{"id":"https://openalex.org/W2080972147","doi":"https://doi.org/10.1002/mrm.21148","title":"Novel strategy for cerebral 13C MRS using very low RF power for proton decoupling","display_name":"Novel strategy for cerebral 13C MRS using very low RF power for proton decoupling","publication_year":2007,"publication_date":"2007-01-26","ids":{"openalex":"https://openalex.org/W2080972147","doi":"https://doi.org/10.1002/mrm.21148","mag":"2080972147","pmid":"https://pubmed.ncbi.nlm.nih.gov/17260369"},"language":"en","primary_location":{"id":"doi:10.1002/mrm.21148","doi":"https://doi.org/10.1002/mrm.21148","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrm.21148","pdf_url":null,"source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079681219","display_name":"Shizhe Li","orcid":"https://orcid.org/0000-0002-7086-6753","observed_orcids":["https://orcid.org/0000-0002-7086-6753"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shizhe Li","raw_affiliation_strings":["Magnetic Resonance Spectroscopy Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1527, USA","Magnetic Resonance Spectroscopy Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Magnetic Resonance Spectroscopy Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1527, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]},{"raw_affiliation_string":"Magnetic Resonance Spectroscopy Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015480620","display_name":"Jehoon Yang","orcid":"https://orcid.org/0000-0002-5808-9998","observed_orcids":["https://orcid.org/0000-0002-5808-9998"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jehoon Yang","raw_affiliation_strings":["Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042335626","display_name":"Jun Shen","orcid":"https://orcid.org/0000-0003-0167-6988","observed_orcids":["https://orcid.org/0000-0003-0167-6988","https://orcid.org/0000-0003-3545-059X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun Shen","raw_affiliation_strings":["Magnetic Resonance Spectroscopy Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA","Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Magnetic Resonance Spectroscopy Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]},{"raw_affiliation_string":"Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042335626"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":1.6799,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.82926097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"57","issue":"2","first_page":"265","last_page":"271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.8101000189781189,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.8101000189781189,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.1868000030517578,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proton-decoupling","display_name":"proton decoupling","score":0.9359999895095825},{"id":"https://openalex.org/keywords/1-13c-glucose","display_name":"[1-13C]glucose","score":0.9570000171661377},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.6980000138282776},{"id":"https://openalex.org/keywords/lipid-contamination","display_name":"lipid contamination","score":0.39800000190734863},{"id":"https://openalex.org/keywords/rhesus-monkey-brain","display_name":"rhesus monkey brain","score":0.8669999837875366},{"id":"https://openalex.org/keywords/in-vivo-brain-metabolism","display_name":"in vivo brain metabolism","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C205606062","wikidata":"https://www.wikidata.org/wiki/Q5249645","display_name":"Decoupling (probability)","level":2,"score":0.6717347502708435},{"id":"https://openalex.org/C57691317","wikidata":"https://www.wikidata.org/wiki/Q1289248","display_name":"Scalar (mathematics)","level":2,"score":0.5790264010429382},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.5739559531211853},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.54462069272995},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5204377770423889},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.4487612545490265},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.42079320549964905},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.32394275069236755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1490464210510254},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1452888548374176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10655131936073303},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.10320407152175903},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/mrm.21148","doi":"https://doi.org/10.1002/mrm.21148","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrm.21148","pdf_url":null,"source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},{"id":"pmid:17260369","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17260369","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic resonance in medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1510632009","https://openalex.org/W1949132276","https://openalex.org/W1963582557","https://openalex.org/W1970987536","https://openalex.org/W1976527433","https://openalex.org/W1984617545","https://openalex.org/W1989134852","https://openalex.org/W1990353567","https://openalex.org/W1993823258","https://openalex.org/W2002252682","https://openalex.org/W2010340087","https://openalex.org/W2013122896","https://openalex.org/W2042539749","https://openalex.org/W2043400693","https://openalex.org/W2045316236","https://openalex.org/W2052750469","https://openalex.org/W2054850086","https://openalex.org/W2060528621","https://openalex.org/W2060657193","https://openalex.org/W2063937701","https://openalex.org/W2064898829","https://openalex.org/W2068953489","https://openalex.org/W2080959570","https://openalex.org/W2089863048","https://openalex.org/W2091774457","https://openalex.org/W2092977480","https://openalex.org/W2093224200","https://openalex.org/W2115417231","https://openalex.org/W2121587775","https://openalex.org/W2127866826","https://openalex.org/W2136447950","https://openalex.org/W2138180264","https://openalex.org/W2141260428","https://openalex.org/W2142442304","https://openalex.org/W2155698942","https://openalex.org/W2217719122"],"related_works":["https://openalex.org/W2110771459","https://openalex.org/W2730786105","https://openalex.org/W2025567735","https://openalex.org/W2581101934","https://openalex.org/W1967557084","https://openalex.org/W2107545996","https://openalex.org/W1671499284","https://openalex.org/W2972620318","https://openalex.org/W2899472221","https://openalex.org/W2805324440"],"abstract_inverted_index":{"One":[0],"of":[1,5,62,74,109,121,126,132,147,158],"the":[2,11,15,59,110,119,130,145,148],"major":[3],"difficulties":[4],"in":[6,21,49,144],"vivo":[7,50],"13C":[8,52,164],"MRS":[9,53,165],"is":[10,54,70,129],"need":[12],"to":[13,23,39,72,86],"decouple":[14],"large,":[16],"one-bond,":[17],"1H-13C":[18,92,112],"scalar":[19,93,113],"couplings":[20,114],"order":[22],"obtain":[24],"useful":[25],"signal-to-noise":[26],"ratios":[27],"(SNRs)":[28],"and":[29,151],"spectral":[30],"resolution":[31],"at":[32,102,170],"magnetic":[33],"field":[34],"strengths":[35],"that":[36,58,73],"are":[37,83,139],"accessible":[38],"clinical":[40],"studies.":[41],"In":[42],"this":[43,127,159],"report":[44],"a":[45],"new":[46],"strategy":[47,128,160],"for":[48],"cerebral":[51],"proposed.":[55],"We":[56],"realized":[57],"turnover":[60],"kinetics":[61],"glutamate":[63],"(Glu)":[64],"C5":[65,150,154],"from":[66,77,134],"exogenous":[67,78],"[2-(13)C]glucose":[68],"(Glc)":[69],"identical":[71],"Glu":[75,149],"C4":[76],"[1-(13)C]Glc.":[79],"The":[80,156],"carboxylic/amide":[81],"carbons":[82],"only":[84],"coupled":[85],"protons":[87],"via":[88],"very":[89,103],"weak":[90],"long-range":[91],"couplings.":[94],"As":[95],"such,":[96],"they":[97],"can":[98,115],"be":[99,116],"effectively":[100],"decoupled":[101],"low":[104],"RF":[105],"power.":[106],"Therefore,":[107],"decoupling":[108],"large":[111],"avoided":[117],"by":[118],"use":[120],"[2-(13)C]Glc.":[122],"An":[123],"additional":[124],"advantage":[125],"lack":[131],"contamination":[133],"subcutaneous":[135],"lipids":[136],"because":[137],"there":[138],"no":[140],"overlapping":[141],"fat":[142],"signals":[143],"vicinity":[146],"glutamine":[152],"(Gln)":[153],"peaks.":[155],"feasibility":[157],"was":[161],"demonstrated":[162],"using":[163],"on":[166],"rhesus":[167],"monkey":[168],"brains":[169],"4.7T.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
