{"id":"https://openalex.org/W2080543752","doi":"https://doi.org/10.1002/hep.20001","title":"Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells","display_name":"Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2080543752","doi":"https://doi.org/10.1002/hep.20001","mag":"2080543752","pmid":"https://pubmed.ncbi.nlm.nih.gov/14752826"},"language":"en","primary_location":{"id":"doi:10.1002/hep.20001","doi":"https://doi.org/10.1002/hep.20001","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.20001","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109325586","display_name":"Jinah Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinah Choi","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA","Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084081712","display_name":"Ki Jeong Lee","orcid":"https://orcid.org/0000-0002-8039-7436","observed_orcids":["https://orcid.org/0000-0002-8039-7436"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ki Jeong Lee","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101970479","display_name":"Yanyan Zheng","orcid":"https://orcid.org/0000-0001-7742-7684","observed_orcids":["https://orcid.org/0000-0001-7742-7684"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanyan Zheng","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038637731","display_name":"Ardath K. Yamaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ardath K. Yamaga","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA","Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029206852","display_name":"Michael M. C. Lai","orcid":"https://orcid.org/0000-0002-5206-9451","observed_orcids":["https://orcid.org/0000-0002-5206-9451"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M.C. Lai","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052882932","display_name":"Jing\u2010hsiung James Ou","orcid":"https://orcid.org/0000-0002-8274-5705","observed_orcids":["https://orcid.org/0000-0002-8274-5705"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jing-hsiung Ou","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA","fax: 323-442-1721"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"fax: 323-442-1721","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052882932"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":5.1378,"has_fulltext":false,"cited_by_count":180,"citation_normalized_percentile":{"value":0.95167022,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"39","issue":"1","first_page":"81","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9629999995231628},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9940000176429749},{"id":"https://openalex.org/keywords/viral-rna-replication","display_name":"viral RNA replication","score":0.7829999923706055},{"id":"https://openalex.org/keywords/hcv-replicon","display_name":"HCV replicon","score":0.6269999742507935},{"id":"https://openalex.org/keywords/peroxides","display_name":"peroxides","score":0.6129999756813049},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.7120000123977661},{"id":"https://openalex.org/keywords/ns3","display_name":"NS3","score":0.7839999794960022},{"id":"https://openalex.org/keywords/ns5a","display_name":"NS5A","score":1.0},{"id":"https://openalex.org/keywords/replication-complex","display_name":"replication complex","score":0.6620000004768372},{"id":"https://openalex.org/keywords/human-hepatoma-cells","display_name":"human hepatoma cells","score":0.8050000071525574},{"id":"https://openalex.org/keywords/antioxidant-response","display_name":"antioxidant response","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7060976028442383},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.636538028717041},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6078047752380371},{"id":"https://openalex.org/C2777103181","wikidata":"https://www.wikidata.org/wiki/Q83141840","display_name":"NS5A","level":5,"score":0.5918794274330139},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5849279761314392},{"id":"https://openalex.org/C18103114","wikidata":"https://www.wikidata.org/wiki/Q1720369","display_name":"Replicon","level":4,"score":0.5639070868492126},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5454448461532593},{"id":"https://openalex.org/C41258723","wikidata":"https://www.wikidata.org/wiki/Q2919111","display_name":"RNA-dependent RNA polymerase","level":4,"score":0.5202706456184387},{"id":"https://openalex.org/C83100098","wikidata":"https://www.wikidata.org/wiki/Q106297070","display_name":"NS2-3 protease","level":4,"score":0.4994621276855469},{"id":"https://openalex.org/C189819185","wikidata":"https://www.wikidata.org/wiki/Q384283","display_name":"Subgenomic mRNA","level":4,"score":0.4592246115207672},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4385935664176941},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.41488149762153625},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4129175543785095},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.40315374732017517},{"id":"https://openalex.org/C2781463415","wikidata":"https://www.wikidata.org/wiki/Q2082778","display_name":"Hepacivirus","level":4,"score":0.1996084749698639},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15234601497650146},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14799919724464417},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10098022222518921},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.096332848072052}],"mesh":[{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/hep.20001","doi":"https://doi.org/10.1002/hep.20001","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.20001","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:14752826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14752826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W170604759","https://openalex.org/W1535124446","https://openalex.org/W1568529372","https://openalex.org/W1572444605","https://openalex.org/W1586099293","https://openalex.org/W1969728880","https://openalex.org/W1976844675","https://openalex.org/W1979630577","https://openalex.org/W1981667885","https://openalex.org/W1985055250","https://openalex.org/W1987984630","https://openalex.org/W2010094123","https://openalex.org/W2011616562","https://openalex.org/W2015098253","https://openalex.org/W2024648656","https://openalex.org/W2026543492","https://openalex.org/W2028633594","https://openalex.org/W2030918073","https://openalex.org/W2056466917","https://openalex.org/W2076815050","https://openalex.org/W2078887917","https://openalex.org/W2082796737","https://openalex.org/W2082933842","https://openalex.org/W2083412018","https://openalex.org/W2084291231","https://openalex.org/W2088430031","https://openalex.org/W2089829321","https://openalex.org/W2099644089","https://openalex.org/W2106132583","https://openalex.org/W2110671968","https://openalex.org/W2117304280","https://openalex.org/W2119371081","https://openalex.org/W2127370405","https://openalex.org/W2132444008","https://openalex.org/W2132963547","https://openalex.org/W2137177799","https://openalex.org/W2142775406","https://openalex.org/W2149781618","https://openalex.org/W2151898297","https://openalex.org/W2155431764","https://openalex.org/W2159993558","https://openalex.org/W2169757199","https://openalex.org/W2182463865","https://openalex.org/W2187591934","https://openalex.org/W2402977919","https://openalex.org/W4299322507"],"related_works":["https://openalex.org/W7096663163","https://openalex.org/W4302080005","https://openalex.org/W2076817708","https://openalex.org/W2063381420","https://openalex.org/W2266870413","https://openalex.org/W4382791439","https://openalex.org/W1994742809","https://openalex.org/W2978201693","https://openalex.org/W2913736932","https://openalex.org/W2112514395"],"abstract_inverted_index":{"Hepatitis":[0],"C":[1,222],"virus":[2,8],"(HCV)":[3],"is":[4,42],"a":[5,80,86,139],"positive-stranded":[6],"RNA":[7,24,83,88,119,168,194,210],"that":[9,89,102,137,204],"causes":[10],"severe":[11],"liver":[12],"diseases,":[13],"such":[14,138],"as":[15,178],"cirrhosis":[16],"and":[17,30,85,185],"hepatocellular":[18],"carcinoma.":[19],"HCV":[20,40,60,77,118,151,158,175,193,209,234],"uses":[21],"an":[22,31,45,227],"RNA-dependent":[23],"polymerase":[25],"to":[26,36,64,142,147,172],"replicate":[27,91],"its":[28,38],"genome":[29],"internal":[32],"ribosomal":[33],"entry":[34],"site":[35],"translate":[37],"proteins.":[39],"infection":[41],"characterized":[43],"by":[44,130],"increase":[46],"in":[47,92,113,116,121,187,212,220,230],"the":[48,55,72,117,122,131,148,155,165,181,188,231],"concentrations":[49,101],"of":[50,57,74,150,157,167,183,233],"reactive":[51],"oxygen":[52],"species":[53],"(ROS),":[54],"effect":[56,73],"which":[58],"on":[59,76],"replication":[61,176,195,211],"has":[62],"yet":[63],"be":[65,127],"determined.":[66],"In":[67,199],"this":[68],"report,":[69],"we":[70],"investigated":[71],"ROS":[75,143,170,205,218],"replication,":[78],"using":[79],"bicistronic":[81],"subgenomic":[82],"replicon":[84],"genomic":[87],"can":[90,206],"human":[93,213],"hepatoma":[94,214],"cells.":[95,123,215],"The":[96,216],"treatment":[97],"with":[98],"peroxide":[99],"at":[100,164],"did":[103],"not":[104,145],"deplete":[105],"intracellular":[106],"glutathione":[107],"or":[108,154],"induce":[109],"cell":[110],"death":[111],"resulted":[112],"significant":[114],"decreases":[115],"level":[120,166],"This":[124],"response":[125,141],"could":[126],"partially":[128],"reversed":[129],"antioxidant":[132],"N-acetylcysteine.":[133],"Further":[134],"studies":[135],"indicated":[136],"suppressive":[140],"was":[144],"due":[146],"suppression":[149,232],"protein":[152],"synthesis":[153],"destabilization":[156],"RNA.":[159],"Rather,":[160],"it":[161],"occurred":[162],"rapidly":[163,207],"replication.":[169,235],"appeared":[171],"disrupt":[173],"active":[174,192],"complexes,":[177],"they":[179],"reduced":[180],"amount":[182],"NS3":[184],"NS5A":[186],"subcellular":[189],"fraction":[190],"where":[191],"complexes":[196],"were":[197],"found.":[198],"conclusion,":[200],"our":[201],"results":[202],"show":[203],"inhibit":[208],"increased":[217],"levels":[219],"hepatitis":[221],"patients":[223],"may":[224],"therefore":[225],"play":[226],"important":[228],"role":[229]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":14}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}