{"id":"https://openalex.org/W2080136883","doi":"https://doi.org/10.1002/jor.20339","title":"Anti\u2010catabolic effect of OP\u20101 in chronically compressed intervertebral discs","display_name":"Anti\u2010catabolic effect of OP\u20101 in chronically compressed intervertebral discs","publication_year":2007,"publication_date":"2007-01-04","ids":{"openalex":"https://openalex.org/W2080136883","doi":"https://doi.org/10.1002/jor.20339","mag":"2080136883","pmid":"https://pubmed.ncbi.nlm.nih.gov/17205567"},"language":"en","primary_location":{"id":"doi:10.1002/jor.20339","doi":"https://doi.org/10.1002/jor.20339","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.20339","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.20339","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.20339","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014537259","display_name":"Susan Chubinskaya","orcid":"https://orcid.org/0009-0007-1693-0519","observed_orcids":["https://orcid.org/0009-0007-1693-0519"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan Chubinskaya","raw_affiliation_strings":["Department of Biochemistry and Section of Rheumatology, Rush University Medical Center, 1735 W. Harrison, Chicago, Illinois 60612, USA. schubins@rush.edu","Department of Biochemistry and Section of Rheumatology, Rush University Medical Center, 1735 W. Harrison, Chicago, Illinois 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Section of Rheumatology, Rush University Medical Center, 1735 W. Harrison, Chicago, Illinois 60612, USA. schubins@rush.edu","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Biochemistry and Section of Rheumatology, Rush University Medical Center, 1735 W. Harrison, Chicago, Illinois 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081103837","display_name":"Mamoru Kawakami","orcid":"https://orcid.org/0000-0002-2182-3132","observed_orcids":["https://orcid.org/0000-0002-2182-3132","https://orcid.org/0009-0001-6913-3755"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mamoru Kawakami","raw_affiliation_strings":["Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033478459","display_name":"Lev Rappoport","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lev Rappoport","raw_affiliation_strings":["Department of Biochemistry and Section of Rheumatology, Rush University Medical Center, 1735 W. Harrison, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Section of Rheumatology, Rush University Medical Center, 1735 W. Harrison, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111933796","display_name":"Takuji Matsumoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuji Matsumoto","raw_affiliation_strings":["Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070584941","display_name":"Nami Migita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nami Migita","raw_affiliation_strings":["Stryker Biotech, 35 South Street, Hopkinton, Massachusetts 01748"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stryker Biotech, 35 South Street, Hopkinton, Massachusetts 01748","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046875556","display_name":"David C. Rueger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David C. Rueger","raw_affiliation_strings":["Stryker Biotech, 35 South Street, Hopkinton, Massachusetts 01748"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stryker Biotech, 35 South Street, Hopkinton, Massachusetts 01748","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014537259"],"corresponding_institution_ids":["https://openalex.org/I1285301757"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":null,"fwci":4.9566,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.95166415,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"25","issue":"4","first_page":"517","last_page":"530"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11518","display_name":"Cervical and Thoracic Myelopathy","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteogenic-protein-1","display_name":"osteogenic protein-1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/op-1","display_name":"OP-1","score":0.703000009059906},{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.9710000157356262},{"id":"https://openalex.org/keywords/nucleus-pulposus","display_name":"nucleus pulposus","score":0.8389999866485596},{"id":"https://openalex.org/keywords/disc-compression","display_name":"disc compression","score":0.7170000076293945},{"id":"https://openalex.org/keywords/intradiscal-injection","display_name":"intradiscal injection","score":0.8500000238418579},{"id":"https://openalex.org/keywords/anabolic-effects","display_name":"anabolic effects","score":0.6859999895095825},{"id":"https://openalex.org/keywords/anti-catabolic-effects","display_name":"anti-catabolic effects","score":0.9829999804496765},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8880000114440918},{"id":"https://openalex.org/keywords/aggrecanase","display_name":"aggrecanase","score":0.953000009059906},{"id":"https://openalex.org/keywords/mmp-13","display_name":"MMP-13","score":0.9890000224113464},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.871999979019165},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/annulus-fibrosus","display_name":"annulus fibrosus","score":0.8309999704360962},{"id":"https://openalex.org/keywords/end-plates","display_name":"end plates","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.8158231973648071},{"id":"https://openalex.org/C2776157581","wikidata":"https://www.wikidata.org/wiki/Q4692239","display_name":"Aggrecanase","level":5,"score":0.7680034637451172},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.5250511169433594},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5217791199684143},{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.505828857421875},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5036517977714539},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.4791968762874603},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.47629156708717346},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4490552246570587},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.429909884929657},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41230159997940063},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.4104020297527313},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3970460891723633},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3359431028366089},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.312265545129776},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.30137932300567627},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10722064971923828},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.06887760758399963},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007405","descriptor_name":"Intervertebral Disc Displacement","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007405","descriptor_name":"Intervertebral Disc Displacement","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055419","descriptor_name":"Bone Morphogenetic Protein 7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jor.20339","doi":"https://doi.org/10.1002/jor.20339","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.20339","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.20339","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},{"id":"pmid:17205567","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17205567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic research : official publication of the Orthopaedic Research Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jor.20339","doi":"https://doi.org/10.1002/jor.20339","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.20339","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.20339","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310842","display_name":"Stryker","ror":"https://ror.org/043affe91"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2080136883.pdf","grobid_xml":"https://content.openalex.org/works/W2080136883.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W11062661","https://openalex.org/W62447960","https://openalex.org/W130198362","https://openalex.org/W1581461985","https://openalex.org/W1595864962","https://openalex.org/W1743986849","https://openalex.org/W1905957769","https://openalex.org/W1964559562","https://openalex.org/W1966630310","https://openalex.org/W1974889608","https://openalex.org/W1980435560","https://openalex.org/W1981113633","https://openalex.org/W1984418249","https://openalex.org/W1989599927","https://openalex.org/W1991625786","https://openalex.org/W1992735807","https://openalex.org/W1994077598","https://openalex.org/W1994619728","https://openalex.org/W1994877694","https://openalex.org/W1997318094","https://openalex.org/W1998384062","https://openalex.org/W2008776067","https://openalex.org/W2018559769","https://openalex.org/W2022675831","https://openalex.org/W2024700191","https://openalex.org/W2036264639","https://openalex.org/W2036586548","https://openalex.org/W2040796174","https://openalex.org/W2041244298","https://openalex.org/W2046428210","https://openalex.org/W2056362017","https://openalex.org/W2057042920","https://openalex.org/W2060900183","https://openalex.org/W2066698984","https://openalex.org/W2073645604","https://openalex.org/W2076466392","https://openalex.org/W2077969224","https://openalex.org/W2093135693","https://openalex.org/W2106134409","https://openalex.org/W2113641726","https://openalex.org/W2116827538","https://openalex.org/W2148350900","https://openalex.org/W2158681892","https://openalex.org/W2164545627","https://openalex.org/W2170490653","https://openalex.org/W2269254642","https://openalex.org/W2323837976","https://openalex.org/W4313333840"],"related_works":["https://openalex.org/W2076466392","https://openalex.org/W1994834259","https://openalex.org/W2572037180","https://openalex.org/W2112529721","https://openalex.org/W1969999120","https://openalex.org/W2032739162","https://openalex.org/W2570023047","https://openalex.org/W3125616396","https://openalex.org/W7051557213","https://openalex.org/W3141131163"],"abstract_inverted_index":{"Experimental":[0],"animal":[1],"models":[2],"of":[3,25,36,39,91,98,140,144,155,161,176,197,213,219,238,250],"disc":[4,48,131,220],"degeneration":[5,49],"have":[6],"been":[7],"used":[8],"to":[9,29,128],"assess":[10],"the":[11,20,31,89,107,129,138,141,145,152,156,166,194,211,217,236,248],"biomechanical":[12],"behavior,":[13],"biochemical":[14],"composition,":[15],"and":[16,33,45,69,82,95,104,111,122,159,171,189,206,231],"biological":[17],"changes":[18],"in":[19,47,151,165,202,216,235],"intervertebral":[21],"discs.":[22],"The":[23,125,173],"objective":[24],"our":[26,243],"study":[27,192],"was":[28,76,86,178],"evaluate":[30],"anabolic":[32,134],"anti-catabolic":[34,96,174,195],"effects":[35,97],"intradiscal":[37,79],"injection":[38,127],"Osteogenic":[40],"Protein-1":[41],"(OP-1)":[42],"by":[43,102,137,180],"histology":[44,103],"immunohistochemistry":[46,105],"model.":[50],"Thirty-four":[51],"rats":[52],"were":[53,100],"divided":[54],"into":[55],"five":[56],"groups:":[57,72],"intact":[58],"control;":[59,61],"sham":[60],"compressed":[62],"nucleus":[63],"pulposus":[64],"(NP)":[65],"injected":[66],"with":[67,106,229],"saline;":[68],"two":[70],"OP-1":[71,80,92,99,126,163,177,198,214,251],"COP-1":[73],"group":[74,84],"(compression":[75,85],"continued":[77],"after":[78],"injection)":[81],"ROP-1":[83],"released":[87],"at":[88],"time":[90],"injection).":[93],"Anabolic":[94],"evaluated":[101],"following":[108],"antibodies:":[109],"anti-pro-":[110],"anti-mature":[112],"OP-1,":[113],"anti-MMP-13,":[114],"anti-aggrecanase,":[115],"anti-substance":[116],"P,":[117,187],"anti-tumor":[118],"necrosis":[119],"factor-alpha":[120],"(TNF-alpha),":[121],"anti-interleukin-1beta":[123],"(IL-1beta).":[124],"degenerative":[130],"stimulated":[132],"an":[133],"response":[135],"characterized":[136],"restoration":[139],"normal":[142],"morphology":[143],"disc,":[146],"increased":[147],"Safranin":[148],"O":[149],"staining":[150],"NP,":[153,167],"extention":[154],"extracellular":[157],"matrix,":[158],"stimulation":[160],"endogenous":[162],"synthesis":[164],"annulus":[168],"fibrosis":[169],"(AF),":[170],"end-plate.":[172],"effect":[175,249],"documented":[179],"reduced":[181],"immunostaining":[182],"for":[183,210],"aggrecanase,":[184],"MMP-13,":[185],"substance":[186,223],"TNF-alpha,":[188],"IL-1beta.":[190],"This":[191],"confirmed":[193],"activity":[196],"as":[199],"demonstrated":[200],"previously":[201,244],"human":[203],"articular":[204],"cartilage":[205],"provided":[207],"critical":[208],"evidence":[209],"potential":[212],"therapy":[215],"treatment":[218],"degeneration.":[221],"Because":[222],"P":[224],"is":[225],"a":[226,233],"neuropeptide":[227],"linked":[228],"inflammation":[230],"pain,":[232],"reduction":[234],"level":[237],"this":[239],"protein":[240],"may":[241],"support":[242],"reported":[245],"results":[246],"on":[247,252],"pain-related":[253],"behavior.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
