{"id":"https://openalex.org/W2080252570","doi":"https://doi.org/10.1073/pnas.1213530109","title":"Transcriptional burst frequency and burst size are equally modulated across the human genome","display_name":"Transcriptional burst frequency and burst size are equally modulated across the human genome","publication_year":2012,"publication_date":"2012-10-11","ids":{"openalex":"https://openalex.org/W2080252570","doi":"https://doi.org/10.1073/pnas.1213530109","mag":"2080252570","pmid":"https://pubmed.ncbi.nlm.nih.gov/23064634","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3491463"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1213530109","doi":"https://doi.org/10.1073/pnas.1213530109","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1213530109","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3491463","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023527494","display_name":"Roy D. Dar","orcid":"https://orcid.org/0000-0002-6006-4888","observed_orcids":["https://orcid.org/0000-0002-6006-4888"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]},{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I4390039300","display_name":"Center for Nanophase Materials Sciences","ror":"https://ror.org/01wass480","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294","https://openalex.org/I4390039300"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy D. Dar","raw_affiliation_strings":["Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831;","Department of Physics and Astronomy, University of Tennessee, Knoxville, TN 37996;","Gladstone Institutes, San Francisco, CA 94158;","Gladstone Institutes, San Francisco, CA, 94158 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831;","institution_ids":["https://openalex.org/I1289243028","https://openalex.org/I4390039300"]},{"raw_affiliation_string":"Department of Physics and Astronomy, University of Tennessee, Knoxville, TN 37996;","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"Gladstone Institutes, San Francisco, CA 94158;","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"Gladstone Institutes, San Francisco, CA, 94158 USA","institution_ids":["https://openalex.org/I1321430492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047074285","display_name":"Brandon S. Razooky","orcid":"https://orcid.org/0000-0002-5263-1512","observed_orcids":["https://orcid.org/0000-0002-5263-1512"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon S. Razooky","raw_affiliation_strings":["Biophysics Graduate Group, University of California, San Francisco, CA 94158;","Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093;","Gladstone Institutes, San Francisco, CA 94158;","aGladstone Institutes, San Francisco, CA 94158;","dDepartment of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093;","eBiophysics Graduate Group, University of California, San Francisco, CA 94158;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics Graduate Group, University of California, San Francisco, CA 94158;","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093;","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Gladstone Institutes, San Francisco, CA 94158;","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"aGladstone Institutes, San Francisco, CA 94158;","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"dDepartment of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093;","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"eBiophysics Graduate Group, University of California, San Francisco, CA 94158;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022267407","display_name":"Abhyudai Singh","orcid":"https://orcid.org/0000-0002-1451-2838","observed_orcids":["https://orcid.org/0000-0002-1451-2838"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhyudai Singh","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093;","dDepartment of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093;","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"dDepartment of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093;","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076795756","display_name":"Thomas V. Trimeloni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas V. Trimeloni","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Virginia Commonwealth University, Richmond, VA 23284\u20133072"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Virginia Commonwealth University, Richmond, VA 23284\u20133072","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111645503","display_name":"James M. McCollum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. McCollum","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Virginia Commonwealth University, Richmond, VA 23284\u20133072"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Virginia Commonwealth University, Richmond, VA 23284\u20133072","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023450780","display_name":"Chris D. Cox","orcid":"https://orcid.org/0000-0001-9818-5477","observed_orcids":["https://orcid.org/0000-0001-9818-5477"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris D. Cox","raw_affiliation_strings":["Center for Environmental Biotechnology, University of Tennessee, Knoxville, TN 37996;","Department of Civil and Environmental Engineering, University of Tennessee, Knoxville, TN 37996;","hDepartment of Civil and Environmental Engineering, University of Tennessee, Knoxville, TN 37996;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Environmental Biotechnology, University of Tennessee, Knoxville, TN 37996;","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"Department of Civil and Environmental Engineering, University of Tennessee, Knoxville, TN 37996;","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"hDepartment of Civil and Environmental Engineering, University of Tennessee, Knoxville, TN 37996;","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035253833","display_name":"Michael L. Simpson","orcid":"https://orcid.org/0000-0002-3933-3457","observed_orcids":["https://orcid.org/0000-0002-3933-3457"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]},{"id":"https://openalex.org/I4390039300","display_name":"Center for Nanophase Materials Sciences","ror":"https://ror.org/01wass480","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294","https://openalex.org/I4390039300"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Simpson","raw_affiliation_strings":["Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831;","Department of Materials Science and Engineering, University of Tennessee, Knoxville, TN 37996;","IDepartment of Materials Science and Engineering, University of Tennessee, Knoxville, TN 37996;","bCenter for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831;","institution_ids":["https://openalex.org/I1289243028","https://openalex.org/I4390039300"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Tennessee, Knoxville, TN 37996;","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"IDepartment of Materials Science and Engineering, University of Tennessee, Knoxville, TN 37996;","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"bCenter for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831;","institution_ids":["https://openalex.org/I1289243028","https://openalex.org/I4390039300"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043702774","display_name":"Leor S. Weinberger","orcid":"https://orcid.org/0000-0002-9987-6357","observed_orcids":["https://orcid.org/0000-0002-9987-6357"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leor S. Weinberger","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158; and","Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093;","Gladstone Institutes, San Francisco, CA 94158;","aGladstone Institutes, San Francisco, CA 94158;","dDepartment of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093;","jDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158; and","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093;","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Gladstone Institutes, San Francisco, CA 94158;","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"aGladstone Institutes, San Francisco, CA 94158;","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"dDepartment of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093;","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"jDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158; and","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.504,"has_fulltext":true,"cited_by_count":512,"citation_normalized_percentile":{"value":0.98923446,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"109","issue":"43","first_page":"17454","last_page":"17459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.13330000638961792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptional-bursting","display_name":"transcriptional bursting","score":0.9539999961853027},{"id":"https://openalex.org/keywords/burst-rate","display_name":"burst frequency","score":0.8510000109672546},{"id":"https://openalex.org/keywords/burst-size","display_name":"burst size","score":0.9990000128746033},{"id":"https://openalex.org/keywords/constitutive-expression","display_name":"constitutive expression","score":0.875},{"id":"https://openalex.org/keywords/promoter","display_name":"promoter","score":0.593999981880188},{"id":"https://openalex.org/keywords/chromosome-location","display_name":"chromosomal location","score":0.7049999833106995},{"id":"https://openalex.org/keywords/transcriptional-activator","display_name":"transcriptional activator","score":0.796999990940094},{"id":"https://openalex.org/keywords/trichostatin-a","display_name":"trichostatin A","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/human-genome","display_name":"human genome","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7110891342163086},{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.6573300957679749},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5838969945907593},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4739941358566284},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4691699147224426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46770307421684265},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4409109652042389},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.4270380437374115},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.36975812911987305},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32108569145202637},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.1213530109","doi":"https://doi.org/10.1073/pnas.1213530109","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1213530109","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2626751","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3491463","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3491463","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3491463","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:23064634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23064634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt0ph1j5vm","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0ph1j5vm","pdf_url":"https://escholarship.org/content/qt0ph1j5vm/qt0ph1j5vm.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, vol 109, iss 43","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2626751","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3491463","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1037007809","display_name":null,"funder_award_id":"GM 08326","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1349401600","display_name":null,"funder_award_id":"GM 085764","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2386431169","display_name":"Exploring Design Principles of Cellular Control Circuits","funder_award_id":"P50GM081879","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2828275257","display_name":"Developing Transmissible Antivirals by Exploiting Gene-Expression Circuitry","funder_award_id":"DP2OD006677","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4408384788","display_name":"San Diego Center for Systems Biology: From Maps to Models","funder_award_id":"P50GM085764","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4985329915","display_name":null,"funder_award_id":"GM081879","funder_id":"https://openalex.org/F4320332622","funder_display_name":"University of California, San Francisco"},{"id":"https://openalex.org/G5348288991","display_name":"The Role of Transcriptional Noise in the Establishment of HIV-1 Latency","funder_award_id":"F32AI104380","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6224987012","display_name":"Graduate Research Fellowship Program (GRFP)","funder_award_id":"1144247","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6276702551","display_name":null,"funder_award_id":"GM081879","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8976673989","display_name":"MOLECULAR BIOPHYSICS TRAINING PROGRAM","funder_award_id":"T32GM008326","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000035401","display_name":null,"funder_award_id":"GM085764","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000218453","display_name":null,"funder_award_id":"GM081879","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000898549","display_name":"UCSF-Bay Area Center for AIDS Research","funder_award_id":"P30AI027763","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"},{"id":"https://openalex.org/F4320338287","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1590436404","https://openalex.org/W1641228030","https://openalex.org/W1964660012","https://openalex.org/W1984916226","https://openalex.org/W1986247529","https://openalex.org/W1993009001","https://openalex.org/W2006765654","https://openalex.org/W2011372623","https://openalex.org/W2019472515","https://openalex.org/W2031822229","https://openalex.org/W2035444138","https://openalex.org/W2036349801","https://openalex.org/W2037281088","https://openalex.org/W2037768790","https://openalex.org/W2042321087","https://openalex.org/W2046156611","https://openalex.org/W2050826226","https://openalex.org/W2051598492","https://openalex.org/W2053460598","https://openalex.org/W2054350561","https://openalex.org/W2056406543","https://openalex.org/W2062113614","https://openalex.org/W2064743809","https://openalex.org/W2069280583","https://openalex.org/W2070723035","https://openalex.org/W2072077152","https://openalex.org/W2074087817","https://openalex.org/W2076445195","https://openalex.org/W2077046573","https://openalex.org/W2086584161","https://openalex.org/W2087004443","https://openalex.org/W2098258688","https://openalex.org/W2103018966","https://openalex.org/W2105512180","https://openalex.org/W2111167674","https://openalex.org/W2118623812","https://openalex.org/W2122044177","https://openalex.org/W2129297473","https://openalex.org/W2141688036","https://openalex.org/W2147745135","https://openalex.org/W2148119611","https://openalex.org/W2151827426","https://openalex.org/W2167244112","https://openalex.org/W2167813790","https://openalex.org/W2171228793"],"related_works":["https://openalex.org/W2906180136","https://openalex.org/W2910972626","https://openalex.org/W7169881737","https://openalex.org/W2765839245","https://openalex.org/W2808955860","https://openalex.org/W2621349699","https://openalex.org/W7168296928","https://openalex.org/W4413929751","https://openalex.org/W4296665976","https://openalex.org/W2075865654"],"abstract_inverted_index":{"Gene":[0],"expression":[1,33,88,117,127,194],"occurs":[2],"either":[3],"as":[4,13,138],"an":[5],"episodic":[6,73],"process,":[7,16],"characterized":[8,17],"by":[9,18,47,160,179],"pulsatile":[10],"bursts,":[11],"or":[12,41],"a":[14,19,39,155],"constitutive":[15,77],"Poisson-like":[20],"accumulation":[21],"of":[22,31,82,86,101,112,196],"gene":[23,32],"products.":[24],"It":[25],"is":[26],"not":[27],"clear":[28],"which":[29],"mode":[30,81],"(constitutive":[34],"versus":[35],"bursty)":[36],"predominates":[37],"across":[38,107,168],"genome":[40],"how":[42],"transcriptional":[43,103,165,183],"dynamics":[44,89],"are":[45],"influenced":[46],"genomic":[48,64],"position":[49],"and":[50,66,99,142,152,175,182,188],"promoter":[51,113],"sequence.":[52,114],"Here,":[53],"we":[54],"use":[55],"time-lapse":[56],"fluorescence":[57],"microscopy":[58],"to":[59,76,122,132],"analyze":[60],"8,000":[61,92],"individual":[62],"human":[63,109,170],"loci":[65,93,118,128],"find":[67],"that":[68,95],"at":[69,90],"virtually":[70],"all":[71],"loci,":[72],"bursting--as":[74],"opposed":[75],"expression--is":[78],"the":[79,87,97,102,108,161,169,193,197],"predominant":[80],"expression.":[83],"Quantitative":[84],"analysis":[85],"these":[91],"indicates":[94],"both":[96,172],"frequency":[98,121,153,174,187],"size":[100,131,151,177],"bursts":[104],"varies":[105],"equally":[106],"genome,":[110,171],"independent":[111],"Strikingly,":[115],"weaker":[116],"modulate":[119,129,149],"burst":[120,130,150,173,176,186,189],"increase":[123,133],"activity,":[124],"whereas":[125],"stronger":[126],"activity.":[134],"Transcriptional":[135],"activators":[136,184],"such":[137],"trichostatin":[139],"A":[140],"(TSA)":[141],"tumor":[143],"necrosis":[144],"factor":[145],"\u03b1":[146],"(TNF)":[147],"only":[148],"along":[154],"constrained":[156],"trend":[157],"line":[158],"governed":[159],"promoter.":[162],"In":[163],"summary,":[164],"bursting":[166],"dominates":[167],"vary":[178],"chromosomal":[180],"location,":[181],"alter":[185],"size,":[190],"depending":[191],"on":[192],"level":[195],"locus.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":36},{"year":2024,"cited_by_count":54},{"year":2023,"cited_by_count":34},{"year":2022,"cited_by_count":45},{"year":2021,"cited_by_count":37},{"year":2020,"cited_by_count":47},{"year":2019,"cited_by_count":52},{"year":2018,"cited_by_count":50},{"year":2017,"cited_by_count":30},{"year":2016,"cited_by_count":28},{"year":2015,"cited_by_count":39},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":20}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
