{"id":"https://openalex.org/W2080312893","doi":"https://doi.org/10.1172/jci112072","title":"Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site. Functional consequences of the alteration and effects of bezafibrate on the oxygen bindings.","display_name":"Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site. Functional consequences of the alteration and effects of bezafibrate on the oxygen bindings.","publication_year":1985,"publication_date":"1985-09-01","ids":{"openalex":"https://openalex.org/W2080312893","doi":"https://doi.org/10.1172/jci112072","mag":"2080312893","pmid":"https://pubmed.ncbi.nlm.nih.gov/3930571","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/424016"},"language":"en","primary_location":{"id":"doi:10.1172/jci112072","doi":"https://doi.org/10.1172/jci112072","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci112072","pdf_url":"http://www.jci.org/articles/view/112072/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/112072/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074357152","display_name":"Jun Sugihara","orcid":"https://orcid.org/0000-0001-8565-1635","observed_orcids":["https://orcid.org/0000-0001-8565-1635","https://orcid.org/0000-0002-9372-9671"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"J Sugihara","raw_affiliation_strings":["First Department ofMedicine, Faculty ofMedicine, Kyushu University, Fukuoka 812, Japan","Duke University Marine Biomedical Research Center, Beaufort, North Carolina 78726","Faculty of Medicine, Kyushu University, Fukuoka 812, Japan","First Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department ofMedicine, Faculty ofMedicine, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Duke University Marine Biomedical Research Center, Beaufort, North Carolina 78726","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Faculty of Medicine, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"First Department of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"T Imamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"T Imamura","raw_affiliation_strings":["First Department ofMedicine, Faculty ofMedicine, Kyushu University, Fukuoka 812, Japan","Duke University Marine Biomedical Research Center, Beaufort, North Carolina 78726","Faculty of Medicine, Kyushu University, Fukuoka 812, Japan","First Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department ofMedicine, Faculty ofMedicine, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Duke University Marine Biomedical Research Center, Beaufort, North Carolina 78726","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Faculty of Medicine, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"First Department of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047558590","display_name":"Seiho Nagafuchi","orcid":"https://orcid.org/0000-0002-8790-8358","observed_orcids":["https://orcid.org/0000-0002-8790-8358"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"S Nagafuchi","raw_affiliation_strings":["First Department ofMedicine, Faculty ofMedicine, Kyushu University, Fukuoka 812, Japan","Duke University Marine Biomedical Research Center, Beaufort, North Carolina 78726","Faculty of Medicine, Kyushu University, Fukuoka 812, Japan","First Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department ofMedicine, Faculty ofMedicine, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Duke University Marine Biomedical Research Center, Beaufort, North Carolina 78726","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Faculty of Medicine, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"First Department of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107412810","display_name":"Joseph Bonaventura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"J Bonaventura","raw_affiliation_strings":["Duke University Marine Biomedical Research Center, Beaufort, North Carolina 78726","Faculty of Medicine, Kyushu University, Fukuoka 812, Japan","First Department of Medicine,","First Department ofMedicine, Faculty ofMedicine, Kyushu University, Fukuoka 812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Marine Biomedical Research Center, Beaufort, North Carolina 78726","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Faculty of Medicine, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"First Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"First Department ofMedicine, Faculty ofMedicine, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060269662","display_name":"Celia Bonaventura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"C Bonaventura","raw_affiliation_strings":["Duke University Marine Biomedical Research Center, Beaufort, North Carolina 78726","Faculty of Medicine, Kyushu University, Fukuoka 812, Japan","First Department of Medicine,","First Department ofMedicine, Faculty ofMedicine, Kyushu University, Fukuoka 812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Marine Biomedical Research Center, Beaufort, North Carolina 78726","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Faculty of Medicine, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"First Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"First Department ofMedicine, Faculty ofMedicine, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002135390","display_name":"Robert E. Cashon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"R Cashon","raw_affiliation_strings":["Duke University Marine Biomedical Research Center, Beaufort, North Carolina 78726","Faculty of Medicine, Kyushu University, Fukuoka 812, Japan","First Department of Medicine,","First Department ofMedicine, Faculty ofMedicine, Kyushu University, Fukuoka 812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Marine Biomedical Research Center, Beaufort, North Carolina 78726","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Faculty of Medicine, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"First Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"First Department ofMedicine, Faculty ofMedicine, Kyushu University, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":0.1659,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.46429893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"76","issue":"3","first_page":"1169","last_page":"1173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.711899995803833,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.711899995803833,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.28200000524520874,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemoglobin-variants","display_name":"hemoglobin variants","score":0.824999988079071},{"id":"https://openalex.org/keywords/threonine-substitution","display_name":"threonine substitution","score":0.8339999914169312},{"id":"https://openalex.org/keywords/erythrocytosis","display_name":"erythrocytosis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/oxygen-affinity","display_name":"oxygen affinity","score":0.925000011920929},{"id":"https://openalex.org/keywords/bezafibrate","display_name":"bezafibrate","score":0.8429999947547913},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/positive-charge-density","display_name":"positive charge density","score":0.593999981880188},{"id":"https://openalex.org/keywords/japanese-family","display_name":"Japanese family","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2909111029","wikidata":"https://www.wikidata.org/wiki/Q5279760","display_name":"Diphosphoglycerate","level":3,"score":0.9117097854614258},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.8179829120635986},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7396316528320312},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.5723311305046082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47637006640434265},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.4716189205646515},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.46310800313949585},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4567720293998718},{"id":"https://openalex.org/C2777393523","wikidata":"https://www.wikidata.org/wiki/Q50008082","display_name":"Hemoglobin A","level":3,"score":0.45140019059181213},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.44696542620658875},{"id":"https://openalex.org/C2776317666","wikidata":"https://www.wikidata.org/wiki/Q2496436","display_name":"Fetal hemoglobin","level":4,"score":0.42732226848602295},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.4138835668563843},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3004217743873596},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.18925067782402039},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18242111802101135},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11832177639007568},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.07979947328567505},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.06118428707122803},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001629","descriptor_name":"Bezafibrate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001797","descriptor_name":"Blood Protein Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004163","descriptor_name":"Diphosphoglyceric Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006455","descriptor_name":"Hemoglobins, Abnormal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006455","descriptor_name":"Hemoglobins, Abnormal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006455","descriptor_name":"Hemoglobins, Abnormal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011086","descriptor_name":"Polycythemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019794","descriptor_name":"2,3-Diphosphoglycerate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci112072","doi":"https://doi.org/10.1172/jci112072","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci112072","pdf_url":"http://www.jci.org/articles/view/112072/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:424016","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/424016","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:3930571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3930571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1172/jci112072","doi":"https://doi.org/10.1172/jci112072","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci112072","pdf_url":"http://www.jci.org/articles/view/112072/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3651700737","display_name":"\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u306e\u69cb\u9020\u3068\u5408\u6210\u306e\u5909\u7570\u306b\u95a2\u3059\u308b\u7814\u7a76","funder_award_id":"548175","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2080312893.pdf","grobid_xml":"https://content.openalex.org/works/W2080312893.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1521226608","https://openalex.org/W1547680166","https://openalex.org/W1591032267","https://openalex.org/W1604356881","https://openalex.org/W1969536021","https://openalex.org/W1973175248","https://openalex.org/W1998567323","https://openalex.org/W1999411315","https://openalex.org/W2000076929","https://openalex.org/W2005436544","https://openalex.org/W2007713771","https://openalex.org/W2009989970","https://openalex.org/W2017470279","https://openalex.org/W2026911129","https://openalex.org/W2031079498","https://openalex.org/W2044770738","https://openalex.org/W2053611938","https://openalex.org/W2061600809","https://openalex.org/W2065173763","https://openalex.org/W2067953773","https://openalex.org/W2090782306","https://openalex.org/W2094751995","https://openalex.org/W2158956932","https://openalex.org/W2322315864","https://openalex.org/W6601579946"],"related_works":["https://openalex.org/W2278989778","https://openalex.org/W2044770738","https://openalex.org/W1521226608","https://openalex.org/W1591032267","https://openalex.org/W1982249365","https://openalex.org/W1965711509","https://openalex.org/W2003757953","https://openalex.org/W2090782306","https://openalex.org/W1604356881","https://openalex.org/W2036491781"],"abstract_inverted_index":{"We":[0],"encountered":[1],"an":[2],"abnormal":[3],"hemoglobin":[4,52,69,114,117],"(Rahere),":[5],"with":[6,105,144],"a":[7,34,39,55],"thre-":[8],"onine":[9],"residue":[10,16,122],"replacing":[11],"the":[12,18,44,58,63,73,77,84,92,99,119,124,139],",682":[13],"(EF6)":[14],"lysine":[15,121],"at":[17,62,123],"bind-":[19],"ing":[20],"site":[21,126],"of":[22,33,46,66,91,101,110,127],"2,3-diphosphoglycerate,":[23],"which":[24,103],"was":[25,131],"responsible":[26],"for":[27],"overt":[28],"erythrocytosis":[29],"in":[30,57,68,112],"two":[31],"individuals":[32],"Japanese":[35],"family.Hemoglobin":[36],"Rahere":[37,70,115],"shows":[38],"lower":[40],"oxygen":[41,89],"affinity":[42,79,90],"on":[43],"binding":[45,64,125,140],"2,3-diphosphoglycerate":[47,67,111],"or":[48,116],"chloride":[49],"ions":[50],"than":[51],"A.":[53],"Although":[54],"decrease":[56],"positive":[59],"charge":[60],"density":[61],"sites":[65,106],"apparently":[71],"shifts":[72],"allosteric":[74],"equilibrium":[75],"toward":[76],"low":[78],"state,":[80],"it":[81],"greatly":[82],"diminishes":[83],"cofactor":[85],"effects":[86],"by":[87,98],"anions.The":[88],"patient's":[93],"erythrocytes":[94],"is":[95],"substantially":[96],"lowered":[97],"presence":[100],"bezafibrate,":[102],"combines":[104],"different":[107],"from":[108],"those":[109],"either":[113],"A.for":[118],"1382":[120],"2,3-DPG":[128],"(5).This":[129],"study":[130],"undertaken":[132],"to":[133],"determine":[134],"how":[135],"this":[136],"substitution":[137],"affects":[138],"ofnatural":[141],"anionic":[142],"cofactors":[143],"hemoglobins,":[145]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
