{"id":"https://openalex.org/W2081483020","doi":"https://doi.org/10.1089/hgtb.2012.048","title":"Ischemia-Reperfusion Increases Transfection Efficiency of Intracoronary Adenovirus Type 5 in Pig Heart In Situ","display_name":"Ischemia-Reperfusion Increases Transfection Efficiency of Intracoronary Adenovirus Type 5 in Pig Heart In Situ","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W2081483020","doi":"https://doi.org/10.1089/hgtb.2012.048","mag":"2081483020","pmid":"https://pubmed.ncbi.nlm.nih.gov/22816318","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4015071"},"language":"en","primary_location":{"id":"doi:10.1089/hgtb.2012.048","doi":"https://doi.org/10.1089/hgtb.2012.048","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hgtb.2012.048","pdf_url":null,"source":{"id":"https://openalex.org/S2495496942","display_name":"Human Gene Therapy Methods","issn_l":"1946-6536","issn":["1946-6536","1946-6544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC4015071","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031994389","display_name":"Weiwei Shi","orcid":"https://orcid.org/0009-0002-8282-7193","observed_orcids":["https://orcid.org/0009-0002-8282-7193","https://orcid.org/0000-0002-5004-4787"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Weiwei Shi","raw_affiliation_strings":["Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory University, Atlanta, GA 30308"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory University, Atlanta, GA 30308","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007906131","display_name":"L. Susan Schmarkey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Susan Schmarkey","raw_affiliation_strings":["Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory University, Atlanta, GA 30308"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory University, Atlanta, GA 30308","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103539437","display_name":"Rong Jiang","orcid":"https://orcid.org/0009-0008-9305-4978","observed_orcids":["https://orcid.org/0009-0008-9305-4978"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Jiang","raw_affiliation_strings":["Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory University, Atlanta, GA 30308"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory University, Atlanta, GA 30308","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057757530","display_name":"C. Collin Bone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Collin Bone","raw_affiliation_strings":["Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory University, Atlanta, GA 30308"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory University, Atlanta, GA 30308","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053947071","display_name":"Marah E. Condit","orcid":"https://orcid.org/0000-0001-7084-4952","observed_orcids":["https://orcid.org/0000-0001-7084-4952"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marah E. Condit","raw_affiliation_strings":["Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory University, Atlanta, GA 30308"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory University, Atlanta, GA 30308","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054055816","display_name":"Dirck L. Dillehay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dirck L. Dillehay","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine and Division of Animal Resources, Emory University, Atlanta, GA 30022"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine and Division of Animal Resources, Emory University, Atlanta, GA 30022","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049533029","display_name":"Robert L. Engler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Engler","raw_affiliation_strings":["Cardium Therapeutics, Inc., San Diego, CA, 92130","School of Medicine, University of California, San Diego, CA, 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardium Therapeutics, Inc., San Diego, CA, 92130","institution_ids":[]},{"raw_affiliation_string":"School of Medicine, University of California, San Diego, CA, 92093","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038979268","display_name":"Gabor M. Rubanyi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabor M. Rubanyi","raw_affiliation_strings":["Cardium Therapeutics, Inc., San Diego, CA, 92130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardium Therapeutics, Inc., San Diego, CA, 92130","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017018658","display_name":"Jakob Vinten\u2010Johansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jakob Vinten-Johansen","raw_affiliation_strings":["Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory University, Atlanta, GA 30308"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory University, Atlanta, GA 30308","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031994389"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":null,"apc_paid":null,"fwci":1.1505,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.78072595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"23","issue":"3","first_page":"204","last_page":"212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-type-5","display_name":"adenovirus type 5","score":0.8859999775886536},{"id":"https://openalex.org/keywords/transfection-efficiency","display_name":"transfection efficiency","score":0.8090000152587891},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9580000042915344},{"id":"https://openalex.org/keywords/coronary-artery-occlusion","display_name":"coronary artery occlusion","score":0.8849999904632568},{"id":"https://openalex.org/keywords/nitroglycerin","display_name":"nitroglycerin","score":0.8790000081062317},{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":0.9919999837875366},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.9319999814033508},{"id":"https://openalex.org/keywords/luciferase-reporter","display_name":"luciferase reporter","score":0.7419999837875366},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.7217043042182922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6319421529769897},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5639896392822266},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.5581023693084717},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5392817854881287},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.5035890936851501},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4675672650337219},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4271456003189087},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4035230278968811},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39252761006355286},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3627083897590637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24364367127418518},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1111883819103241},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10312357544898987},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.07546341419219971},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006328","descriptor_name":"Cardiac Catheterization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021721","descriptor_name":"Balloon Occlusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1089/hgtb.2012.048","doi":"https://doi.org/10.1089/hgtb.2012.048","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hgtb.2012.048","pdf_url":null,"source":{"id":"https://openalex.org/S2495496942","display_name":"Human Gene Therapy Methods","issn_l":"1946-6536","issn":["1946-6536","1946-6544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy Methods","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2996948","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC4015071","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4015071","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4015071","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Gene Ther Methods","raw_type":"Text"},{"id":"pmid:22816318","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22816318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human gene therapy methods","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2996948","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC4015071","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309381","display_name":"Emory University","ror":"https://ror.org/03czfpz43"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W122651877","https://openalex.org/W1496229851","https://openalex.org/W1593294300","https://openalex.org/W1974040453","https://openalex.org/W1977624384","https://openalex.org/W1978368006","https://openalex.org/W1981459637","https://openalex.org/W1985695559","https://openalex.org/W1992855266","https://openalex.org/W1995229436","https://openalex.org/W2014414897","https://openalex.org/W2016626897","https://openalex.org/W2018284472","https://openalex.org/W2018619273","https://openalex.org/W2020491908","https://openalex.org/W2022473516","https://openalex.org/W2031102459","https://openalex.org/W2039618053","https://openalex.org/W2053913645","https://openalex.org/W2067377891","https://openalex.org/W2073762202","https://openalex.org/W2121555488","https://openalex.org/W2136812723","https://openalex.org/W2141670982","https://openalex.org/W2149458703","https://openalex.org/W2162844134","https://openalex.org/W2174986562"],"related_works":["https://openalex.org/W2287463346","https://openalex.org/W3174607425","https://openalex.org/W2020491908","https://openalex.org/W2244161543","https://openalex.org/W2014414897","https://openalex.org/W2035575505","https://openalex.org/W2312258002","https://openalex.org/W2090603176","https://openalex.org/W1993384245","https://openalex.org/W2348102749"],"abstract_inverted_index":{"Efficiency":[0],"of":[1,34,85,99,116,122,134,164,181,190,214,245,252],"intracoronary":[2,220],"(IC)":[3],"adenoviral":[4,25,35,61],"vector":[5,26,36,64,218],"transfection":[6,27,158,212,266],"is":[7,40],"impaired":[8],"by":[9,42,45,82,113,229,236],"the":[10,53,66,141,146,179,211,269],"vascular":[11,18,231],"endothelium.":[12],"Ischemia":[13],"and":[14,59,78,107,136,150,207,275],"substances":[15],"that":[16,178,257],"increase":[17,103],"permeability":[19,232],"(sodium":[20],"nitroprusside,":[21],"nitroglycerin)":[22],"may":[23],"augment":[24],"efficiency":[28,213],"(TE).":[29],"We":[30,176],"tested":[31],"whether":[32,210],"TE":[33,73],"following":[37,203,219],"IC":[38,83,114,162,182,191],"infusion":[39,221],"improved":[41,227],"nitrates":[43,234],"or":[44,173,235],"ischemia.":[46,205,237],"Fluoroscopically":[47],"guided":[48],"angioplasty":[49],"balloon":[50],"catheters":[51],"occluded":[52],"coronary":[54,123],"artery":[55,124],"in":[56,140,159,195,201,222,259,268],"Yorkshire":[57,223],"pigs":[58,224],"delivered":[60],"type":[62,216],"5":[63,217],"encoding":[65],"luciferase":[67,104,108,126],"gene":[68,198],"(Ad5Luc,":[69],"1011":[70],"viral":[71],"particles).":[72],"(luciferase":[74],"activity)":[75],"was":[76,79,110,128,137,156],"minimal":[77],"not":[80,95],"augmented":[81],"co-administration":[84,115,251],"50":[86],"\u03bcg/min":[87],"sodium":[88],"nitroprusside":[89],"to":[90,102,145,184,263],"nonischemic":[91,160],"myocardium.":[92,161],"Two":[93],"(but":[94],"one)":[96],"3-min":[97],"episodes":[98],"occlusion":[100],"tended":[101],"activity":[105,109,127,239,267],"(p=0.06),":[106],"further":[111],"increased":[112,240],"nitroglycerin":[117],"(p<0.001).":[118],"After":[119],"75":[120],"min":[121],"occlusion,":[125],"greater":[129,139,265],"than":[130],"with":[131,233,241,250],"shorter":[132],"periods":[133,244,256],"ischemia,":[135],"significantly":[138,264],"ischemia-reperfused":[142,270],"zone":[143,148],"compared":[144],"border":[147],"3":[149,274],"14":[151,276],"days":[152,277],"after":[153,278],"infusion;":[154],"there":[155],"no":[157,170],"delivery":[163,193],"Ad5Luc":[165],"into":[166],"post-ischemic":[167],"myocardium":[168,187],"caused":[169],"local":[171],"inflammation":[172],"hemodynamic":[174],"instability.":[175],"conclude":[177],"uptake":[180],"Ad5":[183,192],"ischemic":[185,255],"reperfused":[186],"validates":[188],"use":[189],"protocols":[194],"future":[196],"human":[197],"therapy":[199],"trials":[200],"patients":[202],"myocardial":[204,260],"Shi":[206],"colleagues":[208],"evaluate":[209],"adenovirus":[215],"can":[225],"be":[226],"either":[228],"increasing":[230],"Transgene":[238],"two":[242],"3-minute":[243],"ischemia":[246],"as":[247,249],"well":[248],"nitroglycerin.":[253],"Longer":[254],"result":[258],"infarction":[261],"led":[262],"area,":[271],"at":[272],"both":[273],"infusion.":[279]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}