{"id":"https://openalex.org/W2081497965","doi":"https://doi.org/10.1182/blood-2009-10-251660","title":"GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death","display_name":"GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death","publication_year":2010,"publication_date":"2010-02-27","ids":{"openalex":"https://openalex.org/W2081497965","doi":"https://doi.org/10.1182/blood-2009-10-251660","mag":"2081497965","pmid":"https://pubmed.ncbi.nlm.nih.gov/20190189","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5292593"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2009-10-251660","doi":"https://doi.org/10.1182/blood-2009-10-251660","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2009-10-251660","pdf_url":"https://ashpublications.org/blood/article-pdf/115/19/3939/1324565/zh801910003939.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/115/19/3939/1324565/zh801910003939.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062329233","display_name":"Matthew J. Streetly","orcid":"https://orcid.org/0000-0002-6342-8923","observed_orcids":["https://orcid.org/0000-0002-6342-8923"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew J. Streetly","raw_affiliation_strings":["Centre for Haematology, Institute of Cell and Molecular Science, and","Department of Haematology, Guys Hospital, Guys and St Thomas' Foundation Trust, London;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haematology, Institute of Cell and Molecular Science, and","institution_ids":[]},{"raw_affiliation_string":"Department of Haematology, Guys Hospital, Guys and St Thomas' Foundation Trust, London;","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113537997","display_name":"Lenushka Maharaj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lenushka Maharaj","raw_affiliation_strings":["Centre for Experimental Cancer Medicine, Barts and the London School of Medicine, London; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Experimental Cancer Medicine, Barts and the London School of Medicine, London; and","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010636488","display_name":"Simon Joel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Joel","raw_affiliation_strings":["Centre for Experimental Cancer Medicine, Barts and the London School of Medicine, London; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Experimental Cancer Medicine, Barts and the London School of Medicine, London; and","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023885828","display_name":"Steve Schey","orcid":"https://orcid.org/0000-0002-2474-9484","observed_orcids":["https://orcid.org/0000-0002-2474-9484"]},"institutions":[{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steve A. Schey","raw_affiliation_strings":["Department of Haematology, Kings College Hospital Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Kings College Hospital Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I4210153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067154165","display_name":"John G. Gribben","orcid":"https://orcid.org/0000-0002-8505-7430","observed_orcids":["https://orcid.org/0000-0002-8505-7430"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John G. Gribben","raw_affiliation_strings":["Centre for Experimental Cancer Medicine, Barts and the London School of Medicine, London; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Experimental Cancer Medicine, Barts and the London School of Medicine, London; and","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113550534","display_name":"Finbarr E. Cotter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Finbarr E. Cotter","raw_affiliation_strings":["Centre for Experimental Cancer Medicine, Barts and the London School of Medicine, London; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Experimental Cancer Medicine, Barts and the London School of Medicine, London; and","institution_ids":["https://openalex.org/I166337079"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":5.2959,"has_fulltext":true,"cited_by_count":133,"citation_normalized_percentile":{"value":0.96007025,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"115","issue":"19","first_page":"3939","last_page":"3948"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.09009999781847,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.996999979019165},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/pmaip1","display_name":"Noxa","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8920000195503235},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.8930000066757202},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.8619999885559082},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9470000267028809},{"id":"https://openalex.org/keywords/bortezomib-resistance","display_name":"bortezomib resistance","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6462576985359192},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5383738875389099},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.5355128645896912},{"id":"https://openalex.org/C199649820","wikidata":"https://www.wikidata.org/wiki/Q14911762","display_name":"Cyclin-dependent kinase 6","level":5,"score":0.5310457348823547},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4772486686706543},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.46894192695617676},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4456866979598999},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4449896216392517},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.4260398745536804},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4223296642303467},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4024336338043213},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.39077481627464294},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.297340989112854},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.29558682441711426},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22173720598220825},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1011209785938263}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2009-10-251660","doi":"https://doi.org/10.1182/blood-2009-10-251660","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2009-10-251660","pdf_url":"https://ashpublications.org/blood/article-pdf/115/19/3939/1324565/zh801910003939.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5292593","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5292593","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmid:20190189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20190189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood-2009-10-251660","doi":"https://doi.org/10.1182/blood-2009-10-251660","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2009-10-251660","pdf_url":"https://ashpublications.org/blood/article-pdf/115/19/3939/1324565/zh801910003939.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2081497965.pdf","grobid_xml":"https://content.openalex.org/works/W2081497965.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W199959815","https://openalex.org/W1482905183","https://openalex.org/W1495816485","https://openalex.org/W1525857207","https://openalex.org/W1549447766","https://openalex.org/W1759028523","https://openalex.org/W1971377557","https://openalex.org/W1986388339","https://openalex.org/W2006058034","https://openalex.org/W2007998678","https://openalex.org/W2009324803","https://openalex.org/W2013907250","https://openalex.org/W2015975538","https://openalex.org/W2024969918","https://openalex.org/W2038289139","https://openalex.org/W2038745273","https://openalex.org/W2039869443","https://openalex.org/W2048509801","https://openalex.org/W2056756517","https://openalex.org/W2057942504","https://openalex.org/W2058412130","https://openalex.org/W2060490044","https://openalex.org/W2070739194","https://openalex.org/W2072493113","https://openalex.org/W2078534859","https://openalex.org/W2084913318","https://openalex.org/W2085546686","https://openalex.org/W2090475723","https://openalex.org/W2094188666","https://openalex.org/W2097844867","https://openalex.org/W2098483493","https://openalex.org/W2098712005","https://openalex.org/W2100115439","https://openalex.org/W2102042192","https://openalex.org/W2118310862","https://openalex.org/W2126109855","https://openalex.org/W2135491950","https://openalex.org/W2138102966","https://openalex.org/W2143894503","https://openalex.org/W2150476216","https://openalex.org/W2169727811","https://openalex.org/W2274690506","https://openalex.org/W2291817532","https://openalex.org/W6631537372","https://openalex.org/W6632786779","https://openalex.org/W6680277760"],"related_works":["https://openalex.org/W2560055090","https://openalex.org/W2471595114","https://openalex.org/W2560082516","https://openalex.org/W2562677591","https://openalex.org/W2126109855","https://openalex.org/W2240381431","https://openalex.org/W2211620077","https://openalex.org/W2068473916","https://openalex.org/W2218294681","https://openalex.org/W2979340900"],"abstract_inverted_index":{"GCS-100":[0,35,46],"is":[1,175],"a":[2,82,159,176],"galectin-3":[3],"antagonist":[4],"with":[5,61,126],"an":[6,17],"acceptable":[7],"human":[8],"safety":[9],"profile":[10],"that":[11,169],"has":[12,191],"been":[13],"demonstrated":[14],"to":[15],"have":[16],"antimyeloma":[18],"effect":[19],"in":[20,38,54,73,121,162],"the":[21,27,30,108,170],"context":[22],"of":[23,32,34,49,52,63,85,129,140,179],"bortezomib":[24],"resistance.":[25],"In":[26],"present":[28],"study,":[29],"mechanisms":[31],"action":[33],"are":[36],"elucidated":[37],"myeloma":[39,156,180,194],"cell":[40,181,185],"lines":[41],"and":[42,56,59,66,70,75,95,115,134,142,164,187,190],"primary":[43],"tumor":[44,152],"cells.":[45],"induced":[47],"inhibition":[48],"proliferation,":[50],"accumulation":[51],"cells":[53,157],"sub-G(1)":[55],"G(1)":[57],"phases,":[58],"apoptosis":[60],"activation":[62,144],"both":[64],"caspase-8":[65],"-9":[67],"pathways.":[68],"Dose-":[69],"time-dependent":[71],"decreases":[72],"MCL-1":[74],"BCL-X(L)":[76],"levels":[77,128],"also":[78],"occurred,":[79],"accompanied":[80],"by":[81,105],"rapid":[83],"induction":[84],"NOXA":[86],"protein,":[87],"whereas":[88,107],"BCL-2,":[89],"BAX,":[90],"BAK,":[91],"BIM,":[92],"BAD,":[93],"BID,":[94],"PUMA":[96],"remained":[97],"unchanged.":[98],"The":[99],"cell-cycle":[100],"inhibitor":[101],"p21(Cip1)":[102],"was":[103,124],"up-regulated":[104],"GCS-100,":[106,174],"procycling":[109],"proteins":[110],"CYCLIN":[111,113],"E2,":[112],"D2,":[114],"CDK6":[116],"were":[117],"all":[118],"reduced.":[119],"Reduction":[120],"signal":[122],"transduction":[123],"associated":[125],"lower":[127],"activated":[130],"IkappaBalpha,":[131],"IkappaB":[132],"kinase,":[133],"AKT":[135,143],"as":[136,138],"well":[137],"lack":[139],"IkappaBalpha":[141],"after":[145],"appropriate":[146],"cytokine":[147],"stimulation":[148],"(insulin-like":[149],"growth":[150],"factor-1,":[151],"necrosis":[153],"factor-alpha).":[154],"Primary":[155],"showed":[158],"direct":[160],"reduction":[161],"proliferation":[163],"viability.":[165],"These":[166],"data":[167],"demonstrate":[168],"novel":[171],"therapeutic":[172],"molecule,":[173],"potent":[177],"modifier":[178],"biology":[182],"targeting":[183],"apoptosis,":[184],"cycle,":[186],"intracellular":[188],"signaling":[189],"potential":[192],"for":[193],"therapy.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
