{"id":"https://openalex.org/W2080378383","doi":"https://doi.org/10.1038/ncb2407","title":"Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system","display_name":"Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system","publication_year":2012,"publication_date":"2012-02-01","ids":{"openalex":"https://openalex.org/W2080378383","doi":"https://doi.org/10.1038/ncb2407","mag":"2080378383","pmid":"https://pubmed.ncbi.nlm.nih.gov/22298039"},"language":"en","primary_location":{"id":"doi:10.1038/ncb2407","doi":"https://doi.org/10.1038/ncb2407","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ncb2407","pdf_url":null,"source":{"id":"https://openalex.org/S151741590","display_name":"Nature Cell Biology","issn_l":"1465-7392","issn":["1465-7392","1476-4679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cell Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036633620","display_name":"Hemmo H Meyer","orcid":"https://orcid.org/0000-0003-1883-1796","observed_orcids":["https://orcid.org/0000-0003-1883-1796"]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hemmo Meyer","raw_affiliation_strings":["Centre for Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, 45117 Essen, Germany. hemmo.meyer@uni-due.de","Centre for Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, 45117 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, 45117 Essen, Germany. hemmo.meyer@uni-due.de","institution_ids":["https://openalex.org/I62318514"]},{"raw_affiliation_string":"Centre for Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, 45117 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021956889","display_name":"Monika Bug","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Monika Bug","raw_affiliation_strings":["Hemmo Meyer, Monika Bug and Sebastian Bremer are at the Centre for Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, 45117 Essen, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemmo Meyer, Monika Bug and Sebastian Bremer are at the Centre for Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, 45117 Essen, Germany,","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"last","author":{"id":null,"display_name":"Sebastian Bremer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Bremer","raw_affiliation_strings":["Hemmo Meyer, Monika Bug and Sebastian Bremer are at the Centre for Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, 45117 Essen, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemmo Meyer, Monika Bug and Sebastian Bremer are at the Centre for Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, 45117 Essen, Germany,","institution_ids":["https://openalex.org/I62318514"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036633620"],"corresponding_institution_ids":["https://openalex.org/I62318514"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":6.6852,"has_fulltext":false,"cited_by_count":842,"citation_normalized_percentile":{"value":0.988982,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"14","issue":"2","first_page":"117","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vcp-p97","display_name":"VCP/p97","score":0.9639999866485596},{"id":"https://openalex.org/keywords/aaa-proteins","display_name":"AAA+ ATPase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ubiquitin-system","display_name":"ubiquitin system","score":0.9380000233650208},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.8289999961853027},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.6510000228881836},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/endosomal-sorting","display_name":"endosomal sorting","score":0.9860000014305115},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/chromatin","display_name":"chromatin","score":0.847000002861023},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ubiquitin-mediated-degradation","display_name":"ubiquitin-mediated proteolysis","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C101635128","wikidata":"https://www.wikidata.org/wiki/Q4649768","display_name":"AAA proteins","level":4,"score":0.8214225769042969},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7521045207977295},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7069672346115112},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5997044444084167},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.5550715923309326},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.5456358790397644},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.5390986204147339},{"id":"https://openalex.org/C158619295","wikidata":"https://www.wikidata.org/wiki/Q21101062","display_name":"Endoplasmic-reticulum-associated protein degradation","level":4,"score":0.5182349681854248},{"id":"https://openalex.org/C559089031","wikidata":"https://www.wikidata.org/wiki/Q658882","display_name":"Protein targeting","level":4,"score":0.5070898532867432},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5065654516220093},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.49616727232933044},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.39960479736328125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30002009868621826},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.2905251979827881},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2642044723033905},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.2523585259914398},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.24236199259757996},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11979582905769348},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.10722184181213379},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09913599491119385},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.07732832431793213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074405","descriptor_name":"Valosin Containing Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/ncb2407","doi":"https://doi.org/10.1038/ncb2407","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ncb2407","pdf_url":null,"source":{"id":"https://openalex.org/S151741590","display_name":"Nature Cell Biology","issn_l":"1465-7392","issn":["1465-7392","1476-4679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cell Biology","raw_type":"journal-article"},{"id":"pmid:22298039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22298039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W1252231383","https://openalex.org/W1527254461","https://openalex.org/W1528145391","https://openalex.org/W1749528961","https://openalex.org/W1885748186","https://openalex.org/W1965249601","https://openalex.org/W1965839025","https://openalex.org/W1966993307","https://openalex.org/W1967559627","https://openalex.org/W1973024953","https://openalex.org/W1978922366","https://openalex.org/W1980144348","https://openalex.org/W1981551685","https://openalex.org/W1981835453","https://openalex.org/W1982491440","https://openalex.org/W1983633543","https://openalex.org/W1988418140","https://openalex.org/W1989634299","https://openalex.org/W1991105254","https://openalex.org/W1991989590","https://openalex.org/W1994561883","https://openalex.org/W1997770122","https://openalex.org/W1997799182","https://openalex.org/W1997925338","https://openalex.org/W1998479277","https://openalex.org/W2001993306","https://openalex.org/W2006821616","https://openalex.org/W2007071879","https://openalex.org/W2007185935","https://openalex.org/W2011325147","https://openalex.org/W2011754116","https://openalex.org/W2014540581","https://openalex.org/W2014609759","https://openalex.org/W2014697177","https://openalex.org/W2017764563","https://openalex.org/W2018325704","https://openalex.org/W2018467767","https://openalex.org/W2025497897","https://openalex.org/W2028997060","https://openalex.org/W2030376871","https://openalex.org/W2030983566","https://openalex.org/W2032565934","https://openalex.org/W2034183549","https://openalex.org/W2040551057","https://openalex.org/W2041417196","https://openalex.org/W2042708317","https://openalex.org/W2045603269","https://openalex.org/W2046690157","https://openalex.org/W2047350942","https://openalex.org/W2047455709","https://openalex.org/W2049512057","https://openalex.org/W2051939475","https://openalex.org/W2052286278","https://openalex.org/W2054372365","https://openalex.org/W2055402356","https://openalex.org/W2056607803","https://openalex.org/W2057283530","https://openalex.org/W2057608934","https://openalex.org/W2058077965","https://openalex.org/W2063442590","https://openalex.org/W2065102063","https://openalex.org/W2065391274","https://openalex.org/W2065554944","https://openalex.org/W2065825563","https://openalex.org/W2066107334","https://openalex.org/W2066303760","https://openalex.org/W2068306128","https://openalex.org/W2070226794","https://openalex.org/W2078644413","https://openalex.org/W2082069715","https://openalex.org/W2084789302","https://openalex.org/W2084858513","https://openalex.org/W2085245426","https://openalex.org/W2085946149","https://openalex.org/W2091276600","https://openalex.org/W2095326195","https://openalex.org/W2099208822","https://openalex.org/W2104412320","https://openalex.org/W2106969933","https://openalex.org/W2116170771","https://openalex.org/W2121431496","https://openalex.org/W2121948672","https://openalex.org/W2122551230","https://openalex.org/W2126446637","https://openalex.org/W2132865043","https://openalex.org/W2137717902","https://openalex.org/W2139772062","https://openalex.org/W2143514140","https://openalex.org/W2148714800","https://openalex.org/W2151049734","https://openalex.org/W2152351845","https://openalex.org/W2153811192","https://openalex.org/W2154439667","https://openalex.org/W2155971660","https://openalex.org/W2162194331","https://openalex.org/W2166032633","https://openalex.org/W2168838455","https://openalex.org/W2170230784","https://openalex.org/W2171862076","https://openalex.org/W2318064529"],"related_works":["https://openalex.org/W2047422395","https://openalex.org/W2126753299","https://openalex.org/W584904434","https://openalex.org/W1980186883","https://openalex.org/W2050370747","https://openalex.org/W2293268779","https://openalex.org/W7221437315","https://openalex.org/W2045440634","https://openalex.org/W2056583923","https://openalex.org/W2416219095"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":41},{"year":2025,"cited_by_count":48},{"year":2024,"cited_by_count":62},{"year":2023,"cited_by_count":36},{"year":2022,"cited_by_count":51},{"year":2021,"cited_by_count":57},{"year":2020,"cited_by_count":57},{"year":2019,"cited_by_count":46},{"year":2018,"cited_by_count":54},{"year":2017,"cited_by_count":71},{"year":2016,"cited_by_count":82},{"year":2015,"cited_by_count":65},{"year":2014,"cited_by_count":73},{"year":2013,"cited_by_count":70},{"year":2012,"cited_by_count":29}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
