{"id":"https://openalex.org/W2080667183","doi":"https://doi.org/10.1016/s0959-440x(98)80069-9","title":"Finding the genes in genomic DNA","display_name":"Finding the genes in genomic DNA","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2080667183","doi":"https://doi.org/10.1016/s0959-440x(98)80069-9","mag":"2080667183","pmid":"https://pubmed.ncbi.nlm.nih.gov/9666331"},"language":"en","primary_location":{"id":"doi:10.1016/s0959-440x(98)80069-9","doi":"https://doi.org/10.1016/s0959-440x(98)80069-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0959-440x(98)80069-9","pdf_url":null,"source":{"id":"https://openalex.org/S175155502","display_name":"Current Opinion in Structural Biology","issn_l":"0959-440X","issn":["0959-440X","1879-033X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Structural Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0959-440x(98)80069-9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048799588","display_name":"Christopher B. Burge","orcid":"https://orcid.org/0000-0001-9047-5648","observed_orcids":["https://orcid.org/0000-0001-9047-5648"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher B Burge","raw_affiliation_strings":["Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA. cburge@mit.edu","Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA. cburge@mit.edu","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054404005","display_name":"Samuel Karlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samuel Karlin","raw_affiliation_strings":["Department of Mathematics, Stanford University, 450 Serra Mall, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Stanford University, 450 Serra Mall, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054404005"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":4360,"currency":"USD","value_usd":4360},"apc_paid":{"value":4360,"currency":"USD","value_usd":4360},"fwci":1.9991,"has_fulltext":false,"cited_by_count":590,"citation_normalized_percentile":{"value":0.89379169,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"8","issue":"3","first_page":"346","last_page":"354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-prediction","display_name":"gene prediction","score":0.8240000009536743},{"id":"https://openalex.org/keywords/human-genome","display_name":"human genome","score":0.7450000047683716},{"id":"https://openalex.org/keywords/genome-sequencing","display_name":"genome sequencing","score":0.5080000162124634},{"id":"https://openalex.org/keywords/gene-structure-prediction","display_name":"gene structure prediction","score":0.7009999752044678},{"id":"https://openalex.org/keywords/novel-genes","display_name":"novel genes","score":0.6000000238418579},{"id":"https://openalex.org/keywords/computational-genomics","display_name":"computational genomics","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6859332323074341},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.6688240766525269},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6351203322410583},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6163365840911865},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6008344292640686},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.5819591283798218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.579839825630188},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.54198157787323},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5395609140396118},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4830766022205353},{"id":"https://openalex.org/C105565629","wikidata":"https://www.wikidata.org/wiki/Q1248292","display_name":"Gene prediction","level":4,"score":0.4244784116744995}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0959-440x(98)80069-9","doi":"https://doi.org/10.1016/s0959-440x(98)80069-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0959-440x(98)80069-9","pdf_url":null,"source":{"id":"https://openalex.org/S175155502","display_name":"Current Opinion in Structural Biology","issn_l":"0959-440X","issn":["0959-440X","1879-033X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Structural Biology","raw_type":"journal-article"},{"id":"pmid:9666331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9666331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in structural biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0959-440x(98)80069-9","doi":"https://doi.org/10.1016/s0959-440x(98)80069-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0959-440x(98)80069-9","pdf_url":null,"source":{"id":"https://openalex.org/S175155502","display_name":"Current Opinion in Structural Biology","issn_l":"0959-440X","issn":["0959-440X","1879-033X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Structural Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1404158910","display_name":null,"funder_award_id":"5R01GM10452-33","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2796108777","display_name":"MOLECULAR SEQUENCE DATA","funder_award_id":"R01HG000335","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G375561716","display_name":null,"funder_award_id":"5R01HG00335-10","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G6891181748","display_name":"Gene Expression Levels Across Diverse Genomes","funder_award_id":"R01GM010452","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1493951357","https://openalex.org/W1511730061","https://openalex.org/W1565521845","https://openalex.org/W1652691445","https://openalex.org/W1966833356","https://openalex.org/W1977790594","https://openalex.org/W1980101442","https://openalex.org/W1981053737","https://openalex.org/W1985061774","https://openalex.org/W1988171432","https://openalex.org/W1989401029","https://openalex.org/W1992396120","https://openalex.org/W1996942642","https://openalex.org/W1999966058","https://openalex.org/W2019573310","https://openalex.org/W2021525576","https://openalex.org/W2026531601","https://openalex.org/W2027699344","https://openalex.org/W2032726945","https://openalex.org/W2032870665","https://openalex.org/W2033049603","https://openalex.org/W2039680623","https://openalex.org/W2047333953","https://openalex.org/W2051631967","https://openalex.org/W2054016888","https://openalex.org/W2070906314","https://openalex.org/W2074952408","https://openalex.org/W2075435641","https://openalex.org/W2081530255","https://openalex.org/W2083833254","https://openalex.org/W2088635433","https://openalex.org/W2106882534","https://openalex.org/W2107246857","https://openalex.org/W2112302812","https://openalex.org/W2116390865","https://openalex.org/W2123886059","https://openalex.org/W2125838338","https://openalex.org/W2149238618","https://openalex.org/W2149429041","https://openalex.org/W2152222870","https://openalex.org/W2153632714","https://openalex.org/W2158714788","https://openalex.org/W2164302672","https://openalex.org/W2165687893","https://openalex.org/W2166187656","https://openalex.org/W2169351355","https://openalex.org/W2610443297","https://openalex.org/W4239833500","https://openalex.org/W4247292500"],"related_works":["https://openalex.org/W2131185306","https://openalex.org/W1994017531","https://openalex.org/W1819041927","https://openalex.org/W148859436","https://openalex.org/W61434478","https://openalex.org/W2129126689","https://openalex.org/W4388228134","https://openalex.org/W1982824252","https://openalex.org/W149180018","https://openalex.org/W7098163950"],"abstract_inverted_index":{"Genome":[0],"sequencing":[1],"efforts":[2],"will":[3],"soon":[4],"generate":[5],"hundreds":[6],"of":[7,9,11,17,26,40,55],"millions":[8],"bases":[10],"human":[12],"genomic":[13,47],"DNA":[14],"containing":[15],"thousands":[16],"novel":[18],"genes.":[19],"In":[20],"the":[21,24,34,41],"past":[22],"year,":[23],"accuracy":[25],"computational":[27],"gene-finding":[28],"methods":[29],"has":[30],"improved":[31],"significantly,":[32],"to":[33],"point":[35],"where":[36],"a":[37],"reasonable":[38],"approximation":[39],"gene":[42],"structures":[43],"within":[44],"an":[45],"extended":[46],"region":[48],"can":[49],"often":[50],"be":[51],"predicted":[52],"in":[53],"advance":[54],"more":[56],"detailed":[57],"experimental":[58],"studies.":[59]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
