{"id":"https://openalex.org/W2080680239","doi":"https://doi.org/10.3892/or.2015.3749","title":"Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer","display_name":"Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer","publication_year":2015,"publication_date":"2015-01-26","ids":{"openalex":"https://openalex.org/W2080680239","doi":"https://doi.org/10.3892/or.2015.3749","mag":"2080680239","pmid":"https://pubmed.ncbi.nlm.nih.gov/25625299"},"language":"en","primary_location":{"id":"doi:10.3892/or.2015.3749","doi":"https://doi.org/10.3892/or.2015.3749","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2015.3749","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2015.3749/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/or.2015.3749/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113746051","display_name":"Junmin Song","orcid":"https://orcid.org/0000-0001-5111-9894","observed_orcids":["https://orcid.org/0000-0001-5111-9894"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JUNMIN SONG","raw_affiliation_strings":["Department of General Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou\u00a0450052, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou\u00a0450052, P.R. China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":null,"display_name":"HONGXIANG LIU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HONGXIANG LIU","raw_affiliation_strings":["Department of General Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou\u00a0450052, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou\u00a0450052, P.R. China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100332555","display_name":"Zhen Li","orcid":"https://orcid.org/0000-0001-8037-4245","observed_orcids":["https://orcid.org/0000-0001-8037-4245"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ZHEN LI","raw_affiliation_strings":["Department of General Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou\u00a0450052, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou\u00a0450052, P.R. China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101518998","display_name":"Chao Yang","orcid":"https://orcid.org/0000-0003-3359-7483","observed_orcids":["https://orcid.org/0000-0003-3359-7483"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"CHAO YANG","raw_affiliation_strings":["Department of General Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou\u00a0450052, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou\u00a0450052, P.R. China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"last","author":{"id":null,"display_name":"CHAOJIE WANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"CHAOJIE WANG","raw_affiliation_strings":["Department of Oncology, Henan Provincial People's Hospital, Zhengzhou\u00a0450003, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Henan Provincial People's Hospital, Zhengzhou\u00a0450003, P.R.\u00a0China","institution_ids":["https://openalex.org/I4210133534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2404,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.78213254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"33","issue":"4","first_page":"1867","last_page":"1871"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12370","display_name":"Advances in Cucurbitaceae Research","score":0.2476000040769577,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12370","display_name":"Advances in Cucurbitaceae Research","score":0.2476000040769577,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.1737000048160553,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.10819999873638153,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cucurbitacin-i","display_name":"cucurbitacin I","score":1.0},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.9679999947547913},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.9649999737739563},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8109999895095825},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9980000257492065},{"id":"https://openalex.org/keywords/colo-205-cells","display_name":"COLO 205 cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cucurbitaceae","display_name":"Cucurbitaceae","score":0.7820000052452087},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.768380880355835},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.7215167880058289},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6685553193092346},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6476341485977173},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6412934064865112},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5560222268104553},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5498960018157959},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.4645030200481415},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.46342408657073975},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4312419295310974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41259026527404785},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4123346507549286},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3539513945579529},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33077239990234375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2666837275028229},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0386715829372406}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/or.2015.3749","doi":"https://doi.org/10.3892/or.2015.3749","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2015.3749","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2015.3749/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:25625299","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25625299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/or.2015.3749","doi":"https://doi.org/10.3892/or.2015.3749","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2015.3749","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2015.3749/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2080680239.pdf","grobid_xml":"https://content.openalex.org/works/W2080680239.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W204604656","https://openalex.org/W1584223654","https://openalex.org/W1821858011","https://openalex.org/W1966609073","https://openalex.org/W1968638668","https://openalex.org/W1969218281","https://openalex.org/W1987678124","https://openalex.org/W1988645824","https://openalex.org/W1989159177","https://openalex.org/W1989183491","https://openalex.org/W2004154588","https://openalex.org/W2006382528","https://openalex.org/W2010819389","https://openalex.org/W2020313062","https://openalex.org/W2026546029","https://openalex.org/W2029994348","https://openalex.org/W2039412512","https://openalex.org/W2040415295","https://openalex.org/W2040804147","https://openalex.org/W2045576105","https://openalex.org/W2056385780","https://openalex.org/W2061070237","https://openalex.org/W2065676042","https://openalex.org/W2069538062","https://openalex.org/W2070310392","https://openalex.org/W2073990298","https://openalex.org/W2077293849","https://openalex.org/W2083631019","https://openalex.org/W2089260591","https://openalex.org/W2096687091","https://openalex.org/W2102978104","https://openalex.org/W2122891169","https://openalex.org/W2126150441","https://openalex.org/W2132631303","https://openalex.org/W2134871530","https://openalex.org/W2142869757","https://openalex.org/W2146383480","https://openalex.org/W2165948908","https://openalex.org/W4211147392","https://openalex.org/W4211213217","https://openalex.org/W6634886735"],"related_works":["https://openalex.org/W2770048804","https://openalex.org/W2040804147","https://openalex.org/W2921124697","https://openalex.org/W2536821522","https://openalex.org/W2150714963","https://openalex.org/W2161978284","https://openalex.org/W2327949229","https://openalex.org/W2103866858","https://openalex.org/W2245175764","https://openalex.org/W3210143633"],"abstract_inverted_index":{"Colorectal":[0],"cancers":[1,9],"are":[2],"the":[3,30,35,48,52,84,99,104,111],"third":[4],"most":[5],"common":[6],"types":[7],"of":[8,38,47,83,126],"worldwide.":[10],"Surgical":[11],"resection":[12],"is":[13],"unable":[14],"to":[15,20,76,87],"eliminate":[16],"tumors":[17],"completely":[18],"due":[19],"metastasis.":[21],"A":[22],"demand":[23],"for":[24,98,151],"new":[25],"chemotherapeutic":[26,149],"tools":[27],"exists.":[28],"In":[29],"present":[31],"study,":[32],"we":[33],"examined":[34],"chemopreventive":[36],"potential":[37],"cucurbitacin":[39,61,88,107,127,142],"I,":[40],"a":[41,146],"natural":[42],"component":[43],"extracted":[44],"from":[45],"plants":[46],"Cucurbitaceae":[49],"family,":[50],"in":[51,103],"colon":[53,65,73,121,152],"cancer":[54,66,74,153],"cell":[55,67,92,112],"line":[56],"COLO205.":[57],"We":[58],"hypothesized":[59],"that":[60,81,102,141],"I":[62,89,108,128,143],"would":[63],"prevent":[64],"migration":[68,113],"and":[69,71,114,116,134,157],"invasion,":[70,115],"sensitize":[72],"cells":[75,86],"chemotherapy.":[77],"Our":[78],"data":[79,96],"demonstrated":[80,97],"exposure":[82],"COLO205":[85,105],"significantly":[90],"decreased":[91],"viability.":[93],"Furthermore":[94],"our":[95,138],"first":[100],"time":[101],"cells,":[106],"could":[109],"suppress":[110],"harbor":[117],"chemosensitization":[118],"activity":[119,125],"against":[120],"cancer.":[122],"The":[123],"anticancer":[124],"was":[129],"accomplished":[130],"by":[131],"downregulating":[132],"p-STAT3":[133],"MMP-9":[135],"expression.":[136],"Collectively,":[137],"results":[139],"suggest":[140],"may":[144],"be":[145],"potent":[147],"adjuvant":[148],"agent":[150],"with":[154],"anti-migration,":[155],"anti-invasion":[156],"chemosensitizing":[158],"activities.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
