{"id":"https://openalex.org/W2080899182","doi":"https://doi.org/10.1016/j.sbi.2003.10.006","title":"Structural biology of enzymes of the thiamin biosynthesis pathway","display_name":"Structural biology of enzymes of the thiamin biosynthesis pathway","publication_year":2003,"publication_date":"2003-11-15","ids":{"openalex":"https://openalex.org/W2080899182","doi":"https://doi.org/10.1016/j.sbi.2003.10.006","mag":"2080899182","pmid":"https://pubmed.ncbi.nlm.nih.gov/14675553"},"language":"en","primary_location":{"id":"doi:10.1016/j.sbi.2003.10.006","doi":"https://doi.org/10.1016/j.sbi.2003.10.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.sbi.2003.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S175155502","display_name":"Current Opinion in Structural Biology","issn_l":"0959-440X","issn":["0959-440X","1879-033X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Structural Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027236219","display_name":"Ethan C. Settembre","orcid":"https://orcid.org/0000-0002-3021-4638","observed_orcids":["https://orcid.org/0000-0002-3021-4638"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Settembre","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA","Department of Chemistry & Chemical Biology, Cornell University, Ithaca NY 14850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Cornell University, Ithaca NY 14850, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064237607","display_name":"Tadhg P. Begley","orcid":"https://orcid.org/0000-0001-5134-2623","observed_orcids":["https://orcid.org/0000-0001-5134-2623"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tadhg P Begley","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA","Department of Chemistry & Chemical Biology, Cornell University, Ithaca NY 14850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Cornell University, Ithaca NY 14850, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019164857","display_name":"S.E. Ealick","orcid":"https://orcid.org/0000-0001-8548-112X","observed_orcids":["https://orcid.org/0000-0001-8548-112X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven E Ealick","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA","Department of Chemistry & Chemical Biology, Cornell University, Ithaca NY 14850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Cornell University, Ithaca NY 14850, USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019164857"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":4360,"currency":"USD","value_usd":4360},"apc_paid":null,"fwci":0.5084,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.3507109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"6","first_page":"739","last_page":"747"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12494","display_name":"Alcoholism and Thiamine Deficiency","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thiamine-biosynthesis","display_name":"thiamine biosynthesis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/thiamine-pyrophosphate","display_name":"thiamine pyrophosphate","score":0.9710000157356262},{"id":"https://openalex.org/keywords/thiazole-biosynthesis","display_name":"thiazole biosynthesis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/enzyme-structure","display_name":"enzyme structure","score":0.5640000104904175},{"id":"https://openalex.org/keywords/enzyme-mechanism","display_name":"enzyme mechanism","score":0.8989999890327454},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9259999990463257},{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":1.0},{"id":"https://openalex.org/keywords/phylogenetic-relationships","display_name":"phylogenetic relationships","score":0.5099999904632568},{"id":"https://openalex.org/keywords/cofactor-metabolism","display_name":"cofactor metabolism","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.8655179738998413},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.7394520044326782},{"id":"https://openalex.org/C2780047943","wikidata":"https://www.wikidata.org/wiki/Q415003","display_name":"Thiamine pyrophosphate","level":4,"score":0.7299388647079468},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.6891497373580933},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6363058686256409},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.534709095954895},{"id":"https://openalex.org/C2776203871","wikidata":"https://www.wikidata.org/wiki/Q83187","display_name":"Thiamine","level":2,"score":0.5210099220275879},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5025591850280762},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46665191650390625},{"id":"https://openalex.org/C2776043855","wikidata":"https://www.wikidata.org/wiki/Q55506489","display_name":"Pyrophosphate","level":3,"score":0.4613651633262634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39922159910202026},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.28616225719451904},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1213790774345398},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11981353163719177}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013831","descriptor_name":"Thiamine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013831","descriptor_name":"Thiamine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.sbi.2003.10.006","doi":"https://doi.org/10.1016/j.sbi.2003.10.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.sbi.2003.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S175155502","display_name":"Current Opinion in Structural Biology","issn_l":"0959-440X","issn":["0959-440X","1879-033X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Structural Biology","raw_type":"journal-article"},{"id":"pmid:14675553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14675553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in structural biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5132381092","display_name":null,"funder_award_id":"DK44083","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306159","display_name":"W. M. Keck Foundation","ror":"https://ror.org/000dswa46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W202055246","https://openalex.org/W1480873359","https://openalex.org/W1522582794","https://openalex.org/W1547856877","https://openalex.org/W1578299567","https://openalex.org/W1578374139","https://openalex.org/W1602334599","https://openalex.org/W1607874074","https://openalex.org/W1828505669","https://openalex.org/W1851952707","https://openalex.org/W1855089018","https://openalex.org/W1964819391","https://openalex.org/W1965453772","https://openalex.org/W1968033829","https://openalex.org/W1976230930","https://openalex.org/W1978600547","https://openalex.org/W1978663690","https://openalex.org/W1984606900","https://openalex.org/W1988225072","https://openalex.org/W1992621107","https://openalex.org/W1995950751","https://openalex.org/W1999623718","https://openalex.org/W2002810194","https://openalex.org/W2006873685","https://openalex.org/W2010993019","https://openalex.org/W2013458947","https://openalex.org/W2023454927","https://openalex.org/W2025538655","https://openalex.org/W2028834878","https://openalex.org/W2030918960","https://openalex.org/W2033040705","https://openalex.org/W2034174616","https://openalex.org/W2043893670","https://openalex.org/W2046474288","https://openalex.org/W2049766815","https://openalex.org/W2052712522","https://openalex.org/W2053334963","https://openalex.org/W2069931262","https://openalex.org/W2071744938","https://openalex.org/W2075693395","https://openalex.org/W2082408062","https://openalex.org/W2086851301","https://openalex.org/W2089624815","https://openalex.org/W2096982350","https://openalex.org/W2109284962","https://openalex.org/W2114138956","https://openalex.org/W2121699726","https://openalex.org/W2123748366","https://openalex.org/W2126190334","https://openalex.org/W2136209632","https://openalex.org/W2136699027","https://openalex.org/W2149535707","https://openalex.org/W2150624227","https://openalex.org/W2152302193","https://openalex.org/W2159371227","https://openalex.org/W2182435607","https://openalex.org/W2204079924","https://openalex.org/W2291304384","https://openalex.org/W2399691103","https://openalex.org/W2406536058","https://openalex.org/W4251838592","https://openalex.org/W6712938959"],"related_works":["https://openalex.org/W3020870132","https://openalex.org/W2128474182","https://openalex.org/W2029281605","https://openalex.org/W2111819350","https://openalex.org/W2326413685","https://openalex.org/W2063167476","https://openalex.org/W3176495066","https://openalex.org/W2070507835","https://openalex.org/W2029159902","https://openalex.org/W177410874"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
