gov/20384299"},"language":"en","primary_location":{"id":"doi:10.1021/ar9002015","doi":"https://doi.org/10.1021/ar9002015","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ar9002015","pdf_url":null,"source":{"id":"https://openalex.org/S145378405","display_name":"Accounts of Chemical Research","issn_l":"0001-4842","issn":["0001-4842","1520-4898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of Chemical Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2081832007"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005437626","display_name":"Adam Heller","orcid":"https://orcid.org/0000-0003-0181-1246","observed_orcids":["https://orcid.org/0000-0003-0181-1246"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adam Heller","raw_affiliation_strings":["Department of Chemical Engineering, University of Texas, Austin, Texas 78712"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Texas, Austin, Texas 78712","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056690046","display_name":"Ben Feldman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400573185","display_name":"Abbott Diabetes Care (United States)","ror":"https://ror.org/03vb88585","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555","https://openalex.org/I4400573185"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben Feldman","raw_affiliation_strings":["Abbott Diabetes Care, 1360 South Loop Road, Alameda, California 94502"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbott Diabetes Care, 1360 South Loop Road, Alameda, California 94502","institution_ids":["https://openalex.org/I4400573185"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005437626"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":14.4061,"has_fulltext":false,"cited_by_count":259,"citation_normalized_percentile":{"value":0.99648889,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"43","issue":"7","first_page":"963","last_page":"973"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetes-management","display_name":"diabetes management","score":0.8199999928474426},{"id":"https://openalex.org/keywords/blood-glucose-monitoring","display_name":"blood glucose monitoring","score":0.8420000076293945},{"id":"https://openalex.org/keywords/continuous-glucose-monitoring","display_name":"continuous glucose monitoring","score":0.8180000185966492},{"id":"https://openalex.org/keywords/glucose-dehydrogenase","display_name":"glucose dehydrogenase","score":0.8159999847412109},{"id":"https://openalex.org/keywords/amperometric-glucose-biosensor","display_name":"amperometric glucose sensor","score":0.7049999833106995},{"id":"https://openalex.org/keywords/printed-electrodes","display_name":"printed electrodes","score":0.5149999856948853},{"id":"https://openalex.org/keywords/glucose-electrooxidation","display_name":"electrocatalytic glucose oxidation","score":0.46399998664855957},{"id":"https://openalex.org/keywords/fad-dependent-glucose-dehydrogenase","display_name":"FAD-dependent glucose dehydrogenase","score":0.765999972820282},{"id":"https://openalex.org/keywords/pqq-dependent-glucose-dehydrogenase","display_name":"PQQ-dependent glucose dehydrogenase","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6383056640625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5466830730438232},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39627009630203247},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3385036587715149},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3076459765434265}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005182","descriptor_name":"Flavin-Adenine Dinucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005948","descriptor_name":"Glucose Dehydrogenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005949","descriptor_name":"Glucose Oxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019095","descriptor_name":"Point-of-Care Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020136","descriptor_name":"Hydrogel, Polyethylene Glycol Dimethacrylate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055664","descriptor_name":"Electrochemical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ar9002015","doi":"https://doi.org/10.1021/ar9002015","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ar9002015","pdf_url":null,"source":{"id":"https://openalex.org/S145378405","display_name":"Accounts of Chemical Research","issn_l":"0001-4842","issn":["0001-4842","1520-4898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of Chemical Research","raw_type":"journal-article"},{"id":"pmid:20384299","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20384299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of chemical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1769550528","https://openalex.org/W1969278644","https://openalex.org/W1971694648","https://openalex.org/W1974210454","https://openalex.org/W1981049234","https://openalex.org/W1985704490","https://openalex.org/W1987444770","https://openalex.org/W1988024774","https://openalex.org/W1988037818","https://openalex.org/W1989622288","https://openalex.org/W1992419785","https://openalex.org/W1994446500","https://openalex.org/W1995401918","https://openalex.org/W1998734017","https://openalex.org/W1999206571","https://openalex.org/W2013021920","https://openalex.org/W2018675764","https://openalex.org/W2022366091","https://openalex.org/W2029073332","https://openalex.org/W2030153280","https://openalex.org/W2034940691","https://openalex.org/W2038975778","https://openalex.org/W2043324182","https://openalex.org/W2043765610","https://openalex.org/W2048651003","https://openalex.org/W2053084878","https://openalex.org/W2055729674","https://openalex.org/W2066466684","https://openalex.org/W2069720757","https://openalex.org/W2093133634","https://openalex.org/W2094405050","https://openalex.org/W2122101263","https://openalex.org/W2138208850","https://openalex.org/W2177450209","https://openalex.org/W2769264260"],"related_works":["https://openalex.org/W4392941293","https://openalex.org/W2077658360","https://openalex.org/W2141602487","https://openalex.org/W2033242189","https://openalex.org/W4315642106","https://openalex.org/W2066876353","https://openalex.org/W2403572724","https://openalex.org/W4401321202","https://openalex.org/W2136694994","https://openalex.org/W3177202728"],"abstract_inverted_index":{"Diabetes":[0,48],"devastates":[1],"lives":[2,60],"and":[3,12,30,50,85,120,157,183,195,258,320,346,371,390,421,475],"burdens":[4],"society.":[5],"Hypoglycemic":[6],"(low":[7],"glucose)":[8,21],"episodes":[9],"cause":[10,22],"blackouts,":[11],"severe":[13],"ones":[14],"are":[15,222,350],"life-threatening.":[16],"Periods":[17],"of":[18,40,46,53,61,131,163,230,263,272,333,367,417,433,436,448,460,467],"hyperglycemia":[19],"(high":[20],"circulatory":[23],"disease,":[24],"stroke,":[25],"amputations,":[26],"blindness,":[27],"kidney":[28],"failure":[29],"nerve":[31],"degeneration.":[32],"In":[33,90],"this":[34,92],"Account,":[35],"we":[36],"describe":[37],"the":[38,51,59,74,83,105,118,124,132,166,192,199,203,219,233,239,243,264,270,277,283,292,322,368,386,395,434,437,446,461,464,468,478,495],"founding":[39],"TheraSense,":[41],"now":[42,211],"a":[43,67,139,145,154,158,179,226,251,273,306,314,325,334,353,375,402,414,422,428],"major":[44],"part":[45],"Abbott":[47],"Care,":[49],"development":[52],"two":[54,150,278],"products":[55],"that":[56,262],"have":[57,250],"improved":[58],"people":[62],"with":[63,144,238,457,484],"diabetes.":[64],"The":[65,103,129,161,172,298,330,356,470,487],"first,":[66],"virtually":[68,280],"painless":[69],"microcoulometer":[70],"(300":[71],"nL":[72],"volume),":[73],"FreeStyle":[75,109,133,299],"blood":[76,101,134,164],"glucose":[77,112,135,173,180,302,392,406,418],"monitoring":[78,113,136,303],"system,":[79,114],"was":[80,94,115],"approved":[81,116],"by":[82,117,178,191,224,232,374,477],"FDA":[84,119],"became":[86,121],"available":[87,122],"in":[88,96,123,127,352,385,445,455],"2000.":[89],"2009,":[91],"system":[93,137,204,304],"used":[95,205],"more":[97,293],"than":[98],"one":[99],"billion":[100],"assays.":[102],"second,":[104],"enzyme-wiring":[106],"based,":[107],"subcutaneously-implanted":[108],"Navigator":[110,300],"continuous":[111,301],"United":[125],"States":[126],"2008.":[128],"strips":[130],"comprise":[138],"printed":[140,152,351],"parallel":[141],"plate":[142],"coulometer,":[143],"50":[146],"microm":[147],"gap":[148],"between":[149,165,256,276],"facing":[151,167,220,265],"electrodes,":[153],"carbon":[155,200,347],"electrode":[156,370],"Ag/AgCl":[159,266,296,344],"electrode.":[160,201,267,297],"volume":[162],"plates":[168],"is":[169,174,189,196,247,372,472],"accurately":[170],"controlled.":[171],"electrooxidized":[175,197],"through":[176],"catalysis":[177],"dehydrogenase":[181],"(GDH)":[182],"an":[184,409],"Os(2+/3+)":[185,244,430],"redox":[186,234,245,425],"mediator,":[187],"which":[188,342],"reduced":[190,290],"glucose-reduced":[193],"enzyme":[194,359],"on":[198,341],"Initially":[202],"pyrroloquinoline":[206],"quinone":[207],"(PQQ)-dependent":[208],"GDH":[209],"but":[210],"uses":[212,305],"flavin":[213],"adenine":[214],"dinucleotide":[215],"(FAD)-dependent":[216],"GDH.":[217],"Because":[218,432],"electrodes":[221,279,349],"separated":[223],"such":[225],"small":[227],"distance,":[228],"shuttling":[229,274],"electrons":[231],"couple":[235],"could":[236],"interfere":[237],"coulometric":[240],"assay.":[241],"However,":[242],"mediator":[246],"selected":[248],"to":[249,313,316,324],"substantially":[252],"negative":[253],"formal":[254],"potential,":[255],"0.0":[257],"-0.2":[259],"V,":[260],"versus":[261],"This":[268],"makes":[269],"flow":[271],"current":[275,443],"impossible":[281],"because":[282],"oxidized":[284],"Os(3+)":[285],"complex":[286],"cannot":[287],"be":[288],"appreciably":[289],"at":[291,380],"positively":[294],"poised":[295],"subcutaneously":[307,474],"implanted":[308,473],"miniature":[309],"plastic":[310,339],"sensor":[311,331,471],"connected":[312],"transmitter":[315],"measure":[317],"glycemia":[318],"amperometrically":[319],"sends":[321],"information":[323],"PDA-like":[326],"device":[327],"every":[328],"minute.":[329],"consists":[332],"narrow":[335],"(0.6":[336],"mm":[337,383],"wide)":[338],"substrate":[340],"carbon-working,":[343],"reference,":[345],"counter":[348],"stacked":[354],"geometry.":[355],"active":[357],"wired":[358],"sensing":[360],"layer":[361],"covers":[362],"only":[363],"about":[364,381],"0.1":[365],"mm(2)":[366],"working":[369],"overlaid":[373],"flux-limiting":[376],"membrane.":[377],"It":[378],"resides":[379],"5":[382,481],"depth":[384],"subcutaneous":[387],"adipose":[388],"tissue":[389],"monitors":[391],"concentrations":[393],"over":[394],"range":[396],"20-500":[397],"mg/dL.":[398],"Its":[399],"core":[400],"component,":[401],"miniature,":[403],"disposable,":[404],"amperometric":[405],"sensor,":[407,462],"has":[408],"electrooxidation":[410],"catalyst":[411,438],"made":[412],"from":[413],"crosslinked":[415],"adduct":[416],"oxidase":[419],"(GOx)":[420],"GOx":[423],"wiring":[424],"hydrogel":[426],"containing":[427],"polymer-bound":[429],"complex.":[431],"selectivity":[435],"for":[439],"glucose,":[440],"very":[441],"little":[442],"flows":[444],"absence":[447],"glucose.":[449],"That":[450],"feature,":[451],"either":[452],"alone":[453],"or":[454],"combination":[456],"other":[458],"features":[459],"facilitates":[463],"one-point":[465],"calibration":[466],"system.":[469],"replaced":[476],"patient":[479],"after":[480],"days":[482],"use":[483],"minimal":[485],"pain.":[486],"wearer":[488],"does":[489],"not":[490],"feel":[491],"its":[492],"presence":[493],"under":[494],"skin.":[496]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":28},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
