{"id":"https://openalex.org/W2081686578","doi":"https://doi.org/10.1093/infdis/jiu603","title":"Combination Treatment With Meropenem Plus Levofloxacin Is Synergistic Against Pseudomonas aeruginosa Infection in a Murine Model of Pneumonia","display_name":"Combination Treatment With Meropenem Plus Levofloxacin Is Synergistic Against Pseudomonas aeruginosa Infection in a Murine Model of Pneumonia","publication_year":2014,"publication_date":"2014-10-31","ids":{"openalex":"https://openalex.org/W2081686578","doi":"https://doi.org/10.1093/infdis/jiu603","mag":"2081686578","pmid":"https://pubmed.ncbi.nlm.nih.gov/25362196","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4447837"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/jiu603","doi":"https://doi.org/10.1093/infdis/jiu603","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiu603","pdf_url":"https://academic.oup.com/jid/article-pdf/211/8/1326/13806121/jiu603.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jid/article-pdf/211/8/1326/13806121/jiu603.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011691262","display_name":"Arnold Louie","orcid":"https://orcid.org/0000-0001-6227-7580","observed_orcids":["https://orcid.org/0000-0001-6227-7580"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arnold Louie","raw_affiliation_strings":["Institute for Therapeutic Innovation, University of Florida, Lake Nona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Therapeutic Innovation, University of Florida, Lake Nona","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100620779","display_name":"Weiguo Liu","orcid":"https://orcid.org/0000-0003-4399-7683","observed_orcids":["https://orcid.org/0000-0003-4399-7683"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiguo Liu","raw_affiliation_strings":["Institute for Therapeutic Innovation, University of Florida, Lake Nona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Therapeutic Innovation, University of Florida, Lake Nona","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030326988","display_name":"Michael VanGuilder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael VanGuilder","raw_affiliation_strings":["Laboratory of Applied Pharmacokinetics, University of Southern California, Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Applied Pharmacokinetics, University of Southern California, Los Angeles","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026635936","display_name":"Michael Noel Neely","orcid":"https://orcid.org/0000-0002-1675-8276","observed_orcids":["https://orcid.org/0000-0002-1675-8276"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael N. Neely","raw_affiliation_strings":["Laboratory of Applied Pharmacokinetics, University of Southern California, Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Applied Pharmacokinetics, University of Southern California, Los Angeles","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054296777","display_name":"Alan Schumitzky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Schumitzky","raw_affiliation_strings":["Laboratory of Applied Pharmacokinetics, University of Southern California, Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Applied Pharmacokinetics, University of Southern California, Los Angeles","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068354167","display_name":"Roger W. Jelliffe","orcid":"https://orcid.org/0000-0002-0736-6705","observed_orcids":["https://orcid.org/0000-0002-0736-6705"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger Jelliffe","raw_affiliation_strings":["Laboratory of Applied Pharmacokinetics, University of Southern California, Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Applied Pharmacokinetics, University of Southern California, Los Angeles","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082157349","display_name":"Steven Fikes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Fikes","raw_affiliation_strings":["Institute for Therapeutic Innovation, University of Florida, Lake Nona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Therapeutic Innovation, University of Florida, Lake Nona","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025494259","display_name":"Stephanie Kurhanewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Kurhanewicz","raw_affiliation_strings":["Institute for Therapeutic Innovation, University of Florida, Lake Nona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Therapeutic Innovation, University of Florida, Lake Nona","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083976131","display_name":"Nichole Robbins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nichole Robbins","raw_affiliation_strings":["Institute for Therapeutic Innovation, University of Florida, Lake Nona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Therapeutic Innovation, University of Florida, Lake Nona","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074271819","display_name":"David Lee Brown","orcid":"https://orcid.org/0000-0002-1778-3465","observed_orcids":["https://orcid.org/0000-0002-1778-3465"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Brown","raw_affiliation_strings":["Institute for Therapeutic Innovation, University of Florida, Lake Nona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Therapeutic Innovation, University of Florida, Lake Nona","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054100847","display_name":"Dodge L. Baluya","orcid":"https://orcid.org/0000-0003-2255-8024","observed_orcids":["https://orcid.org/0000-0003-2255-8024"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dodge Baluya","raw_affiliation_strings":["Institute for Therapeutic Innovation, University of Florida, Lake Nona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Therapeutic Innovation, University of Florida, Lake Nona","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036512885","display_name":"George L. Drusano","orcid":"https://orcid.org/0000-0001-9162-7332","observed_orcids":["https://orcid.org/0000-0001-9162-7332"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George L. Drusano","raw_affiliation_strings":["Institute for Therapeutic Innovation, University of Florida, Lake Nona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Therapeutic Innovation, University of Florida, Lake Nona","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011691262"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":3.1512,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.90539166,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"211","issue":"8","first_page":"1326","last_page":"1333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.048900000751018524,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meropenem","display_name":"meropenem","score":0.9980000257492065},{"id":"https://openalex.org/keywords/levofloxacin","display_name":"levofloxacin","score":1.0},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9539999961853027},{"id":"https://openalex.org/keywords/combination-antibiotic-therapy","display_name":"combination antibiotic therapy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/synergistic-effect","display_name":"synergistic effect","score":0.550000011920929},{"id":"https://openalex.org/keywords/murine-pneumonia-model","display_name":"murine pneumonia model","score":0.7519999742507935},{"id":"https://openalex.org/keywords/granulocytopenia","display_name":"granulocytopenia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8199999928474426},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.5989999771118164},{"id":"https://openalex.org/keywords/resistance-suppression","display_name":"resistance suppression","score":0.5109999775886536},{"id":"https://openalex.org/keywords/hollow-fiber-infection-model","display_name":"hollow-fiber infection model","score":0.7160000205039978},{"id":"https://openalex.org/keywords/dose-ranging-study","display_name":"dose-ranging","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2781276175","wikidata":"https://www.wikidata.org/wiki/Q424193","display_name":"Levofloxacin","level":3,"score":0.954883337020874},{"id":"https://openalex.org/C2779375183","wikidata":"https://www.wikidata.org/wiki/Q421670","display_name":"Meropenem","level":4,"score":0.9290384650230408},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.6862640976905823},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5866696834564209},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.5506632924079895},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.542873203754425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5181776285171509},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47482237219810486},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.45364096760749817},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4101964235305786},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.34929078817367554},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.3148173689842224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22872483730316162},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20681065320968628},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.18695521354675293},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077731","descriptor_name":"Meropenem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013845","descriptor_name":"Thienamycins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064704","descriptor_name":"Levofloxacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/infdis/jiu603","doi":"https://doi.org/10.1093/infdis/jiu603","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiu603","pdf_url":"https://academic.oup.com/jid/article-pdf/211/8/1326/13806121/jiu603.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3800078","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4447837","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4447837","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4447837","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Infect Dis","raw_type":"Text"},{"id":"pmid:25362196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25362196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/infdis/jiu603","doi":"https://doi.org/10.1093/infdis/jiu603","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiu603","pdf_url":"https://academic.oup.com/jid/article-pdf/211/8/1326/13806121/jiu603.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1549063741","display_name":"Population Pharmacokinetic Modeling and Dual Optimal Control","funder_award_id":"R01GM068968","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G193674214","display_name":"Resistance Suppression for P. Aeruginosa using Novel Combination Therapy Modeling","funder_award_id":"R01AI079578","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4143058222","display_name":"Resistance Suppression for Influenza Virus With Combination Chemotherapy","funder_award_id":"R01AI079729","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2081686578.pdf","grobid_xml":"https://content.openalex.org/works/W2081686578.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1505626160","https://openalex.org/W2020864288","https://openalex.org/W2021298363","https://openalex.org/W2047105340","https://openalex.org/W2097842992","https://openalex.org/W2106080885","https://openalex.org/W2106692990","https://openalex.org/W2112597664","https://openalex.org/W2124358959","https://openalex.org/W2144973926","https://openalex.org/W2158168780","https://openalex.org/W2167425482","https://openalex.org/W2170187421","https://openalex.org/W2223501982"],"related_works":["https://openalex.org/W2170187421","https://openalex.org/W2408691244","https://openalex.org/W2055417751","https://openalex.org/W1970784109","https://openalex.org/W4226162870","https://openalex.org/W2358117995","https://openalex.org/W4225966201","https://openalex.org/W2004910087","https://openalex.org/W2134782630","https://openalex.org/W2032645945"],"abstract_inverted_index":{"BACKGROUND:":[0],"Meropenem":[1,55,99],"plus":[2,177],"levofloxacin":[3,39,57,101,146,178],"treatment":[4],"was":[5,47,86,127,135,149,179],"shown":[6,136],"to":[7,22,60,145,160],"be":[8,200],"a":[9,27,50,95],"promising":[10],"combination":[11,43,126,169,174,198],"in":[12,14,26,42,49,66,88,137,151,167],"our":[13],"vitro":[15],"hollow":[16,139],"fiber":[17,140],"infection":[18,141],"model.":[19,31,54,97,142],"We":[20],"strove":[21],"validate":[23],"this":[24,197],"finding":[25],"murine":[28,52],"Pseudomonas":[29,45],"pneumonia":[30,53],"METHODS:":[32],"A":[33],"dose-ranging":[34],"study":[35],"with":[36],"meropenem":[37,148,176],"and":[38,41,56,70,90,100,109,147,185],"alone":[40],"against":[44],"aeruginosa":[46],"performed":[48,87],"granulocytopenic":[51],"were":[58,74,107,165],"administered":[59],"partially":[61],"humanize":[62],"their":[63],"pharmacokinetic":[64],"profiles":[65],"mouse":[67],"serum.":[68],"Total":[69],"resistant":[71,144,163],"bacterial":[72,183],"populations":[73],"estimated":[75],"after":[76],"24":[77],"hours":[78],"of":[79,83,175,192,194,202],"therapy.":[80],"Pharmacokinetic":[81],"profiling":[82],"both":[84],"drugs":[85],"plasma":[89],"epithelial":[91,104],"lining":[92,105],"fluid,":[93],"using":[94],"population":[96],"RESULTS:":[98],"penetrations":[102],"into":[103],"fluid":[106],"39.3%":[108],"64.3%,":[110],"respectively.":[111],"Both":[112],"monotherapies":[113],"demonstrated":[114,123],"good":[115,182],"exposure":[116],"responses.":[117],"An":[118],"innovative":[119],"combination-therapy":[120],"analytic":[121],"approach":[122],"that":[124],"the":[125,138,152,189],"statistically":[128],"significantly":[129],"synergistic":[130],"(\u03b1":[131],"=":[132],"2.475),":[133],"as":[134],"Bacterial":[143],"seen":[150],"control":[153],"arm.":[154,171],"Levofloxacin":[155],"monotherapy":[156],"selected":[157],"for":[158],"resistance":[159,186],"itself.":[161],"No":[162],"subpopulations":[164],"observed":[166],"any":[168],"therapy":[170],"CONCLUSIONS:":[172],"The":[173],"synergistic,":[180],"producing":[181],"kill":[184],"suppression.":[187],"Given":[188],"track":[190],"record":[191],"safety":[193],"each":[195],"agent,":[196],"may":[199],"worthy":[201],"clinical":[203],"trial.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}