{"id":"https://openalex.org/W2080615652","doi":"https://doi.org/10.1021/ma201678r","title":"Water-Soluble Polypeptides with Elongated, Charged Side Chains Adopt Ultrastable Helical Conformations","display_name":"Water-Soluble Polypeptides with Elongated, Charged Side Chains Adopt Ultrastable Helical Conformations","publication_year":2011,"publication_date":"2011-08-08","ids":{"openalex":"https://openalex.org/W2080615652","doi":"https://doi.org/10.1021/ma201678r","mag":"2080615652","pmid":"https://pubmed.ncbi.nlm.nih.gov/22049249","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3204311"},"language":"en","primary_location":{"id":"doi:10.1021/ma201678r","doi":"https://doi.org/10.1021/ma201678r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ma201678r","pdf_url":null,"source":{"id":"https://openalex.org/S177196338","display_name":"Macromolecules","issn_l":"0024-9297","issn":["0024-9297","1520-5835"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecules","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3204311","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100367504","display_name":"Yanfeng Zhang","orcid":"https://orcid.org/0000-0003-4711-8690","observed_orcids":["https://orcid.org/0000-0003-4711-8690"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanfeng Zhang","raw_affiliation_strings":["Department of Materials Science and Engineering, University of Illinois at Urbana\u2014Champaign, Urbana, Illinois 61801, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Illinois at Urbana\u2014Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074729923","display_name":"Hua Lu","orcid":"https://orcid.org/0000-0003-2180-3091","observed_orcids":["https://orcid.org/0000-0003-2180-3091"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Lu","raw_affiliation_strings":["Department of Materials Science and Engineering, University of Illinois at Urbana\u2014Champaign, Urbana, Illinois 61801, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Illinois at Urbana\u2014Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050302972","display_name":"Yao Lin","orcid":"https://orcid.org/0000-0001-5227-2663","observed_orcids":["https://orcid.org/0000-0001-5227-2663"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yao Lin","raw_affiliation_strings":["Polymer Program, Institute of Materials Science & Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States","Polymer Program, Institute of Materials Science and Department of Chemistry, University of Connecticut , Storrs, Connecticut 06269, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polymer Program, Institute of Materials Science & Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"Polymer Program, Institute of Materials Science and Department of Chemistry, University of Connecticut , Storrs, Connecticut 06269, United States","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010902410","display_name":"Jianjun Cheng","orcid":"https://orcid.org/0000-0003-2561-9291","observed_orcids":["https://orcid.org/0000-0003-2561-9291","https://orcid.org/0009-0000-5867-8015"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jianjun Cheng","raw_affiliation_strings":["Department of Materials Science and Engineering, University of Illinois at Urbana\u2014Champaign, Urbana, Illinois 61801, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Illinois at Urbana\u2014Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010902410"],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.1192,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.92634529,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"44","issue":"17","first_page":"6641","last_page":"6644"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.49540001153945923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.49540001153945923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.22709999978542328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10405","display_name":"Advanced Polymer Synthesis and Characterization","score":0.10849999636411667,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-helix","display_name":"alpha-helix","score":0.8309999704360962},{"id":"https://openalex.org/keywords/helical-content","display_name":"alpha-helix content","score":0.675000011920929},{"id":"https://openalex.org/keywords/charged-side-chains","display_name":"charged side chains","score":0.843999981880188},{"id":"https://openalex.org/keywords/side-chain-length","display_name":"side chain length","score":0.5299999713897705},{"id":"https://openalex.org/keywords/poly-gamma-benzyl-l-glutamate","display_name":"poly(\u03b3-benzyl-L-glutamate)","score":0.5130000114440918},{"id":"https://openalex.org/keywords/helical-stability","display_name":"helical stability","score":0.45500001311302185},{"id":"https://openalex.org/keywords/extreme-ph","display_name":"extreme pH","score":0.5519999861717224},{"id":"https://openalex.org/keywords/high-temperature","display_name":"high temperature","score":0.7519999742507935},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.6019999980926514},{"id":"https://openalex.org/keywords/urea","display_name":"urea","score":0.9769999980926514}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.6646040678024292},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.48077791929244995},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44010990858078003},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33396103978157043}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/ma201678r","doi":"https://doi.org/10.1021/ma201678r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ma201678r","pdf_url":null,"source":{"id":"https://openalex.org/S177196338","display_name":"Macromolecules","issn_l":"0024-9297","issn":["0024-9297","1520-5835"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecules","raw_type":"journal-article"},{"id":"pmid:22049249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22049249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecules","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2442678","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3204311","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3204311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3204311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Macromolecules","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2442678","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3204311","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G463203351","display_name":"Developing Clinically Applicable, Cancer-Targeting Polymeric Nanoconjugates","funder_award_id":"1dp2od007246-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8518767632","display_name":"Development of Functional Poly(alpha-hydroxy acids) for Drug Delivery Application","funder_award_id":"R21EB009486","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1927730430","https://openalex.org/W1964815923","https://openalex.org/W1965819962","https://openalex.org/W1970417043","https://openalex.org/W1973897761","https://openalex.org/W1979679909","https://openalex.org/W1981916797","https://openalex.org/W1982052532","https://openalex.org/W1984763049","https://openalex.org/W1986513210","https://openalex.org/W1989489362","https://openalex.org/W1992777087","https://openalex.org/W1995076811","https://openalex.org/W2002021814","https://openalex.org/W2002825909","https://openalex.org/W2009581291","https://openalex.org/W2012353244","https://openalex.org/W2014070367","https://openalex.org/W2018833025","https://openalex.org/W2019137326","https://openalex.org/W2029699554","https://openalex.org/W2030713462","https://openalex.org/W2033103812","https://openalex.org/W2038560836","https://openalex.org/W2039677477","https://openalex.org/W2040576705","https://openalex.org/W2044483297","https://openalex.org/W2057553906","https://openalex.org/W2058106463","https://openalex.org/W2060874059","https://openalex.org/W2063780640","https://openalex.org/W2067053828","https://openalex.org/W2070783701","https://openalex.org/W2076606960","https://openalex.org/W2077693157","https://openalex.org/W2083939457","https://openalex.org/W2087082736","https://openalex.org/W2087125825","https://openalex.org/W2088409695","https://openalex.org/W2089273634","https://openalex.org/W2090265120","https://openalex.org/W2090688839","https://openalex.org/W2094375457","https://openalex.org/W2111299176","https://openalex.org/W2114277014","https://openalex.org/W2115956744","https://openalex.org/W2142567897","https://openalex.org/W2146386329","https://openalex.org/W2166027129","https://openalex.org/W2951138539"],"related_works":["https://openalex.org/W2063780640","https://openalex.org/W7100909558","https://openalex.org/W7098403028","https://openalex.org/W2007326604","https://openalex.org/W2078255315","https://openalex.org/W1969043476","https://openalex.org/W2063472488","https://openalex.org/W2119908249","https://openalex.org/W1969310010","https://openalex.org/W2026016704"],"abstract_inverted_index":{"Water-soluble":[0],"polypeptides":[1,67],"adopting":[2],"\u03b1-helical":[3],"conformations":[4,63],"with":[5,37],"unprecedented":[6],"high":[7,48,80,83],"helicities":[8],"were":[9,68],"obtained":[10],"by":[11],"elongating":[12],"the":[13,18,24,32],"charge-containing":[14],"side":[15],"chains":[16],"of":[17,42,55,64],"constituent":[19],"amino":[20],"acids":[21],"to":[22,27],"allow":[23],"terminal":[25],"charges":[26],"be":[28],"situated":[29],"distally":[30],"from":[31],"peptide":[33],"backbone.":[34],"Poly(\u03b3-(4-aminoethylthiopropoxyl)-benzyl-(L)-glutamate)":[35],"(PAOBLG-AET)":[36],"a":[38,46,53],"charge-peptide":[39],"backbone":[40],"distance":[41],"17":[43],"\u03c3-bonds":[44],"exhibited":[45],"remarkably":[47],"helical":[49,62],"content":[50],"(81%)":[51],"at":[52],"degree":[54],"polymerization":[56],"as":[57,59,77],"low":[58],"10.":[60],"The":[61],"these":[65],"short":[66],"very":[69],"stable":[70],"against":[71],"various":[72],"harsh,":[73],"protein-denaturing":[74],"conditions,":[75],"such":[76],"extreme":[78],"pH,":[79],"temperature,":[81],"and":[82],"salt":[84],"or":[85],"urea":[86],"concentrations.":[87]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}