{"id":"https://openalex.org/W2081207136","doi":"https://doi.org/10.1016/j.cclet.2013.11.039","title":"Design, synthesis, and biological evaluation of N-hydroxycinnamamide/salicylic acid hybrids as histone deacetylase inhibitors","display_name":"Design, synthesis, and biological evaluation of N-hydroxycinnamamide/salicylic acid hybrids as histone deacetylase inhibitors","publication_year":2013,"publication_date":"2013-11-28","ids":{"openalex":"https://openalex.org/W2081207136","doi":"https://doi.org/10.1016/j.cclet.2013.11.039","mag":"2081207136"},"language":"en","primary_location":{"id":"doi:10.1016/j.cclet.2013.11.039","doi":"https://doi.org/10.1016/j.cclet.2013.11.039","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cclet.2013.11.039","pdf_url":null,"source":{"id":"https://openalex.org/S167919573","display_name":"Chinese Chemical Letters","issn_l":"1001-8417","issn":["1001-8417","1878-5964"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Chemical Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112657990","display_name":"Tao You","orcid":"https://orcid.org/0000-0003-2381-7382","observed_orcids":["https://orcid.org/0000-0003-2381-7382"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao You","raw_affiliation_strings":["Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452007","display_name":"Ke Chen","orcid":"https://orcid.org/0000-0002-6914-6257","observed_orcids":["https://orcid.org/0000-0002-6914-6257"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Chen","raw_affiliation_strings":["School of Clinical Medicine, Wenzhou Medical University, Wenzhou 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, Wenzhou Medical University, Wenzhou 325035, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013463878","display_name":"Fei-Hai Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei-Hai Wang","raw_affiliation_strings":["Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039332183","display_name":"Pihong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pi-Hong Li","raw_affiliation_strings":["Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100767884","display_name":"Liyi Li","orcid":"https://orcid.org/0000-0003-0809-6388","observed_orcids":["https://orcid.org/0000-0003-0809-6388"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Yi Li","raw_affiliation_strings":["Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhi-Hao Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Hao Wu","raw_affiliation_strings":["Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022192222","display_name":"Kong-Hai Ni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kong-Hai Ni","raw_affiliation_strings":["Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013415958","display_name":"Zhiqiang Zheng","orcid":"https://orcid.org/0000-0003-1028-3246","observed_orcids":["https://orcid.org/0000-0003-1028-3246"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhi-Qiang Zheng","raw_affiliation_strings":["Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China","institution_ids":["https://openalex.org/I27781120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013415958"],"corresponding_institution_ids":["https://openalex.org/I27781120"],"apc_list":null,"apc_paid":null,"fwci":0.3299,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.54928659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"25","issue":"3","first_page":"474","last_page":"478"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9940000176429749},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8820000290870667},{"id":"https://openalex.org/keywords/colon-cancer-cells","display_name":"colon cancer cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hdac-isoform-selectivity","display_name":"HDAC isoform selectivity","score":0.824999988079071},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6290000081062317},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.9032337665557861},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.7927810549736023},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.7370999455451965},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6603180766105652},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.6108915209770203},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5818735361099243},{"id":"https://openalex.org/C2778221352","wikidata":"https://www.wikidata.org/wiki/Q193572","display_name":"Salicylic acid","level":2,"score":0.563186764717102},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5042449235916138},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.48898565769195557},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4277879297733307},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.411008358001709},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4107586145401001},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4085145592689514},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.3760935366153717},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36932241916656494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21656715869903564},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07648098468780518},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cclet.2013.11.039","doi":"https://doi.org/10.1016/j.cclet.2013.11.039","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cclet.2013.11.039","pdf_url":null,"source":{"id":"https://openalex.org/S167919573","display_name":"Chinese Chemical Letters","issn_l":"1001-8417","issn":["1001-8417","1878-5964"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Chemical Letters","raw_type":"journal-article"},{"id":"mag:3151757475","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/84039X/201403/49013849.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541529","display_name":"\u4e2d\u56fd\u5316\u5b66\u5feb\u62a5\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u5316\u5b66\u5feb\u62a5\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1576011410","https://openalex.org/W1949662878","https://openalex.org/W1968408039","https://openalex.org/W1979886338","https://openalex.org/W1985515161","https://openalex.org/W2007434989","https://openalex.org/W2007579571","https://openalex.org/W2009497825","https://openalex.org/W2014941193","https://openalex.org/W2015645056","https://openalex.org/W2015780246","https://openalex.org/W2029148944","https://openalex.org/W2042246926","https://openalex.org/W2043129038","https://openalex.org/W2086384126","https://openalex.org/W2089626640","https://openalex.org/W2099948357","https://openalex.org/W2102650381","https://openalex.org/W2159405578","https://openalex.org/W2169613803","https://openalex.org/W2312208839","https://openalex.org/W2569844665","https://openalex.org/W4255691026","https://openalex.org/W6640745409"],"related_works":["https://openalex.org/W2560511362","https://openalex.org/W2150377707","https://openalex.org/W2411411494","https://openalex.org/W2959493622","https://openalex.org/W4406144777","https://openalex.org/W1984947563","https://openalex.org/W2075322759","https://openalex.org/W649409076","https://openalex.org/W4408078407","https://openalex.org/W2003394088"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
