{"id":"https://openalex.org/W2081443513","doi":"https://doi.org/10.1016/s0002-9378(94)70100-8","title":"Maternal serum \u03b1-fetoprotein screening for chromosomal abnormalities: A prospective study in women aged 35 and older","display_name":"Maternal serum \u03b1-fetoprotein screening for chromosomal abnormalities: A prospective study in women aged 35 and older","publication_year":1994,"publication_date":"1994-04-01","ids":{"openalex":"https://openalex.org/W2081443513","doi":"https://doi.org/10.1016/s0002-9378(94)70100-8","mag":"2081443513","pmid":"https://pubmed.ncbi.nlm.nih.gov/7513121"},"language":"en","primary_location":{"id":"doi:10.1016/s0002-9378(94)70100-8","doi":"https://doi.org/10.1016/s0002-9378(94)70100-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0002-9378(94)70100-8","pdf_url":null,"source":{"id":"https://openalex.org/S122347013","display_name":"American Journal of Obstetrics and Gynecology","issn_l":"0002-9378","issn":["0002-9378","1085-8709","1097-6868"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Obstetrics and Gynecology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103544796","display_name":"Nancy C. Rose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy C. Rose","raw_affiliation_strings":["Univeristy of Pennsylvania Medical Center, Philadelphia 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univeristy of Pennsylvania Medical Center, Philadelphia 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040488093","display_name":"Glenn E. Palomaki","orcid":"https://orcid.org/0000-0001-6154-8449","observed_orcids":["https://orcid.org/0000-0001-6154-8449"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glenn E. Palomaki","raw_affiliation_strings":["Philadelphia, Pennsylvania, and Scarborough, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philadelphia, Pennsylvania, and Scarborough, Maine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043890834","display_name":"James E. Haddow","orcid":"https://orcid.org/0000-0001-7725-6184","observed_orcids":["https://orcid.org/0000-0001-7725-6184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James E. Haddow","raw_affiliation_strings":["Philadelphia, Pennsylvania, and Scarborough, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philadelphia, Pennsylvania, and Scarborough, Maine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109867111","display_name":"David B. P. Goodman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David B.P. Goodman","raw_affiliation_strings":["Philadelphia, Pennsylvania, and Scarborough, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philadelphia, Pennsylvania, and Scarborough, Maine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109055248","display_name":"Michael T. Mennuti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael T. Mennuti","raw_affiliation_strings":["Philadelphia, Pennsylvania, and Scarborough, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philadelphia, Pennsylvania, and Scarborough, Maine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5410,"currency":"USD","value_usd":5410},"apc_paid":null,"fwci":2.2917,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.87209677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"170","issue":"4","first_page":"1073","last_page":"1080"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-serum-alpha-fetoprotein","display_name":"maternal serum alpha-fetoprotein","score":0.9929999709129333},{"id":"https://openalex.org/keywords/down-syndrome-screening","display_name":"Down syndrome screening","score":0.8309999704360962},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.7839999794960022},{"id":"https://openalex.org/keywords/advanced-maternal-age","display_name":"advanced maternal age","score":0.9909999966621399},{"id":"https://openalex.org/keywords/prenatal-screening","display_name":"prenatal screening","score":0.5289999842643738},{"id":"https://openalex.org/keywords/sex-chromosome-aneuploidy","display_name":"sex chromosome aneuploidy","score":0.8769999742507935},{"id":"https://openalex.org/keywords/translocation","display_name":"translocation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/false-positive-rate","display_name":"false positive rate","score":0.6779999732971191},{"id":"https://openalex.org/keywords/amniocentesis","display_name":"amniocentesis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/prenatal-counselling","display_name":"prenatal counseling","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8775662183761597},{"id":"https://openalex.org/C2777966818","wikidata":"https://www.wikidata.org/wiki/Q473768","display_name":"Amniocentesis","level":5,"score":0.869448184967041},{"id":"https://openalex.org/C2776352029","wikidata":"https://www.wikidata.org/wiki/Q4686351","display_name":"Advanced maternal age","level":4,"score":0.7701323628425598},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.7205432057380676},{"id":"https://openalex.org/C2779954681","wikidata":"https://www.wikidata.org/wiki/Q47715","display_name":"Down syndrome","level":2,"score":0.6411547064781189},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.54881352186203},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5448758602142334},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.49764493107795715},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46115660667419434},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4423254728317261},{"id":"https://openalex.org/C2780624289","wikidata":"https://www.wikidata.org/wiki/Q306076","display_name":"Alpha-fetoprotein","level":3,"score":0.42840132117271423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13915857672691345},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0848265290260315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.059881389141082764},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008423","descriptor_name":"Maternal Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018566","descriptor_name":"Pregnancy, High-Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025063","descriptor_name":"Chromosome Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0002-9378(94)70100-8","doi":"https://doi.org/10.1016/s0002-9378(94)70100-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0002-9378(94)70100-8","pdf_url":null,"source":{"id":"https://openalex.org/S122347013","display_name":"American Journal of Obstetrics and Gynecology","issn_l":"0002-9378","issn":["0002-9378","1085-8709","1097-6868"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Obstetrics and Gynecology","raw_type":"journal-article"},{"id":"pmid:7513121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7513121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of obstetrics and gynecology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W30338573","https://openalex.org/W334175076","https://openalex.org/W1964682494","https://openalex.org/W1967853679","https://openalex.org/W1986493381","https://openalex.org/W1997808063","https://openalex.org/W2015609935","https://openalex.org/W2029359751","https://openalex.org/W2030645242","https://openalex.org/W2048855777","https://openalex.org/W2066839254","https://openalex.org/W2075474855","https://openalex.org/W2085809389","https://openalex.org/W2121955062","https://openalex.org/W2135713437","https://openalex.org/W2152525100","https://openalex.org/W2162675940","https://openalex.org/W2239887153","https://openalex.org/W2318140695","https://openalex.org/W2340186011","https://openalex.org/W2406867736","https://openalex.org/W2407820413","https://openalex.org/W6601209139","https://openalex.org/W6808367961"],"related_works":["https://openalex.org/W1991356548","https://openalex.org/W4248649654","https://openalex.org/W2048855777","https://openalex.org/W2340186011","https://openalex.org/W2140935286","https://openalex.org/W2135713437","https://openalex.org/W30338573","https://openalex.org/W1998861400","https://openalex.org/W2409096526","https://openalex.org/W2069590144"],"abstract_inverted_index":null,"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}