{"id":"https://openalex.org/W2080235504","doi":"https://doi.org/10.1021/bi00295a001","title":"Detection of early changes in androgen-induced mouse renal .beta.-glucuronidase messenger ribonucleic acid using cloned complementary deoxyribonucleic acid","display_name":"Detection of early changes in androgen-induced mouse renal .beta.-glucuronidase messenger ribonucleic acid using cloned complementary deoxyribonucleic acid","publication_year":1983,"publication_date":"1983-12-01","ids":{"openalex":"https://openalex.org/W2080235504","doi":"https://doi.org/10.1021/bi00295a001","mag":"2080235504","pmid":"https://pubmed.ncbi.nlm.nih.gov/6689271"},"language":"en","primary_location":{"id":"doi:10.1021/bi00295a001","doi":"https://doi.org/10.1021/bi00295a001","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00295a001","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074183604","display_name":"James F. Catterall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James F. Catterall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086329783","display_name":"Susan L. Leary","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan L. Leary","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.3076,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.95831162,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"22","issue":"26","first_page":"6049","last_page":"6053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.44429999589920044,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.44429999589920044,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.1306000053882599,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.09040000289678574,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-glucuronidase","display_name":"beta-glucuronidase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.6859999895095825},{"id":"https://openalex.org/keywords/mrna-purification","display_name":"mRNA purification","score":0.4740000069141388},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.44600000977516174},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.5889999866485596},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.7669880390167236},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7365769743919373},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.6975187659263611},{"id":"https://openalex.org/C65666806","wikidata":"https://www.wikidata.org/wiki/Q970614","display_name":"Polysome","level":5,"score":0.6450785994529724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5882593393325806},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5816667675971985},{"id":"https://openalex.org/C2777322866","wikidata":"https://www.wikidata.org/wiki/Q288855","display_name":"Beta-glucuronidase","level":4,"score":0.4544523060321808},{"id":"https://openalex.org/C2779181561","wikidata":"https://www.wikidata.org/wiki/Q16783924","display_name":"Glucuronidase","level":3,"score":0.4249546527862549},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.35228753089904785},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24511414766311646},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2126520276069641},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.10756197571754456}],"mesh":[{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005966","descriptor_name":"Glucuronidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005966","descriptor_name":"Glucuronidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013196","descriptor_name":"Dihydrotestosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi00295a001","doi":"https://doi.org/10.1021/bi00295a001","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00295a001","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:6689271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6689271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Comparative Study"},{"id":"pmh:oai:mouseion.jax.org:ssbb1983-10011","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1983/1976","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1983","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1419303435","https://openalex.org/W1512156790","https://openalex.org/W1531481785","https://openalex.org/W1570776822","https://openalex.org/W1576798844","https://openalex.org/W1976937903","https://openalex.org/W1978380320","https://openalex.org/W1991486518","https://openalex.org/W2011308797","https://openalex.org/W2024878014","https://openalex.org/W2026324976","https://openalex.org/W2039579097","https://openalex.org/W2040298111","https://openalex.org/W2049635421","https://openalex.org/W2051539192","https://openalex.org/W2064487242","https://openalex.org/W2064538564","https://openalex.org/W2066160869","https://openalex.org/W2077077811","https://openalex.org/W2081689083","https://openalex.org/W2090162704","https://openalex.org/W2100837269","https://openalex.org/W2101181033","https://openalex.org/W2106515985","https://openalex.org/W2165046801","https://openalex.org/W2410723876"],"related_works":["https://openalex.org/W2050675067","https://openalex.org/W1983340566","https://openalex.org/W1984662915","https://openalex.org/W2026324976","https://openalex.org/W1899454125","https://openalex.org/W2042099086","https://openalex.org/W1526049569","https://openalex.org/W1512156790","https://openalex.org/W2003957440","https://openalex.org/W2005718070"],"abstract_inverted_index":{"beta-Glucuronidase":[0],"mRNA":[1,18,32,39,42,79,101,105,124,161],"was":[2,44,89,110,131],"purified":[3,38],"from":[4,20,106],"androgen-induced":[5,107],"mouse":[6,108],"kidney":[7,109],"by":[8,27,51,67,80,91],"immunoadsorption":[9],"of":[10,17,36,99,125,143,147,154],"polysomes":[11],"to":[12,46,112,122,164],"protein":[13,22],"A-Sepharose.":[14],"Cell-free":[15],"translation":[16],"isolated":[19],"the":[21,37,62,97],"A":[23,83],"bound":[24],"RNA":[25],"followed":[26],"immunoprecipitation":[28],"revealed":[29,158],"that":[30,58,159],"beta-glucuronidase":[31,78,84,100,118,160],"represented":[33],"approximately":[34],"2%":[35],"fraction.":[40],"This":[41],"preparation":[43],"used":[45],"produce":[47],"complementary":[48],"DNA":[49],"clones":[50],"recombination":[52],"with":[53,77,150],"pBR322.":[54],"Clones":[55],"containing":[56],"sequences":[57],"were":[59,65,72],"enriched":[60],"during":[61],"purification":[63],"procedure":[64],"selected":[66],"differential":[68],"colony":[69],"hybridization.":[70],"These":[71],"further":[73],"screened":[74],"for":[75],"homology":[76],"hybrid-selected":[81],"translation.":[82],"cDNA":[85,119],"clone,":[86],"designated":[87],"pGUS7,":[88],"identified":[90],"these":[92],"criteria.":[93],"With":[94],"this":[95],"plasmid,":[96],"abundance":[98],"in":[102,128,133],"total":[103],"poly(A)":[104],"estimated":[111],"be":[113],"less":[114],"than":[115],"0.04%.":[116],"The":[117],"plasmid":[120],"hybridized":[121],"a":[123,140,151],"2.6":[126],"kb":[127],"length,":[129],"which":[130],"induced":[132],"an":[134],"androgen":[135],"receptor":[136],"dependent":[137],"fashion":[138],"over":[139],"time":[141],"course":[142],"21":[144],"days.":[145],"Treatment":[146],"female":[148],"mice":[149],"single":[152],"dose":[153],"testosterone":[155],"(10":[156],"mg)":[157],"concentration":[162],"begins":[163],"increase":[165],"between":[166],"12":[167],"and":[168],"24":[169],"h":[170],"after":[171],"hormone":[172],"administration.":[173]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}