{"id":"https://openalex.org/W2080165022","doi":"https://doi.org/10.1001/archotol.134.11.1218","title":"Modulation of Tumor Cell Growth In Vivo by Extracellular Matrix Metalloprotease Inducer","display_name":"Modulation of Tumor Cell Growth In Vivo by Extracellular Matrix Metalloprotease Inducer","publication_year":2008,"publication_date":"2008-11-17","ids":{"openalex":"https://openalex.org/W2080165022","doi":"https://doi.org/10.1001/archotol.134.11.1218","mag":"2080165022","pmid":"https://pubmed.ncbi.nlm.nih.gov/19015455","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2676729"},"language":"en","primary_location":{"id":"doi:10.1001/archotol.134.11.1218","doi":"https://doi.org/10.1001/archotol.134.11.1218","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archotol.134.11.1218","pdf_url":null,"source":{"id":"https://openalex.org/S101791497","display_name":"Archives of Otolaryngology - Head and Neck Surgery","issn_l":"0886-4470","issn":["0886-4470","1538-361X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Otolaryngology\u2013Head &amp; Neck Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2676729","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. Robert Newman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Robert Newman","raw_affiliation_strings":["Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079114404","display_name":"Isaac A. Bohannon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isaac A. Bohannon","raw_affiliation_strings":["Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery (Drs Newman, Bohannon, Skipper, and Rosenthal and Mr Zhang), and Department of Pathology (Dr Grizzle), University of Alabama at Birmingham","University of Alabama at, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery (Drs Newman, Bohannon, Skipper, and Rosenthal and Mr Zhang), and Department of Pathology (Dr Grizzle), University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"University of Alabama at, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041193704","display_name":"Wenyue Zhang","orcid":"https://orcid.org/0000-0001-8181-8282","observed_orcids":["https://orcid.org/0000-0001-8181-8282"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenyue Zhang","raw_affiliation_strings":["Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery (Drs Newman, Bohannon, Skipper, and Rosenthal and Mr Zhang), and Department of Pathology (Dr Grizzle), University of Alabama at Birmingham","University of Alabama at, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery (Drs Newman, Bohannon, Skipper, and Rosenthal and Mr Zhang), and Department of Pathology (Dr Grizzle), University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"University of Alabama at, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031944403","display_name":"Joni B. Skipper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joni B. Skipper","raw_affiliation_strings":["Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery (Drs Newman, Bohannon, Skipper, and Rosenthal and Mr Zhang), and Department of Pathology (Dr Grizzle), University of Alabama at Birmingham","University of Alabama at, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery (Drs Newman, Bohannon, Skipper, and Rosenthal and Mr Zhang), and Department of Pathology (Dr Grizzle), University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"University of Alabama at, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076077003","display_name":"William E. Grizzle","orcid":"https://orcid.org/0000-0001-9245-0401","observed_orcids":["https://orcid.org/0000-0001-9245-0401"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Grizzle","raw_affiliation_strings":["Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery (Drs Newman, Bohannon, Skipper, and Rosenthal and Mr Zhang), and Department of Pathology (Dr Grizzle), University of Alabama at Birmingham","University of Alabama at, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery (Drs Newman, Bohannon, Skipper, and Rosenthal and Mr Zhang), and Department of Pathology (Dr Grizzle), University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"University of Alabama at, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086275218","display_name":"Eben Lloyd Rosenthal","orcid":"https://orcid.org/0000-0003-0294-5203","observed_orcids":["https://orcid.org/0000-0003-0294-5203"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eben L. Rosenthal","raw_affiliation_strings":["Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery (Drs Newman, Bohannon, Skipper, and Rosenthal and Mr Zhang), and Department of Pathology (Dr Grizzle), University of Alabama at Birmingham","Division of Otolaryngology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery (Drs Newman, Bohannon, Skipper, and Rosenthal and Mr Zhang), and Department of Pathology (Dr Grizzle), University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Division of Otolaryngology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5691,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.70248515,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"134","issue":"11","first_page":"1218","last_page":"1218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emmprin","display_name":"EMMPRIN","score":0.9409999847412109},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.8790000081062317},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5139999985694885},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.8209999799728394},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.6890000104904175},{"id":"https://openalex.org/keywords/fadu-cells","display_name":"FaDu cells","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/ki-67-proliferation-index","display_name":"Ki-67 proliferation index","score":0.8389999866485596},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7059999704360962},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7931911945343018},{"id":"https://openalex.org/C2225953","wikidata":"https://www.wikidata.org/wiki/Q1661899","display_name":"Inducer","level":3,"score":0.7740957736968994},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.641257643699646},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6093148589134216},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5890486240386963},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.5479103326797485},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5421155691146851},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.44765082001686096},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.435322642326355},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3457273840904236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30217164754867554},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2025839388370514},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09299764037132263},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06883186101913452},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06730404496192932},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010039","descriptor_name":"Otorhinolaryngologic Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D010039","descriptor_name":"Otorhinolaryngologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010039","descriptor_name":"Otorhinolaryngologic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051926","descriptor_name":"Basigin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1001/archotol.134.11.1218","doi":"https://doi.org/10.1001/archotol.134.11.1218","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archotol.134.11.1218","pdf_url":null,"source":{"id":"https://openalex.org/S101791497","display_name":"Archives of Otolaryngology - Head and Neck Surgery","issn_l":"0886-4470","issn":["0886-4470","1538-361X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Otolaryngology\u2013Head &amp; Neck Surgery","raw_type":"journal-article"},{"id":"pmid:19015455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19015455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of otolaryngology--head & neck surgery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2676729","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2676729","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Arch Otolaryngol Head Neck Surg","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2676729","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2676729","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Arch Otolaryngol Head Neck Surg","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5116832305","display_name":"CD147 as a Novel Target in Head and Neck Cancer","funder_award_id":"R01CA142637","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5703746443","display_name":"Research Training Program in Surgical Oncology","funder_award_id":"T32CA091078","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8882703604","display_name":"Tumor Stromal Interactions in Head and Neck Cancer","funder_award_id":"K08CA102154","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1481451464","https://openalex.org/W1886431664","https://openalex.org/W1988232005","https://openalex.org/W2034124119","https://openalex.org/W2041816417","https://openalex.org/W2050224943","https://openalex.org/W2055486683","https://openalex.org/W2069838189","https://openalex.org/W2119007498","https://openalex.org/W2164756915","https://openalex.org/W4233417260"],"related_works":["https://openalex.org/W2069838189","https://openalex.org/W2330003159","https://openalex.org/W2171216413","https://openalex.org/W1952843274","https://openalex.org/W2128465219","https://openalex.org/W2014033770","https://openalex.org/W1481451464","https://openalex.org/W1600224233","https://openalex.org/W2372471288","https://openalex.org/W1988232005"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"if":[3],"loss":[4],"of":[5,15,107,154,167,228],"extracellular":[6],"matrix":[7,47],"metalloprotease":[8],"inducer":[9],"(EMMPRIN)":[10],"will":[11],"inhibit":[12],"the":[13,105,120,200,226],"growth":[14,171,185],"head":[16,155],"and":[17,36,55,124,138,156,174,234],"neck":[18,157],"squamous":[19],"cell":[20,24,52,78,159],"carcinoma":[21],"(HNSCC)":[22],"tumor":[23,51,63,125,184,235],"lines":[25,160],"in":[26,34,218,225,259],"vivo.":[27],"Tumor":[28,96,170],"cell-derived":[29],"EMMPRIN":[30,84,94,181,242],"is":[31,37],"highly":[32],"overexpressed":[33],"HNSCC":[35,77],"thought":[38],"to":[39,45,163,253],"be":[40,254],"induced":[41],"by":[42],"surrounding":[43],"fibroblasts":[44],"stimulate":[46],"metalloproteases,":[48],"which":[49,118],"modulate":[50],"invasion,":[53],"growth,":[54],"angiogenesis.":[56],"DESIGN:":[57],"In":[58],"vivo":[59],"study":[60,246],"using":[61],"FaDu":[62,80,194,203],"xenografts.":[64],"SETTING:":[65],"Academic":[66],"research":[67],"facility.":[68],"SUBJECTS:":[69],"Severe":[70],"combined":[71,98],"immunodeficiency":[72],"(SCID)":[73],"mice.":[74,109],"INTERVENTIONS:":[75],"The":[76],"line":[79],"was":[81,186],"transfected":[82],"with":[83,99,179,193,241],"(FaDu/E),":[85],"control":[86,201],"vector":[87],"(FaDu),":[88],"or":[89],"plasmid-expressing":[90],"small-interfering":[91],"RNA":[92],"against":[93],"(FaDu/siE).":[95],"cells":[97,101],"fibroblast":[100],"were":[102,111,122,127,205],"xenografted":[103],"onto":[104],"flank":[106],"SCID":[108],"Tumors":[110],"measured":[112],"biweekly":[113],"over":[114],"4":[115,190],"weeks,":[116],"at":[117,189],"time":[119],"mice":[121],"killed,":[123],"samples":[126],"analyzed":[128],"for":[129],"proliferation":[130],"(Ki-67":[131],"immunohistochemical":[132],"analysis),":[133],"vascularization":[134],"(factor":[135],"VIII":[136],"staining),":[137],"apoptosis":[139,229],"(TUNEL":[140],"[terminal":[141],"deoxynucleotidyl":[142],"transferase-mediated":[143],"deoxyuridine":[144],"triphosphate-biotin":[145],"nick":[146],"end":[147],"labeling]":[148],"assay).":[149],"MAIN":[150],"OUTCOME":[151],"MEASURE:":[152],"Growth":[153],"cancer":[158],"genetically":[161],"engineered":[162],"express":[164],"variable":[165],"levels":[166],"EMMPRIN.":[168],"RESULTS:":[169],"positively":[172],"correlated":[173,178],"animal":[175],"survival":[176],"negatively":[177],"increasing":[180],"expression.":[182,243],"FaDu/E":[183],"significantly":[187,206,240],"larger":[188,207],"weeks":[191],"compared":[192],"tumors":[195,204],"(P":[196,210],"=":[197],".006).":[198],"Similarly,":[199],"vector-transfected":[202],"than":[208],"FaDu/siE":[209],"<":[211],".001).":[212],"Immunohistochemical":[213],"analysis":[214],"demonstrated":[215],"increased":[216,239],"Ki-67":[217],"EMMPRIN-transfected":[219],"cells,":[220],"without":[221],"a":[222,255],"significant":[223],"change":[224],"rate":[227,237],"between":[230],"groups.":[231],"Vascular":[232],"density":[233],"formation":[236],"also":[238],"CONCLUSION:":[244],"This":[245],"suggests":[247],"that":[248],"anti-EMMPRIN-targeted":[249],"therapy":[250],"may":[251],"prove":[252],"novel":[256],"treatment":[257],"option":[258],"HNSCC.":[260]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}