{"id":"https://openalex.org/W2081662576","doi":"https://doi.org/10.1172/jci117974","title":"Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8.","display_name":"Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8.","publication_year":1995,"publication_date":"1995-06-01","ids":{"openalex":"https://openalex.org/W2081662576","doi":"https://doi.org/10.1172/jci117974","mag":"2081662576","pmid":"https://pubmed.ncbi.nlm.nih.gov/7769111","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/295955"},"language":"en","primary_location":{"id":"doi:10.1172/jci117974","doi":"https://doi.org/10.1172/jci117974","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci117974","pdf_url":"http://www.jci.org/articles/view/117974/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/117974/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021336761","display_name":"Claire L. Ivey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C L Ivey","raw_affiliation_strings":["Department of Applied Pharmacology, National Heart and Lung Institute, London, UK","Department of Applied Pharmacology, National Heart & Lung Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Pharmacology, National Heart and Lung Institute, London, UK","institution_ids":[]},{"raw_affiliation_string":"Department of Applied Pharmacology, National Heart & Lung Institute, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054779890","display_name":"Frances M. K. Williams","orcid":"https://orcid.org/0000-0002-2998-2744","observed_orcids":["https://orcid.org/0000-0002-2998-2744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F M Williams","raw_affiliation_strings":["Department ofApplied Pharmacology, National Heart and Lung Institute, Dovehouse Street, London. SW3 6LY. UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofApplied Pharmacology, National Heart and Lung Institute, Dovehouse Street, London. SW3 6LY. UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"P D Collins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P D Collins","raw_affiliation_strings":["Department ofApplied Pharmacology, National Heart and Lung Institute, Dovehouse Street, London. SW3 6LY. UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofApplied Pharmacology, National Heart and Lung Institute, Dovehouse Street, London. SW3 6LY. UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111590961","display_name":"Peter J. Jose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J Jose","raw_affiliation_strings":["Department ofApplied Pharmacology, National Heart and Lung Institute, Dovehouse Street, London. SW3 6LY. UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofApplied Pharmacology, National Heart and Lung Institute, Dovehouse Street, London. SW3 6LY. UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112189625","display_name":"T.J. Williams","orcid":"https://orcid.org/0000-0003-1072-0223","observed_orcids":["https://orcid.org/0000-0003-1072-0223"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T J Williams","raw_affiliation_strings":["Department of Applied Pharmacology, National Heart and Lung Institute, Dovehouse Street, London. SW3 6LY. UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Pharmacology, National Heart and Lung Institute, Dovehouse Street, London. SW3 6LY. UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":8.2078,"has_fulltext":true,"cited_by_count":196,"citation_normalized_percentile":{"value":0.97885691,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"95","issue":"6","first_page":"2720","last_page":"2728"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.0885000005364418,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.08209999650716782,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-chemoattractants","display_name":"neutrophil chemoattractants","score":0.953000009059906},{"id":"https://openalex.org/keywords/c5a","display_name":"C5a","score":0.8389999866485596},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9929999709129333},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.8600000143051147},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.921999990940094},{"id":"https://openalex.org/keywords/neutrophil-accumulation","display_name":"neutrophil accumulation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.6439999938011169},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.7565924525260925},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.660488486289978},{"id":"https://openalex.org/C71318922","wikidata":"https://www.wikidata.org/wiki/Q426181","display_name":"Complement component 5","level":4,"score":0.5632977485656738},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5534030199050903},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5474420785903931},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5306282043457031},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4725579619407654},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4712275266647339},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4487263262271881},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.432588130235672},{"id":"https://openalex.org/C198677920","wikidata":"https://www.wikidata.org/wiki/Q3299937","display_name":"Neutrophile","level":3,"score":0.4317556917667389},{"id":"https://openalex.org/C2779133491","wikidata":"https://www.wikidata.org/wiki/Q25401","display_name":"Lagomorpha","level":2,"score":0.4115496277809143},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.31503793597221375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.286945641040802},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.28396499156951904},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25253164768218994},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.21280360221862793},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17975863814353943},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.1507951319217682}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002449","descriptor_name":"Cell Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002630","descriptor_name":"Chemotactic Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015936","descriptor_name":"Complement C5a","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci117974","doi":"https://doi.org/10.1172/jci117974","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci117974","pdf_url":"http://www.jci.org/articles/view/117974/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:295955","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/295955","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:7769111","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7769111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Comment"}],"best_oa_location":{"id":"doi:10.1172/jci117974","doi":"https://doi.org/10.1172/jci117974","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci117974","pdf_url":"http://www.jci.org/articles/view/117974/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2081662576.pdf","grobid_xml":"https://content.openalex.org/works/W2081662576.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W161035681","https://openalex.org/W1524903400","https://openalex.org/W1537362928","https://openalex.org/W1604781829","https://openalex.org/W1611385761","https://openalex.org/W1638095527","https://openalex.org/W1780460389","https://openalex.org/W1805243746","https://openalex.org/W1855585131","https://openalex.org/W1967194466","https://openalex.org/W1968235120","https://openalex.org/W1968409023","https://openalex.org/W1972593824","https://openalex.org/W1975742983","https://openalex.org/W1979008403","https://openalex.org/W1989851755","https://openalex.org/W1999730887","https://openalex.org/W2010258932","https://openalex.org/W2011513090","https://openalex.org/W2013573272","https://openalex.org/W2018149966","https://openalex.org/W2020973480","https://openalex.org/W2026653177","https://openalex.org/W2042291656","https://openalex.org/W2052327108","https://openalex.org/W2059309737","https://openalex.org/W2067264620","https://openalex.org/W2068101083","https://openalex.org/W2070261994","https://openalex.org/W2071177681","https://openalex.org/W2072614008","https://openalex.org/W2074912991","https://openalex.org/W2091599164","https://openalex.org/W2094086361","https://openalex.org/W2100295490","https://openalex.org/W2107568363","https://openalex.org/W2124896411","https://openalex.org/W2144402764","https://openalex.org/W2145432598","https://openalex.org/W2148788956","https://openalex.org/W2151067784","https://openalex.org/W2166123671","https://openalex.org/W2200496349","https://openalex.org/W2263442396","https://openalex.org/W2339444913","https://openalex.org/W2339882834","https://openalex.org/W2395969380","https://openalex.org/W2412190053","https://openalex.org/W2417880370"],"related_works":["https://openalex.org/W2757175803","https://openalex.org/W2112568641","https://openalex.org/W2188104222","https://openalex.org/W7096393554","https://openalex.org/W2017405235","https://openalex.org/W305637074","https://openalex.org/W2258508809","https://openalex.org/W1968409023","https://openalex.org/W2029453743","https://openalex.org/W2094086361"],"abstract_inverted_index":{"The":[0],"neutrophil":[1,97,135],"chemoattractants":[2,105],"generated":[3,174,181],"in":[4,10,35,146,157,175],"a":[5,66,78,165],"model":[6],"of":[7,32,96,104,150,168],"myocardial":[8,33,160],"infarction":[9],"the":[11,51,84,102,125,142,147,158,170,187],"anesthetized":[12],"rabbit":[13],"were":[14,40,81],"investigated.":[15],"Coronary":[16],"artery":[17],"occlusion":[18],"was":[19,56,139],"followed":[20,178],"by":[21,141,179,182],"reperfusion":[22],"for":[23,42],"periods":[24],"from":[25,130],"5":[26,59],"min":[27,60],"to":[28,64,196],"4.5":[29,89],"h.":[30,70,90],"Extracts":[31],"tissue":[34],"normal":[36],"and":[37,44,61,80,110,116,127],"post-ischemic":[38,52,159],"zones":[39],"tested":[41],"C5a":[43,55,115,126,172,201],"interleukin-8":[45],"(IL-8)":[46],"using":[47],"specific":[48],"radioimmunoassays.":[49,148],"In":[50,71],"zone,":[53],"immunoreactive":[54,73,114,155],"detected":[57],"within":[58],"rose":[62,76,99],"progressively":[63,100],"reach":[65],"plateau":[67],"at":[68,83,124],"3-4.5":[69],"contrast,":[72],"IL-8":[74,117,128,156,180,191],"concentrations":[75,103],"after":[77],"delay":[79],"highest":[82],"last":[85],"time":[86,188],"point":[87],"tested,":[88],"Myeloperoxidase":[91],"activity":[92,137],"levels,":[93],"an":[94],"index":[95],"accumulation,":[98],"as":[101],"increased.":[106],"Using":[107],"cation":[108],"exchange":[109],"reversed":[111,131],"phase":[112,132],"HPLC,":[113],"co-eluted":[118],"with":[119],"authentic":[120],"standards.":[121],"Fractions":[122],"taken":[123],"peaks":[129],"HPLC":[133],"exhibited":[134],"aggregating":[136],"which":[138],"neutralized":[140],"respective":[143],"antibody":[144],"used":[145],"Depletion":[149],"circulating":[151],"neutrophils":[152],"virtually":[153],"abolished":[154],"tissue.":[161],"These":[162],"observations":[163],"suggest":[164],"sequential":[166],"release":[167],"chemoattractants:":[169],"first,":[171],"is":[173],"interstitial":[176],"fluid,":[177],"infiltrating":[183],"neutrophils.":[184],"Thus,":[185],"over":[186],"period":[189],"studied,":[190],"generation":[192],"would":[193],"be":[194,197],"expected":[195],"indirectly":[198],"dependent":[199],"on":[200],"production.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}