{"id":"https://openalex.org/W2080985284","doi":"https://doi.org/10.1021/jm301099x","title":"Optimization of a Small Tropomyosin-Related Kinase B (TrkB) Agonist 7,8-Dihydroxyflavone Active in Mouse Models of Depression","display_name":"Optimization of a Small Tropomyosin-Related Kinase B (TrkB) Agonist 7,8-Dihydroxyflavone Active in Mouse Models of Depression","publication_year":2012,"publication_date":"2012-09-17","ids":{"openalex":"https://openalex.org/W2080985284","doi":"https://doi.org/10.1021/jm301099x","mag":"2080985284","pmid":"https://pubmed.ncbi.nlm.nih.gov/22984948","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3491656"},"language":"en","primary_location":{"id":"doi:10.1021/jm301099x","doi":"https://doi.org/10.1021/jm301099x","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm301099x","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3491656","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100373211","display_name":"Xia Liu","orcid":"https://orcid.org/0000-0002-0180-2166","observed_orcids":["https://orcid.org/0000-0002-0180-2166"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xia Liu","raw_affiliation_strings":["Department of Pathology and Laboratory\rMedicine, Emory University School of Medicine, 615 Michael Street, Atlanta, Georgia 30322, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory\rMedicine, Emory University School of Medicine, 615 Michael Street, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090732907","display_name":"Chi Bun Chan","orcid":"https://orcid.org/0000-0002-2787-9575","observed_orcids":["https://orcid.org/0000-0002-2787-9575"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi-Bun Chan","raw_affiliation_strings":["Department of Pathology and Laboratory\rMedicine, Emory University School of Medicine,  615 Michael Street, Atlanta, Georgia 30322, United States","Department of Pathology and Laboratory#R#Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, Georgia 30322, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory\rMedicine, Emory University School of Medicine,  615 Michael Street, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Pathology and Laboratory#R#Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100406589","display_name":"Qi Qi","orcid":"https://orcid.org/0000-0003-4460-0713","observed_orcids":["https://orcid.org/0000-0003-4460-0713"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Qi","raw_affiliation_strings":["Department of Pathology and Laboratory\rMedicine, Emory University School of Medicine,  615 Michael Street, Atlanta, Georgia 30322, United States","Department of Pathology and Laboratory#R#Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, Georgia 30322, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory\rMedicine, Emory University School of Medicine,  615 Michael Street, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Pathology and Laboratory#R#Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111785694","display_name":"Ge\ufffd Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ge Xiao","raw_affiliation_strings":["Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, Georgia 30341, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, Georgia 30341, United States","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084705026","display_name":"Hongbo Robert Luo","orcid":"https://orcid.org/0000-0002-8545-0451","observed_orcids":["https://orcid.org/0000-0002-8545-0451"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongbo R. Luo","raw_affiliation_strings":["Department of Pathology and Lab Medicine, Harvard Medical School and Children\u2019s Hospital Boston, 10214\rKarp Research Building, 1 Blackfan Circle, Boston, Massachusetts 02115,\rUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Lab Medicine, Harvard Medical School and Children\u2019s Hospital Boston, 10214\rKarp Research Building, 1 Blackfan Circle, Boston, Massachusetts 02115,\rUnited States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108629224","display_name":"Xiaolin L. He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaolin He","raw_affiliation_strings":["Department\rof Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, 303 E. Chicago\rAvenue, Searle 8-417, Chicago, Illinois 60611, United States","Department#R#of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, 303 E. Chicago#R#Avenue, Searle 8-417, Chicago, Illinois 60611, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, 303 E. Chicago\rAvenue, Searle 8-417, Chicago, Illinois 60611, United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department#R#of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, 303 E. Chicago#R#Avenue, Searle 8-417, Chicago, Illinois 60611, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073266870","display_name":"Keqiang Ye","orcid":"https://orcid.org/0000-0002-7657-8154","observed_orcids":["https://orcid.org/0000-0002-7657-8154"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Keqiang Ye","raw_affiliation_strings":["Department of Pathology and Laboratory\rMedicine, Emory University School of Medicine,  615 Michael Street, Atlanta, Georgia 30322, United States","Department of Pathology and Laboratory#R#Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, Georgia 30322, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory\rMedicine, Emory University School of Medicine,  615 Michael Street, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Pathology and Laboratory#R#Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5073266870"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":6.4652,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.97376591,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"55","issue":"19","first_page":"8524","last_page":"8537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.10360000282526016,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.06539999693632126,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/7-8-dihydroxyflavone","display_name":"7,8-dihydroxyflavone","score":0.9800000190734863},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.5849999785423279},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.875},{"id":"https://openalex.org/keywords/catechol-groups","display_name":"catechol groups","score":0.9300000071525574},{"id":"https://openalex.org/keywords/bioisosteres","display_name":"bioisosteres","score":0.8650000095367432},{"id":"https://openalex.org/keywords/pharmacokinetic-optimization","display_name":"pharmacokinetic optimization","score":0.6259999871253967},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.7329999804496765},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tail-suspension-test","display_name":"tail suspension test","score":1.0},{"id":"https://openalex.org/keywords/admet-properties","display_name":"ADMET properties","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C97124661","wikidata":"https://www.wikidata.org/wiki/Q14897782","display_name":"Tropomyosin receptor kinase B","level":4,"score":0.8294520378112793},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8219041228294373},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6666258573532104},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.622735857963562},{"id":"https://openalex.org/C2781001258","wikidata":"https://www.wikidata.org/wiki/Q7676084","display_name":"Tail suspension test","level":5,"score":0.617051899433136},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.5918040871620178},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5895599126815796},{"id":"https://openalex.org/C2777713698","wikidata":"https://www.wikidata.org/wiki/Q282440","display_name":"Catechol","level":2,"score":0.5218871235847473},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4718995988368988},{"id":"https://openalex.org/C111771559","wikidata":"https://www.wikidata.org/wiki/Q66295","display_name":"Derivative (finance)","level":2,"score":0.432227224111557},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.41566652059555054},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.40077710151672363},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3707262873649597},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.27838897705078125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2359699010848999},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2109670639038086},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.17872491478919983},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.11255627870559692},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08936026692390442},{"id":"https://openalex.org/C106159729","wikidata":"https://www.wikidata.org/wiki/Q2294553","display_name":"Financial economics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020813","descriptor_name":"Receptor, trkB","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D044950","descriptor_name":"Flavanones","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D044950","descriptor_name":"Flavanones","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D044950","descriptor_name":"Flavanones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1021/jm301099x","doi":"https://doi.org/10.1021/jm301099x","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm301099x","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:22984948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22984948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2785755","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3491656","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3491656","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3491656","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Med Chem","raw_type":"Text"},{"id":"pmh:oai:dash.harvard.edu:1/13350198","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:13350198","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:hub.hku.hk:10722/225039","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/225039","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2785755","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3491656","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7005575901","display_name":"Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor","funder_award_id":"R01DC010204","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1976185410","https://openalex.org/W1979702721","https://openalex.org/W1994345197","https://openalex.org/W1994910955","https://openalex.org/W1996166611","https://openalex.org/W2000508433","https://openalex.org/W2006733352","https://openalex.org/W2009297402","https://openalex.org/W2011207394","https://openalex.org/W2037111632","https://openalex.org/W2040826404","https://openalex.org/W2064133502","https://openalex.org/W2068671706","https://openalex.org/W2072368655","https://openalex.org/W2078035790","https://openalex.org/W2078678809","https://openalex.org/W2091927578","https://openalex.org/W2093850848","https://openalex.org/W2113927644","https://openalex.org/W2121651624","https://openalex.org/W2127667517","https://openalex.org/W2131167630","https://openalex.org/W2133230336","https://openalex.org/W2142181595","https://openalex.org/W2143834680","https://openalex.org/W2149414643","https://openalex.org/W2159031404","https://openalex.org/W2168950597","https://openalex.org/W2172173997","https://openalex.org/W2313102230","https://openalex.org/W3085899260"],"related_works":["https://openalex.org/W2142181595","https://openalex.org/W1986711579","https://openalex.org/W2533694554","https://openalex.org/W2957948073","https://openalex.org/W1974359116","https://openalex.org/W2533228406","https://openalex.org/W2008021112","https://openalex.org/W3186036424","https://openalex.org/W2509550520","https://openalex.org/W2204781633"],"abstract_inverted_index":{"Structure-activity":[0],"relationship":[1],"study":[2],"shows":[3],"that":[4,55,107],"the":[5,23,34,38,43,56,73,111,116],"catechol":[6],"group":[7],"in":[8,75,96,102],"7,8-dihdyroxyflavone,":[9],"a":[10,127],"selective":[11],"small":[12],"TrkB":[13,62,94],"receptor":[14],"agonist,":[15],"is":[16,90],"critical":[17],"for":[18,131,135],"agonistic":[19,35],"activity.":[20,64],"To":[21],"improve":[22],"poor":[24],"pharmacokinetic":[25],"profiles":[26],"intrinsic":[27],"to":[28,32,115],"catechol-containing":[29],"molecules":[30],"and":[31,79],"elevate":[33],"effect":[36],"of":[37,68,98],"lead":[39,44,118,129],"compound,":[40],"we":[41,53],"initiated":[42],"optimization":[45],"campaign":[46],"by":[47,92],"synthesizing":[48],"various":[49,137],"bioisosteric":[50],"derivatives.":[51],"Here":[52],"show":[54],"optimized":[57,122],"2-methyl-8-(4'-(pyrrolidin-1-yl)phenyl)chromeno[7,8-d]imidazol-6(1H)-one":[58],"derivative":[59],"possesses":[60,110],"enhanced":[61],"stimulatory":[63],"Chronic":[65],"oral":[66],"administration":[67],"this":[69,108,121],"compound":[70,109,123],"significantly":[71],"reduces":[72],"immobility":[74],"forced":[76],"swim":[77],"test":[78],"tail":[80],"suspension":[81],"test,":[82],"two":[83],"classical":[84],"antidepressant":[85],"behavioral":[86],"animal":[87],"models,":[88],"which":[89],"accompanied":[91],"robust":[93],"activation":[95],"hippocampus":[97],"mouse":[99],"brain.":[100],"Further,":[101],"vitro":[103],"ADMET":[104],"studies":[105],"demonstrate":[106],"improved":[112],"features":[113],"compared":[114],"previous":[117],"compound.":[119],"Hence,":[120],"may":[124],"act":[125],"as":[126],"promising":[128],"candidate":[130],"in-depth":[132],"drug":[133],"development":[134],"treating":[136],"neurological":[138],"disorders":[139],"including":[140],"depression.":[141]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}