{"id":"https://openalex.org/W2080717772","doi":"https://doi.org/10.1016/j.cbi.2004.10.002","title":"An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR","display_name":"An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2080717772","doi":"https://doi.org/10.1016/j.cbi.2004.10.002","mag":"2080717772","pmid":"https://pubmed.ncbi.nlm.nih.gov/15607757"},"language":"en","primary_location":{"id":"doi:10.1016/j.cbi.2004.10.002","doi":"https://doi.org/10.1016/j.cbi.2004.10.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbi.2004.10.002","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063907460","display_name":"Marcella Martignoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Marcella Martignoni","raw_affiliation_strings":["Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy. marcella.martignoni@nervianoms.com","Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy. marcella.martignoni@nervianoms.com","institution_ids":["https://openalex.org/I4210127540"]},{"raw_affiliation_string":"Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009110074","display_name":"Ruben de Kanter","orcid":"https://orcid.org/0000-0001-7503-9776","observed_orcids":["https://orcid.org/0000-0001-7503-9776"]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ruben de Kanter","raw_affiliation_strings":["Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077682175","display_name":"Pietro Grossi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pietro Grossi","raw_affiliation_strings":["Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027300807","display_name":"Axel Mahnke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Axel Mahnke","raw_affiliation_strings":["Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111489266","display_name":"Grazia Saturno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Grazia Saturno","raw_affiliation_strings":["Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076065245","display_name":"Mario Monshouwer","orcid":"https://orcid.org/0000-0001-9605-4692","observed_orcids":["https://orcid.org/0000-0001-9605-4692"]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Monshouwer","raw_affiliation_strings":["Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy","institution_ids":["https://openalex.org/I4210127540"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063907460"],"corresponding_institution_ids":["https://openalex.org/I4210127540"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":2.83,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.90161169,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"151","issue":"1","first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450-induction","display_name":"cytochrome P450 induction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/liver-slices","display_name":"liver slices","score":0.8569999933242798},{"id":"https://openalex.org/keywords/beta-naphthoflavone","display_name":"beta-naphthoflavone","score":0.8970000147819519},{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":1.0},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":1.0},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyp2b1","display_name":"CYP2B1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cyp3a1","display_name":"CYP3A1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cyp-gene-expression","display_name":"CYP gene expression","score":0.5839999914169312},{"id":"https://openalex.org/keywords/in-vitro-in-vivo-correlation","display_name":"in vitro-in vivo correlation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.6200000047683716},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8843955993652344},{"id":"https://openalex.org/C86745063","wikidata":"https://www.wikidata.org/wiki/Q3737406","display_name":"CYP1A2","level":4,"score":0.7702462673187256},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.626704216003418},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6226567029953003},{"id":"https://openalex.org/C132154277","wikidata":"https://www.wikidata.org/wiki/Q5381545","display_name":"Enzyme inducer","level":3,"score":0.5514019727706909},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5205934047698975},{"id":"https://openalex.org/C2778793413","wikidata":"https://www.wikidata.org/wiki/Q407241","display_name":"Phenobarbital","level":2,"score":0.41552871465682983},{"id":"https://openalex.org/C2225953","wikidata":"https://www.wikidata.org/wiki/Q1661899","display_name":"Inducer","level":3,"score":0.4152519702911377},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4021671712398529},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3394186794757843},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33707183599472046},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.30688154697418213},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11915898323059082},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019324","descriptor_name":"beta-Naphthoflavone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cbi.2004.10.002","doi":"https://doi.org/10.1016/j.cbi.2004.10.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbi.2004.10.002","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},{"id":"pmid:15607757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15607757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-biological interactions","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W970450957","https://openalex.org/W1790955152","https://openalex.org/W1951544661","https://openalex.org/W1972097392","https://openalex.org/W1974826990","https://openalex.org/W1976421128","https://openalex.org/W1982128407","https://openalex.org/W2008824596","https://openalex.org/W2011233017","https://openalex.org/W2012225201","https://openalex.org/W2014313435","https://openalex.org/W2022075679","https://openalex.org/W2023424961","https://openalex.org/W2030021013","https://openalex.org/W2045376363","https://openalex.org/W2048647475","https://openalex.org/W2051608380","https://openalex.org/W2061720023","https://openalex.org/W2062786215","https://openalex.org/W2063731843","https://openalex.org/W2067080504","https://openalex.org/W2077740060","https://openalex.org/W2079197731","https://openalex.org/W2096556937","https://openalex.org/W2106697292","https://openalex.org/W2111828865","https://openalex.org/W2144430308","https://openalex.org/W2161386949","https://openalex.org/W2162814146","https://openalex.org/W2170098897","https://openalex.org/W2332605520","https://openalex.org/W2766368224","https://openalex.org/W6638206976","https://openalex.org/W6640689680","https://openalex.org/W6675930987"],"related_works":["https://openalex.org/W2049440268","https://openalex.org/W2082087711","https://openalex.org/W2065228188","https://openalex.org/W2140501574","https://openalex.org/W4238279442","https://openalex.org/W2067080504","https://openalex.org/W2104055312","https://openalex.org/W2433366488","https://openalex.org/W2144430308","https://openalex.org/W2024711184"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}