{"id":"https://openalex.org/W2080942012","doi":"https://doi.org/10.1002/chir.20320","title":"Non\u2010racemic atropisomeric (thio)ureas as neutral enantioselective anion receptors for amino\u2010acid derivatives: Origin of smaller Kass with thiourea than urea derivatives","display_name":"Non\u2010racemic atropisomeric (thio)ureas as neutral enantioselective anion receptors for amino\u2010acid derivatives: Origin of smaller Kass with thiourea than urea derivatives","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2080942012","doi":"https://doi.org/10.1002/chir.20320","mag":"2080942012","pmid":"https://pubmed.ncbi.nlm.nih.gov/16871519"},"language":"en","primary_location":{"id":"doi:10.1002/chir.20320","doi":"https://doi.org/10.1002/chir.20320","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chir.20320","pdf_url":null,"source":{"id":"https://openalex.org/S67976470","display_name":"Chirality","issn_l":"0899-0042","issn":["0899-0042","1520-636X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chirality","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011482554","display_name":"Christian Roussel","orcid":"https://orcid.org/0000-0003-1377-7081","observed_orcids":["https://orcid.org/0000-0003-1377-7081"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4405264346","display_name":"Universit\u00e9 Aix-Marseille-III","ror":"https://ror.org/01n0sdq82","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767","https://openalex.org/I4405264346"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Christian Roussel","raw_affiliation_strings":["Laboratoire St\u00e9r\u00e9ochimie dynamique et Chiralit\u00e9, UMR 6180, Chirotechnologies, catalyse et biocatalyse, CNRS-Universit\u00e9 Paul C\u00e9zanne-Aix-Marseille III, Marseille, France. christian.roussel@univ-cezanne.fr","Laboratoire St\u00e9r\u00e9ochimie dynamique et Chiralit\u00e9, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS\u2010Universit\u00e9 \u201cPaul C\u00e9zanne\u201d\u2010Aix\u2010Marseille III, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire St\u00e9r\u00e9ochimie dynamique et Chiralit\u00e9, UMR 6180, Chirotechnologies, catalyse et biocatalyse, CNRS-Universit\u00e9 Paul C\u00e9zanne-Aix-Marseille III, Marseille, France. christian.roussel@univ-cezanne.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4405264346"]},{"raw_affiliation_string":"Laboratoire St\u00e9r\u00e9ochimie dynamique et Chiralit\u00e9, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS\u2010Universit\u00e9 \u201cPaul C\u00e9zanne\u201d\u2010Aix\u2010Marseille III, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010982867","display_name":"Mihaela Roman","orcid":"https://orcid.org/0000-0003-2694-9233","observed_orcids":["https://orcid.org/0000-0003-2694-9233"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405264346","display_name":"Universit\u00e9 Aix-Marseille-III","ror":"https://ror.org/01n0sdq82","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767","https://openalex.org/I4405264346"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mihaela Roman","raw_affiliation_strings":["Laboratoire Ste\u0301re\u0301ochimie dynamique et Chiralite\u0301, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS-Universite\u0301 \u201cPaul Ce\u0301zanne\u201d-Aix-Marseille III, Marseille, France","Laboratoire St\u00e9r\u00e9ochimie dynamique et Chiralit\u00e9, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS\u2010Universit\u00e9 \u201cPaul C\u00e9zanne\u201d\u2010Aix\u2010Marseille III, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Ste\u0301re\u0301ochimie dynamique et Chiralite\u0301, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS-Universite\u0301 \u201cPaul Ce\u0301zanne\u201d-Aix-Marseille III, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264346"]},{"raw_affiliation_string":"Laboratoire St\u00e9r\u00e9ochimie dynamique et Chiralit\u00e9, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS\u2010Universit\u00e9 \u201cPaul C\u00e9zanne\u201d\u2010Aix\u2010Marseille III, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115598886","display_name":"Federico Andreoli","orcid":"https://orcid.org/0009-0004-2348-1537","observed_orcids":["https://orcid.org/0009-0004-2348-1537"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405264346","display_name":"Universit\u00e9 Aix-Marseille-III","ror":"https://ror.org/01n0sdq82","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767","https://openalex.org/I4405264346"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Federico Andreoli","raw_affiliation_strings":["Laboratoire Ste\u0301re\u0301ochimie dynamique et Chiralite\u0301, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS-Universite\u0301 \u201cPaul Ce\u0301zanne\u201d-Aix-Marseille III, Marseille, France","Laboratoire St\u00e9r\u00e9ochimie dynamique et Chiralit\u00e9, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS\u2010Universit\u00e9 \u201cPaul C\u00e9zanne\u201d\u2010Aix\u2010Marseille III, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Ste\u0301re\u0301ochimie dynamique et Chiralite\u0301, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS-Universite\u0301 \u201cPaul Ce\u0301zanne\u201d-Aix-Marseille III, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264346"]},{"raw_affiliation_string":"Laboratoire St\u00e9r\u00e9ochimie dynamique et Chiralit\u00e9, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS\u2010Universit\u00e9 \u201cPaul C\u00e9zanne\u201d\u2010Aix\u2010Marseille III, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081139093","display_name":"Alberto Del R\u00edo","orcid":"https://orcid.org/0000-0002-1890-6797","observed_orcids":["https://orcid.org/0000-0002-1890-6797"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405264346","display_name":"Universit\u00e9 Aix-Marseille-III","ror":"https://ror.org/01n0sdq82","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767","https://openalex.org/I4405264346"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alberto Del Rio","raw_affiliation_strings":["Laboratoire Ste\u0301re\u0301ochimie dynamique et Chiralite\u0301, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS-Universite\u0301 \u201cPaul Ce\u0301zanne\u201d-Aix-Marseille III, Marseille, France","Laboratoire St\u00e9r\u00e9ochimie dynamique et Chiralit\u00e9, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS\u2010Universit\u00e9 \u201cPaul C\u00e9zanne\u201d\u2010Aix\u2010Marseille III, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Ste\u0301re\u0301ochimie dynamique et Chiralite\u0301, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS-Universite\u0301 \u201cPaul Ce\u0301zanne\u201d-Aix-Marseille III, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264346"]},{"raw_affiliation_string":"Laboratoire St\u00e9r\u00e9ochimie dynamique et Chiralit\u00e9, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS\u2010Universit\u00e9 \u201cPaul C\u00e9zanne\u201d\u2010Aix\u2010Marseille III, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113526235","display_name":"Robert Faure","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405264346","display_name":"Universit\u00e9 Aix-Marseille-III","ror":"https://ror.org/01n0sdq82","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767","https://openalex.org/I4405264346"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Robert Faure","raw_affiliation_strings":["Laboratoire Ste\u0301re\u0301ochimie dynamique et Chiralite\u0301, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS-Universite\u0301 \u201cPaul Ce\u0301zanne\u201d-Aix-Marseille III, Marseille, France","Laboratoire St\u00e9r\u00e9ochimie dynamique et Chiralit\u00e9, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS\u2010Universit\u00e9 \u201cPaul C\u00e9zanne\u201d\u2010Aix\u2010Marseille III, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Ste\u0301re\u0301ochimie dynamique et Chiralite\u0301, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS-Universite\u0301 \u201cPaul Ce\u0301zanne\u201d-Aix-Marseille III, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264346"]},{"raw_affiliation_string":"Laboratoire St\u00e9r\u00e9ochimie dynamique et Chiralit\u00e9, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS\u2010Universit\u00e9 \u201cPaul C\u00e9zanne\u201d\u2010Aix\u2010Marseille III, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076740332","display_name":"Nicolas Vanthuyne","orcid":"https://orcid.org/0000-0003-2598-7940","observed_orcids":["https://orcid.org/0000-0003-2598-7940"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405264346","display_name":"Universit\u00e9 Aix-Marseille-III","ror":"https://ror.org/01n0sdq82","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767","https://openalex.org/I4405264346"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Vanthuyne","raw_affiliation_strings":["Laboratoire Ste\u0301re\u0301ochimie dynamique et Chiralite\u0301, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS-Universite\u0301 \u201cPaul Ce\u0301zanne\u201d-Aix-Marseille III, Marseille, France","Laboratoire St\u00e9r\u00e9ochimie dynamique et Chiralit\u00e9, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS\u2010Universit\u00e9 \u201cPaul C\u00e9zanne\u201d\u2010Aix\u2010Marseille III, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Ste\u0301re\u0301ochimie dynamique et Chiralite\u0301, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS-Universite\u0301 \u201cPaul Ce\u0301zanne\u201d-Aix-Marseille III, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264346"]},{"raw_affiliation_string":"Laboratoire St\u00e9r\u00e9ochimie dynamique et Chiralit\u00e9, UMR 6180, Chirotechnologies: catalyse et biocatalyse, CNRS\u2010Universit\u00e9 \u201cPaul C\u00e9zanne\u201d\u2010Aix\u2010Marseille III, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011482554"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4405264346"],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":1.8631,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.83773972,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"18","issue":"9","first_page":"762","last_page":"771"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13115","display_name":"Axial and Atropisomeric Chirality Synthesis","score":0.5981000065803528,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13115","display_name":"Axial and Atropisomeric Chirality Synthesis","score":0.5981000065803528,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.25099998712539673,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atropisomerism","display_name":"atropisomerism","score":0.843999981880188},{"id":"https://openalex.org/keywords/thiourea","display_name":"thiourea","score":0.6480000019073486},{"id":"https://openalex.org/keywords/urea","display_name":"urea","score":0.9750000238418579},{"id":"https://openalex.org/keywords/anion-receptors","display_name":"anion receptors","score":0.796999990940094},{"id":"https://openalex.org/keywords/chiral-recognition","display_name":"chiral recognition","score":0.781000018119812},{"id":"https://openalex.org/keywords/amino-acid-derivatives","display_name":"amino acid derivatives","score":0.6980000138282776},{"id":"https://openalex.org/keywords/tetrabutylammonium-salts","display_name":"tetrabutylammonium salts","score":0.8679999709129333},{"id":"https://openalex.org/keywords/binding-constant","display_name":"binding constant","score":0.7039999961853027},{"id":"https://openalex.org/keywords/intramolecular-hydrogen-bonding","display_name":"intramolecular hydrogen bonding","score":0.7390000224113464},{"id":"https://openalex.org/keywords/conformational-analysis","display_name":"conformational analysis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/bifunctional-organocatalysis","display_name":"bifunctional organocatalysis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/nmr-titration","display_name":"NMR titration","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2780538656","wikidata":"https://www.wikidata.org/wiki/Q528995","display_name":"Thiourea","level":2,"score":0.9621065855026245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9552879333496094},{"id":"https://openalex.org/C2781253882","wikidata":"https://www.wikidata.org/wiki/Q770860","display_name":"Thio-","level":2,"score":0.7929924726486206},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.6783248782157898},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.6577945947647095},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.6004849076271057},{"id":"https://openalex.org/C2780443040","wikidata":"https://www.wikidata.org/wiki/Q3737863","display_name":"Bifunctional","level":3,"score":0.5468896627426147},{"id":"https://openalex.org/C124668440","wikidata":"https://www.wikidata.org/wiki/Q2305173","display_name":"Chirality (physics)","level":5,"score":0.5272573232650757},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.506634533405304},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.48143407702445984},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.44410938024520874},{"id":"https://openalex.org/C103319777","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton NMR","level":2,"score":0.42225125432014465},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3982430398464203},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2723022699356079},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.2039966881275177},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.1947707235813141},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C7602139","wikidata":"https://www.wikidata.org/wiki/Q6718","display_name":"Quark","level":2,"score":0.0},{"id":"https://openalex.org/C52703039","wikidata":"https://www.wikidata.org/wiki/Q5101837","display_name":"Chiral symmetry breaking","level":3,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C20621625","wikidata":"https://www.wikidata.org/wiki/Q6961432","display_name":"Nambu\u2013Jona-Lasinio model","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000432","descriptor_name":"Methanol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000838","descriptor_name":"Anions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/chir.20320","doi":"https://doi.org/10.1002/chir.20320","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chir.20320","pdf_url":null,"source":{"id":"https://openalex.org/S67976470","display_name":"Chirality","issn_l":"0899-0042","issn":["0899-0042","1520-636X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chirality","raw_type":"journal-article"},{"id":"pmid:16871519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16871519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chirality","raw_type":"Comparative Study"},{"id":"pmh:oai:HAL:hal-02516150v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-02516150","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chirality, 2006, 18 (9), pp.762-771. ⟨10.1002/Chir.20320⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W35752629","https://openalex.org/W1964240476","https://openalex.org/W1964666522","https://openalex.org/W1965610346","https://openalex.org/W1965688351","https://openalex.org/W1966134912","https://openalex.org/W1969987885","https://openalex.org/W1971956699","https://openalex.org/W1988080620","https://openalex.org/W1993533895","https://openalex.org/W1993788822","https://openalex.org/W1997878009","https://openalex.org/W1999394651","https://openalex.org/W2000127113","https://openalex.org/W2001410426","https://openalex.org/W2001628796","https://openalex.org/W2004986011","https://openalex.org/W2005619234","https://openalex.org/W2020527840","https://openalex.org/W2028341518","https://openalex.org/W2036057652","https://openalex.org/W2036945885","https://openalex.org/W2037152760","https://openalex.org/W2038340042","https://openalex.org/W2039746582","https://openalex.org/W2046089618","https://openalex.org/W2046327131","https://openalex.org/W2051952747","https://openalex.org/W2055798314","https://openalex.org/W2061231949","https://openalex.org/W2063011691","https://openalex.org/W2066395648","https://openalex.org/W2067123456","https://openalex.org/W2072679396","https://openalex.org/W2073825007","https://openalex.org/W2075799511","https://openalex.org/W2077513254","https://openalex.org/W2081608184","https://openalex.org/W2082756364","https://openalex.org/W2087723568","https://openalex.org/W2092603303","https://openalex.org/W2095191961","https://openalex.org/W2101626288","https://openalex.org/W2101925719","https://openalex.org/W2102147148","https://openalex.org/W2105085837","https://openalex.org/W2121280623","https://openalex.org/W2124477556","https://openalex.org/W2129718204","https://openalex.org/W2135914001","https://openalex.org/W2141165026","https://openalex.org/W2154327352","https://openalex.org/W2155604981","https://openalex.org/W2158088781","https://openalex.org/W2158284762","https://openalex.org/W2371479001","https://openalex.org/W2949100507","https://openalex.org/W2949913607","https://openalex.org/W2951112480","https://openalex.org/W2951649116","https://openalex.org/W2951743030","https://openalex.org/W2951828883","https://openalex.org/W2951927279","https://openalex.org/W2952097536","https://openalex.org/W2952115637","https://openalex.org/W2952921574","https://openalex.org/W2953173383","https://openalex.org/W3004493973","https://openalex.org/W4232641842","https://openalex.org/W4256209136"],"related_works":["https://openalex.org/W2124477556","https://openalex.org/W2952280813","https://openalex.org/W2159789943","https://openalex.org/W1979710644","https://openalex.org/W1992287727","https://openalex.org/W4211116004","https://openalex.org/W3123786548","https://openalex.org/W2133930842","https://openalex.org/W2046037694","https://openalex.org/W1988429999"],"abstract_inverted_index":{"The":[0,54,172],"synthesis":[1],"of":[2,6,19,23,30,44,67,98,148,175,181],"a":[3,105,111,122,130],"limited":[4],"series":[5],"non-racemic":[7],"atropisomeric":[8],"1-(2-(4-methyl-2-thioxothiazol-3(2H)-yl)phenyl)-3-(hetero)aryl-(thio)ureas":[9],"is":[10,152,184],"described.":[11],"Using":[12],"NMR":[13,94],"titration":[14],"experiments":[15],"monitoring":[16],"the":[17,20,24,27,31,33,42,65,68,76,82,86,96,102,116,119,135,145,149,155,160,166,170,179],"shift":[18],"two":[21],"NH":[22,69,143],"(thio)urea":[25],"and":[26,93,144,157],"C-5":[28],"hydrogen":[29,113,139],"heterocycle,":[32,150],"binding":[34],"constants":[35,78],"for":[36,110,169],"some":[37],"optically":[38],"pure":[39],"(thio)-ureas":[40],"with":[41,81,85,115],"enantiomers":[43],"N-protected":[45],"amino":[46],"acid":[47],"tetrabutylammonium":[48],"salts":[49],"were":[50,57,79],"determined":[51],"in":[52,71,129,134,154,159,178],"CD3CN.":[53],"obtained":[55],"enantioselectivities":[56],"modest.":[58],"Contrary":[59],"to":[60,165],"what":[61],"was":[62],"expected":[63],"on":[64],"basis":[66],"acidity":[70],"thiourea":[72,83,120,156],"versus":[73],"urea":[74,103],"group,":[75],"association":[77],"smaller":[80,167],"than":[84],"corresponding":[87],"urea.":[88],"X-ray":[89],"data,":[90],"DFT":[91],"calculations,":[92],"provided":[95],"explanation":[97],"that":[99],"unexpected":[100],"behavior:":[101],"presents":[104,121],"pre-organized":[106],"(Z,Z)":[107,132],"conformation":[108,133],"suitable":[109],"double":[112],"bond":[114,140],"carboxylate":[117],"anion,":[118],"(Z,E)":[123],"conformation,":[124],"which":[125,151],"must":[126],"be":[127],"reorganized":[128],"constrained":[131],"complex.":[136],"An":[137],"intramolecular":[138],"between":[141],"one":[142],"thiocarbonyl":[146],"group":[147],"present":[153],"absent":[158],"urea,":[161],"might":[162],"also":[163],"contribute":[164],"K(ass)":[168],"thiourea.":[171],"possible":[173],"implication":[174],"these":[176],"observations":[177],"field":[180],"bifunctional":[182],"organocatalysis":[183],"briefly":[185],"discussed.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}