{"id":"https://openalex.org/W2081330516","doi":"https://doi.org/10.1016/j.cllc.2014.11.006","title":"Intercalated Dosing Schedule of Erlotinib and Docetaxel as a Therapeutic Strategy to Avoid Antagonism and Optimize Its Benefits in Advanced Non\u2013Small-Cell Lung Cancer. A Randomized Phase II Clinical Trial","display_name":"Intercalated Dosing Schedule of Erlotinib and Docetaxel as a Therapeutic Strategy to Avoid Antagonism and Optimize Its Benefits in Advanced Non\u2013Small-Cell Lung Cancer. A Randomized Phase II Clinical Trial","publication_year":2014,"publication_date":"2014-11-22","ids":{"openalex":"https://openalex.org/W2081330516","doi":"https://doi.org/10.1016/j.cllc.2014.11.006","mag":"2081330516","pmid":"https://pubmed.ncbi.nlm.nih.gov/25547902"},"language":"en","primary_location":{"id":"doi:10.1016/j.cllc.2014.11.006","doi":"https://doi.org/10.1016/j.cllc.2014.11.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cllc.2014.11.006","pdf_url":null,"source":{"id":"https://openalex.org/S32518486","display_name":"Clinical Lung Cancer","issn_l":"1525-7304","issn":["1525-7304","1938-0690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lung Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008290108","display_name":"\u00d3scar Juan","orcid":"https://orcid.org/0000-0002-7772-9030","observed_orcids":["https://orcid.org/0000-0002-7772-9030"]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"\u00d3scar Juan","raw_affiliation_strings":["Hospital Universitari i Polit\u00e8cnic La Fe, Medical Oncology Department, Valencia, Spain. Electronic address: juan_osc@gva.es","Hospital Universitari i Polit\u00e8cnic La Fe, Medical Oncology Department, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitari i Polit\u00e8cnic La Fe, Medical Oncology Department, Valencia, Spain. Electronic address: juan_osc@gva.es","institution_ids":["https://openalex.org/I3019010403"]},{"raw_affiliation_string":"Hospital Universitari i Polit\u00e8cnic La Fe, Medical Oncology Department, Valencia, Spain","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036354181","display_name":"Francisco Aparisi","orcid":"https://orcid.org/0000-0002-1468-1375","observed_orcids":["https://orcid.org/0000-0002-1468-1375"]},"institutions":[{"id":"https://openalex.org/I4210158207","display_name":"Hospital Virgen de los Lirios","ror":"https://ror.org/04ssfah06","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158207"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Aparisi","raw_affiliation_strings":["Hospital Virgen de los Lirios, Medical Oncology Department, Alcoy, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Virgen de los Lirios, Medical Oncology Department, Alcoy, Spain","institution_ids":["https://openalex.org/I4210158207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021894737","display_name":"Alfredo S\u00e1nchez-Hern\u00e1ndez","orcid":"https://orcid.org/0000-0001-5826-8390","observed_orcids":["https://orcid.org/0000-0001-5826-8390"]},"institutions":[{"id":"https://openalex.org/I4210096764","display_name":"Consorcio Hospitalario Provincial de Castell\u00f3n","ror":"https://ror.org/00t7jb983","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096764"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alfredo S\u00e1nchez-Hern\u00e1ndez","raw_affiliation_strings":["Consorcio Hospitalario Provincial de Castell\u00f3n, Medical Oncology Department, Castell\u00f3n, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consorcio Hospitalario Provincial de Castell\u00f3n, Medical Oncology Department, Castell\u00f3n, Spain","institution_ids":["https://openalex.org/I4210096764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057408102","display_name":"Jos\u00e9 Mu\u00f1oz-Langa","orcid":"https://orcid.org/0000-0002-6942-8916","observed_orcids":["https://orcid.org/0000-0002-6942-8916"]},"institutions":[{"id":"https://openalex.org/I4210126200","display_name":"Hospital Universitario Doctor Peset","ror":"https://ror.org/03971n288","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210126200"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Mu\u00f1oz-Langa","raw_affiliation_strings":["Hospital Universitario Dr Peset, Medical Oncology Department, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Dr Peset, Medical Oncology Department, Valencia, Spain","institution_ids":["https://openalex.org/I4210126200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046690861","display_name":"G. Esquerdo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107553","display_name":"Hospital Cl\u00ednica Benidorm","ror":"https://ror.org/01smtb607","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210107553"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gaspar Esquerdo","raw_affiliation_strings":["ITIC-Cl\u00ednica Benidorm, Benidorm, Alicante, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ITIC-Cl\u00ednica Benidorm, Benidorm, Alicante, Spain","institution_ids":["https://openalex.org/I4210107553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101676978","display_name":"Jos\u00e9 Garc\u00eda-S\u00e1nchez","orcid":"https://orcid.org/0000-0003-0642-9118","observed_orcids":["https://orcid.org/0000-0003-0642-9118"]},"institutions":[{"id":"https://openalex.org/I4210119293","display_name":"Hospital Arnau de Vilanova","ror":"https://ror.org/02s7fkk92","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210119293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Garc\u00eda-S\u00e1nchez","raw_affiliation_strings":["Hospital Arnau de Vilanova, Medical Oncology Department, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Arnau de Vilanova, Medical Oncology Department, Valencia, Spain","institution_ids":["https://openalex.org/I4210119293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111510706","display_name":"Antonio L\u00f3pez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091477","display_name":"Hospital Universitari Sant Joan D'Alacant","ror":"https://ror.org/00f6kbf47","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210091477"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio L\u00f3pez","raw_affiliation_strings":["Hospital Universitari Sant Joan de Alicante, Medical Oncology Department, Alicante, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitari Sant Joan de Alicante, Medical Oncology Department, Alicante, Spain","institution_ids":["https://openalex.org/I4210091477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004800809","display_name":"Javier Garde","orcid":"https://orcid.org/0000-0001-7043-067X","observed_orcids":["https://orcid.org/0000-0001-7043-067X"]},"institutions":[{"id":"https://openalex.org/I4210119293","display_name":"Hospital Arnau de Vilanova","ror":"https://ror.org/02s7fkk92","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210119293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Garde","raw_affiliation_strings":["Hospital Arnau de Vilanova, Medical Oncology Department, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Arnau de Vilanova, Medical Oncology Department, Valencia, Spain","institution_ids":["https://openalex.org/I4210119293"]}]},{"author_position":"last","author":{"id":null,"display_name":"Vicente Giner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133617","display_name":"Hospital de Sagunto","ror":"https://ror.org/04kbvfy96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210133617"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Vicente Giner","raw_affiliation_strings":["Hospital de Sagunto, Medical Oncology Department, Sagunto, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de Sagunto, Medical Oncology Department, Sagunto, Spain","institution_ids":["https://openalex.org/I4210133617"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5008290108"],"corresponding_institution_ids":["https://openalex.org/I3019010403"],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":null,"fwci":1.6938,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.83815704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"3","first_page":"193","last_page":"199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.996999979019165},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":1.0},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9049999713897705},{"id":"https://openalex.org/keywords/intermittent-dosing","display_name":"intermittent dosing","score":0.7250000238418579},{"id":"https://openalex.org/keywords/drug-antagonism","display_name":"drug antagonism","score":0.6129999756813049},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8970000147819519},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8629999756813049},{"id":"https://openalex.org/keywords/disease-control-rate","display_name":"disease control rate","score":0.722000002861023},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9100008606910706},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.8580054044723511},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.7979189157485962},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.7319731712341309},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7113357186317444},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5775335431098938},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5657521486282349},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.551548957824707},{"id":"https://openalex.org/C2777383412","wikidata":"https://www.wikidata.org/wiki/Q4770891","display_name":"Antagonism","level":3,"score":0.5402858257293701},{"id":"https://openalex.org/C68387754","wikidata":"https://www.wikidata.org/wiki/Q7271585","display_name":"Schedule","level":2,"score":0.4458499550819397},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3914775252342224},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38905972242355347},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.37295517325401306},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3373548984527588},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.16079258918762207},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069347","descriptor_name":"Erlotinib Hydrochloride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cllc.2014.11.006","doi":"https://doi.org/10.1016/j.cllc.2014.11.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cllc.2014.11.006","pdf_url":null,"source":{"id":"https://openalex.org/S32518486","display_name":"Clinical Lung Cancer","issn_l":"1525-7304","issn":["1525-7304","1938-0690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lung Cancer","raw_type":"journal-article"},{"id":"pmid:25547902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25547902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical lung cancer","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307779","display_name":"Roche","ror":"https://ror.org/00by1q217"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1986001758","https://openalex.org/W2034685364","https://openalex.org/W2050249255","https://openalex.org/W2053394601","https://openalex.org/W2097026987","https://openalex.org/W2108198466","https://openalex.org/W2110835998","https://openalex.org/W2111662961","https://openalex.org/W2116869138","https://openalex.org/W2117316096","https://openalex.org/W2124967121","https://openalex.org/W2128082578","https://openalex.org/W2130652363","https://openalex.org/W2131891275","https://openalex.org/W2132157071","https://openalex.org/W2134667653","https://openalex.org/W2138297714","https://openalex.org/W2144180913","https://openalex.org/W2144660856","https://openalex.org/W2145835533","https://openalex.org/W2152755651","https://openalex.org/W2162724777","https://openalex.org/W2270409815","https://openalex.org/W2345494564","https://openalex.org/W2417668197","https://openalex.org/W2626223149"],"related_works":["https://openalex.org/W2589496344","https://openalex.org/W2599286596","https://openalex.org/W2053394601","https://openalex.org/W2183863864","https://openalex.org/W3187898247","https://openalex.org/W2589994163","https://openalex.org/W2954726900","https://openalex.org/W2288052493","https://openalex.org/W2121926293","https://openalex.org/W2041814933"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}