{"id":"https://openalex.org/W208043967","doi":null,"title":"Chemistry and biology of DNA damage by malondialdehyde.","display_name":"Chemistry and biology of DNA damage by malondialdehyde.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W208043967","mag":"208043967","pmid":"https://pubmed.ncbi.nlm.nih.gov/10626205"},"language":"en","primary_location":{"id":"pmid:10626205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10626205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IARC scientific publications","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089031929","display_name":"Lawrence J. Marnett","orcid":"https://orcid.org/0000-0002-7834-6285","observed_orcids":["https://orcid.org/0000-0002-7834-6285"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L J Marnett","raw_affiliation_strings":["A.B. Hancock Jr Memorial Laboratory for Cancer Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.B. Hancock Jr Memorial Laboratory for Cancer Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089031929"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":1.1327,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.7535109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":null,"issue":"150","first_page":"17","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.8199999928474426},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/deoxyguanosine-adducts","display_name":"deoxyguanosine adducts","score":0.7979999780654907},{"id":"https://openalex.org/keywords/deoxyadenosine-adducts","display_name":"deoxyadenosine adducts","score":0.9710000157356262},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.875},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.7649999856948853},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/32p-postlabeling","display_name":"32P-postlabeling","score":0.7590000033378601},{"id":"https://openalex.org/keywords/immunochemical-detection","display_name":"immunochemical detection","score":0.7099999785423279},{"id":"https://openalex.org/keywords/mass-spectrometric-detection","display_name":"mass spectrometry detection","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7871770858764648},{"id":"https://openalex.org/C2781247443","wikidata":"https://www.wikidata.org/wiki/Q4153410","display_name":"DNA adduct","level":3,"score":0.7526141405105591},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.7132192254066467},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.699482798576355},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5717079639434814},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5579012632369995},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5519676208496094},{"id":"https://openalex.org/C2780441211","wikidata":"https://www.wikidata.org/wiki/Q422488","display_name":"Deoxyguanosine","level":3,"score":0.540629506111145},{"id":"https://openalex.org/C2780636463","wikidata":"https://www.wikidata.org/wiki/Q422457","display_name":"Deoxyadenosine","level":3,"score":0.5362955927848816},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.49543488025665283},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.45664283633232117},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33428484201431274},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1607259213924408},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.14547064900398254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12202486395835876},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08266359567642212}],"mesh":[{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10626205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10626205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IARC scientific publications","raw_type":"Journal Article"},{"id":"mag:208043967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10626205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7799678986","display_name":"POLYUNSATURATED FATTY ACID METABOLISM AND CARCINOGENESIS","funder_award_id":"R35CA047479","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000880732","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1971424572","https://openalex.org/W2083806934","https://openalex.org/W2070213944","https://openalex.org/W1965796676","https://openalex.org/W1997630319","https://openalex.org/W2075908319","https://openalex.org/W2153930686","https://openalex.org/W2298491078","https://openalex.org/W2003647365","https://openalex.org/W2131930444"],"abstract_inverted_index":{"Malondialdehyde":[0],"is":[1,13,33,46,51],"a":[2,34,104],"naturally":[3],"occurring":[4],"product":[5],"of":[6,40,131],"lipid":[7],"peroxidation":[8],"and":[9,15,26,50,67,121,129],"prostaglandin":[10],"biosynthesis":[11],"which":[12,90],"mutagenic":[14,47],"carcinogenic.":[16],"It":[17],"reacts":[18],"with":[19],"DNA":[20,32,107],"to":[21,24,31,78,102,116,119],"form":[22],"adducts":[23],"deoxyguanosine":[25],"deoxyadenosine.":[27],"The":[28],"major":[29,105],"adduct":[30,108],"pyrimidopurinone":[35],"called":[36],"pyrimido[1,2-a]purin-10(3H)-one":[37],"(M1G).":[38],"Studies":[39],"site-specific":[41],"mutagenesis":[42],"indicate":[43],"that":[44,112],"M1G":[45,59,86,100,132],"in":[48,63,109,126],"bacteria":[49],"repaired":[52],"by":[53],"the":[54,127],"nucleotide":[55],"excision":[56],"repair":[57],"pathway.":[58],"has":[60],"been":[61,88],"detected":[62],"liver,":[64],"leukocytes,":[65],"pancreas":[66],"breast":[68],"from":[69,76],"healthy":[70],"human":[71,110],"beings":[72,111],"at":[73],"levels":[74],"ranging":[75],"1":[77],"120":[79],"per":[80],"10(8)":[81],"nucleotides.":[82],"Several":[83],"assays":[84],"for":[85],"have":[87],"described":[89],"are":[91,133],"based":[92],"on":[93],"mass":[94],"spectrometry,":[95],"32P-postlabelling":[96],"or":[97],"immunochemical":[98],"techniques.":[99],"appears":[101],"be":[103],"endogenous":[106],"may":[113],"contribute":[114],"significantly":[115],"cancer":[117],"linked":[118],"lifestyle":[120],"dietary":[122],"factors.":[123],"Recent":[124],"advances":[125],"chemistry":[128],"biology":[130],"reviewed.":[134]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
