{"id":"https://openalex.org/W2080211548","doi":"https://doi.org/10.1002/jcp.10206","title":"Role of CTGF/HCS24/ecogenin in skeletal growth control","display_name":"Role of CTGF/HCS24/ecogenin in skeletal growth control","publication_year":2003,"publication_date":"2003-01-13","ids":{"openalex":"https://openalex.org/W2080211548","doi":"https://doi.org/10.1002/jcp.10206","mag":"2080211548","pmid":"https://pubmed.ncbi.nlm.nih.gov/12548546"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.10206","doi":"https://doi.org/10.1002/jcp.10206","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcp.10206","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.10206","source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.10206","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015963255","display_name":"Masaharu Takigawa","orcid":"https://orcid.org/0000-0002-1068-1677","observed_orcids":["https://orcid.org/0000-0002-1068-1677"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masaharu Takigawa","raw_affiliation_strings":["Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. takigawa@md.okayama-u.ac.jp","Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. takigawa@md.okayama-u.ac.jp","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056265260","display_name":"Tohru Nakanishi","orcid":"https://orcid.org/0000-0001-7927-6525","observed_orcids":["https://orcid.org/0000-0001-7927-6525"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohru Nakanishi","raw_affiliation_strings":["Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019500344","display_name":"Satoshi Kubota","orcid":"https://orcid.org/0000-0003-0795-5072","observed_orcids":["https://orcid.org/0000-0003-0795-5072"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Kubota","raw_affiliation_strings":["Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101886808","display_name":"Takashi Nishida","orcid":"https://orcid.org/0000-0002-6138-4648","observed_orcids":["https://orcid.org/0000-0002-6138-4648"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nishida","raw_affiliation_strings":["Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015963255"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":1.1281,"has_fulltext":true,"cited_by_count":181,"citation_normalized_percentile":{"value":0.75055188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"194","issue":"3","first_page":"256","last_page":"266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.9440000057220459},{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"endochondral ossification","score":0.906000018119812},{"id":"https://openalex.org/keywords/skeletal-development","display_name":"skeletal development","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hypertrophic-chondrocytes","display_name":"hypertrophic chondrocytes","score":0.9240000247955322},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.8769999742507935},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.972000002861023},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/intramembranous-ossification","display_name":"intramembranous ossification","score":0.9570000171661377},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.8090000152587891},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.6639999747276306},{"id":"https://openalex.org/keywords/wounding","display_name":"wounding","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C17938293","wikidata":"https://www.wikidata.org/wiki/Q3312710","display_name":"Endochondral ossification","level":3,"score":0.9188717603683472},{"id":"https://openalex.org/C2780631158","wikidata":"https://www.wikidata.org/wiki/Q14907752","display_name":"CTGF","level":4,"score":0.8762811422348022},{"id":"https://openalex.org/C188945261","wikidata":"https://www.wikidata.org/wiki/Q10746904","display_name":"Intramembranous ossification","level":2,"score":0.7632182836532593},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6791874170303345},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6322377920150757},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.6259250044822693},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5424841046333313},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.48337453603744507},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4377286732196808},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4137720763683319},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.371015340089798},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3693457543849945},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3380112051963806},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.20254266262054443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1726982593536377},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1709032952785492},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09860745072364807},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055513","descriptor_name":"Connective Tissue Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.10206","doi":"https://doi.org/10.1002/jcp.10206","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcp.10206","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.10206","source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:12548546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12548546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jcp.10206","doi":"https://doi.org/10.1002/jcp.10206","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcp.10206","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcp.10206","source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G119509233","display_name":null,"funder_award_id":"JSPS-RFTF98I00201","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309785","display_name":"Naito Foundation","ror":"https://ror.org/02s016q17"},{"id":"https://openalex.org/F4320310657","display_name":"Sumitomo Foundation","ror":"https://ror.org/01nmpj461"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2080211548.pdf","grobid_xml":"https://content.openalex.org/works/W2080211548.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W26433322","https://openalex.org/W187255854","https://openalex.org/W569944157","https://openalex.org/W601334014","https://openalex.org/W1488147817","https://openalex.org/W1498514627","https://openalex.org/W1524146716","https://openalex.org/W1607010134","https://openalex.org/W1940784716","https://openalex.org/W1964916553","https://openalex.org/W1964941505","https://openalex.org/W1967236086","https://openalex.org/W1971318940","https://openalex.org/W1977979821","https://openalex.org/W1978471137","https://openalex.org/W1979093446","https://openalex.org/W1982183335","https://openalex.org/W1985650583","https://openalex.org/W1986403962","https://openalex.org/W1989316513","https://openalex.org/W1997812904","https://openalex.org/W1999512677","https://openalex.org/W2000883904","https://openalex.org/W2005463323","https://openalex.org/W2005619692","https://openalex.org/W2008473742","https://openalex.org/W2009816486","https://openalex.org/W2013157338","https://openalex.org/W2014326933","https://openalex.org/W2014563658","https://openalex.org/W2017603039","https://openalex.org/W2027232305","https://openalex.org/W2034812824","https://openalex.org/W2037889124","https://openalex.org/W2039957138","https://openalex.org/W2040433060","https://openalex.org/W2042249648","https://openalex.org/W2042838239","https://openalex.org/W2047968060","https://openalex.org/W2050875708","https://openalex.org/W2057126191","https://openalex.org/W2057452914","https://openalex.org/W2059059445","https://openalex.org/W2063980632","https://openalex.org/W2066504997","https://openalex.org/W2066969290","https://openalex.org/W2069956524","https://openalex.org/W2077355093","https://openalex.org/W2087027548","https://openalex.org/W2090619182","https://openalex.org/W2092622290","https://openalex.org/W2098118477","https://openalex.org/W2102059629","https://openalex.org/W2102138077","https://openalex.org/W2106232223","https://openalex.org/W2112417973","https://openalex.org/W2113331004","https://openalex.org/W2116324780","https://openalex.org/W2118983508","https://openalex.org/W2133070487","https://openalex.org/W2135664105","https://openalex.org/W2135930613","https://openalex.org/W2142185633","https://openalex.org/W2142799375","https://openalex.org/W2149718794","https://openalex.org/W2150666277","https://openalex.org/W2156553323","https://openalex.org/W2158545941","https://openalex.org/W2161189488","https://openalex.org/W2161993127","https://openalex.org/W2166371031","https://openalex.org/W2167807541","https://openalex.org/W2169804478","https://openalex.org/W2169883682","https://openalex.org/W2313217491","https://openalex.org/W2430402603","https://openalex.org/W4319688072"],"related_works":["https://openalex.org/W2472223251","https://openalex.org/W2050959723","https://openalex.org/W2039957138","https://openalex.org/W7097842205","https://openalex.org/W2090619182","https://openalex.org/W4233417918","https://openalex.org/W649420700","https://openalex.org/W7095963646","https://openalex.org/W2042838239","https://openalex.org/W2166371031"],"abstract_inverted_index":{"Connective":[0],"tissue":[1],"growth":[2,12,28,40,253],"factor/hypertrophic":[3],"chondrocyte-specific":[4],"gene":[5,103],"product":[6],"24":[7],"(CTGF/Hcs24)":[8],"is":[9,85,203,242],"a":[10,115,145,172],"multifunctional":[11],"factor":[13,46,121,135],"for":[14,87,119,206],"chondrocytes,":[15,162],"osteoblasts,":[16],"and":[17,25,31,37,51,63,78,101,198,209,254,265],"vascular":[18,66],"endothelial":[19,67,215],"cells.":[20,56],"CTGF/Hcs24":[21,58,106,149,194,212,241],"promotes":[22,59],"the":[23,49,60,76,88,95,112,124,127,134,138,191,235,245],"proliferation":[24,50],"maturation":[26],"of":[27,39,53,65,90,98,105,126,130,142,176,193,240],"cartilage":[29,33,41,91],"cells":[30,34,42,77,143,216],"articular":[32],"in":[35,43,81,108,111,180,183,195,214,228,251],"culture":[36],"hypertrophy":[38],"culture.":[44],"The":[45],"also":[47,170,204,224,247],"stimulates":[48],"differentiation":[52],"cultured":[54],"osteoblastic":[55],"Moreover,":[57],"adhesion,":[61],"proliferation,":[62],"migration":[64],"cells,":[68],"as":[69,71,144],"well":[70],"induces":[72],"tube":[73],"formation":[74],"by":[75,165,218],"strong":[79],"angiogenesis":[80,84,202],"vivo.":[82],"Because":[83,201],"critical":[86,205],"replacement":[89],"with":[92,133,182],"bone":[93,199,210,230],"at":[94],"final":[96],"stage":[97],"endochondral":[99,131,154],"ossification":[100,155,197,208],"because":[102],"expression":[104],"predominates":[107],"hypertrophic":[109,161],"chondrocytes":[110],"physiological":[113,117,238,264],"state,":[114],"major":[116],"role":[118,239],"this":[120],"should":[122,150],"be":[123,151],"promotion":[125],"entire":[128],"process":[129],"ossification,":[132],"acting":[136],"on":[137,260],"above":[139,189],"three":[140],"types":[141],"paracrine":[146],"factor.":[147],"Thus,":[148],"called":[152],"\"ecogenin:":[153],"genetic":[156],"factor.\"":[157],"In":[158,232],"addition":[159],"to":[160],"osteoblasts":[163,187,261],"activated":[164,217],"various":[166,219],"stimuli":[167,220],"including":[168,221],"wounding":[169,222],"express":[171],"significantly":[173],"high":[174],"level":[175],"CTGF/Hcs24.":[177],"These":[178],"findings":[179,185],"conjunction":[181],"vitro":[184],"about":[186],"mentioned":[188],"suggest":[190],"involvement":[192],"intramembranous":[196,207],"modeling/remodeling.":[200],"remodeling,":[211],"expressed":[213],"may":[223],"play":[225,248],"important":[226,237,249],"roles":[227,250],"direct":[229,258],"formation.":[231],"conclusion,":[233],"although":[234],"most":[236],"ecogenin":[243],"action,":[244],"factors":[246],"skeletal":[252],"modeling/remodeling":[255],"via":[256],"its":[257],"action":[259],"under":[262],"both":[263],"pathological":[266],"conditions.":[267]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}