{"id":"https://openalex.org/W2081178049","doi":"https://doi.org/10.1196/annals.1352.005","title":"The Vaccinia Virus N1L Protein Influences Cytokine Secretion in Vitro after Infection","display_name":"The Vaccinia Virus N1L Protein Influences Cytokine Secretion in Vitro after Infection","publication_year":2005,"publication_date":"2005-11-01","ids":{"openalex":"https://openalex.org/W2081178049","doi":"https://doi.org/10.1196/annals.1352.005","mag":"2081178049","pmid":"https://pubmed.ncbi.nlm.nih.gov/16387678"},"language":"en","primary_location":{"id":"doi:10.1196/annals.1352.005","doi":"https://doi.org/10.1196/annals.1352.005","is_oa":false,"landing_page_url":"https://doi.org/10.1196/annals.1352.005","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037593651","display_name":"ZHOUNING ZHANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ZHOUNING ZHANG","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Louisville School of Medicine, Kentucky 40202, USA","Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Louisville School of Medicine, Kentucky 40202, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060669865","display_name":"Melissa-Rose Abrahams","orcid":"https://orcid.org/0000-0002-1907-4929","observed_orcids":["https://orcid.org/0000-0002-1907-4929"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"MELISSA\u2010ROSE ABRAHAMS","raw_affiliation_strings":["Division of Medical Virology, University of Cape Town Medical School, IIDMM, Observatory 7925, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Virology, University of Cape Town Medical School, IIDMM, Observatory 7925, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105212365","display_name":"Lawrence A. Hunt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"LAWRENCE A. HUNT","raw_affiliation_strings":["Division of Medical Virology, University of Cape Town Medical School, IIDMM, Observatory 7925, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Virology, University of Cape Town Medical School, IIDMM, Observatory 7925, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076113010","display_name":"Jill Suttles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JILL SUTTLES","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Louisville, School of Medicine, Louisville, Kentucky 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Louisville, School of Medicine, Louisville, Kentucky 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016136372","display_name":"William R. Marshall","orcid":"https://orcid.org/0000-0003-3636-3877","observed_orcids":["https://orcid.org/0000-0003-3636-3877"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WILLIAM MARSHALL","raw_affiliation_strings":["Department of Medicine, University of Massachusetts School of Medicine, Worchester, Massachusetts 01605, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Massachusetts School of Medicine, Worchester, Massachusetts 01605, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083481724","display_name":"Debomoy K. Lahiri","orcid":"https://orcid.org/0000-0002-1664-5933","observed_orcids":["https://orcid.org/0000-0002-1664-5933"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DEBOMOY K. LAHIRI","raw_affiliation_strings":["Laboratory of Molecular Genetics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012445084","display_name":"Girish Jayant Kotwal","orcid":"https://orcid.org/0000-0002-9925-3539","observed_orcids":["https://orcid.org/0000-0002-9925-3539"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]},{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["US","ZA"],"is_corresponding":true,"raw_author_name":"GIRISH J. KOTWAL","raw_affiliation_strings":["Department of Medicine, University of Massachusetts School of Medicine, Worchester, Massachusetts 01605, USA","Department of Microbiology and Immunology, University of Louisville, School of Medicine, Louisville, Kentucky 40202, USA","Division of Medical Virology, University of Cape Town Medical School, IIDMM, Observatory 7925, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Massachusetts School of Medicine, Worchester, Massachusetts 01605, USA","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Louisville, School of Medicine, Louisville, Kentucky 40202, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Division of Medical Virology, University of Cape Town Medical School, IIDMM, Observatory 7925, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5012445084"],"corresponding_institution_ids":["https://openalex.org/I142740786","https://openalex.org/I157614274","https://openalex.org/I166722992","https://openalex.org/I4405266898"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.3391,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.53971215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1056","issue":"1","first_page":"69","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vaccinia-virus","display_name":"vaccinia virus","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.8550000190734863},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.7820000052452087},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.828000009059906},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9559999704360962},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.5270000100135803},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.996999979019165},{"id":"https://openalex.org/keywords/virus-virulence","display_name":"viral virulence","score":0.7620000243186951},{"id":"https://openalex.org/keywords/antiviral-cytokines","display_name":"antiviral cytokines","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2781356689","wikidata":"https://www.wikidata.org/wiki/Q1986297","display_name":"Vaccinia","level":4,"score":0.9244146347045898},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6925414800643921},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6663040518760681},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6153590083122253},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5996392369270325},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5493946075439453},{"id":"https://openalex.org/C2779094796","wikidata":"https://www.wikidata.org/wiki/Q740335","display_name":"Orthopoxvirus","level":5,"score":0.4746204912662506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4552137553691864},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3954113721847534},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34748417139053345},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2557520568370819},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06680035591125488},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06464266777038574},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D010843","descriptor_name":"Pichia","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1196/annals.1352.005","doi":"https://doi.org/10.1196/annals.1352.005","is_oa":false,"landing_page_url":"https://doi.org/10.1196/annals.1352.005","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:16387678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16387678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7900000214576721}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1503200131","https://openalex.org/W1559266323","https://openalex.org/W1559601682","https://openalex.org/W1654592908","https://openalex.org/W1663779312","https://openalex.org/W1860020110","https://openalex.org/W1946706174","https://openalex.org/W1975302315","https://openalex.org/W1976215218","https://openalex.org/W1981384391","https://openalex.org/W1982170462","https://openalex.org/W2001040275","https://openalex.org/W2017523822","https://openalex.org/W2022152140","https://openalex.org/W2029180686","https://openalex.org/W2036044011","https://openalex.org/W2054933631","https://openalex.org/W2062449148","https://openalex.org/W2068665787","https://openalex.org/W2070737639","https://openalex.org/W2073372936","https://openalex.org/W2074239102","https://openalex.org/W2075300931","https://openalex.org/W2075928204","https://openalex.org/W2079295092","https://openalex.org/W2080963865","https://openalex.org/W2087504527","https://openalex.org/W2091554591","https://openalex.org/W2094344877","https://openalex.org/W2104726858","https://openalex.org/W2118762274","https://openalex.org/W2119705958","https://openalex.org/W2123796332","https://openalex.org/W2136314388","https://openalex.org/W2138820761","https://openalex.org/W2144575453","https://openalex.org/W2145410013","https://openalex.org/W2150195134","https://openalex.org/W2154189950","https://openalex.org/W2161074777","https://openalex.org/W2172039135","https://openalex.org/W2418317794"],"related_works":["https://openalex.org/W2062710711","https://openalex.org/W1984471158","https://openalex.org/W7095215873","https://openalex.org/W1972487217","https://openalex.org/W2073372936","https://openalex.org/W2145410013","https://openalex.org/W4309827681","https://openalex.org/W7058142147","https://openalex.org/W2120861506","https://openalex.org/W2136072376"],"abstract_inverted_index":{"The":[0,64],"vaccinia":[1],"virus":[2,15],"N1L":[3,67,104],"ORF":[4],"encodes":[5],"a":[6],"protein":[7],"that":[8],"enhances":[9],"virulence":[10],"and":[11,31,36,89],"replication":[12,30],"of":[13,52,66,71,80,102],"the":[14,34,50,69,81,90,100,103],"by":[16,99],"an":[17,43],"unknown":[18],"mechanism.":[19],"It":[20],"has":[21,39],"been":[22,40],"studied":[23],"for":[24],"its":[25],"ability":[26],"to":[27,42,96],"enhance":[28],"viral":[29],"dissemination":[32],"in":[33,46,56],"brain":[35],"more":[37],"recently":[38],"linked":[41],"immunomodulatory":[44],"role":[45],"which":[47],"it":[48],"inhibits":[49],"activation":[51],"cytokine":[53,92],"transcription":[54],"activators":[55],"Toll-like":[57],"receptor":[58],"signaling":[59],"pathways":[60],"after":[61],"pathogen":[62],"recognition.":[63],"effect":[65],"on":[68],"release":[70],"cytokines":[72,84],"from":[73],"human":[74],"primary":[75],"monocytes":[76],"was":[77,94],"investigated.":[78],"Secretion":[79],"proinflammatory,":[82],"antiviral":[83],"TNF-alpha,":[85],"IL-1beta,":[86],"IFN-alpha,":[87],"IFN-beta,":[88],"anti-inflammatory":[91],"IL-10":[93],"found":[95],"be":[97],"inhibited":[98],"presence":[101],"protein.":[105]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}