{"id":"https://openalex.org/W2080189306","doi":"https://doi.org/10.1046/j.1432-1327.1998.2580923.x","title":"Importance of heptameric ring integrity for activity of Escherichia coli ClpP","display_name":"Importance of heptameric ring integrity for activity of Escherichia coli ClpP","publication_year":1998,"publication_date":"1998-12-15","ids":{"openalex":"https://openalex.org/W2080189306","doi":"https://doi.org/10.1046/j.1432-1327.1998.2580923.x","mag":"2080189306","pmid":"https://pubmed.ncbi.nlm.nih.gov/9990309"},"language":"en","primary_location":{"id":"doi:10.1046/j.1432-1327.1998.2580923.x","doi":"https://doi.org/10.1046/j.1432-1327.1998.2580923.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1432-1327.1998.2580923.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1432-1327.1998.2580923.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1432-1327.1998.2580923.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109125194","display_name":"Mark W. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark W. Thompson","raw_affiliation_strings":["Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA","Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I4210087962"]},{"raw_affiliation_string":"Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000848773","display_name":"Jay H. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay Miller","raw_affiliation_strings":["Laboratory of Physical Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physical Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087235422","display_name":"Michael R. Maurizi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Maurizi","raw_affiliation_strings":["Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111636297","display_name":"Ellis S. Kempner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellis Kempner","raw_affiliation_strings":["Laboratory of Physical Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physical Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0969,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.36027502,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"258","issue":"3","first_page":"923","last_page":"928"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clpp","display_name":"ClpP","score":0.9890000224113464},{"id":"https://openalex.org/keywords/atp-dependent-proteolysis","display_name":"ATP-dependent proteolysis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/oligomeric-structure","display_name":"oligomeric structure","score":0.6520000100135803},{"id":"https://openalex.org/keywords/proteolytic-activity","display_name":"proteolytic activity","score":0.7329999804496765},{"id":"https://openalex.org/keywords/quaternary-structure","display_name":"quaternary structure","score":0.7710000276565552},{"id":"https://openalex.org/keywords/subunit-interactions","display_name":"subunit interactions","score":0.5360000133514404},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.43299999833106995},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6505485773086548},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.6086856126785278},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.6073873043060303},{"id":"https://openalex.org/C7927669","wikidata":"https://www.wikidata.org/wiki/Q898529","display_name":"Protein quaternary structure","level":4,"score":0.5605576038360596},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5505833029747009},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5504992604255676},{"id":"https://openalex.org/C13935069","wikidata":"https://www.wikidata.org/wiki/Q2157266","display_name":"Oligopeptide","level":3,"score":0.5141492486000061},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.508110761642456},{"id":"https://openalex.org/C141315368","wikidata":"https://www.wikidata.org/wiki/Q4654881","display_name":"ATP hydrolysis","level":4,"score":0.5002686977386475},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.4968707859516144},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49238479137420654},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.46266698837280273},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.4619138240814209},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3773336410522461},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36572587490081787},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33658552169799805},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31400084495544434},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2844246029853821},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.14448896050453186},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06207427382469177},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049071","descriptor_name":"Endopeptidase Clp","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1432-1327.1998.2580923.x","doi":"https://doi.org/10.1046/j.1432-1327.1998.2580923.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1432-1327.1998.2580923.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1432-1327.1998.2580923.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:9990309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9990309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1046/j.1432-1327.1998.2580923.x","doi":"https://doi.org/10.1046/j.1432-1327.1998.2580923.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1432-1327.1998.2580923.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1432-1327.1998.2580923.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2080189306.pdf","grobid_xml":"https://content.openalex.org/works/W2080189306.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W970012429","https://openalex.org/W977082017","https://openalex.org/W1483989022","https://openalex.org/W1499918582","https://openalex.org/W1538899778","https://openalex.org/W1542150214","https://openalex.org/W1602037468","https://openalex.org/W1651280426","https://openalex.org/W1897176773","https://openalex.org/W2000761906","https://openalex.org/W2008561447","https://openalex.org/W2010190199","https://openalex.org/W2033148434","https://openalex.org/W2057666694","https://openalex.org/W2058570720","https://openalex.org/W2065146040","https://openalex.org/W2073761890","https://openalex.org/W2077410449","https://openalex.org/W2145571109","https://openalex.org/W2175093343","https://openalex.org/W4237644605","https://openalex.org/W6611186726"],"related_works":["https://openalex.org/W2023721865","https://openalex.org/W1989249139","https://openalex.org/W2029171915","https://openalex.org/W2081746541","https://openalex.org/W1532942255","https://openalex.org/W1592902260","https://openalex.org/W2127928442","https://openalex.org/W2122964795","https://openalex.org/W1973507897","https://openalex.org/W2088593000"],"abstract_inverted_index":{"Radiation":[0,26,109],"target":[1,27,90],"analysis":[2],"has":[3],"been":[4],"used":[5],"to":[6,112,119],"identify":[7],"the":[8,18,22,55,66,142,153,160,164],"minimal":[9],"functional":[10],"unit":[11],"for":[12,30,34,42,97,104,158],"expression":[13,105],"of":[14,16,21,58,73,83,100,106,114,122,128,163],"activity":[15,57],"ClpP,":[17,59],"proteolytic":[19,165],"component":[20],"ATP-dependent":[23,44],"ClpAP":[24],"protease.":[25],"sizes":[28,91],"determined":[29,75],"small":[31],"peptide":[32],"hydrolysis,":[33],"ClpA":[35],"activated":[36],"and":[37,41,50,79,133],"nucleotide-activated":[38],"oligopeptide":[39],"cleavage,":[40],"ClpA-activated":[43],"protein":[45],"degradation":[46],"were":[47],"154,":[48],"118,":[49],"160":[51],"kDa,":[52],"respectively.":[53],"Thus,":[54,124],"hydrolytic":[56,107],"subunit":[60],"M,":[61],"21,500,":[62],"is":[63],"dependent":[64],"on":[65],"native":[67],"oligomeric":[68],"structure.":[69],"The":[70,88],"quaternary":[71],"structure":[72],"ClpP":[74,129,154],"by":[76],"electron":[77],"microscopy":[78],"hydrodynamic":[80],"studies":[81],"consists":[82],"two":[84],"face-to-face":[85],"seven-membered":[86],"rings.":[87,143],"radiation":[89],"are":[92,130,156],"consistent":[93],"with":[94],"a":[95],"requirement":[96],"conformational":[98],"integrity":[99],"an":[101],"entire":[102],"ring":[103],"activity.":[108],"damage":[110],"led":[111],"disruption":[113],"inter-ring":[115],"contacts,":[116],"giving":[117],"rise":[118],"isolated":[120],"rings":[121,127,155],"ClpP.":[123],"contacts":[125,138],"between":[126,139,150],"less":[131],"stable":[132],"more":[134],"easily":[135],"disrupted":[136],"than":[137],"subunits":[140,151],"within":[141,152],"Our":[144],"data":[145],"suggest":[146],"that":[147],"cooperative":[148],"interactions":[149],"important":[157],"maintaining":[159],"active":[161,166],"conformation":[162],"site.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
