{"id":"https://openalex.org/W208092209","doi":null,"title":"New molecular approaches to lung cancer: biological and clinical implications of P53, P16 and K-RAS studies.","display_name":"New molecular approaches to lung cancer: biological and clinical implications of P53, P16 and K-RAS studies.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W208092209","mag":"208092209","pmid":"https://pubmed.ncbi.nlm.nih.gov/11374847"},"language":"en","primary_location":{"id":"pmid:11374847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11374847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia histochemica et cytobiologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070045448","display_name":"Wies\u0142awa Nikli\u0144ska","orcid":"https://orcid.org/0000-0002-4587-1323","observed_orcids":["https://orcid.org/0000-0002-4587-1323"]},"institutions":[{"id":"https://openalex.org/I146122375","display_name":"Medical University of Bia\u0142ystok","ror":"https://ror.org/00y4ya841","country_code":"PL","type":"education","lineage":["https://openalex.org/I146122375"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"W Niklinska","raw_affiliation_strings":["Department of Histology and Embryology, Medical Academy, Bia\u0142ystok, Poland. niklinsj@cksr.ac.bialystok.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Medical Academy, Bia\u0142ystok, Poland. niklinsj@cksr.ac.bialystok.pl","institution_ids":["https://openalex.org/I146122375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089158210","display_name":"L Chyczewski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Chyczewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054692461","display_name":"Jacek Nikli\u0144ski","orcid":"https://orcid.org/0000-0002-8437-1401","observed_orcids":["https://orcid.org/0000-0002-8437-1401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Niklinski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5014,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.67548115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"39","issue":"2","first_page":"99","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.2542000114917755,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.13379999995231628,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":1.0},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8880000114440918},{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":0.9869999885559082},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/p16-promoter-methylation","display_name":"p16 promoter methylation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/yeast-functional-assay","display_name":"yeast functional assay","score":0.6890000104904175},{"id":"https://openalex.org/keywords/methylation-specific-pcr","display_name":"methylation-specific PCR","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7985785007476807},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.7172865867614746},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.7058165073394775},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.669903039932251},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5985195636749268},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.587260901927948},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5778459906578064},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5534994006156921},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5160648226737976},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.4522084891796112},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.450324684381485},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.3380506932735443},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24256515502929688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23657360672950745},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.18480849266052246}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019942","descriptor_name":"Genes, p16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11374847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11374847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia histochemica et cytobiologica","raw_type":"Journal Article"},{"id":"mag:208092209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11374847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2392969207","https://openalex.org/W1975498428","https://openalex.org/W2383736125","https://openalex.org/W937838438","https://openalex.org/W2109317141","https://openalex.org/W958227100","https://openalex.org/W2022312444","https://openalex.org/W2055103019","https://openalex.org/W2315905831","https://openalex.org/W1989900033"],"abstract_inverted_index":{"The":[0,51],"most":[1],"common":[2],"genetic":[3],"changes":[4],"associated":[5],"with":[6,65],"lung":[7,48,63],"cancer":[8,49,64],"involve":[9],"abnormalities":[10],"of":[11,21,43,57,83],"the":[12,16,81],"genes":[13,27],"that":[14],"regulate":[15],"cell":[17,36],"cycle.":[18],"Molecular":[19],"networking":[20],"P53":[22,86],"and":[23,28,39,60,70,97],"P16":[24,59,91],"tumor":[25],"suppressor":[26],"K-RAS":[29,61,98],"oncogene":[30],"exerts":[31],"a":[32],"crucial":[33],"impact":[34],"on":[35,68,76],"cycle":[37],"regulation":[38],"appears":[40],"to":[41,80],"be":[42],"major":[44],"clinical":[45,71],"significance":[46],"for":[47],"evaluation.":[50],"present":[52],"review":[53],"article":[54],"summarizes":[55],"evaluations":[56],"P53,":[58],"in":[62],"particular":[66],"focus":[67],"biological":[69],"implications,":[72],"as":[73,75],"well":[74],"new":[77],"molecular":[78],"approaches":[79],"study":[82],"these":[84],"genes:":[85],"by":[87,92,99],"yeast":[88],"functional":[89],"assay,":[90],"methylation":[93],"specific":[94],"PCR":[95,101],"(MSP)":[96],"enriched":[100],"technique.":[102]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}