{"id":"https://openalex.org/W2080148571","doi":"https://doi.org/10.1002/jbm.a.32944","title":"The role of complement C3 and fibrinogen in monocyte adhesion to PEO\u2010like plasma deposited tetraglyme","display_name":"The role of complement C3 and fibrinogen in monocyte adhesion to PEO\u2010like plasma deposited tetraglyme","publication_year":2010,"publication_date":"2010-10-11","ids":{"openalex":"https://openalex.org/W2080148571","doi":"https://doi.org/10.1002/jbm.a.32944","mag":"2080148571","pmid":"https://pubmed.ncbi.nlm.nih.gov/20939050","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2975874"},"language":"en","primary_location":{"id":"doi:10.1002/jbm.a.32944","doi":"https://doi.org/10.1002/jbm.a.32944","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.32944","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2975874/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060261961","display_name":"Luisa Mayorga Szott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luisa M. Szott","raw_affiliation_strings":["Department of Bioengineering, University of Washington, Seattle, Washington, USA","Department of Bioengineering, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112202859","display_name":"Thomas A. Horbett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas A. Horbett","raw_affiliation_strings":["Department of Bioengineering, University of Washington, Seattle, Washington","Department of Chemical Engineering, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112202859"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":0.6341,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61967182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"95A","issue":"4","first_page":"1252","last_page":"1260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.9480000138282776},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9959999918937683},{"id":"https://openalex.org/keywords/monocyte-adhesion","display_name":"monocyte adhesion","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tetraglyme","display_name":"tetraglyme","score":0.9120000004768372},{"id":"https://openalex.org/keywords/plasma-protein-adsorption","display_name":"plasma protein adsorption","score":0.7770000100135803},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.5619999766349792},{"id":"https://openalex.org/keywords/implant-encapsulation","display_name":"implant encapsulation","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.7818384170532227},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.6535184979438782},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6363921761512756},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.6192736625671387},{"id":"https://openalex.org/C88001094","wikidata":"https://www.wikidata.org/wiki/Q7251453","display_name":"Protein adsorption","level":3,"score":0.5021281242370605},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49038004875183105},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.4849962890148163},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.4360877275466919},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.43291985988616943},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.41321122646331787},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3746466040611267},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24071183800697327},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.238376647233963},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1417061984539032},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09059903025627136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07092055678367615},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000475","descriptor_name":"Alkenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005026","descriptor_name":"Ethylene Glycols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058626","descriptor_name":"Plasma Gases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/jbm.a.32944","doi":"https://doi.org/10.1002/jbm.a.32944","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.32944","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},{"id":"pmid:20939050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20939050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research. Part A","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2975874","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2975874/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Biomed Mater Res A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2975874","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2975874/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Biomed Mater Res A","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7830724188","display_name":"Surface Analysis Facility for Biomedical Problems","funder_award_id":"P41EB002027","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G7844593470","display_name":"Training in Engineered Biomaterials","funder_award_id":"T32GM065098","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1563081363","https://openalex.org/W1572786395","https://openalex.org/W1815659686","https://openalex.org/W1969991492","https://openalex.org/W1979851126","https://openalex.org/W1983651055","https://openalex.org/W1985359125","https://openalex.org/W1986917358","https://openalex.org/W1990312664","https://openalex.org/W1995063875","https://openalex.org/W1996045920","https://openalex.org/W1996180151","https://openalex.org/W1997133573","https://openalex.org/W1998652882","https://openalex.org/W2006153397","https://openalex.org/W2014770216","https://openalex.org/W2023124533","https://openalex.org/W2026077248","https://openalex.org/W2028805384","https://openalex.org/W2030695078","https://openalex.org/W2044099088","https://openalex.org/W2046391247","https://openalex.org/W2046624163","https://openalex.org/W2059849792","https://openalex.org/W2069666749","https://openalex.org/W2080229416","https://openalex.org/W2082426134","https://openalex.org/W2083345634","https://openalex.org/W2086888505","https://openalex.org/W2090187350","https://openalex.org/W2109310258","https://openalex.org/W2118734174","https://openalex.org/W2128091651","https://openalex.org/W2136445687","https://openalex.org/W2143040331","https://openalex.org/W2155353280","https://openalex.org/W2162804001","https://openalex.org/W2333038355"],"related_works":["https://openalex.org/W2507079450","https://openalex.org/W2023124533","https://openalex.org/W2069666749","https://openalex.org/W1998652882","https://openalex.org/W2026077248","https://openalex.org/W2069870790","https://openalex.org/W2049059816","https://openalex.org/W4231522410","https://openalex.org/W2080229416","https://openalex.org/W1975383019"],"abstract_inverted_index":{"The":[0],"role":[1,198,211],"of":[2,8,95,110,174],"complement":[3],"C3":[4,177,214],"in":[5,26,55,71,80,87,148,199,215],"mediating":[6,27,200],"adhesion":[7,54,61,123,161,188,202],"monocytes":[9],"to":[10,98,124,167,178,182,189,203],"plasma":[11,30],"deposited":[12,31],"tetraglyme":[13,96,114,125,155,190,204],"surfaces":[14,115,185],"was":[15,162],"studied.":[16],"Although":[17],"fibrinogen":[18],"(Fg)":[19],"is":[20],"usually":[21],"considered":[22],"the":[23,85,93,131,146,179,184,206],"main":[24],"factor":[25],"phagocyte":[28,60],"attachment,":[29],"PEO-like":[32],"tetraethylene":[33],"glycol":[34],"dimethyl":[35],"ether":[36],"(tetraglyme)":[37],"coatings":[38],"that":[39,153],"have":[40],"ultra-low":[41],"Fg":[42,77,99,112,133,141,193],"adsorption":[43,78],"(<10":[44],"ng":[45],"cm(-2))":[46],"from":[47,116],"low":[48,52],"concentration":[49,118],"solutions":[50],"and":[51,65,105],"monocyte":[53,122,160,187,201,216],"vitro":[56],"still":[57],"show":[58,208],"high":[59],"after":[62],"short":[63],"implantations":[64],"later":[66],"become":[67],"encapsulated":[68],"when":[69],"tested":[70],"vivo.":[72],"To":[73],"test":[74],"whether":[75],"higher":[76,86,117],"under":[79],"vivo":[81,88,149],"conditions":[82],"could":[83],"explain":[84],"reactivity,":[89],"we":[90],"again":[91],"measured":[92],"resistance":[94],"films":[97],"adsorption.":[100,134],"We":[101,135,151],"found":[102,152],"a":[103],"surprising":[104],"previously":[106],"unreported":[107],"increased":[108,132,147],"amount":[109],"adsorbed":[111,169,213],"on":[113,154],"protein":[119],"solutions.":[120],"However,":[121],"did":[126],"not":[127],"markedly":[128],"increase":[129],"despite":[130],"thus":[136],"suspected":[137],"proteins":[138],"other":[139],"than":[140],"must":[142],"be":[143],"responsible":[144],"for":[145,212],"reactivity.":[150],"preadsorbed":[156],"with":[157,170],"C3-depleted":[158],"serum,":[159],"greatly":[163],"reduced":[164],"as":[165],"compared":[166],"samples":[168],"normal":[171],"serum.":[172],"Addition":[173],"exogenous":[175],"pure":[176],"serum":[180],"used":[181],"preadsorb":[183],"restored":[186],"coatings.":[191],"While":[192],"clearly":[194],"plays":[195],"an":[196,209],"important":[197],"surfaces,":[205],"results":[207],"additional":[210],"adhesion.":[217]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}