{"id":"https://openalex.org/W2080980694","doi":"https://doi.org/10.1002/1097-0142(19910601)67:11<2859::aid-cncr2820671126>3.0.co;2-w","title":"Preoperative high-dose leucovorin/5-fluorouracil and radiation therapy for unresectable rectal cancer","display_name":"Preoperative high-dose leucovorin/5-fluorouracil and radiation therapy for unresectable rectal cancer","publication_year":1991,"publication_date":"1991-06-01","ids":{"openalex":"https://openalex.org/W2080980694","doi":"https://doi.org/10.1002/1097-0142(19910601)67:11<2859::aid-cncr2820671126>3.0.co;2-w","mag":"2080980694","pmid":"https://pubmed.ncbi.nlm.nih.gov/2025851"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19910601)67:11<2859::aid-cncr2820671126>3.0.co;2-w","doi":"https://doi.org/10.1002/1097-0142(19910601)67:11<2859::aid-cncr2820671126>3.0.co;2-w","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19910601)67:11<2859::aid-cncr2820671126>3.0.co;2-w","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819910601%2967%3A11%3C2859%3A%3AAID-CNCR2820671126%3E3.0.CO%3B2-W","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819910601%2967%3A11%3C2859%3A%3AAID-CNCR2820671126%3E3.0.CO%3B2-W","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087201995","display_name":"Bruce D. Minsky","orcid":"https://orcid.org/0000-0001-8434-7930","observed_orcids":["https://orcid.org/0000-0001-8434-7930"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bruce D. Minsky","raw_affiliation_strings":["Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021","Department of Radiation Oncology, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York","Recipient of an American Cancer Society Clinical Oncology Career Development Award"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Radiation Oncology, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Recipient of an American Cancer Society Clinical Oncology Career Development Award","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069644669","display_name":"Nancy E. Kemeny","orcid":"https://orcid.org/0000-0002-0929-9542","observed_orcids":["https://orcid.org/0000-0002-0929-9542"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Kemeny","raw_affiliation_strings":["Gastrointestinal Oncology Section, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Oncology Section, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069929201","display_name":"David Paul Kelsen","orcid":"https://orcid.org/0000-0001-6139-438X","observed_orcids":["https://orcid.org/0000-0001-6139-438X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David P. Kelsen","raw_affiliation_strings":["Gastrointestinal Oncology Section, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Oncology Section, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108399805","display_name":"Bonnie S. Reichman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bonnie Reichman","raw_affiliation_strings":["Gastrointestinal Oncology Section, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Oncology Section, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037120205","display_name":"Leonard B. Saltz","orcid":"https://orcid.org/0000-0001-8353-4670","observed_orcids":["https://orcid.org/0000-0001-8353-4670"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard Saltz","raw_affiliation_strings":["Gastrointestinal Oncology Section, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Oncology Section, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111664092","display_name":"Alfred M. Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred M. Cohen","raw_affiliation_strings":["Colorectal Service, Department of Surgery, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colorectal Service, Department of Surgery, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109565348","display_name":"Warren E. Enker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren E. Enker","raw_affiliation_strings":["Colorectal Service, Department of Surgery, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colorectal Service, Department of Surgery, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031110316","display_name":"Elin Ruth Sigurdson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elin R. Sigurdson","raw_affiliation_strings":["Colorectal Service, Department of Surgery, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colorectal Service, Department of Surgery, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049902010","display_name":"Joanne Frankel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne Frankel","raw_affiliation_strings":["Department of Nursing, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, The Memorial Sloan\u2014Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087201995"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":3.1468,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.9311679,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"67","issue":"11","first_page":"2859","last_page":"2866"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unresectable-rectal-cancer","display_name":"unresectable rectal cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/neoadjuvant-chemoradiotherapy","display_name":"neoadjuvant chemoradiotherapy","score":0.6919999718666077},{"id":"https://openalex.org/keywords/leucovorin","display_name":"leucovorin","score":0.8600000143051147},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9929999709129333},{"id":"https://openalex.org/keywords/high-dose-chemotherapy","display_name":"high-dose chemotherapy","score":0.7149999737739563},{"id":"https://openalex.org/keywords/pelvic-radiotherapy","display_name":"pelvic radiotherapy","score":0.7960000038146973},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8190000057220459},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/resectability","display_name":"resectability","score":0.6489999890327454},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.972000002861023},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.7760000228881836},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tenesmus","display_name":"tenesmus","score":0.5830000042915344},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.5230000019073486},{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9512481689453125},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.695871114730835},{"id":"https://openalex.org/C2776845205","wikidata":"https://www.wikidata.org/wiki/Q1269399","display_name":"Dysuria","level":3,"score":0.5376793742179871},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5170732140541077},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.5007712841033936},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4522727429866791},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.41835203766822815},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.41788172721862793},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39122629165649414},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3790324330329895},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.32666274905204773},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2877844274044037},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27638697624206543},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.10418826341629028}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001918","descriptor_name":"Brachytherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011300","descriptor_name":"Preoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012811","descriptor_name":"Sigmoid Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19910601)67:11<2859::aid-cncr2820671126>3.0.co;2-w","doi":"https://doi.org/10.1002/1097-0142(19910601)67:11<2859::aid-cncr2820671126>3.0.co;2-w","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19910601)67:11<2859::aid-cncr2820671126>3.0.co;2-w","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819910601%2967%3A11%3C2859%3A%3AAID-CNCR2820671126%3E3.0.CO%3B2-W","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:2025851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2025851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(19910601)67:11<2859::aid-cncr2820671126>3.0.co;2-w","doi":"https://doi.org/10.1002/1097-0142(19910601)67:11<2859::aid-cncr2820671126>3.0.co;2-w","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19910601)67:11<2859::aid-cncr2820671126>3.0.co;2-w","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819910601%2967%3A11%3C2859%3A%3AAID-CNCR2820671126%3E3.0.CO%3B2-W","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2080980694.pdf","grobid_xml":"https://content.openalex.org/works/W2080980694.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W108351000","https://openalex.org/W129347924","https://openalex.org/W627608281","https://openalex.org/W1964576482","https://openalex.org/W1976333089","https://openalex.org/W1976432234","https://openalex.org/W2010512189","https://openalex.org/W2027805048","https://openalex.org/W2043691565","https://openalex.org/W2052383027","https://openalex.org/W2053325046","https://openalex.org/W2069474927","https://openalex.org/W2084481942","https://openalex.org/W2132039541","https://openalex.org/W2135398482","https://openalex.org/W2150985317","https://openalex.org/W2227373247","https://openalex.org/W2253033732","https://openalex.org/W2604338383","https://openalex.org/W4253234031"],"related_works":["https://openalex.org/W2155789163","https://openalex.org/W1975194596","https://openalex.org/W2000581687","https://openalex.org/W1979358180","https://openalex.org/W2023512957","https://openalex.org/W2036419069","https://openalex.org/W2003530585","https://openalex.org/W2052144062","https://openalex.org/W2147571138","https://openalex.org/W2164574127"],"abstract_inverted_index":{"Twenty":[0],"patients":[1,164],"with":[2,255,260],"primary":[3],"or":[4],"recurrent":[5],"unresectable":[6],"rectal":[7],"cancer":[8],"limited":[9],"to":[10,183,190,200,300],"the":[11,72,109,127,162,169,173,243,261,269,285,290,303],"pelvis":[12],"were":[13,53,84,152,177,226,275],"entered":[14],"on":[15],"a":[16,232,306],"Phase":[17],"I":[18],"trial":[19,151],"of":[20,31,45,82,130,138,205,220,238,305],"preoperative":[21,56,282],"pelvic":[22],"radiation":[23],"therapy":[24],"(RT)":[25],"(5040":[26],"cGy)":[27],"and":[28,36,42,59,61,87,91,108,121,159,193,213,258,271],"two":[29],"cycles":[30,44],"combined":[32,57,85,119,256,291],"high-dose":[33,249],"leucovorin":[34],"(LV)":[35],"5-fluorouracil":[37],"(5-FU),":[38],"followed":[39],"by":[40,289],"surgery":[41],"ten":[43],"postoperative":[46,63],"LV/5-FU":[47,58,86,93,120,142],"(sequential).":[48],"Maximum":[49],"tolerated":[50],"doses":[51,81,219,237],"(MTD)":[52],"determined":[54],"for":[55,62,118,140,281],"RT":[60,88,122,259,283],"sequential":[64,92,141],"LV/5-FU.":[65],"5-FU":[66,83,131,139,167,221,239,257],"was":[67,100,106,114,123,210,231],"escalated":[68],"50":[69],"mg/m2":[70],"while":[71],"LV":[73,250,308],"remained":[74],"constant":[75],"at":[76,168],"200":[77],"mg/m2.":[78,134,145],"The":[79,96,103,116,135,146,202,217],"initial":[80],"(200":[89],"mg/m2)":[90],"(325":[94],"mg/m2).":[95],"median":[97,174],"follow-up":[98],"time":[99],"14":[101],"months.":[102],"resectability":[104,270],"rate":[105,113,204],"89%,":[107],"pathologic":[110],"complete":[111,272],"response":[112,273],"21%.":[115],"MTD":[117],"300":[124],"mg/m2;":[125],"therefore,":[126],"recommended":[128,136,170,218],"dose":[129,137,171],"is":[132,143,310],"250":[133],"375":[144],"dose-limiting":[147],"toxicities":[148],"in":[149,223,253],"this":[150,224],"diarrhea,":[153],"tenesmus,":[154],"increased":[155],"bowel":[156,215],"movements,":[157],"dysuria,":[158],"myelosuppression.":[160],"For":[161],"six":[163],"who":[165],"received":[166],"level,":[172],"low":[175],"counts":[176],"leukocyte":[178],"count,":[179],"3.7/microliters":[180],"(range,":[181,188,198],"2.4":[182],"4.9/microliters);":[184],"hemoglobin,":[185],"9.0":[186],"g/dl":[187],"8.2":[189],"11.9":[191],"g/dl);":[192],"platelet":[194],"count":[195],"(X1000),":[196],"146/microliters":[197],"89":[199],"182/microliters).":[201],"incidence":[203],"any":[206],"Grade":[207],"3":[208],"toxicity":[209],"17%":[211],"(diarrhea":[212],"frequent":[214],"movements).":[216],"used":[222,252],"protocol":[225],"well":[227],"tolerated.":[228],"Because":[229],"there":[230],"long":[233],"delay":[234],"before":[235],"optimal":[236],"could":[240],"be":[241,251],"delivered,":[242],"authors":[244,286],"do":[245],"not":[246],"recommend":[247],"that":[248],"conjunction":[254],"treatment":[262],"regimen":[263,309],"as":[264],"currently":[265,297],"designed.":[266],"However,":[267],"because":[268],"rates":[274],"higher":[276],"than":[277],"those":[278],"previously":[279],"reported":[280],"alone,":[284],"are":[287,296],"encouraged":[288],"technique":[292],"approach.":[293],"New":[294],"trials":[295],"being":[298],"undertaken":[299],"determine":[301],"if":[302],"use":[304],"low-dose":[307],"more":[311],"tolerable.":[312]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}