{"id":"https://openalex.org/W2081756741","doi":"https://doi.org/10.1021/bi00187a043","title":"Myosin S1 Changes the Orientation of Caldesmon on Actin","display_name":"Myosin S1 Changes the Orientation of Caldesmon on Actin","publication_year":1994,"publication_date":"1994-05-01","ids":{"openalex":"https://openalex.org/W2081756741","doi":"https://doi.org/10.1021/bi00187a043","mag":"2081756741","pmid":"https://pubmed.ncbi.nlm.nih.gov/8204606"},"language":"en","primary_location":{"id":"doi:10.1021/bi00187a043","doi":"https://doi.org/10.1021/bi00187a043","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00187a043","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021985581","display_name":"Danuta Szczesna\u2010Cordary","orcid":"https://orcid.org/0000-0002-8441-0722","observed_orcids":["https://orcid.org/0000-0002-8441-0722"]},"institutions":[{"id":"https://openalex.org/I1309400984","display_name":"Boston Biomedical Research Institute","ror":"https://ror.org/04rqpth59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1309400984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danuta Szczesna","raw_affiliation_strings":["Boston Biomedical Research Institute, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Biomedical Research Institute, Massachusetts 02114","institution_ids":["https://openalex.org/I1309400984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057469369","display_name":"Philip Graceffa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1309400984","display_name":"Boston Biomedical Research Institute","ror":"https://ror.org/04rqpth59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1309400984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Graceffa","raw_affiliation_strings":["Boston Biomedical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Biomedical Research Institute","institution_ids":["https://openalex.org/I1309400984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091566907","display_name":"C.-L. Albert Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1309400984","display_name":"Boston Biomedical Research Institute","ror":"https://ror.org/04rqpth59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1309400984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.-L. Albert Wang","raw_affiliation_strings":["Boston Biomedical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Biomedical Research Institute","institution_ids":["https://openalex.org/I1309400984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064474716","display_name":"Sherwin S. Lehrer","orcid":"https://orcid.org/0000-0002-0284-4472","observed_orcids":["https://orcid.org/0000-0002-0284-4472"]},"institutions":[{"id":"https://openalex.org/I1309400984","display_name":"Boston Biomedical Research Institute","ror":"https://ror.org/04rqpth59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1309400984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherwin S. Lehrer","raw_affiliation_strings":["Boston Biomedical Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Biomedical Research Institute","institution_ids":["https://openalex.org/I1309400984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1309400984"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.3018,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.61538763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"21","first_page":"6716","last_page":"6720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.8115000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.8115000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.05460000038146973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.05209999904036522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caldesmon","display_name":"caldesmon","score":0.9779999852180481},{"id":"https://openalex.org/keywords/myosin-subfragment-1","display_name":"myosin subfragment 1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/actin-binding-site","display_name":"actin-binding site","score":0.6620000004768372},{"id":"https://openalex.org/keywords/ternary-complex","display_name":"ternary complex","score":0.7490000128746033},{"id":"https://openalex.org/keywords/mgadp","display_name":"MgADP","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2779360546","wikidata":"https://www.wikidata.org/wiki/Q5019078","display_name":"Caldesmon","level":4,"score":0.7221251130104065},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.6939371824264526},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.584567666053772},{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.53128582239151},{"id":"https://openalex.org/C2778407487","wikidata":"https://www.wikidata.org/wiki/Q14565201","display_name":"Altmetrics","level":2,"score":0.5158359408378601},{"id":"https://openalex.org/C518677369","wikidata":"https://www.wikidata.org/wiki/Q202833","display_name":"Social media","level":2,"score":0.4380730390548706},{"id":"https://openalex.org/C16345878","wikidata":"https://www.wikidata.org/wiki/Q107472979","display_name":"Orientation (vector space)","level":2,"score":0.4166225790977478},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.3799089193344116},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3284059762954712},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.32028958201408386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1611769199371338},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08696725964546204},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08597072958946228},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002148","descriptor_name":"Calmodulin-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015879","descriptor_name":"Myosin Subfragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00187a043","doi":"https://doi.org/10.1021/bi00187a043","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00187a043","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:8204606","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8204606","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2332034925","display_name":"Tropomyosin and the Regulation of Muscle Contraction","funder_award_id":"R01HL022461","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G595124065","display_name":"COMPARATIVE STUDY OF TROPONIN C AND CALMODULIN","funder_award_id":"R01HL041411","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7356949689","display_name":"SMOOTH MUSCLE AND NONMUSCLE CALDESMON","funder_award_id":"R01AR030917","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1496193127","https://openalex.org/W1503195546","https://openalex.org/W1520250133","https://openalex.org/W1523556909","https://openalex.org/W1528202931","https://openalex.org/W1542089964","https://openalex.org/W1546526949","https://openalex.org/W1565313767","https://openalex.org/W1578846125","https://openalex.org/W1578984770","https://openalex.org/W1588034855","https://openalex.org/W1726148612","https://openalex.org/W1757420305","https://openalex.org/W1788082166","https://openalex.org/W1962362996","https://openalex.org/W1988039849","https://openalex.org/W1994673901","https://openalex.org/W2004546144","https://openalex.org/W2005949513","https://openalex.org/W2008847227","https://openalex.org/W2022436249","https://openalex.org/W2022966651","https://openalex.org/W2025524794","https://openalex.org/W2026907550","https://openalex.org/W2031796765","https://openalex.org/W2045913132","https://openalex.org/W2072366123","https://openalex.org/W2129995310","https://openalex.org/W2397366915"],"related_works":["https://openalex.org/W2028369450","https://openalex.org/W2397366915","https://openalex.org/W2004546144","https://openalex.org/W2128554456","https://openalex.org/W1997862377","https://openalex.org/W1832713597","https://openalex.org/W2045279252","https://openalex.org/W2035074892","https://openalex.org/W2059038254","https://openalex.org/W1588034855"],"abstract_inverted_index":{"Changes":[0],"in":[1,9,72,86,92,123,128,169,189,206,228],"the":[2,15,64,124,129,132,170,185,190,229],"orientation":[3,163,186],"of":[4,17,56,63,69,79,104,156,164,187,202,231],"caldesmon":[5,144,203],"bound":[6,42,65,120,133,232],"to":[7,43,75,121,179],"actin":[8,44,149,205],"skeletal":[10],"ghost":[11],"myofibrils":[12],"caused":[13],"by":[14,24,52],"binding":[16,150,200,218],"myosin":[18,59,141,182],"subfragment":[19],"1":[20,209],"(S1)":[21],"were":[22],"measured":[23],"fluorescence-detected":[25],"linear":[26],"dichroism":[27],"using":[28],"fluorescence":[29],"microscopy.":[30],"Gizzard":[31],"caldesmon,":[32,105],"labeled":[33,106],"with":[34,45,58,81,107,161,197,216],"acrylodan":[35,108],"at":[36,109],"its":[37,73,110],"two":[38],"Cys":[39,112],"residues":[40],"(CaD*),":[41],"a":[46,82,99,147,153,198,211,223],"probe":[47,87,93],"angle":[48,94],"that":[49,139,168,213,225],"was":[50,95,115],"unaffected":[51],"actin-bound":[53],"tropomyosin.":[54],"Irrigation":[55],"fibrils":[57],"S1":[60,122,217],"dissociated":[61],"most":[62],"CaD*,":[66],"but":[67],"reintroduction":[68],"CaD*":[70,134,165,188],"resulted":[71],"rebinding":[74],"actin,":[76],"without":[77],"dissociation":[78],"S1,":[80,183],"7":[83],"degrees":[84],"difference":[85],"angle.":[88],"A":[89],"similar":[90],"change":[91],"also":[96],"observed":[97],"when":[98],"27-kDa":[100],"actin-binding":[101],"C-terminal":[102],"fragment":[103],"single":[111],"580":[113],"(CaD-27*),":[114],"used.":[116],"Introducing":[117],"MgADP,":[118,176],"which":[119,177,207],"CaD*-actin-S1":[125,157],"ternary":[126,154,191],"complex":[127,155],"fibril,":[130],"reversed":[131],"dichroism.":[135],"These":[136,193],"results":[137,194],"indicate":[138],"(i)":[140],"heads":[142],"and":[143,174,180,219],"compete":[145],"for":[146,204],"common":[148],"site;":[151],"(ii)":[152],"can":[158],"be":[159],"formed":[160,227],"an":[162],"different":[166],"from":[167],"CaD*-actin":[171],"binary":[172],"complex,":[173],"(iii)":[175],"binds":[178],"reorients":[181],"affects":[184],"complex.":[192],"are":[195],"consistent":[196],"two-state":[199],"model":[201],"state":[208,220],"involves":[210,222],"site":[212,224],"is":[214,226],"competitive":[215],"2":[221],"presence":[230],"S1.":[233]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}