{"id":"https://openalex.org/W2080765971","doi":"https://doi.org/10.1016/0002-8703(75)90156-8","title":"Mechanism of immediate hemodynamic effects of chlorothiazide","display_name":"Mechanism of immediate hemodynamic effects of chlorothiazide","publication_year":1975,"publication_date":"1975-04-01","ids":{"openalex":"https://openalex.org/W2080765971","doi":"https://doi.org/10.1016/0002-8703(75)90156-8","mag":"2080765971","pmid":"https://pubmed.ncbi.nlm.nih.gov/1114981"},"language":"en","primary_location":{"id":"doi:10.1016/0002-8703(75)90156-8","doi":"https://doi.org/10.1016/0002-8703(75)90156-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0002-8703(75)90156-8","pdf_url":null,"source":{"id":"https://openalex.org/S46995015","display_name":"American Heart Journal","issn_l":"0002-8703","issn":["0002-8703","1097-6744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057554716","display_name":"G Lohm\u00f6ller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georg Lohm\u00f6ller","raw_affiliation_strings":["University of Oklahoma Health Sciences Center, Oklahoma City, Okla., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oklahoma Health Sciences Center, Oklahoma City, Okla., USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084250571","display_name":"R. Lohm\u00f6ller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reinhilde Lohm\u00f6ller","raw_affiliation_strings":["University of Oklahoma Health Sciences Center, Oklahoma City, Okla., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oklahoma Health Sciences Center, Oklahoma City, Okla., USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031560506","display_name":"Marc Alan Pfeffer","orcid":"https://orcid.org/0000-0003-3876-7568","observed_orcids":["https://orcid.org/0000-0003-3876-7568"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc A. Pfeffer","raw_affiliation_strings":["University of Oklahoma Health Sciences Center, Oklahoma City, Okla., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oklahoma Health Sciences Center, Oklahoma City, Okla., USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113901706","display_name":"Janice M. Pfeffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janice M. Pfeffer","raw_affiliation_strings":["University of Oklahoma Health Sciences Center, Oklahoma City, Okla., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oklahoma Health Sciences Center, Oklahoma City, Okla., USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112042724","display_name":"Edward David Frohlich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward D. Frohlich","raw_affiliation_strings":["University of Oklahoma Health Sciences Center, Oklahoma City, Okla., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oklahoma Health Sciences Center, Oklahoma City, Okla., USA","institution_ids":["https://openalex.org/I49332381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112042724"],"corresponding_institution_ids":["https://openalex.org/I49332381"],"apc_list":{"value":4070,"currency":"USD","value_usd":4070},"apc_paid":null,"fwci":0.9376,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.77363812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"89","issue":"4","first_page":"487","last_page":"492"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.04089999943971634,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlorothiazide","display_name":"chlorothiazide","score":1.0},{"id":"https://openalex.org/keywords/thiazide-diuretics","display_name":"thiazide diuretics","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hemodynamic-effects","display_name":"hemodynamic effects","score":0.765999972820282},{"id":"https://openalex.org/keywords/diuresis","display_name":"diuresis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/plasma-volume-contraction","display_name":"plasma volume contraction","score":0.6830000281333923},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.878000020980835},{"id":"https://openalex.org/keywords/stroke-volume","display_name":"stroke volume","score":0.9959999918937683},{"id":"https://openalex.org/keywords/venous-return","display_name":"venous return","score":0.8050000071525574},{"id":"https://openalex.org/keywords/left-ventricular-end-diastolic-pressure","display_name":"left ventricular end-diastolic pressure","score":0.8579999804496765},{"id":"https://openalex.org/keywords/central-venous-pressure","display_name":"central venous pressure","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.6639999747276306},{"id":"https://openalex.org/keywords/serum-protein-levels","display_name":"serum protein levels","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.6790000200271606},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C2779660313","wikidata":"https://www.wikidata.org/wiki/Q2603363","display_name":"Chlorothiazide","level":3,"score":0.9048857092857361},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.868657112121582},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.7183698415756226},{"id":"https://openalex.org/C2779547328","wikidata":"https://www.wikidata.org/wiki/Q584691","display_name":"Diuresis","level":3,"score":0.7105625867843628},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.6769636869430542},{"id":"https://openalex.org/C47323905","wikidata":"https://www.wikidata.org/wiki/Q3506185","display_name":"Venous return curve","level":3,"score":0.6197248101234436},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.6144848465919495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4986729621887207},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.48533645272254944},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4623952805995941},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.4582926034927368},{"id":"https://openalex.org/C2781309813","wikidata":"https://www.wikidata.org/wiki/Q1320276","display_name":"Hypovolemia","level":2,"score":0.42230290174484253},{"id":"https://openalex.org/C2778230795","wikidata":"https://www.wikidata.org/wiki/Q1614115","display_name":"Hypervolemia","level":3,"score":0.41658201813697815},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3408990502357483},{"id":"https://openalex.org/C2779918671","wikidata":"https://www.wikidata.org/wiki/Q200656","display_name":"Diuretic","level":2,"score":0.27013033628463745},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.22781527042388916},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.20027494430541992},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.15406948328018188}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002496","descriptor_name":"Central Venous Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002740","descriptor_name":"Chlorothiazide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004231","descriptor_name":"Diuresis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014513","descriptor_name":"Ureter","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D014682","descriptor_name":"Vena Cava, Inferior","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0002-8703(75)90156-8","doi":"https://doi.org/10.1016/0002-8703(75)90156-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0002-8703(75)90156-8","pdf_url":null,"source":{"id":"https://openalex.org/S46995015","display_name":"American Heart Journal","issn_l":"0002-8703","issn":["0002-8703","1097-6744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Heart Journal","raw_type":"journal-article"},{"id":"pmid:1114981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1114981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American heart journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1978249661","https://openalex.org/W1979384063","https://openalex.org/W1981030543","https://openalex.org/W1987480023","https://openalex.org/W2022522033","https://openalex.org/W2029659143","https://openalex.org/W2042505601","https://openalex.org/W2043281154","https://openalex.org/W2045934368","https://openalex.org/W2047161663","https://openalex.org/W2068197522","https://openalex.org/W2072241013","https://openalex.org/W2084721965","https://openalex.org/W2089754759","https://openalex.org/W2095734280","https://openalex.org/W2163313131","https://openalex.org/W2318549211","https://openalex.org/W2339267217","https://openalex.org/W2397489032","https://openalex.org/W2400066852","https://openalex.org/W2416280448","https://openalex.org/W2421289646"],"related_works":["https://openalex.org/W2047161663","https://openalex.org/W2028896592","https://openalex.org/W2318549211","https://openalex.org/W2042505601","https://openalex.org/W7099602157","https://openalex.org/W2022522033","https://openalex.org/W1997914357","https://openalex.org/W2145362170","https://openalex.org/W2089361593","https://openalex.org/W7097392042"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}