{"id":"https://openalex.org/W2080766637","doi":"https://doi.org/10.1073/pnas.80.18.5515","title":"Inducible transcription of five globin genes in K562 human leukemia cells.","display_name":"Inducible transcription of five globin genes in K562 human leukemia cells.","publication_year":1983,"publication_date":"1983-09-01","ids":{"openalex":"https://openalex.org/W2080766637","doi":"https://doi.org/10.1073/pnas.80.18.5515","mag":"2080766637","pmid":"https://pubmed.ncbi.nlm.nih.gov/6310580","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/384288"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.80.18.5515","doi":"https://doi.org/10.1073/pnas.80.18.5515","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.80.18.5515","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC384288","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006789693","display_name":"Ann Dean","orcid":"https://orcid.org/0000-0001-6558-747X","observed_orcids":["https://orcid.org/0000-0001-6558-747X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Dean","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076598094","display_name":"Timothy James Ley","orcid":"https://orcid.org/0000-0002-9913-0520","observed_orcids":["https://orcid.org/0000-0002-9913-0520"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T J Ley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024703985","display_name":"R. Keith Humphries","orcid":"https://orcid.org/0000-0003-0540-7005","observed_orcids":["https://orcid.org/0000-0003-0540-7005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R K Humphries","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009723907","display_name":"M Fordis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Fordis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047048178","display_name":"Alan N. Schechter","orcid":"https://orcid.org/0000-0002-6055-6452","observed_orcids":["https://orcid.org/0000-0002-6055-6452","https://orcid.org/0000-0002-5235-9408"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A N Schechter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.08,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.97808391,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"80","issue":"18","first_page":"5515","last_page":"5519"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.034699998795986176,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/globin-genes","display_name":"globin genes","score":0.847000002861023},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hemin-induction","display_name":"hemin induction","score":0.9179999828338623},{"id":"https://openalex.org/keywords/hemoglobin-synthesis","display_name":"hemoglobin synthesis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/alpha-globin-mrna","display_name":"alpha-globin mRNA","score":0.8550000190734863},{"id":"https://openalex.org/keywords/gamma-globin-mrna","display_name":"gamma-globin mRNA","score":0.8740000128746033},{"id":"https://openalex.org/keywords/beta-globin-mrna","display_name":"beta-globin mRNA","score":0.8809999823570251},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/erythroid-differentiation","display_name":"erythroid differentiation","score":0.640999972820282},{"id":"https://openalex.org/keywords/leukemia-cells","display_name":"leukemia cells","score":0.5370000004768372},{"id":"https://openalex.org/keywords/mrna-levels","display_name":"mRNA levels","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C125996951","wikidata":"https://www.wikidata.org/wiki/Q412234","display_name":"Globin","level":3,"score":0.778084397315979},{"id":"https://openalex.org/C2777723881","wikidata":"https://www.wikidata.org/wiki/Q107315604","display_name":"Hemin","level":4,"score":0.750495970249176},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7461903095245361},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.7432811856269836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.607385516166687},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6007175445556641},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5592331290245056},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5055336952209473},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.5010206699371338},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4792901873588562},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.443851113319397},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.3070032596588135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1743226945400238},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13353422284126282},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1170855164527893},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015719","descriptor_name":"Single-Strand Specific DNA and RNA Endonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.80.18.5515","doi":"https://doi.org/10.1073/pnas.80.18.5515","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.80.18.5515","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:63718","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC384288","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:384288","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/384288","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:6310580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6310580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:63718","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC384288","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W130020229","https://openalex.org/W253845798","https://openalex.org/W1547680166","https://openalex.org/W1724131118","https://openalex.org/W1991102898","https://openalex.org/W1994268106","https://openalex.org/W1995608753","https://openalex.org/W2001019121","https://openalex.org/W2010310450","https://openalex.org/W2021889598","https://openalex.org/W2024457805","https://openalex.org/W2025206980","https://openalex.org/W2026969402","https://openalex.org/W2028379614","https://openalex.org/W2038126541","https://openalex.org/W2041515266","https://openalex.org/W2048404769","https://openalex.org/W2066160869","https://openalex.org/W2066960428","https://openalex.org/W2067231547","https://openalex.org/W2068065077","https://openalex.org/W2072573620","https://openalex.org/W2076405876","https://openalex.org/W2092372581","https://openalex.org/W2281483869"],"related_works":["https://openalex.org/W2409597249","https://openalex.org/W1995608753","https://openalex.org/W41804317","https://openalex.org/W2018686296","https://openalex.org/W1965091780","https://openalex.org/W1859241485","https://openalex.org/W2094057946","https://openalex.org/W1590901082","https://openalex.org/W4240933948","https://openalex.org/W2031151216"],"abstract_inverted_index":{"We":[0],"studied":[1],"the":[2,88,111,142],"abundance":[3],"and":[4,15,43,66,80,96,139,146],"structure":[5],"of":[6,18,26,64,90,102,130,144],"globin":[7,47],"mRNAs":[8,48],"present":[9],"in":[10,93,120,150],"K562":[11,30,131,151],"cells":[12,31,68,132,152],"both":[13,94],"before":[14],"after":[16,53],"induction":[17,129],"hemoglobin":[19],"synthesis":[20],"by":[21,59,69],"hemin.":[22],"In":[23,82],"vitro":[24],"translation":[25],"poly(A)+":[27],"RNA":[28],"from":[29,110],"generated":[32],"protein":[33],"products":[34],"corresponding":[35],"to":[36,51,106],"alpha,":[37],"A":[38,99],"gamma-,":[39,41],"G":[40],"epsilon-,":[42],"zeta-globin":[44],"mRNAs.":[45],"Individual":[46],"increased":[49],"1.5-":[50],"3-fold":[52],"induction.":[54],"Similar":[55],"results":[56,124],"were":[57,77],"obtained":[58],"measuring":[60],"steady-state":[61],"mRNA":[62,92,116],"concentrations":[63],"induced":[65,97],"uninduced":[67],"using":[70],"S1":[71,84],"nuclease":[72,85],"mapping.":[73],"Globin":[74],"gene":[75,148],"transcripts":[76,104],"correctly":[78],"initiated":[79,108],"processed.":[81],"addition,":[83],"analysis":[86],"revealed":[87],"presence":[89],"delta-globin":[91,103],"control":[95],"cells.":[98,157],"small":[100],"percentage":[101],"appeared":[105],"be":[107],"upstream":[109],"normal":[112,155],"initiation":[113],"site.":[114],"beta-Globin":[115],"was":[117],"not":[118],"detected":[119],"any":[121],"studies.":[122],"The":[123],"(i)":[125],"suggest":[126],"that":[127],"hemin":[128],"is":[133],"mediated":[134],"at":[135],"a":[136],"transcriptional":[137],"level":[138],"(ii)":[140],"reveal":[141],"dissociation":[143],"delta-":[145],"beta-globin":[147],"expression":[149],"compared":[153],"with":[154],"erythroid":[156]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
