{"id":"https://openalex.org/W2081521208","doi":"https://doi.org/10.1097/00024382-200201000-00010","title":"Differential Alterations in Cardiovascular Responses During the Progression of Polymicrobial Sepsis in the Mouse","display_name":"Differential Alterations in Cardiovascular Responses During the Progression of Polymicrobial Sepsis in the Mouse","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2081521208","doi":"https://doi.org/10.1097/00024382-200201000-00010","mag":"2081521208","pmid":"https://pubmed.ncbi.nlm.nih.gov/11795670"},"language":"en","primary_location":{"id":"doi:10.1097/00024382-200201000-00010","doi":"https://doi.org/10.1097/00024382-200201000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00024382-200201000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101745774","display_name":"Shaolong Yang","orcid":"https://orcid.org/0000-0003-2682-3737","observed_orcids":["https://orcid.org/0000-0003-2682-3737"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shaolong Yang","raw_affiliation_strings":["Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham School of Medicine, 35294, USA","Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham School of Medicine, 35294, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072286032","display_name":"Chun\u2010Shiang Chung","orcid":"https://orcid.org/0000-0003-4089-6182","observed_orcids":["https://orcid.org/0000-0003-4089-6182"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chun-Shiang Chung","raw_affiliation_strings":["Department of Surgery, Brown University School of Medicine and Rhode Island Hospital, Providence, Rhode Island 02903"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Brown University School of Medicine and Rhode Island Hospital, Providence, Rhode Island 02903","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003446329","display_name":"Alfred Ayala","orcid":"https://orcid.org/0000-0002-5034-2995","observed_orcids":["https://orcid.org/0000-0002-5034-2995"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred Ayala","raw_affiliation_strings":["Department of Surgery, Brown University School of Medicine and Rhode Island Hospital, Providence, Rhode Island 02903"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Brown University School of Medicine and Rhode Island Hospital, Providence, Rhode Island 02903","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085171919","display_name":"Irshad H. Chaudry","orcid":"https://orcid.org/0000-0002-3040-4925","observed_orcids":["https://orcid.org/0000-0002-3040-4925"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Irshad H. Chaudry","raw_affiliation_strings":["Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100338632","display_name":"Ping Wang","orcid":"https://orcid.org/0000-0002-1557-0394","observed_orcids":["https://orcid.org/0000-0002-1557-0394"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ping Wang","raw_affiliation_strings":["Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5085171919","https://openalex.org/A5100338632","https://openalex.org/A5101745774"],"corresponding_institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"],"apc_list":null,"apc_paid":null,"fwci":4.7499,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.95084273,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"1","first_page":"55","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polymicrobial-sepsis","display_name":"polymicrobial sepsis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cardiovascular-response","display_name":"cardiovascular response","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.8009999990463257},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.7009999752044678},{"id":"https://openalex.org/keywords/stroke-volume","display_name":"stroke volume","score":0.6520000100135803},{"id":"https://openalex.org/keywords/organ-blood-flow","display_name":"organ blood flow","score":0.8029999732971191},{"id":"https://openalex.org/keywords/oxygen-delivery","display_name":"oxygen delivery","score":0.9300000071525574},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.6499999761581421},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.8514426946640015},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.7649295330047607},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6852859258651733},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.6249104738235474},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.6079379916191101},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5880237221717834},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5771893262863159},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.5691965818405151},{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.5084154009819031},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.480145663022995},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.43801695108413696},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39557144045829773},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.38721752166748047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36071884632110596},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.34629082679748535},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.1798093020915985}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00024382-200201000-00010","doi":"https://doi.org/10.1097/00024382-200201000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00024382-200201000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmid:11795670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11795670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1351997886","display_name":null,"funder_award_id":"GM 57468","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1653469840","display_name":"MODULATION OF HEPATOCELLULAR FUNCTION IN EARLY SEPSIS","funder_award_id":"5k02ai001461-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3553912128","display_name":null,"funder_award_id":"KO2 AI01461","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4285699512","display_name":"Programmed Cell Death: Role in Septic Immune Dysfunction","funder_award_id":"R01GM053209","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4721276613","display_name":"Sepsis and Mediators: the Role of MFG-E8-derived Peptides","funder_award_id":"5r01gm057468-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5771525147","display_name":null,"funder_award_id":"GM 53008","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6849088585","display_name":null,"funder_award_id":"GM53209","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W40001950","https://openalex.org/W138262537","https://openalex.org/W168146901","https://openalex.org/W1974415742","https://openalex.org/W1977478388","https://openalex.org/W1982034147","https://openalex.org/W2005276110","https://openalex.org/W2005759059","https://openalex.org/W2009699206","https://openalex.org/W2010255815","https://openalex.org/W2011229597","https://openalex.org/W2015225665","https://openalex.org/W2022684234","https://openalex.org/W2025305905","https://openalex.org/W2030799192","https://openalex.org/W2031845335","https://openalex.org/W2032901124","https://openalex.org/W2056703413","https://openalex.org/W2056851771","https://openalex.org/W2069791492","https://openalex.org/W2134339804","https://openalex.org/W2170743970","https://openalex.org/W2171856680","https://openalex.org/W2338586164","https://openalex.org/W2396792520","https://openalex.org/W2412473135","https://openalex.org/W2415161489"],"related_works":["https://openalex.org/W2592679747","https://openalex.org/W2095416731","https://openalex.org/W2252537276","https://openalex.org/W3092587184","https://openalex.org/W2389611150","https://openalex.org/W2406854482","https://openalex.org/W2438491553","https://openalex.org/W2071839581","https://openalex.org/W2036970144","https://openalex.org/W2137128200"],"abstract_inverted_index":{"Although":[0],"the":[1,17,90,99,150,180,196,201,208,232,246,248,251,267],"mouse":[2,209],"has":[3],"been":[4,36],"extensively":[5],"used":[6],"to":[7,87,204],"study":[8],"immune":[9,255],"consequences":[10],"of":[11,95,198,269],"sepsis":[12,47,206],"and":[13,58,92,103,117,120,130,144,146,155,179,254],"other":[14,181],"genetic":[15,258],"anomalies,":[16],"changes":[18],"in":[19,38,50,98,106,149,207,245,263],"various":[20,242],"cardiovascular":[21,202,252],"parameters":[22,244],"such":[23],"as":[24,29,31,184,186],"cardiac":[25,101,138],"output,":[26,139],"organ":[27],"perfusion,":[28],"well":[30,185],"oxygen":[32,128,142],"utilization":[33],"have":[34],"not":[35],"characterized":[37,211],"this":[39,264],"species":[40,265],"during":[41,266],"sepsis.":[42,199,270],"To":[43],"determine":[44],"this,":[45],"polymicrobial":[46,205],"was":[48,165],"induced":[49],"male":[51],"adult":[52],"C3H/NeN":[53],"mice":[54],"by":[55,212,223],"cecal":[56],"ligation":[57],"puncture":[59],"(CLP,":[60],"two":[61],"punctures":[62],"with":[63,72,167],"a":[64,112,224,237],"22-gauge":[65],"needle).":[66],"The":[67,134],"animals":[68],"were":[69,109,124,132],"then":[70],"resuscitated":[71],"normal":[73],"saline":[74],"subcutaneously.":[75],"At":[76],"5":[77,160,218],"or":[78,256],"24":[79,193],"h":[80,161,194,219,229],"after":[81,162,195,220],"CLP":[82],"(time":[83],"points":[84],"previously":[85],"shown":[86],"be":[88,261],"within":[89],"hyperdynamic":[91,215],"hypodynamic":[93,226],"stage":[94],"sepsis,":[96],"respectively,":[97],"rat),":[100],"output":[102],"blood":[104,147],"flow":[105,148],"major":[107],"organs":[108],"determined":[110],"using":[111],"well-established":[113],"radioactive":[114,233],"microsphere":[115,234],"method,":[116],"stroke":[118,140],"volume":[119],"total":[121,170,175],"peripheral":[122,171,176],"resistance":[123,177],"calculated.":[125],"In":[126,173],"addition,":[127],"delivery":[129,143],"consumption":[131],"determined.":[133],"results":[135],"indicate":[136],"that":[137],"volume,":[141],"consumption,":[145],"liver,":[151],"small":[152],"intestine,":[153],"spleen,":[154],"kidneys":[156],"increased":[157,178],"significantly":[158,168,191],"at":[159,192],"CLP.":[163],"This":[164],"associated":[166],"decreased":[169,190],"resistance.":[172],"contrast,":[174],"above-mentioned":[182],"parameters,":[183],"mean":[187],"arterial":[188],"pressure,":[189],"onset":[197],"Thus,":[200],"response":[203,253],"is":[210],"an":[213],"early":[214],"phase":[216,227],"(i.e.,":[217],"CLP)":[221],"followed":[222],"late":[225],"(24":[228],"post-CLP).":[230],"Since":[231],"technique":[235],"provides":[236],"reliable":[238],"method":[239],"for":[240],"determining":[241],"hemodynamic":[243],"mouse,":[247],"correlation":[249],"between":[250],"potentially":[257],"alterations":[259],"can":[260],"examined":[262],"progression":[268]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}