{"id":"https://openalex.org/W2081323334","doi":"https://doi.org/10.1016/j.jala.2006.05.002","title":"A Low-Cost, Low-Power, Consumption Miniature Laser-Induced Fluorescence System for DNA Detection on a Microfluidic Device","display_name":"A Low-Cost, Low-Power, Consumption Miniature Laser-Induced Fluorescence System for DNA Detection on a Microfluidic Device","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W2081323334","doi":"https://doi.org/10.1016/j.jala.2006.05.002","mag":"2081323334"},"language":"en","primary_location":{"id":"doi:10.1016/j.jala.2006.05.002","doi":"https://doi.org/10.1016/j.jala.2006.05.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jala.2006.05.002","pdf_url":null,"source":{"id":"https://openalex.org/S4210188720","display_name":"JALA Journal of the Association for Laboratory Automation","issn_l":"1535-5535","issn":["1535-5535","1540-2452"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JALA: Journal of the Association for Laboratory Automation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046072861","display_name":"Sushil Shrinivasan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sushil Shrinivasan","raw_affiliation_strings":["University of Virginia, Charlottesville, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027502995","display_name":"Pamela M. Norris","orcid":"https://orcid.org/0000-0003-2505-2176","observed_orcids":["https://orcid.org/0000-0003-2505-2176"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela M. Norris","raw_affiliation_strings":["University of Virginia, Charlottesville, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031563436","display_name":"James P. Landers","orcid":"https://orcid.org/0000-0002-9310-1796","observed_orcids":["https://orcid.org/0000-0002-9310-1796"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Landers","raw_affiliation_strings":["University of Virginia Health Science Center, Charlottesville, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia Health Science Center, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046014884","display_name":"Jerome P. Ferrance","orcid":"https://orcid.org/0000-0003-1020-8289","observed_orcids":["https://orcid.org/0000-0003-1020-8289"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jerome P. Ferrance","raw_affiliation_strings":["University of Virginia, Charlottesville, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046014884"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":null,"apc_paid":null,"fwci":0.2176,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.60944248,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"4","first_page":"254","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laser-induced-fluorescence","display_name":"laser-induced fluorescence","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dna-detection","display_name":"DNA detection","score":0.871999979019165},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.9049999713897705},{"id":"https://openalex.org/keywords/low-cost-instrumentation","display_name":"low-cost instrumentation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/low-power-consumption","display_name":"low power consumption","score":0.9369999766349792},{"id":"https://openalex.org/keywords/diode-laser-excitation","display_name":"laser diode excitation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/lambda-phage-dna","display_name":"lambda phage DNA","score":0.8820000290870667},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.6838095188140869},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.6138812303543091},{"id":"https://openalex.org/C113879476","wikidata":"https://www.wikidata.org/wiki/Q61897384","display_name":"Photomultiplier","level":3,"score":0.5747073888778687},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5456517338752747},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.530297040939331},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.5184423923492432},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.49244460463523865},{"id":"https://openalex.org/C751236","wikidata":"https://www.wikidata.org/wiki/Q175943","display_name":"Photodiode","level":2,"score":0.4670039415359497},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2793446183204651},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27429425716400146},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.27290797233581543},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1949603259563446},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1478632390499115},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jala.2006.05.002","doi":"https://doi.org/10.1016/j.jala.2006.05.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jala.2006.05.002","pdf_url":null,"source":{"id":"https://openalex.org/S4210188720","display_name":"JALA Journal of the Association for Laboratory Automation","issn_l":"1535-5535","issn":["1535-5535","1540-2452"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JALA: Journal of the Association for Laboratory Automation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1493546459","https://openalex.org/W1881870315","https://openalex.org/W1975128609","https://openalex.org/W2004153110","https://openalex.org/W2008444319","https://openalex.org/W2041232559","https://openalex.org/W2054708243","https://openalex.org/W2056645539","https://openalex.org/W2059014093","https://openalex.org/W2073433638"],"related_works":["https://openalex.org/W2384254216","https://openalex.org/W4402865078","https://openalex.org/W2010048723","https://openalex.org/W2470199772","https://openalex.org/W4394628068","https://openalex.org/W2195292868","https://openalex.org/W2790253684","https://openalex.org/W2042342696","https://openalex.org/W3136159333","https://openalex.org/W1993663992"],"abstract_inverted_index":{"With":[0],"a":[1,8,18,29,55,79,84,111,133,193],"focus":[2],"on":[3,110,132,171],"low-cost":[4],"and":[5,28,50,58,78,90,102,124,152,164,206],"low-power":[6],"consumption,":[7],"miniature":[9,45,107,138,175],"laser-induced":[10],"fluorescence":[11],"(LIF)":[12],"detection":[13,52,100,177,190],"system":[14,139,178,191],"was":[15,140,179],"assembled":[16,72],"using":[17,73,136,173],"635":[19],"nm":[20],"red":[21],"diode":[22],"laser":[23,49,76],"as":[24],"the":[25,44,48,51,88,106,137,174,196,204],"excitation":[26],"source":[27,77],"photodiode":[30],"element":[31],"coupled":[32],"with":[33,144,182],"an":[34,74,145,183],"operational":[35],"amplifier":[36],"for":[37,65,114,209],"signal":[38],"collection.":[39],"The":[40,150],"primary":[41],"elements":[42],"of":[43,63,99,105,129,154,169,185,198],"system,":[46,53,108],"namely":[47],"cost":[54,205],"combined":[56],"$70":[57],"required":[59,208],"only":[60],"270":[61],"mW":[62],"power":[64,96,207],"operation.":[66,210],"When":[67],"compared":[68],"to":[69],"conventional":[70],"systems":[71],"argon-ion":[75],"photomultiplier":[80],"tube,":[81],"this":[82],"represents":[83],"98%":[85],"decrease":[86,94],"in":[87,95,119,195],"cost,":[89],"greater":[91],"than":[92,187],"5000-fold":[93],"consumption.":[97],"Limits":[98],"(LOD)":[101],"quantitation":[103],"(LOQ)":[104],"evaluated":[109],"microfluidic":[112,134,200],"device":[113,135],"Nile":[115],"Blue":[116],"dye":[117],"diluted":[118],"ethanol,":[120],"were":[121,161],"approximately":[122,162],"15":[123],"40":[125],"nM,":[126],"respectively.":[127,167],"Detection":[128],"\u03bb-phage":[130,155],"DNA":[131,156,170],"performed":[141,181],"after":[142,157],"mixing":[143],"intercalating":[146],"dye,":[147],"TO-PRO":[148,158],"3.":[149],"LOD":[151],"LOQ":[153],"3":[159],"intercalation":[160],"1":[163],"4":[165],"ng/\u03bcL,":[166],"Quantitation":[168],"microdevices":[172],"LIF":[176],"also":[180],"error":[184],"less":[186],"15%.":[188],"This":[189],"is":[192],"step":[194],"direction":[197],"commercializing":[199],"instrumentation":[201],"by":[202],"reducing":[203],"(JALA":[211],"2006;11:254\u20139)":[212]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2016-06-24T00:00:00"}