{"id":"https://openalex.org/W2080616631","doi":"https://doi.org/10.1371/journal.pone.0009075","title":"Comprehensive Identification and Modified-Site Mapping of S-Nitrosylated Targets in Prostate Epithelial Cells","display_name":"Comprehensive Identification and Modified-Site Mapping of S-Nitrosylated Targets in Prostate Epithelial Cells","publication_year":2010,"publication_date":"2010-02-04","ids":{"openalex":"https://openalex.org/W2080616631","doi":"https://doi.org/10.1371/journal.pone.0009075","mag":"2080616631","pmid":"https://pubmed.ncbi.nlm.nih.gov/20140087","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2816712"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0009075","doi":"https://doi.org/10.1371/journal.pone.0009075","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0009075","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009075&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009075&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111899805","display_name":"Ying Wai Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Wai Lam","raw_affiliation_strings":["Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America","Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037768587","display_name":"Yong Yuan","orcid":"https://orcid.org/0000-0003-0545-7459","observed_orcids":["https://orcid.org/0000-0003-0545-7459"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Yuan","raw_affiliation_strings":["Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jared Isaac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared Isaac","raw_affiliation_strings":["Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. V. Suresh Babu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. V. Suresh Babu","raw_affiliation_strings":["Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090178417","display_name":"Jarek Meller","orcid":"https://orcid.org/0000-0002-1162-8253","observed_orcids":["https://orcid.org/0000-0002-1162-8253"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jarek Meller","raw_affiliation_strings":["Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America","Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028510658","display_name":"Shuk\u2010Mei Ho","orcid":"https://orcid.org/0000-0001-9369-7342","observed_orcids":["https://orcid.org/0000-0001-9369-7342"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shuk-Mei Ho","raw_affiliation_strings":["Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America","Cincinnati Cancer Consortium, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America","Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Cincinnati Cancer Consortium, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028510658"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.645,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.94039636,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"2","first_page":"e9075","last_page":"e9075"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s-nitrosylation","display_name":"S-nitrosylation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8069999814033508},{"id":"https://openalex.org/keywords/prostate-epithelial-cells","display_name":"prostate epithelial cells","score":0.8759999871253967},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.8650000095367432},{"id":"https://openalex.org/keywords/s-nitrosylated-proteins","display_name":"S-nitrosylated proteins","score":0.8970000147819519},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8029999732971191},{"id":"https://openalex.org/keywords/biotin-switch","display_name":"biotin switch","score":0.921999990940094},{"id":"https://openalex.org/keywords/solvent-accessibility","display_name":"solvent accessibility","score":0.796999990940094},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.6259999871253967},{"id":"https://openalex.org/keywords/prostatic-diseases","display_name":"prostate diseases","score":0.5879999995231628},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.8309999704360962},{"id":"https://openalex.org/keywords/maspin","display_name":"maspin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/integrin-beta-4","display_name":"ITGB4","score":0.9639999866485596},{"id":"https://openalex.org/keywords/alpha-catenin","display_name":"alpha-catenin","score":0.9670000076293945}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5105934739112854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4966121315956116},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4509716033935547},{"id":"https://openalex.org/C2777553025","wikidata":"https://www.wikidata.org/wiki/Q25323683","display_name":"S-Nitrosylation","level":4,"score":0.4129330515861511},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3960978388786316},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35714003443717957},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.33901551365852356},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015538","descriptor_name":"Nitrosation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019921","descriptor_name":"Biotinylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0009075","doi":"https://doi.org/10.1371/journal.pone.0009075","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0009075","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009075&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2816712","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2816712","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:20140087","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20140087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:figshare.com:article/144709","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Comprehensive_Identification_and_Modified_Site_Mapping_of_S_Nitrosylated_Targets_in_Prostate_Epithelial_Cells/144709","pdf_url":"https://figshare.com/articles/dataset/Comprehensive_Identification_and_Modified_Site_Mapping_of_S_Nitrosylated_Targets_in_Prostate_Epithelial_Cells/144709","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:doaj.org/article:a071867ceab64e1b8f85643604f65d3f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a071867ceab64e1b8f85643604f65d3f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 5, Iss 2, p e9075 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0009075","doi":"https://doi.org/10.1371/journal.pone.0009075","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0009075","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009075&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1388951909","display_name":"Optimization of Stuctures and Networks of Proteins","funder_award_id":"R01GM067823","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1514197061","display_name":null,"funder_award_id":"ES-006096","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G1817818929","display_name":null,"funder_award_id":"ES-015584","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G2089913365","display_name":null,"funder_award_id":"CA112532","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2238774867","display_name":"Metallothionein & Cadmium Carcinogenesis in the Prostate","funder_award_id":"R01CA062269","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G393493647","display_name":"Center for Environmental Genetics","funder_award_id":"P30ES006096","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4192450257","display_name":null,"funder_award_id":"CA015776","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6131011810","display_name":"Epigenetic Basis for Prostate Carcinogenesis following Early Estrogenic Exposures","funder_award_id":"R01ES015584","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6703131634","display_name":"Hormone-induced inflammation and prostate cancer","funder_award_id":"R01CA112532","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7063548954","display_name":null,"funder_award_id":"CA062269","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G730208256","display_name":null,"funder_award_id":"GM067823","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8116082314","display_name":"Prostatic Differentiation and Sex Hormone Metabolism","funder_award_id":"R01CA015776","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000215980","display_name":null,"funder_award_id":"ES006096","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310256","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2080616631.pdf","grobid_xml":"https://content.openalex.org/works/W2080616631.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1488196605","https://openalex.org/W1491869245","https://openalex.org/W1525593022","https://openalex.org/W1641337940","https://openalex.org/W1826748004","https://openalex.org/W1970094818","https://openalex.org/W1976981858","https://openalex.org/W1977807849","https://openalex.org/W1988151490","https://openalex.org/W1989397745","https://openalex.org/W1991454533","https://openalex.org/W1992119722","https://openalex.org/W1992120718","https://openalex.org/W1997595809","https://openalex.org/W1997605348","https://openalex.org/W2004484716","https://openalex.org/W2007877913","https://openalex.org/W2009202347","https://openalex.org/W2010973568","https://openalex.org/W2011574071","https://openalex.org/W2018879078","https://openalex.org/W2023448207","https://openalex.org/W2023805007","https://openalex.org/W2024544617","https://openalex.org/W2031389239","https://openalex.org/W2031681500","https://openalex.org/W2033381628","https://openalex.org/W2039112170","https://openalex.org/W2043096852","https://openalex.org/W2047192016","https://openalex.org/W2047517092","https://openalex.org/W2049046201","https://openalex.org/W2049860136","https://openalex.org/W2053025379","https://openalex.org/W2055131998","https://openalex.org/W2056987849","https://openalex.org/W2061133652","https://openalex.org/W2061949605","https://openalex.org/W2065773243","https://openalex.org/W2068036625","https://openalex.org/W2068134342","https://openalex.org/W2074732152","https://openalex.org/W2076649422","https://openalex.org/W2077723879","https://openalex.org/W2081480546","https://openalex.org/W2087638046","https://openalex.org/W2095300799","https://openalex.org/W2097478687","https://openalex.org/W2099655761","https://openalex.org/W2099886875","https://openalex.org/W2101745219","https://openalex.org/W2105209624","https://openalex.org/W2112706362","https://openalex.org/W2119990016","https://openalex.org/W2131340265","https://openalex.org/W2134081782","https://openalex.org/W2137184377","https://openalex.org/W2139794269","https://openalex.org/W2140807512","https://openalex.org/W2141214120","https://openalex.org/W2144436378","https://openalex.org/W2148521147","https://openalex.org/W2152753372","https://openalex.org/W2154885521","https://openalex.org/W2401104169","https://openalex.org/W4236291477","https://openalex.org/W4238590243"],"related_works":["https://openalex.org/W7099229781","https://openalex.org/W70242334","https://openalex.org/W7098847878","https://openalex.org/W2134760535","https://openalex.org/W2085613660","https://openalex.org/W3175380227","https://openalex.org/W2049860136","https://openalex.org/W2052689575","https://openalex.org/W2574705050","https://openalex.org/W2069288489"],"abstract_inverted_index":{"BACKGROUND:":[0],"Although":[1],"overexpression":[2],"of":[3,32,43,112,135,139,143,170,213,226,264,272,281],"nitric":[4],"oxide":[5],"synthases":[6],"(NOSs)":[7],"has":[8],"been":[9],"found":[10,209],"associated":[11],"with":[12,71],"prostate":[13,61,284,298],"diseases,":[14],"the":[15,30,46,75,89,97,110,115,121,133,193,214,239,270,279,291],"underlying":[16],"mechanisms":[17],"for":[18,137,196],"NOS-related":[19],"prostatic":[20],"diseases":[21],"remain":[22],"unclear.":[23],"One":[24],"proposed":[25],"mechanism":[26],"is":[27,290],"related":[28,172],"to":[29,40,53,91,108,147,173],"S-nitrosylation":[31,113],"key":[33],"regulatory":[34],"proteins":[35,95,130,145,274],"in":[36,45,57,96,234,261,283,297],"cell-signaling":[37],"pathways":[38],"due":[39],"elevated":[41],"levels":[42],"NO":[44,282],"prostate.":[47],"Thus,":[48],"our":[49,287],"primary":[50,198],"objective":[51],"was":[52],"identify":[54],"S-nitrosylated":[55,93],"targets":[56,118,171,254,296],"an":[58],"immortalized":[59],"normal":[60],"epithelial":[62,299],"cell":[63,151,177],"line,":[64],"NPrEC.":[65,262],"METHODOLOGY/PRINCIPAL":[66],"FINDINGS:":[67],"We":[68,191,208,248],"treated":[69,98],"NPrEC":[70],"nitroso-cysteine":[72],"and":[73,83,131,162,187,199,204,238,255],"used":[74],"biotin":[76],"switch":[77],"technique":[78],"followed":[79],"by":[80,120],"gel-based":[81],"separation":[82],"mass":[84],"spectrometry":[85],"protein":[86,116,155],"identification":[87],"(using":[88],"LTQ-Orbitrap)":[90],"discover":[92],"(SNO)":[94],"cells.":[99,300],"In":[100],"parallel,":[101],"we":[102],"adapted":[103],"a":[104,168],"peptide":[105],"pull-down":[106],"methodology":[107],"locate":[109],"site(s)":[111],"on":[114,278],"SNO":[117,129,194,215,253,259,295],"identified":[119,127,250],"first":[122,292],"technique.":[123],"This":[124],"combined":[125],"approach":[126],"116":[128,251],"determined":[132],"sites":[134,216,260],"modification":[136,268],"82":[138],"them.":[140],"Over":[141],"60%":[142],"these":[144,273],"belong":[146],"four":[148],"functional":[149],"groups:":[150],"structure/cell":[152],"motility/protein":[153],"trafficking,":[154],"folding/protein":[156],"response/protein":[157],"assembly,":[158],"mRNA":[159],"splicing/processing/transcriptional":[160],"regulation,":[161],"metabolism.":[163],"Western":[164],"blot":[165],"analysis":[166],"validated":[167],"subset":[169],"disease":[174],"development":[175],"(proliferating":[176],"nuclear":[178],"antigen,":[179],"maspin,":[180],"integrin":[181],"beta4,":[182],"alpha-catenin,":[183],"karyopherin":[184],"[importin]":[185],"beta1,":[186],"elongation":[188],"factor":[189],"1A1).":[190],"analyzed":[192],"sequences":[195],"their":[197,235,257],"secondary":[200],"structures,":[201],"solvent":[202],"accessibility,":[203],"three-dimensional":[205,236],"structural":[206],"context.":[207],"that":[210,217],"about":[211],"80%":[212],"can":[218],"be":[219],"mapped":[220,256],"into":[221],"resolved":[222],"structures":[223],"are":[224],"buried,":[225],"which":[227],"approximately":[228],"half":[229,241],"have":[230],"charged":[231],"amino":[232],"acids":[233],"neighborhood,":[237],"other":[240],"residing":[242],"within":[243],"primarily":[244],"hydrophobic":[245],"pockets.":[246],"CONCLUSIONS/SIGNIFICANCE:":[247],"here":[249],"potential":[252],"putative":[258],"Elucidation":[263],"how":[265],"this":[266,289],"post-translational":[267],"alters":[269],"function":[271],"should":[275],"shed":[276],"light":[277],"role":[280],"pathologies.":[285],"To":[286],"knowledge,":[288],"report":[293],"identifying":[294]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":13},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}