{"id":"https://openalex.org/W2081114784","doi":"https://doi.org/10.1111/j.1748-1716.1958.tb01551.x","title":"Effect of Heart Rate on Cardiac Work, Myocardial Oxygen Consumption and Coronary Blood Flow in the Dog","display_name":"Effect of Heart Rate on Cardiac Work, Myocardial Oxygen Consumption and Coronary Blood Flow in the Dog","publication_year":1958,"publication_date":"1958-04-01","ids":{"openalex":"https://openalex.org/W2081114784","doi":"https://doi.org/10.1111/j.1748-1716.1958.tb01551.x","mag":"2081114784","pmid":"https://pubmed.ncbi.nlm.nih.gov/13532951"},"language":"en","primary_location":{"id":"doi:10.1111/j.1748-1716.1958.tb01551.x","doi":"https://doi.org/10.1111/j.1748-1716.1958.tb01551.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1748-1716.1958.tb01551.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210232992","display_name":"Acta Physiologica Scandinavica","issn_l":"0001-6772","issn":["0001-6772","1365-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Physiologica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030541297","display_name":"Erik Berglund","orcid":"https://orcid.org/0000-0001-7049-7348","observed_orcids":["https://orcid.org/0000-0001-7049-7348"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"ERIK BERGLUND","raw_affiliation_strings":["Department of Physiology, Harvard School of Public Health, Boston, Mass., U. S. A","Dept. of Physiology, University of Go\u0308teborg, Medical School, Go\u0308teborg, Sweden","Dept. of Physiology, University of G\u00f6teborg, Medical School, G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Harvard School of Public Health, Boston, Mass., U. S. A","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Dept. of Physiology, University of Go\u0308teborg, Medical School, Go\u0308teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Dept. of Physiology, University of G\u00f6teborg, Medical School, G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113623843","display_name":"Hans Georg Borst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HANS G. BORST","raw_affiliation_strings":["Chirurgisehe Universita\u0308ts-Klinik, Marburg/Lahn, Germany","Department of Physiology, Harvard School of Public Health, Boston, Mass., U. S. A","Chirurgisehe Universit\u00e4ts-Klinik, Marburg/Lahn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chirurgisehe Universita\u0308ts-Klinik, Marburg/Lahn, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology, Harvard School of Public Health, Boston, Mass., U. S. A","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Chirurgisehe Universit\u00e4ts-Klinik, Marburg/Lahn, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032347695","display_name":"F. A. Duff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FRANK DUFF","raw_affiliation_strings":["Department of Physiology, Harvard School of Public Health, Boston, Mass., U. S. A","Dept. of Surgery, Inst, of Clin. Science, Belfast, N. Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Harvard School of Public Health, Boston, Mass., U. S. A","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Dept. of Surgery, Inst, of Clin. Science, Belfast, N. Ireland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043408604","display_name":"G\u00dcNTHER L. SCHREINER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117211","display_name":"Kings County Hospital Center","ror":"https://ror.org/02emy8e21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283621791","https://openalex.org/I4210117211"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G\u00dcNTHER L. SCHREINER","raw_affiliation_strings":["Department of Physiology, Harvard School of Public Health, Boston, Mass., U. S. A","Kings County Hospital, Brooklyn 3, N. Y., U. S. A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Harvard School of Public Health, Boston, Mass., U. S. A","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Kings County Hospital, Brooklyn 3, N. Y., U. S. A","institution_ids":["https://openalex.org/I4210117211"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.37,"has_fulltext":false,"cited_by_count":131,"citation_normalized_percentile":{"value":0.97064443,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"42","issue":"2","first_page":"185","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.7910000085830688,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.7910000085830688,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.06549999862909317,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.04490000009536743,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.7129999995231628},{"id":"https://openalex.org/keywords/stroke-volume","display_name":"stroke volume","score":0.7990000247955322},{"id":"https://openalex.org/keywords/myocardial-oxygen-consumption","display_name":"myocardial oxygen consumption","score":0.9729999899864197},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.9950000047683716},{"id":"https://openalex.org/keywords/coronary-vascular-resistance","display_name":"coronary vascular resistance","score":0.9409999847412109},{"id":"https://openalex.org/keywords/ventricular-function","display_name":"ventricular function","score":0.7749999761581421},{"id":"https://openalex.org/keywords/coronary-vasodilation","display_name":"coronary vasodilation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/aortic-pressure","display_name":"aortic pressure","score":0.6029999852180481},{"id":"https://openalex.org/keywords/pulse-pressure","display_name":"pulse pressure","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.6998563408851624},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.693581223487854},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.6154924035072327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5972030162811279},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5933382511138916},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5856890678405762},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.5797837972640991},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.5683931112289429},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.5553176999092102},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.515303373336792},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.5113834738731384},{"id":"https://openalex.org/C2776157398","wikidata":"https://www.wikidata.org/wiki/Q497232","display_name":"Coronary circulation","level":3,"score":0.4528456926345825},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4433780014514923},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.431460440158844},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3410782217979431},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1645916998386383},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1748-1716.1958.tb01551.x","doi":"https://doi.org/10.1111/j.1748-1716.1958.tb01551.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1748-1716.1958.tb01551.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210232992","display_name":"Acta Physiologica Scandinavica","issn_l":"0001-6772","issn":["0001-6772","1365-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Physiologica Scandinavica","raw_type":"journal-article"},{"id":"pmid:13532951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13532951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta physiologica Scandinavica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W81371074","https://openalex.org/W1841686957","https://openalex.org/W1969787218","https://openalex.org/W1974331046","https://openalex.org/W1988165691","https://openalex.org/W1988516665","https://openalex.org/W1999398150","https://openalex.org/W2007596664","https://openalex.org/W2044171709","https://openalex.org/W2049816543","https://openalex.org/W2070751084","https://openalex.org/W2075241992","https://openalex.org/W2075541556","https://openalex.org/W2110667468","https://openalex.org/W2176916879","https://openalex.org/W2223436670","https://openalex.org/W2331864845","https://openalex.org/W2335872846","https://openalex.org/W2339306970","https://openalex.org/W2415852046","https://openalex.org/W2417646104","https://openalex.org/W2471520023","https://openalex.org/W2607046380","https://openalex.org/W3026419280","https://openalex.org/W4300879866"],"related_works":["https://openalex.org/W2335872846","https://openalex.org/W2080970957","https://openalex.org/W2461462064","https://openalex.org/W7097607624","https://openalex.org/W7217737157","https://openalex.org/W2240146147","https://openalex.org/W2146150343","https://openalex.org/W2102407394","https://openalex.org/W2240268648","https://openalex.org/W2274729131"],"abstract_inverted_index":{"Summary.":[0],"1.":[1],"The":[2,25,37,150],"effects":[3],"of":[4,167,177,181,191,229,235],"variations":[5],"in":[6,21,46,125],"heart":[7,26,206,236],"rate":[8,27,43,237],"on":[9],"ventricular":[10,114,134],"function,":[11],"myocardial":[12,222],"oxygen":[13,101,163,223],"consumption,":[14],"and":[15,64,94,103,244],"coronary":[16,105,126,212,230],"blood":[17,187,231],"flow":[18,106,188],"were":[19,144,152,242],"studied":[20],"anesthetized,":[22],"open\u2010chest":[23],"dogs.":[24],"was":[28,44,81,98,116,121,170,200],"held":[29],"at":[30,68,109,146,155,158,172,204,209],"desired":[31],"rates":[32,69,79,112,207],"by":[33],"electrical":[34],"stimulation.":[35],"2.":[36],"following":[38],"changes":[39],"occurred":[40],"when":[41,113],"the":[42,95,110,139,147,178],"increased":[45,58,193],"steps":[47],"from":[48,71],"33\u201480":[49],"per":[50,54,62,75,165,184,189],"min.":[51,185],"to":[52,60,73],"200\u2014280":[53],"min.:":[55],"cardiac":[56],"output":[57],"0":[59],"73":[61],"cent":[63],"reached":[65],"a":[66,83,122,226],"maximum":[67],"varying":[70],"90":[72],"180":[74],"min.;":[76],"above":[77],"these":[78],"there":[80,120],"usually":[82],"decrease.":[84],"Stroke":[85],"volume":[86],"decreased":[87],"progressively.":[88],"Mean":[89],"aortic":[90],"pressure":[91,97],"rose":[92],"slightly,":[93],"pulse":[96],"diminished.":[99],"Myocardial":[100,162],"consumption":[102,164,224],"left":[104],"increased,":[107],"even":[108],"high":[111,205],"work":[115,136,169,192],"constant":[117],"or":[118],"decreasing;":[119],"marked":[123],"fall":[124],"resistance.":[127],"3.":[128],"Ventricular":[129],"function":[130],"curves,":[131],"i.":[132],"e.":[133],"stroke":[135],"plotted":[137],"against":[138],"respective":[140],"mean":[141],"atrial":[142],"pressure,":[143],"obtained":[145],"various":[148],"rates.":[149,160],"curves":[151],"always":[153,201],"lower":[154,159,203],"higher":[156,173],"than":[157,208],"4.":[161],"unit":[166,190],"mechanical":[168],"greater":[171],"rates,":[174],"probably":[175],"because":[176],"larger":[179],"amount":[180],"\u201cisometric":[182],"work\u201d":[183],"Coronary":[186,197],"similarly":[194],"with":[195],"rate.":[196],"vascular":[198],"resistance":[199],"much":[202],"low,":[210],"indicating":[211],"vasodilation.":[213],"5.":[214],"It":[215],"is":[216,225],"concluded":[217],"that":[218],"during":[219,238],"normal":[220],"circumstances":[221],"major":[227],"determinant":[228],"flow.":[232],"6.":[233],"Effects":[234],"abnormal":[239],"circulatory":[240],"conditions":[241],"illustrated":[243],"discussed.":[245]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}