{"id":"https://openalex.org/W2080433719","doi":"https://doi.org/10.1186/1471-2202-8-s1-p13","title":"Alpha-Synuclein aggregate formation in oligodendroglia OLN-t40 cells stably transfected with alpha-Synuclein","display_name":"Alpha-Synuclein aggregate formation in oligodendroglia OLN-t40 cells stably transfected with alpha-Synuclein","publication_year":2007,"publication_date":"2007-03-01","ids":{"openalex":"https://openalex.org/W2080433719","doi":"https://doi.org/10.1186/1471-2202-8-s1-p13","mag":"2080433719"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2202-8-s1-p13","doi":"https://doi.org/10.1186/1471-2202-8-s1-p13","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2202-8-s1-p13","pdf_url":"https://bmcneurosci.biomedcentral.com/track/pdf/10.1186/1471-2202-8-S1-P13","source":{"id":"https://openalex.org/S82595977","display_name":"BMC Neuroscience","issn_l":"1471-2202","issn":["1471-2202"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcneurosci.biomedcentral.com/track/pdf/10.1186/1471-2202-8-S1-P13","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110156918","display_name":"Michael J Riedel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129877168","display_name":"Carl von Ossietzky Universit\u00e4t Oldenburg","ror":"https://ror.org/033n9gh91","country_code":"DE","type":"education","lineage":["https://openalex.org/I129877168"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Riedel","raw_affiliation_strings":["Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, 26111, Germany","Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, 26111, Germany","institution_ids":["https://openalex.org/I129877168"]},{"raw_affiliation_string":"Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany","institution_ids":["https://openalex.org/I129877168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049594450","display_name":"Olaf Goldbaum","orcid":"https://orcid.org/0000-0002-6161-7018","observed_orcids":["https://orcid.org/0000-0002-6161-7018"]},"institutions":[{"id":"https://openalex.org/I129877168","display_name":"Carl von Ossietzky Universit\u00e4t Oldenburg","ror":"https://ror.org/033n9gh91","country_code":"DE","type":"education","lineage":["https://openalex.org/I129877168"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olaf Goldbaum","raw_affiliation_strings":["Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, 26111, Germany","Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, 26111, Germany","institution_ids":["https://openalex.org/I129877168"]},{"raw_affiliation_string":"Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany","institution_ids":["https://openalex.org/I129877168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002979482","display_name":"Kunihiro Uryu","orcid":"https://orcid.org/0000-0003-2345-4104","observed_orcids":["https://orcid.org/0000-0003-2345-4104"]},"institutions":[{"id":"https://openalex.org/I129877168","display_name":"Carl von Ossietzky Universit\u00e4t Oldenburg","ror":"https://ror.org/033n9gh91","country_code":"DE","type":"education","lineage":["https://openalex.org/I129877168"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kunihiro Uryu","raw_affiliation_strings":["Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, 26111, Germany","Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, 26111, Germany","institution_ids":["https://openalex.org/I129877168"]},{"raw_affiliation_string":"Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany","institution_ids":["https://openalex.org/I129877168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047513952","display_name":"JENNIFER S. BRUCE","orcid":"https://orcid.org/0000-0001-7830-5937","observed_orcids":["https://orcid.org/0000-0001-7830-5937"]},"institutions":[{"id":"https://openalex.org/I129877168","display_name":"Carl von Ossietzky Universit\u00e4t Oldenburg","ror":"https://ror.org/033n9gh91","country_code":"DE","type":"education","lineage":["https://openalex.org/I129877168"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jennifer Bruce","raw_affiliation_strings":["Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, 26111, Germany","Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, 26111, Germany","institution_ids":["https://openalex.org/I129877168"]},{"raw_affiliation_string":"Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany","institution_ids":["https://openalex.org/I129877168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021394368","display_name":"John Q. Trojanowski","orcid":"https://orcid.org/0000-0002-9239-8794","observed_orcids":["https://orcid.org/0000-0002-9239-8794"]},"institutions":[{"id":"https://openalex.org/I129877168","display_name":"Carl von Ossietzky Universit\u00e4t Oldenburg","ror":"https://ror.org/033n9gh91","country_code":"DE","type":"education","lineage":["https://openalex.org/I129877168"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"John Q Trojanowski","raw_affiliation_strings":["Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, 26111, Germany","Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, 26111, Germany","institution_ids":["https://openalex.org/I129877168"]},{"raw_affiliation_string":"Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany","institution_ids":["https://openalex.org/I129877168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065852445","display_name":"Virginia M.\u2010Y. Lee","orcid":"https://orcid.org/0000-0003-3536-6902","observed_orcids":["https://orcid.org/0000-0003-3536-6902"]},"institutions":[{"id":"https://openalex.org/I129877168","display_name":"Carl von Ossietzky Universit\u00e4t Oldenburg","ror":"https://ror.org/033n9gh91","country_code":"DE","type":"education","lineage":["https://openalex.org/I129877168"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Virginia MY Lee","raw_affiliation_strings":["Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, 26111, Germany","Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, 26111, Germany","institution_ids":["https://openalex.org/I129877168"]},{"raw_affiliation_string":"Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany","institution_ids":["https://openalex.org/I129877168"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079940934","display_name":"Christiane Richter\u2010Landsberg","orcid":"https://orcid.org/0000-0003-0623-5460","observed_orcids":["https://orcid.org/0000-0003-0623-5460"]},"institutions":[{"id":"https://openalex.org/I129877168","display_name":"Carl von Ossietzky Universit\u00e4t Oldenburg","ror":"https://ror.org/033n9gh91","country_code":"DE","type":"education","lineage":["https://openalex.org/I129877168"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christiane Richter-Landsberg","raw_affiliation_strings":["Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, 26111, Germany","Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, 26111, Germany","institution_ids":["https://openalex.org/I129877168"]},{"raw_affiliation_string":"Department of Biology, Molecular Neurobiology, University of Oldenburg, Oldenburg, Germany","institution_ids":["https://openalex.org/I129877168"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129877168"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21246193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.8849999904632568},{"id":"https://openalex.org/keywords/synucleinopathies","display_name":"synucleinopathies","score":0.8420000076293945},{"id":"https://openalex.org/keywords/multiple-system-atrophy","display_name":"multiple system atrophy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/glial-cytoplasmic-inclusions","display_name":"glial cytoplasmic inclusions","score":0.9950000047683716},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9190000295639038},{"id":"https://openalex.org/keywords/oxidative-modification","display_name":"oxidative modification","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tau-fibrillization","display_name":"tau fibrillization","score":0.777999997138977},{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.8679999709129333},{"id":"https://openalex.org/keywords/pick-s-disease","display_name":"Pick's disease","score":0.8460000157356262},{"id":"https://openalex.org/keywords/progressive-supranuclear-palsy","display_name":"progressive supranuclear palsy","score":0.9430000185966492},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2777440831","wikidata":"https://www.wikidata.org/wiki/Q2376264","display_name":"Synucleinopathies","level":5,"score":0.8565777540206909},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.8064278364181519},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6783804297447205},{"id":"https://openalex.org/C2776477761","wikidata":"https://www.wikidata.org/wiki/Q945930","display_name":"Progressive supranuclear palsy","level":3,"score":0.6591384410858154},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5157027840614319},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.46985092759132385},{"id":"https://openalex.org/C36124564","wikidata":"https://www.wikidata.org/wiki/Q1286842","display_name":"Cytoplasmic inclusion","level":3,"score":0.4536813795566559},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.44329938292503357},{"id":"https://openalex.org/C2778548049","wikidata":"https://www.wikidata.org/wiki/Q101245788","display_name":"Dementia with Lewy bodies","level":4,"score":0.4117330312728882},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.38401031494140625},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.37404775619506836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.360598087310791},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.3604031205177307},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3366425633430481},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.31274253129959106},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30202969908714294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2821517586708069},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23171758651733398},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.16070342063903809},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/1471-2202-8-s1-p13","doi":"https://doi.org/10.1186/1471-2202-8-s1-p13","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2202-8-s1-p13","pdf_url":"https://bmcneurosci.biomedcentral.com/track/pdf/10.1186/1471-2202-8-S1-P13","source":{"id":"https://openalex.org/S82595977","display_name":"BMC Neuroscience","issn_l":"1471-2202","issn":["1471-2202"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Neuroscience","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/1471-2202-8-s1-p13","doi":"https://doi.org/10.1186/1471-2202-8-s1-p13","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2202-8-s1-p13","pdf_url":"https://bmcneurosci.biomedcentral.com/track/pdf/10.1186/1471-2202-8-S1-P13","source":{"id":"https://openalex.org/S82595977","display_name":"BMC Neuroscience","issn_l":"1471-2202","issn":["1471-2202"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2080433719.pdf","grobid_xml":"https://content.openalex.org/works/W2080433719.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1976830061","https://openalex.org/W4318816035","https://openalex.org/W2027373429","https://openalex.org/W2133068803","https://openalex.org/W2669450162","https://openalex.org/W3159706504","https://openalex.org/W3035460072","https://openalex.org/W3011255036","https://openalex.org/W7164655754","https://openalex.org/W1521681896"],"abstract_inverted_index":{"Alpha-Synuclein":[0],"(alpha-syn)":[1],"is":[2,43],"the":[3,91],"major":[4],"building":[5],"block":[6],"of":[7,48,61,64,93],"cytoplasmic":[8,27],"inclusions":[9,28],"in":[10,31,40],"neurodegenerative":[11],"disorders":[12],"named":[13],"synucleinopathies,":[14],"such":[15],"as":[16],"Parkinson's":[17],"Disease":[18],"and":[19,45,55,74,81],"multiple":[20],"system":[21],"atrophy":[22],"(MSA).":[23],"In":[24],"MSA":[25],"glial":[26],"(GCIs)":[29],"originating":[30],"oligodendrocytes":[32],"are":[33],"prominent.":[34],"During":[35],"disease":[36,73],"progression":[37],"a":[38],"shift":[39],"alpha-syn":[41,49,87],"solubility":[42],"observable,":[44],"oxidative":[46],"modification":[47],"has":[50,78,83],"been":[51,79,84],"linked":[52],"to":[53],"neurodegeneration":[54],"fibril":[56],"formation.":[57],"Furthermore,":[58],"an":[59],"overlap":[60],"pathological":[62],"features":[63],"patients":[65],"with":[66],"tauopathies,":[67],"e.g.":[68],"frontotemporal":[69],"dementias":[70],"including":[71],"Pick's":[72],"progressive":[75],"supranuclear":[76],"palsy,":[77],"reported,":[80],"it":[82],"argued":[85],"that":[86],"aggregation":[88],"can":[89],"induce":[90],"fibrillization":[92],"tau.":[94]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}