{"id":"https://openalex.org/W2081789009","doi":"https://doi.org/10.1172/jci28075","title":"MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals","display_name":"MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W2081789009","doi":"https://doi.org/10.1172/jci28075","mag":"2081789009","pmid":"https://pubmed.ncbi.nlm.nih.gov/16886064","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1523415"},"language":"en","primary_location":{"id":"doi:10.1172/jci28075","doi":"https://doi.org/10.1172/jci28075","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci28075","pdf_url":"http://www.jci.org/articles/view/28075/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/28075/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021261100","display_name":"Chun\u2010Jen Chen","orcid":"https://orcid.org/0000-0002-9211-8641","observed_orcids":["https://orcid.org/0000-0002-9211-8641"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C.-J. Chen","raw_affiliation_strings":["Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Shi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Arron Hearn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arron Hearn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kate Fitzgerald","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kate Fitzgerald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Douglas Golenbock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas Golenbock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"George Reed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Reed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Shizuo Akira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shizuo Akira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Kenneth L Rock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth L Rock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021261100"],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":22.2981,"has_fulltext":true,"cited_by_count":488,"citation_normalized_percentile":{"value":0.99629532,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"116","issue":"8","first_page":"2262","last_page":"2271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.1679999977350235,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.09390000253915787,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myd88","display_name":"MyD88","score":0.871999979019165},{"id":"https://openalex.org/keywords/il-1-signaling","display_name":"IL-1 signaling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.699999988079071},{"id":"https://openalex.org/keywords/monosodium-urate-crystals","display_name":"monosodium urate crystals","score":0.9980000257492065},{"id":"https://openalex.org/keywords/crystal-induced-inflammation","display_name":"crystal-induced inflammation","score":0.6330000162124634},{"id":"https://openalex.org/keywords/trif","display_name":"TRIF","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tram","display_name":"tram","score":0.996999979019165},{"id":"https://openalex.org/keywords/il-18-receptor","display_name":"IL-18 receptor","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/bone-marrow-derived-cells","display_name":"bone marrow-derived cells","score":0.8159999847412109},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.810050368309021},{"id":"https://openalex.org/C43929388","wikidata":"https://www.wikidata.org/wiki/Q4050587","display_name":"TRIF","level":5,"score":0.7146908044815063},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.6952222585678101},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5824429988861084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5222345590591431},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5148343443870544},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4697079062461853},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4389059245586395},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.40715935826301575},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.348192423582077},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2013651728630066},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19884464144706726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19812127947807312},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12107411026954651}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006073","descriptor_name":"Gout","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006073","descriptor_name":"Gout","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci28075","doi":"https://doi.org/10.1172/jci28075","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci28075","pdf_url":"http://www.jci.org/articles/view/28075/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:16886064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16886064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1523415","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1523415/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-1992","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/993","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications by UMass Chan Authors","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1172/jci28075","doi":"https://doi.org/10.1172/jci28075","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci28075","pdf_url":"http://www.jci.org/articles/view/28075/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.766700029373169,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5864376598","display_name":"Diabetes Endocrinology Research Center (DERC)","funder_award_id":"P30DK032520","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2081789009.pdf","grobid_xml":"https://content.openalex.org/works/W2081789009.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W110525163","https://openalex.org/W1481125088","https://openalex.org/W1492075988","https://openalex.org/W1514540900","https://openalex.org/W1528933004","https://openalex.org/W1821995966","https://openalex.org/W1929515229","https://openalex.org/W1969072247","https://openalex.org/W1970714838","https://openalex.org/W1972776583","https://openalex.org/W1978926805","https://openalex.org/W1980273234","https://openalex.org/W1981932944","https://openalex.org/W1982423483","https://openalex.org/W1985987145","https://openalex.org/W1989656760","https://openalex.org/W1991418439","https://openalex.org/W2002563881","https://openalex.org/W2003054051","https://openalex.org/W2003710928","https://openalex.org/W2004465286","https://openalex.org/W2009800174","https://openalex.org/W2014441112","https://openalex.org/W2016207805","https://openalex.org/W2019674978","https://openalex.org/W2038764565","https://openalex.org/W2039401190","https://openalex.org/W2042602646","https://openalex.org/W2045895870","https://openalex.org/W2046327214","https://openalex.org/W2050906978","https://openalex.org/W2057809738","https://openalex.org/W2062105780","https://openalex.org/W2064867029","https://openalex.org/W2068419165","https://openalex.org/W2070597700","https://openalex.org/W2071102240","https://openalex.org/W2077370789","https://openalex.org/W2077448286","https://openalex.org/W2082890018","https://openalex.org/W2088900302","https://openalex.org/W2090640877","https://openalex.org/W2092157690","https://openalex.org/W2092442068","https://openalex.org/W2092873578","https://openalex.org/W2094746130","https://openalex.org/W2116262835","https://openalex.org/W2123641004","https://openalex.org/W2126829776","https://openalex.org/W2130421043","https://openalex.org/W2133369735","https://openalex.org/W2145584783","https://openalex.org/W2148579227","https://openalex.org/W2149723200","https://openalex.org/W2157602051","https://openalex.org/W2161720196","https://openalex.org/W2164300869","https://openalex.org/W2166980815","https://openalex.org/W2167050109","https://openalex.org/W2170526736","https://openalex.org/W2407204698","https://openalex.org/W2807664723","https://openalex.org/W4243832066","https://openalex.org/W4300815417","https://openalex.org/W6629420740"],"related_works":["https://openalex.org/W2078656925","https://openalex.org/W2164113951","https://openalex.org/W2096030268","https://openalex.org/W2045895870","https://openalex.org/W40316094","https://openalex.org/W2331558679","https://openalex.org/W1988073855","https://openalex.org/W2073509401","https://openalex.org/W2119024391","https://openalex.org/W2959937064"],"abstract_inverted_index":{"While":[0],"it":[1,155],"is":[2,44,167,183],"known":[3],"that":[4,30,130,165,175],"monosodium":[5],"urate":[6],"(MSU)":[7],"crystals":[8,18],"cause":[9],"the":[10,13,31,103,151,170,176,193],"disease":[11],"gout,":[12],"mechanism":[14],"by":[15],"which":[16],"these":[17],"stimulate":[19,90],"this":[20,64,181],"inflammatory":[21,108,152,172],"condition":[22],"has":[23],"not":[24,61,81,89,149],"been":[25],"clear.":[26],"Here":[27],"we":[28],"find":[29],"Toll/IL-1R":[32],"(TIR)":[33],"signal":[34],"transduction":[35],"adaptor":[36,54,190],"myeloid":[37],"differentiation":[38],"primary":[39],"response":[40,173],"protein":[41],"88":[42],"(MyD88)":[43],"required":[45,62,157],"for":[46,63,83,169],"acute":[47],"gouty":[48],"inflammation.":[49,85,141],"In":[50,98],"contrast,":[51,99],"other":[52],"TIR":[53],"molecules,":[55],"TIRAP/Mal,":[56],"TRIF,":[57],"and":[58,74,76,133,174],"TRAM,":[59],"are":[60,80],"process.":[65],"The":[66],"MyD88-dependent":[67,104],"TLR1,":[68],"-2,":[69],"-4,":[70],"-6,":[71],"-7,":[72],"-9,":[73],"-11":[75],"IL-18":[77],"receptor":[78],"(IL-18R)":[79],"essential":[82,137,168],"MSU-induced":[84,127,171],"Moreover,":[86],"MSU":[87],"does":[88],"HEK":[91],"cells":[92,147],"expressing":[93],"TLR1-11":[94],"to":[95,111],"activate":[96],"NF-kappaB.":[97],"mice":[100,118],"deficient":[101],"in":[102,114,139,144,158,180,192],"IL-1R":[105,134,142,194],"showed":[106,125],"reduced":[107,126],"responses,":[109],"similar":[110],"those":[112],"observed":[113],"MyD88-deficient":[115],"mice.":[116],"Similarly,":[117],"treated":[119],"with":[120],"IL-1":[121,131,166],"neutralizing":[122],"antibodies":[123],"also":[124],"inflammation,":[128],"demonstrating":[129],"production":[132],"activation":[135],"play":[136],"roles":[138],"MSU-triggered":[140],"deficiency":[143],"bone":[145],"marrow-derived":[146,160],"did":[148],"affect":[150],"response;":[153],"however,":[154],"was":[156],"non-bone":[159],"cells.":[161],"These":[162],"results":[163],"indicate":[164],"requirement":[177],"of":[178],"MyD88":[179],"process":[182],"primarily":[184],"through":[185],"its":[186],"function":[187],"as":[188],"an":[189],"molecule":[191],"signaling":[195],"pathway.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":31},{"year":2013,"cited_by_count":33},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
