{"id":"https://openalex.org/W2081472291","doi":"https://doi.org/10.1126/science.1827531","title":"HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions","display_name":"HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions","publication_year":1991,"publication_date":"1991-05-10","ids":{"openalex":"https://openalex.org/W2081472291","doi":"https://doi.org/10.1126/science.1827531","mag":"2081472291","pmid":"https://pubmed.ncbi.nlm.nih.gov/1827531"},"language":"en","primary_location":{"id":"doi:10.1126/science.1827531","doi":"https://doi.org/10.1126/science.1827531","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1827531","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2081472291"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081858587","display_name":"Hugh F. Maguire","orcid":"https://orcid.org/0009-0006-8571-7829","observed_orcids":["https://orcid.org/0009-0006-8571-7829"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hugh F. Maguire","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Colorado School of Medicine, Denver, CO 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Colorado School of Medicine, Denver, CO 80262","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049792259","display_name":"James P. Hoeffler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Hoeffler","raw_affiliation_strings":["Division ofMedical Oncology, University of Colorado School of Medicine and Cancer Center, Denver, CO 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division ofMedical Oncology, University of Colorado School of Medicine and Cancer Center, Denver, CO 80262","institution_ids":["https://openalex.org/I4210134151","https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005340343","display_name":"Aleem Siddiqui","orcid":"https://orcid.org/0000-0001-5970-7535","observed_orcids":["https://orcid.org/0000-0001-5970-7535"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleem Siddiqui","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Colorado School of Medicine, Denver, CO 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Colorado School of Medicine, Denver, CO 80262","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":22.3938,"has_fulltext":false,"cited_by_count":450,"citation_normalized_percentile":{"value":0.99806875,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"252","issue":"5007","first_page":"842","last_page":"844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus-x-protein","display_name":"hepatitis B virus X protein","score":0.9380000233650208},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.9309999942779541},{"id":"https://openalex.org/keywords/atf2","display_name":"ATF2","score":0.996999979019165},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7879999876022339},{"id":"https://openalex.org/keywords/dna-binding-specificity","display_name":"DNA binding specificity","score":0.972000002861023},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.859000027179718},{"id":"https://openalex.org/keywords/viral-enhancer","display_name":"viral enhancer","score":0.6779999732971191},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.621999979019165},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.9071221351623535},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.7819951772689819},{"id":"https://openalex.org/C2776603820","wikidata":"https://www.wikidata.org/wiki/Q906517","display_name":"CREB-binding protein","level":5,"score":0.5674917101860046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.537986159324646},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5317913889884949},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5021729469299316},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.4797564744949341},{"id":"https://openalex.org/C199172495","wikidata":"https://www.wikidata.org/wiki/Q21116771","display_name":"CREB1","level":5,"score":0.4740692675113678},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4577952027320862},{"id":"https://openalex.org/C77400797","wikidata":"https://www.wikidata.org/wiki/Q24724047","display_name":"Single-stranded binding protein","level":5,"score":0.4334029257297516},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34029334783554077},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.328366219997406},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23738789558410645}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054334","descriptor_name":"Viral Regulatory and Accessory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1827531","doi":"https://doi.org/10.1126/science.1827531","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1827531","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:1827531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1827531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5834399638","display_name":null,"funder_award_id":"P30-CA46934-02","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8757370540","display_name":"EXPRESSION OF HBV GENES AND HEPATOMA","funder_award_id":"R01CA033135","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000891461","display_name":"University of Colorado Cancer Center Support Grant","funder_award_id":"P30CA046934","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1495237614","https://openalex.org/W1509450523","https://openalex.org/W1623494770","https://openalex.org/W1874132424","https://openalex.org/W1912385731","https://openalex.org/W1939804351","https://openalex.org/W1958327809","https://openalex.org/W1970968166","https://openalex.org/W1973135307","https://openalex.org/W1983750916","https://openalex.org/W2000024512","https://openalex.org/W2001788697","https://openalex.org/W2005396212","https://openalex.org/W2013607556","https://openalex.org/W2016560284","https://openalex.org/W2018859290","https://openalex.org/W2019005890","https://openalex.org/W2026156952","https://openalex.org/W2033371710","https://openalex.org/W2042976701","https://openalex.org/W2053706911","https://openalex.org/W2062687382","https://openalex.org/W2063863464","https://openalex.org/W2064529356","https://openalex.org/W2070697949","https://openalex.org/W2091024601","https://openalex.org/W2093089286","https://openalex.org/W2094807913","https://openalex.org/W2095157104","https://openalex.org/W2097794242","https://openalex.org/W2109399660","https://openalex.org/W2111718895","https://openalex.org/W2132781864","https://openalex.org/W2134926960","https://openalex.org/W2150001528","https://openalex.org/W2165409475","https://openalex.org/W2172270130","https://openalex.org/W2411184464","https://openalex.org/W2419420942"],"related_works":["https://openalex.org/W1542004864","https://openalex.org/W2108467973","https://openalex.org/W2012074365","https://openalex.org/W1985563243","https://openalex.org/W2140788887","https://openalex.org/W199634660","https://openalex.org/W2017019224","https://openalex.org/W2062687382","https://openalex.org/W1991854775"],"abstract_inverted_index":{"The":[0,13,24],"hepatitis":[1],"B":[2],"virus":[3],"(HBV)":[4],"X":[5,14],"gene":[6],"product":[7],"trans-activates":[8],"viral":[9,124],"and":[10,42,44,52,93],"cellular":[11,38,82],"genes.":[12],"protein":[15],"(pX)":[16],"does":[17],"not":[18,56],"bind":[19,57,69],"independently":[20],"to":[21,58,70,79,99],"nucleic":[22],"acids.":[23],"data":[25],"presented":[26],"here":[27],"demonstrate":[28],"that":[29,116],"pX":[30,78,98],"entered":[31],"into":[32],"a":[33,63,95],"protein-protein":[34],"complex":[35,67],"with":[36,81],"the":[37,59,71,75,85,112],"transcriptional":[39,102,121],"factors":[40,83,122],"CREB":[41,51],"ATF-2":[43,53],"altered":[45,107],"their":[46],"DNA":[47,86],"binding":[48,87,108],"specificities.":[49],"Although":[50],"alone":[54],"did":[55,68],"HBV":[60,72],"enhancer":[61],"element,":[62],"pX-CREB":[64],"or":[65],"pX-ATF-2":[66],"enhancer.":[73],"Thus,":[74],"ability":[76],"of":[77,89,106,114],"interact":[80],"broadened":[84],"specificity":[88,109],"these":[90],"regulatory":[91],"proteins":[92],"provides":[94],"mechanism":[96],"for":[97],"participate":[100],"in":[101],"regulation.":[103],"This":[104],"strategy":[105],"may":[110],"modify":[111],"repertoire":[113],"genes":[115],"can":[117],"be":[118],"regulated":[119],"by":[120],"during":[123],"infection.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}