{"id":"https://openalex.org/W2080844086","doi":"https://doi.org/10.1016/j.jad.2011.05.057","title":"Hippocampal atrophy in first episode depression: A meta-analysis of magnetic resonance imaging studies","display_name":"Hippocampal atrophy in first episode depression: A meta-analysis of magnetic resonance imaging studies","publication_year":2011,"publication_date":"2011-07-15","ids":{"openalex":"https://openalex.org/W2080844086","doi":"https://doi.org/10.1016/j.jad.2011.05.057","mag":"2080844086","pmid":"https://pubmed.ncbi.nlm.nih.gov/21745692"},"language":"en","primary_location":{"id":"doi:10.1016/j.jad.2011.05.057","doi":"https://doi.org/10.1016/j.jad.2011.05.057","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jad.2011.05.057","pdf_url":null,"source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003288277","display_name":"James Howard Cole","orcid":"https://orcid.org/0000-0003-1908-5588","observed_orcids":["https://orcid.org/0000-0003-1908-5588"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Cole","raw_affiliation_strings":["Institute of Psychiatry, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Psychiatry, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081739897","display_name":"Sergi G. Costafreda","orcid":"https://orcid.org/0000-0001-6914-086X","observed_orcids":["https://orcid.org/0000-0001-6914-086X"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sergi G. Costafreda","raw_affiliation_strings":["Institute of Psychiatry \u2013 King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Psychiatry \u2013 King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045978641","display_name":"Peter McGuffin","orcid":"https://orcid.org/0000-0002-9888-2907","observed_orcids":["https://orcid.org/0000-0002-9888-2907"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter McGuffin","raw_affiliation_strings":["Institute of Psychiatry \u2013 King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Psychiatry \u2013 King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017659667","display_name":"Cynthia H.Y. Fu","orcid":"https://orcid.org/0000-0003-4313-3500","observed_orcids":["https://orcid.org/0000-0003-4313-3500","https://orcid.org/0009-0004-4069-8906"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cynthia H.Y. Fu","raw_affiliation_strings":["Institute of Psychiatry \u2013 King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Psychiatry \u2013 King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I183935753"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":2.4813,"has_fulltext":false,"cited_by_count":319,"citation_normalized_percentile":{"value":0.92037037,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"134","issue":"1-3","first_page":"483","last_page":"487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.11349999904632568,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampal-atrophy","display_name":"hippocampal atrophy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/first-episode-depression","display_name":"first-episode depression","score":0.843999981880188},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hippocampal-volume","display_name":"hippocampal volume","score":0.8939999938011169},{"id":"https://openalex.org/keywords/neurobiomarkers","display_name":"neurobiomarkers","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hippocampal-asymmetry","display_name":"hippocampal asymmetry","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.7366604208946228},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.6319596767425537},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6146442890167236},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5098060965538025},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.4922298491001129},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4720257818698883},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4018707275390625},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3916890323162079},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2254314422607422},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.153304785490036},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13850829005241394},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008280","descriptor_name":"Magnetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jad.2011.05.057","doi":"https://doi.org/10.1016/j.jad.2011.05.057","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jad.2011.05.057","pdf_url":null,"source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},{"id":"pmid:21745692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21745692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of affective disorders","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10036572","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/10036572/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JOURNAL OF AFFECTIVE DISORDERS , 134 (1-3) pp. 483-487. (2011)","raw_type":"Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/f70fdee6-18bf-43db-b806-51b3f901fed9","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/f70fdee6-18bf-43db-b806-51b3f901fed9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cole, J, Costafreda-Gonzalez, S, McGuffin, P & Fu, C H Y 2011, 'Hippocampal atrophy in first episode depression : A meta-analysis of magnetic resonance imaging studies', Journal of Affective Disorders, vol. 134, no. 1-3, pp. 483-487. https://doi.org/10.1016/j.jad.2011.05.057","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[{"id":"https://openalex.org/G791749169","display_name":null,"funder_award_id":"CL-2011-17-003","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1608380975","https://openalex.org/W1719169697","https://openalex.org/W1815861390","https://openalex.org/W1974102924","https://openalex.org/W1974993745","https://openalex.org/W1994228560","https://openalex.org/W2014850687","https://openalex.org/W2017638772","https://openalex.org/W2018031501","https://openalex.org/W2023357818","https://openalex.org/W2024320369","https://openalex.org/W2029769026","https://openalex.org/W2030772288","https://openalex.org/W2041073969","https://openalex.org/W2059527510","https://openalex.org/W2067535960","https://openalex.org/W2072983755","https://openalex.org/W2084453479","https://openalex.org/W2090766610","https://openalex.org/W2094643645","https://openalex.org/W2107328434","https://openalex.org/W2110763068","https://openalex.org/W2120032880","https://openalex.org/W2121358117","https://openalex.org/W2135725784","https://openalex.org/W2153043827","https://openalex.org/W2154758450","https://openalex.org/W2154971711","https://openalex.org/W2155962001","https://openalex.org/W2160674577","https://openalex.org/W2170298556","https://openalex.org/W2570848767","https://openalex.org/W4413981594","https://openalex.org/W6636401950"],"related_works":["https://openalex.org/W2347834690","https://openalex.org/W2890422181","https://openalex.org/W2023357818","https://openalex.org/W4413981594","https://openalex.org/W2019316537","https://openalex.org/W2890853008","https://openalex.org/W2106106014","https://openalex.org/W2892030795","https://openalex.org/W2120032880","https://openalex.org/W1990808724"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":27},{"year":2016,"cited_by_count":29},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":25},{"year":2013,"cited_by_count":29},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}