{"id":"https://openalex.org/W2080418553","doi":"https://doi.org/10.1371/journal.pone.0091216","title":"Molecular Subtypes of Glioblastoma Are Relevant to Lower Grade Glioma","display_name":"Molecular Subtypes of Glioblastoma Are Relevant to Lower Grade Glioma","publication_year":2014,"publication_date":"2014-03-10","ids":{"openalex":"https://openalex.org/W2080418553","doi":"https://doi.org/10.1371/journal.pone.0091216","mag":"2080418553","pmid":"https://pubmed.ncbi.nlm.nih.gov/24614622","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3948818"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0091216","doi":"https://doi.org/10.1371/journal.pone.0091216","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0091216","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pone.0091216","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109365550","display_name":"Xiaowei Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaowei Guan","raw_affiliation_strings":["Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071137560","display_name":"Jaime E. Vengoechea","orcid":"https://orcid.org/0000-0002-6291-935X","observed_orcids":["https://orcid.org/0000-0002-6291-935X"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaime Vengoechea","raw_affiliation_strings":["Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America; Department of Internal Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America","Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","Department of Internal Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America; Department of Internal Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I4210108791","https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Internal Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005930092","display_name":"Siyuan Zheng","orcid":"https://orcid.org/0000-0002-1031-9424","observed_orcids":["https://orcid.org/0000-0002-1031-9424"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siyuan Zheng","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089511408","display_name":"Andrew Edward Sloan","orcid":"https://orcid.org/0000-0001-9607-5063","observed_orcids":["https://orcid.org/0000-0001-9607-5063"]},"institutions":[{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew E. Sloan","raw_affiliation_strings":["Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America; Department of Neurological Surgery, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America","Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","Department of Neurological Surgery, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America; Department of Neurological Surgery, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I4210108791","https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Neurological Surgery, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I4210108791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100732042","display_name":"Yanwen Chen","orcid":"https://orcid.org/0000-0002-3467-2871","observed_orcids":["https://orcid.org/0000-0002-3467-2871","https://orcid.org/0000-0001-7959-5040"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanwen Chen","raw_affiliation_strings":["Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078484855","display_name":"Daniel Jay Brat","orcid":"https://orcid.org/0000-0002-0633-6563","observed_orcids":["https://orcid.org/0000-0002-0633-6563"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Brat","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027267415","display_name":"Brian Patrick O\u2019Neill","orcid":"https://orcid.org/0000-0001-7456-6152","observed_orcids":["https://orcid.org/0000-0001-7456-6152"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Patrick O\u2019Neill","raw_affiliation_strings":["Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055183757","display_name":"John de Groot","orcid":"https://orcid.org/0000-0003-1454-6461","observed_orcids":["https://orcid.org/0000-0003-1454-6461"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John de Groot","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002087578","display_name":"Shlomit Yust\u2010Katz","orcid":"https://orcid.org/0000-0001-8760-1818","observed_orcids":["https://orcid.org/0000-0001-8760-1818"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shlomit Yust-Katz","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111834647","display_name":"Wai-Kwan Alfred Yung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wai-Kwan Alfred Yung","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021873304","display_name":"Mark L. Cohen","orcid":"https://orcid.org/0000-0002-9678-5521","observed_orcids":["https://orcid.org/0000-0002-9678-5521"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark L. Cohen","raw_affiliation_strings":["Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America; Department of Pathology, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America","Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","Department of Pathology, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America; Department of Pathology, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I4210108791","https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Pathology, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063290790","display_name":"Kenneth Aldape","orcid":"https://orcid.org/0000-0001-5119-7550","observed_orcids":["https://orcid.org/0000-0001-5119-7550"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth D. Aldape","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020641571","display_name":"Steven S. Rosenfeld","orcid":"https://orcid.org/0000-0003-1909-7116","observed_orcids":["https://orcid.org/0000-0003-1909-7116"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Rosenfeld","raw_affiliation_strings":["Cleveland Clinic, Cleveland, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000177267","display_name":"Roeland G. W. Verhaak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roeland G. W. Verhaak","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051948022","display_name":"Jill S. Barnholtz\u2010Sloan","orcid":"https://orcid.org/0000-0001-6190-9304","observed_orcids":["https://orcid.org/0000-0001-6190-9304"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jill S. Barnholtz-Sloan","raw_affiliation_strings":["Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5000177267","https://openalex.org/A5051948022"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4390039247","https://openalex.org/I58956616"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":6.5156,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.97630858,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"9","issue":"3","first_page":"e91216","last_page":"e91216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lower-grade-glioma","display_name":"lower-grade glioma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.8550000190734863},{"id":"https://openalex.org/keywords/proneural-subtype","display_name":"proneural subtype","score":0.9509999752044678},{"id":"https://openalex.org/keywords/idh1-mutation","display_name":"IDH1 mutation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/g-cimp","display_name":"G-CIMP","score":0.9399999976158142},{"id":"https://openalex.org/keywords/gene-expression-subtypes","display_name":"gene expression subtypes","score":0.7269999980926514},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/1p-19q-codeletion","display_name":"1p/19q codeletion","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.8669999837875366},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9990000128746033},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9950000047683716},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7820000052452087},{"id":"https://openalex.org/keywords/glioma-progression","display_name":"glioma progression","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C127848430","wikidata":"https://www.wikidata.org/wiki/Q18027543","display_name":"IDH1","level":4,"score":0.8071758151054382},{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.7333720326423645},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7204477787017822},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.701429545879364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6524912118911743},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.49575075507164},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4278402328491211},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.42521920800209045},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4140339493751526},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.41278788447380066},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3684953451156616},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28968697786331177},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2838740348815918},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.05895957350730896},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007521","descriptor_name":"Isocitrate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0091216","doi":"https://doi.org/10.1371/journal.pone.0091216","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0091216","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2933931","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3948818","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3948818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3948818","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24614622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24614622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.773.2598","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.773.2598","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1d/3f/pone.0091216.PMC3948818.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pone00:0091216","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091216","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:11d06f53ffa14d86ae428b8cf35f5a14","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/11d06f53ffa14d86ae428b8cf35f5a14","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 3, p e91216 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/956668","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Molecular_Subtypes_of_Glioblastoma_Are_Relevant_to_Lower_Grade_Glioma_/956668","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0091216","doi":"https://doi.org/10.1371/journal.pone.0091216","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0091216","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5099999904632568,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2797412450","display_name":null,"funder_award_id":"HHSN261201000057I","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G287561616","display_name":null,"funder_award_id":"CA108961","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3542538446","display_name":null,"funder_award_id":"HHSN261201000057C","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4637436490","display_name":null,"funder_award_id":"CA043703","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G566735577","display_name":"Integrative Pipeline for Analysis & Translational Application of TCGA Data (GDAC)","funder_award_id":"U24CA143883","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7637124021","display_name":"Mayo SPORE in Brain Cancer","funder_award_id":"P50CA108961","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000862237","display_name":"Case Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA043703","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000866180","display_name":"Mayo Clinic Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA015083","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1560814177","https://openalex.org/W1893588436","https://openalex.org/W1921809757","https://openalex.org/W1968898951","https://openalex.org/W1977859620","https://openalex.org/W1988756388","https://openalex.org/W1995181458","https://openalex.org/W1996190316","https://openalex.org/W2007632290","https://openalex.org/W2009654197","https://openalex.org/W2021630037","https://openalex.org/W2025183726","https://openalex.org/W2040827479","https://openalex.org/W2046796218","https://openalex.org/W2063445389","https://openalex.org/W2080452140","https://openalex.org/W2096287682","https://openalex.org/W2100795816","https://openalex.org/W2104669585","https://openalex.org/W2105528101","https://openalex.org/W2105642898","https://openalex.org/W2109816625","https://openalex.org/W2112567075","https://openalex.org/W2113942802","https://openalex.org/W2122769974","https://openalex.org/W2123879591","https://openalex.org/W2124648958","https://openalex.org/W2126817554","https://openalex.org/W2127981279","https://openalex.org/W2130410032","https://openalex.org/W2144781683","https://openalex.org/W2154313451","https://openalex.org/W2161289668","https://openalex.org/W2322088975"],"related_works":["https://openalex.org/W2947771292","https://openalex.org/W2010234254","https://openalex.org/W2097656227","https://openalex.org/W1486290736","https://openalex.org/W2157511453","https://openalex.org/W4298043192","https://openalex.org/W2899947827","https://openalex.org/W4297952403","https://openalex.org/W2279945791","https://openalex.org/W4300526299"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gliomas":[1],"are":[2,237],"the":[3,25,70,111,140,151,164,252],"most":[4],"common":[5],"primary":[6],"malignant":[7],"brain":[8],"tumors":[9,196],"in":[10,15,207,219],"adults":[11],"with":[12,78,139,154,214,228,244],"great":[13],"heterogeneity":[14],"histopathology":[16],"and":[17,32,39,55,63,91,103,157,187,210,222,233,242,257,264],"clinical":[18,56],"course.":[19],"The":[20,117],"intent":[21],"was":[22,101,123],"to":[23,36,105,150],"evaluate":[24],"relevance":[26],"of":[27,183,251,266],"known":[28],"glioblastoma":[29],"(GBM)":[30],"expression":[31,48,107,137],"methylation":[33,234],"based":[34,235],"subtypes":[35,108,236,256],"grade":[37,44,65],"II":[38],"III":[40],"gliomas":[41,67],"(ie.":[42],"lower":[43],"gliomas).":[45],"METHODS:":[46],"Gene":[47],"array,":[49],"single":[50],"nucleotide":[51],"polymorphism":[52],"(SNP)":[53],"array":[54],"data":[57],"were":[58,82,147,160,185,212,224],"obtained":[59],"for":[60,239],"228":[61],"GBMs":[62,159,184],"176":[64],"II/II":[66],"(GII/III)":[68],"from":[69,96],"publically":[71],"available":[72,89],"Rembrandt":[73],"dataset.":[74],"Two":[75],"additional":[76],"datasets":[77,86],"IDH1":[79,155,168,190],"mutation":[80,156,191],"status":[81],"utilized":[83],"as":[84],"validation":[85],"(one":[87],"publicly":[88],"dataset":[90,95],"one":[92],"newly":[93],"generated":[94],"MD":[97],"Anderson).":[98],"Unsupervised":[99,133],"clustering":[100,134],"performed":[102],"compared":[104],"gene":[106,136],"assigned":[109,124,149],"using":[110,125],"Verhaak":[112,141],"et":[113,130],"al":[114],"840-gene":[115,142],"classifier.":[116],"glioma-CpG":[118],"Island":[119],"Methylator":[120],"Phenotype":[121],"(G-CIMP)":[122],"prediction":[126],"models":[127],"by":[128,135],"Fine":[129],"al.":[131],"RESULTS:":[132],"aligned":[138],"subtype":[143,153],"group":[144],"assignments.":[145],"GII/IIIs":[146,258],"preferentially":[148],"proneural":[152,186],"G-CIMP.":[158],"evenly":[161],"distributed":[162],"among":[163],"four":[165],"subtypes.":[166,180],"Proneural,":[167],"mutant,":[169],"G-CIMP":[170,193],"GII/III":[171,240],"s":[172,241],"had":[173,188,197],"significantly":[174,198],"better":[175,199,249],"survival":[176,200,246],"than":[177,201],"other":[178,202],"molecular":[179],"Only":[181],"6%":[182],"either":[189],"or":[192],"but":[194],"these":[195,217,255],"GBMs.":[203,229],"Copy":[204],"number":[205],"changes":[206,218],"chromosomes":[208],"1p":[209],"19q":[211],"associated":[213,227],"GII/IIIs,":[215],"while":[216],"CDKN2A,":[220],"PTEN":[221],"EGFR":[223],"more":[225],"commonly":[226],"CONCLUSIONS:":[230],"GBM":[231],"gene-expression":[232],"relevant":[238],"associate":[243],"overall":[245],"differences.":[247],"A":[248],"understanding":[250],"association":[253],"between":[254],"could":[259],"further":[260],"knowledge":[261],"regarding":[262],"prognosis":[263],"mechanisms":[265],"glioma":[267],"progression.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}